Biosciences

Select projects from the list below and contact the supervisor directly by email or telephone (click on the name of the supervisor and you will be taken to their homepage).

Title	Supervisor(s)	Research Centre
A genetic and cytogenetic assessment of radiation- induced leukaemogenesis	Dr Rhona Anderson Dr Sabrina Tosi	Centre for Cell and Chromosome Biology
Analysis of telomerase, telomeres and DNA damage response mechanisms in cells from Dyskeratosis congenita patients	Dr. Predrag Slijepcevic	Brunel Institute of Cancer Genetics and Pharmacogenomics
Characterisation of Wnt-signalling specific Dishevelled point mutants in Drosophila	Dr David Tree	Centre for Cell and Chromosome Biology
Chromatin dynamics, chromosome rearrangement and cancer	Dr Rhona Anderson Dr Joanna Bridger	Centre for Cell and Chromosome Biology
Development of a new hybrid biomaterial for the prevention of surgical adhesions	Dr Ian Kill	Centre for Cell and Chromosome Biology
Using functional genomic tools to identify the transcription program regulated by Egr-2 in the control of autoimmune diseases	Dr Suling Li Professor Xiaohui Liu Professor P. Wang	Brunel Institute of Cancer Genetics and Pharmacogenomics
Differential expression patterns and transport characteristics of aged cells	Dr Gudrun Stenbeck Dr Ian Kill	Centre for Cell and Chromosome Biology
Differential expression patterns associated with the development of systemic sclerosis	Dr Gudrun Stenbeck	Centre for Cell and Chromosome Biology
DNA Damage and Repair in Hutchinson Gilford Progeria Syndrome Cells	Dr Ian Kill	Centre for Cell and Chromosome Biology
Identification of novel anti-cancer drug targets aimed at reactivating oncogene-induced senescence in human tumour cells	Professor R F Newbold Dr T Roberts Dr H Yasaei Professor D Gilbert Professor H Lui	Brunel Institute of Cancer Genetics and Pharmacogenomics
Immunogenic anti-cancer chemotherapy: drug-induced potentiation of anti-cancer immunity	Dr Uday Kishore Professor R F Newbold	Centre for Cell and Chromosome Biology Laboratory of Human Immunology and Infection Biology
In silico modelling of interphase chromosome dynamics within healthy and diseased cell nuclei	Dr Joanna Bridger Prof Xiaohui Liu	Centre for Cell and Chromosome Biology Centre for Intelligent Data Analysis
Innate Immunity against Tuberculosis: Interaction of Mycobacteria Antigens with Lung Surfactant Proteins	Dr Anthony Tsolaki Dr Uday Kishore	Centre for Cell and Chromosome Biology Laboratory of Human Immunology and Infection Biology
Investigating the host-pathogen relationship in Tuberculosis	Dr Anthony Tsolaki Dr Uday Kishore	Centre for Cell and Chromosome Biology Laboratory of Human Immunology and Infection Biology
Investigation of cortisol and oxytocin signalling in human ovarian cancer: when the stress hormone meets the social hormone	Dr Emmanouil Karteris Dr Mariann Rand-Weaver	Brunel Institute of Cancer Genetics and Pharmacogenomics
Involvement of the matrix protein SPARC in the dynamic interaction between tumour and host cells	Dr Gudrun Stenbeck	Centre for Cell and Chromosome Biology
Mycobacterium tuberculosis Rv3018c is a C1q binding protein: Role of Innate Immunity in Tuberculosis	Dr Anthony Tsolaki Dr Uday Kishore	Centre for Cell and Chromosome Biology Laboratory of Human Immunology and Infection Biology
Molecular and cellular studies of Friedreich ataxia	Dr Mark Pook Dr Evgeny Makarov	Centre for Cell and Chromosome Biology Brunel Institute of Cancer Genetics and Pharmacogenomics
Molecular, cellular and systems biology studies of Friedreich ataxia	Dr Mark Pook Professor D Gilbert Professor Xiaohui Liu	Centre for Cell and Chromosome Biology Brunel Institute of Cancer Genetics and Pharmacogenomics
Pulmonary surfactant protein D as a novel therapy for allergy and asthma	Dr Uday Kishore Dr Anthony Tsolaki	Centre for Cell and Chromosome Biology Laboratory of Human Immunology and Infection Biology
Reconstruction of a 3-D model of skin for ageing studies	Dr Ian Kill	Centre for Cell and Chromosome Biology
Regulation of asymmetric stem cell division in Drosophila melanogaster	Dr David Tree	Centre for Cell and Chromosome Biology
Regulation of Brk Expression in Breast Cancer Cell Lines	Dr Amanda Harvey	Brunel Institute for Cancer Genetics and Pharmacogenomics
Role of the classical complement pathway in the pathogenesis of Alzheimer's disease (AD) and familial dementia: novel treatment strategies	Dr Uday Kishore Dr Anthony Tsolaki	Centre for Cell and Chromosome Biology Laboratory of Human Immunology and Infection Biology
Schistosoma parasite interactions with and influences over the host genome	Dr Joanna Bridger Dr Anthony Tsolaki Dr Matty Knight	Centre for Cell and Chromosome Biology
Studies to determine the cause of cancer in mice treated with gene therapy vectors	Dr Michael Themis	Centre for Cell and Chromosome Biology
Study of alternative splicing of the Lamin A pre-mRNA	Dr Evgeny Makarov	Institute for Cancer Genetics and Pharmacogenomics
Study of the hTERT alternative splicing regulation as a potential cancer therapeutic modality	Dr Evgeny Makarov	Institute for Cancer Genetics and Pharmacogenomics
Studying the Effect of Ageing on Drosophila Stem Cells	Dr David Tree	Centre for Cell and Chromosome Biology
The application of Advanced Computing Techniques to image analysis problems in Cancer Research	Dr Rhona Anderson Dr Simon Kent	Centre for Cell and Chromosome Biology Centre for Information and Knowledge Management
The effect of Brk/PTK6 on genome and nuclear organisation in breast cancer cells	Dr Amanda Harvey Dr Joanna Bridger	Brunel Institute for Cancer Genetics and Pharmacogenomics Centre for Cell and Chromosome Biology
The functional control of chromatin dynamics by nuclear motor proteins in normal cells and in cells derived from patients with Hutchinson-Gilford Progeria Syndrome	Dr Joanna Bridger Dr Sabrina Tosi	Centre for Cell and Chromosome Biology Brunel Institute for Ageing Studies
Study of position effect as a mechanism arising from chromosomal translocations in leukaemia	Dr Sabrina Tosi Dr Joanna Bridger	Centre for Cell and Chromosome Biology