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Institute for the Environment

Professor John P. Sumpter

Professor John P. Sumpter

Email: John.Sumpter@brunel.ac.uk
Phone: 01895 274000 Ext: 66303
Direct Line: 01895 266303
Building: Halsbury
Room No: 128

I head a research group focussed on chemicals in the aquatic environment, and their effects on fish. I discovered endocrine disruption in fish, caused by estrogenic chemicals entering rivers in effluents from sewage treatment works. My research group currently consists of 3 post-doctoral fellows and four Ph.D. students. Our main focus has broadened from just estrogenic chemicals, and now includes other human pharmaceuticals present in rivers, such as beta-blockers, other steroid hormones (e.g. progestogens, glucocorticoids), and anti-cancer drugs. Our research ranges from detailed molecular studies of the mechanisms of action of these chemicals through to ecological studies on fish populations.

Qualifications

  • 1973: First-class Honours Degree in Zoology/Marine Zoology from University College of North Wales, Bangor.
  • 1977: PhD from University College of North Wales, Bangor.
  • 1987: Elected Fellow of the Institute of Biology.
  • 1991: Awarded DSc from University of Wales
  • 2004: Made ‘Distinguished Professor’ of Brunel University

Career

  • 1976-78: Post-doctoral Fellow at University College of North Wales, Bangor.
  • 1978-87: Lecturer in Applied Biology, Brunel University.
  • 1987-91: Reader in Department of Biology and Biochemistry, Brunel University.
  • 1991-2005: Professor in Department of Biology and Biochemistry, Brunel University, and Head of the Ecotoxicology Research Group.
  • 2001-03: Head of Department of Biological Sciences, Brunel University
  • 2004: Dean of the Faculty of Life Sciences, Brunel University
  • 2005-present: Professor in Institute for the Environment, Brunel University
  • 2007-2011: Head of Institute for the Environment, Brunel University.

When I came to Brunel University in 1978, the University had a very low research profile; only a few staff were active in research. Over the next twenty years, I built up a large research group, consisting of twenty staff at its peak.

My research can be broken down into two related, though somewhat separate, fields. One, which I began with my PhD, and have continued ever since, is concerned with the hormonal control of fish reproduction (and, to a lesser extent, stress). The other is concerned with endocrine disruption; it is in this area that I now concentrate most of my efforts, and for which I have an international reputation.

Supervision of Research Students

My first PhD student was awarded her degree in 1983. Since then, I have successfully supervised a further 25 full-time PhD students, plus two external PhD students, and 3 M.Phil. students. Presently, I am supervising 1 M.Phil. student, 2 PhD students and 4 post-doctoral fellows.

Membership of Learned Societies

  • Society for Experimental Biology
  • The Fisheries Society of the British Isles
  • European Society for Comparative Endocrinology
  • Society for the Study of Fertility
  • Society for Endocrinology
  • Society for the Study of Reproduction
  • SETAC

I have delivered talks at meetings organised by all of these societies, and at many other national and international meetings

Major Research Grants Awarded

  • Royal Society: Scientific investigation grant of £4,652 for the purchase of an automatic gamma-counter.
  • SERC: £30,430 from 1 October 1980 until 30 September 1983 for a study entitled ‘The characterization and physiological roles of peptides derived from pro-opiomelanocortin in fishes’ (in collaboration with Dr P J Lowry, St Bartholomew’s Hospital).
  • MAFF: £18,050 from 1 January 1981 until 31 March 1984 for a study entitled ‘The purification, characterization and physiological roles of salmonid gonadotrophin.’
  • SERC: £39,340 from 1 October 1984 until 31 September 1987 for a study entitled ‘Ovarian uptake of vitellogenin in the Rainbow Trout’ in collaboration with Dr N R Bromage, University of Aston).
  • Royal Society: £8,520 from 1 May 1984 until 31 December 1984 from the Anglo-Canadian exchange scheme to enable me to spend nine months on sabbatical leave in the laboratory of Dr E M Donaldson in Vancouver.
  • SERC: £18,060 from 1 January 1987 to 31 December 1987 for a study entitled ‘Hormonal control of growth and sea-water adaptation in rainbow trout’ (in collaboration with Dr Vic Bye, MAFF, Lowestoft, though he was not formally named on the grant).
  • MAFF: £37,000 from 1 December 1986 to 31 March 1987 for a study entitled “The effects of environmental stress on the physiology of growth in trout”. (Awarded jointly to Dr A D Pickering, Freshwater Biological Association, Windermere, and myself).
  • Department of the £83,142 from 1 January 1988 to 30 June 1990 for a study entitled “Effects of Environment: trace organics on coarse fish.
  • MAFF: £23,508 from 1 January 1989 to 31 December 1989 for a study entitled “The induction and metabolic demands of vitellogenin synthesis in carp”.
  • EC: £60,000 from 1 June 1990 to 31 May 1992 from the Fisheries Directorate to support a French Post-doctoral Fellow.
  • Department of the £146,025 from 1 October 1991 to 31 March 1995 for a study entitled “Effects of Environment: trace organics on coarse fish: Phase 2”.
  • AFRC: £98,000 from 1 September 1991 to 31 August 1994 for a study entitled "Determination of the physiological function, or functions, of somatolactin, a new member of the growth hormone/prolactin family in trout”.
  • MAFF: £65,597 from 1 June 1992 to 31 May 1995 for a field study of the effects of oestrogens in effluent on fish.
  • EC: £130,000 from 1 November 1993 to 31 October 1996 for a study entitled “Egg quality determinants of teleost fish”.
  • NRA: £142,916 from 1 December 1993 to 31 March 1997 for a study entitled “Identification of estrogenic substances in STW effluent”.
  • NERC: £138,418 from 1 March 1994 to 28 February 1997 for a study entitled “Effects of alkylphenols and related chemicals on gonad development, sex determination, and gamete quality of trout”.
  • BBSRC: £57,540 from 1 September 1994 to 31 August 1995 for a study entitled “Studies of somatolactin in fish and higher vertebrates”.
  • BBSRC: £127,892 from 1 January 1995 to 31 December 1997 for a study entitled “Molecular characterization of the vitellogenin receptor and the dynamics of its expression”, (with Dr C R Tyler).
  • ECETOC: £165,000 from 1 April 1995 to 31 March 1998 for studies on the oestrogenic properties of chemicals.
  • European Union: 97,622 ECU for a study from 1 January 1995 to 31 December 1996 for a study entitled “Molecular characterization of the vitellogenin receptor and control of its expression”.
  • NERC: £250,000 from 1 April 1995 to 31 March 2000 for a study entitled “Oestrogenic chemicals in the aquatic environment and their effects on fish”.
  • NERC: £75,283 from 1 October 1995 to 30 September 1997 for a study entitled “Oestrogenic activity of phthalates”.
  • Brunel University: £200,000 from 1 September 1995 to 31 August 2000, as matching funds to complement the NERC grant of £250,000 (see above).
  • European Union: 90,000 ECU from 1 April 1996 to 31 March 1998 for a study entitled “Male reproductive health and environmental chemicals” (part of a large project).
  • European Union: 105,000 ECU from 1 April 1996 to 31 March 1999, for a study entitled “Environmental halogenated aromatic hydrocarbons and estrogens: mechanism of action, interactions, and test-system development” (part of a large project).
  • Wellcome Trust: £58,038 from 1 September 1996 to 31 August 1999 for a study entitled “Effects of exposure to oestrogenic xenobiotics during early development on the expression of genes controlling sexual development” (with Drs Tyler and Rand-Weaver).
  • Environment Agency: £84,000 from 1 October 1996 to 30 September 1999 for the support of two studentships in the area of endocrine disruption (with Dr Tyler)
  • An industrial Company: £79,400 from 1 August 1996 to 31 July 1998 for a study of some industrial chemicals.
  • European Union £78,540 from 1 January 1998 to 31 December 1999 for a study entitled 'Do environmental estrogens (EEs) disrupt the neuro-endocrine regulation of reproduction in fish?'
  • Dept of Environment: £60,000 from 1 February 1998 to 31 January 2000 for a study entitled Transport and the "Endocrine disruption in the gudgeon". (with Dr Tyler). Regions
  • NERC: £186,145 from 1 July 1998 to 30 June 2001 for a study entitled "Reproductive capabilities of wild intersex fish" (with Dr C Tyler).
  • HEFCE: £51,000 (plus matching funds from Brunel University) to refurbish a laboratory.
  • Brunel University: £68,000 to establish a Fish Ecotoxicology Unit
  • BBSRC: £148,752 from 1 June 1998 to 31 May 2001 for a study entitled "Molecular characterization and developmental expression of enzymes mediating yolk processing (with Dr C Tyler).
  • CEFIC (the European Chemicals Industries £122,195 from 1 September 1998 to 31 August 2000 for a study entitled ") An ecological study to assess Bisphenol-A as an environmental oestrogen."
  • EMSG (an industry consortium £185,906 from 1 October 1998 to 30 September 2003 for a study) “Joint programme on endocrine disruptors in the aquatic environment”.
  • An industrial Company: £39,700 for one year from 16 November 1998 for a study entitled “Endocrine activity of landfill leachate”.
  • European Union: £120,000 from 1 January 1999 to 31 December 2001 for a study entitled “Community Programme of research on environmental hormones and endocrine disruptors” (COMPREHEND).
  • DETR: £132,048 from 1.8.2001-31.2.2004 for a study entitled “A search for evidence of endocrine disruption in top predator fish”.
  • European Union: £372,000 (538,903 Euros) from 1.12.01 to 30.11.04, for a study entitled “Analyzing combination effects of oestrogenic chemicals. This is part of a larger project (ACE), total budget 2.4 million Euros, which I co-ordinate.
  • European Union: £208,000 (322,960 Euros) from 1.12.02 to 30.11.06 for a study entitled “Endocrine Disruptors: Exploring novel endpoints, exposure, low dose and mixture effects in human, aquatic wildlife and laboratory animals”. This was part of a much larger project (EDEN), which has a total budget of 10.8 million Euros.
  • AstraZeneca/Pfizer: £92,610 from 1.3.04 to 28.2.06 for a study entitled “Physiological Responses of Fish to Pharmaceuticals”.
  • European Union: About £180,000 (290,000 Euros) from 1.9.04 to 31.8.07 for a study entitled “Environmental Risk Assessment of Pharmaceuticals”. This was part of a large project (ERAPharm).
  • NERC: £237,517 from 1.1.06 to 31.12.09 for a study entitled “Confounding Factors in the Risk Assessment of mixtures of estrogenic chemicals”
  • DEFRA: £323,400 from 1.1.06 to 31.12.08 for a study entitled “Influence of endocrine disruption on reproduction in roach”.
  • AstraZeneca: £50,540 from 1.3.06 to 28.2.07 for a continuation of the study “Physiological Responses of Fish to Pharmaceuticals”.
  • GlaxoSmithKline (GSK): £100,000 from 1.5.07 to 30.4.2010 for a project entitled “Research on pharmaceuticals in the environment”
  • DEFRA: £230,000 from 1/11/08 to 31/10/10 for a study entitled “Intelligent Ecotoxicology: progestogens as a test case”.
  • CEFAS: £64,000 from 1/1/09 to 31/12/09 for a study entitled “Validating a sexual development test using the 3-spined stickleback”.

TOTAL VALUE OF GRANTS RAISED WHILE AT BRUNEL: APPROXIMATELY £5 million.

Collaboration with Industry

Much of the research done by the Ecotoxicology Research Group is of considerable interest and relevance to many sectors of industry. This is particularly true of our work on persistent man-made chemicals in the environment which have the ability to mimic endogenous hormones, and thus (potentially) disrupt endocrine-mediated physiological processes, such as reproduction.

Some of the Group’s work is funded by industry, both via collective organisations such as the European Centre for the Ecotoxicology and Toxicology of Chemicals (ECETOC) and by industrial companies (including a number of the world’s largest multinationals). We also have a major ongoing collaboration with AstraZeneca, which links two of their main laboratories (the Environment Laboratory in Brixham and the Central Toxicology Laboratory at Alderley Edge) with my Ecotoxicology Research Group at Brunel.

Postdoctoral Researchers

Dr. Tamsin Runnalls

Dr. Catherine Harris

Dr. Jayne Brian

Postgraduate Researchers

Ms Katie Aoki

Mr Luigi Margiotta-Casaluci

Mr Kugathas Subramaniam

Publications

PhD Thesis: Sumpter, J.P. 1977. Biochemical and physiological studies on the reproductive hormones of the dogfish. University College of North Wales, Bangor.

The most cited researchers in: Environment and Ecology. Ranked by total citations.

Full Refereed Papers

  1. Jenkins, N., Sumpter, J.P. and Follett, B.K. 1978. The effects of vertebrate gonadotrophins on androgen release in vitro from testicular cells of Japanese quail, and a comparison with their radioimmunoassay activities. Gen. Comp. Endocrinol. 35, 309‑321.
  2. Sumpter, J.P., Follett, B.K. and Dodd, J.M. 1978. Studies on the purification of gonadotrophin from dogfish (Scyliorhinus canicula L.) pituitary glands. Ann. Biol. Anim. Biochem. Biophys. 18, 787‑791.
  3. Sumpter, J.P., Follett, B.K., Jenkins, N. and Dodd J.M. 1978. Studies on the purification and properties of gonadotrophin from ventral lobes of the pituitary gland of the dogfish (Scyliorhinus canicula L.). Gen. Comp. Endocrinol. 36, 264‑274.
  4. Sumpter, J.P., Jenkins, N. and Dodd, J.M. 1978. Gonadotrophic hormone in the pituitary gland of the dogfish (Scyliorhinus canicula L.): distribution and physiological significance. Gen. Comp. Endocrinol. 36, 275‑285.
  5. Dodd, J.M., Stuart‑Kregor, P.A.C., Sumpter, J.P., Crim, L.W. and Peter, R.E. 1978. Premature sexual maturation in the Atlantic salmon (Salmo salar L.) In: Gaillard, P.J. and Boer, H.H. (eds.) “Comparative Endocrinology” pp. 101‑104. Elsevier/North Holland, Amsterdam.
  6. Sumpter, J.P. and Dodd, J.M. 1979. The annual reproductive cycle of the female lesser spotted dogfish, Scyliorhinus canicula L., and its endocrine control. J. Fish Biol. 15, 687‑695.
  7. Stuart‑Kregor, P.A.C., Sumpter, J.P. and Dodd, J.M. 1981. The involvement of gonadotrophin and sex steroids in the control of reproduction in the parr and adults of Atlantic salmon, Salmo salar. J. Fish Biol. 18, 59‑72.
  8. Arme, C., Griffiths, D.V. and Sumpter, J.P. 1982. Evidence against the hypothesis that the pleroceroid larva of Ligula intestinalis (Cestoda: Pseudophyllidea) produces a sex steroid that interferes with host reproduction. J. Parasitology 68, 169‑171.
  9. Dodd, J.M., Dodd, M.H.I., Sumpter, J.P. and Jenkins, N. 1982. Gonadotrophic activity in the buccal lobe (Rachedachhypophyse) of the pituitary gland of the rabbit fish (Hydrolagus colliei; Chondrichthyes: Holocephali). Gen. Comp. Endocrinol. 48, 174‑180.
  10. Leatherland, J.F., Copeland, P., Sumpter, J.P. and Sonstegard, R.A. 1982. Hormonal control of gonadal maturation and development of secondary sexual characteristics in Coho salmon, Oncorhynchus kisutch, from Lakes Ontario, Erie and Michigan. Gen. Comp. Endocrinol. 48, 196‑204.
  11. Denning‑Kendall, P.A., Sumpter, J.P. and Lowry, P.J. 1982. Peptides derived from proopiocortin in the pituitary gland of the dogfish Squalus acanthias. J. Endocrinol. 93, 381‑390.
  12. Scott, A.P., Sumpter, J.P. and Hardiman, P.A. 1983. Hormone changes during ovulation in the rainbow trout (Salmo gairdneri Richardson). Gen. Comp. Endocrinol. 49, 128‑134 (cited 190 times).
  13. Rodrigues, K.T., Jenks, B.G. and Sumpter, J.P. 1983. The biosynthesis of proopiomelanocortin‑related peptides in the neurointermediate lobe of the pituitary gland of the rainbow trout, Salmo gairdneri. J. Endocrinol. 98, 271‑282.
  14. Rodrigues, K.T. and Sumpter, J.P. 1983. The distribution of some proopiomelanocortin‑related peptides in the pituitary gland of the rainbow trout, Salmo gairdneri. Gen. Comp. Endocrinol. 51, 454‑459.
  15. Scott A.P. and Sumpter, J.P. 1983. A comparison of the female reproductive cycle of autumn‑ spawning and winter‑spawning strains of rainbow trout (Salmo gairdneri Richardson). Gen. Comp. Endocrinol. 52, 79‑85 (cited 124 times).
  16. Rodrigues, K.T. and Sumpter, J.P. 1984. The radioimmunoassay of ‑melanocyte‑stimulating hormone and endorphin in trout (Salmo gairdneri) and the effects of binding on the plasma levels of these peptides. Gen. Comp. Endocrinol. 54, 69‑75
  17. Burke, M.B., Leatherland, J.F. and Sumpter, J.P. 1984. Seasonal changes in serum testosterone, 11‑ketotestosterone, and 17 ß‑estradiol in brown bullhead, Ictalurus nebulosus Lesueur. Can. J. Zool. 62, 1195‑1199.
  18. Rodrigues, K.T. and Sumpter, J.P. 1984. Effects of background adaptation on the pituitary and plasma concentrations of some proopiomelanocortin related peptides in the rainbow trout (Salmo gairdneri). J. Endocrinol. 101, 277‑284.
  19. Sumpter, J.P., Scott, A.P., Baynes, S.M. and Witthames, P.R. 1984. Early stages of the reproductive cycle in virgin female rainbow trout (Salmo gairdneri Richardson). Aquaculture 43, 235‑242.
  20. Sumpter, J.P., Denning‑Kendall, P.A. and Lowry, P.J. 1984. The involvement of melanotrophins in physiological colour change in the dogfish (Scyliorhinus canicula). Gen. Comp. Endocrinol. 56, 360‑367.
  21. Sumpter, J.P. 1985. The purification, radioimmunoassay and plasma levels of vitellogenin from the rainbow trout, Salmo gairdneri. In: Lofts, B. and Holmes, W.N. (eds.) Current Trends in Comparative Endocrinology, Hong Kong University Press, Hong Kong. pp. 355‑357.
  22. Sumpter, J.P., Pickering, A.D. and Pottinger, T.G. 1985. Stress‑induced elevation of plasma ‑MSH and endorphin in brown trout, Salmo trutta L. Gen. Comp. Endocrinol. 59, 257‑265.
  23. Gill, J.A., Sumpter, J.P., Donaldson, E.M., Dye, H.M., Souza, L., Berg, T., Wypych, J. and Langley, K. 1985. Recombinant chicken and bovine growth hormones accelerate growth in aquacultured juvenile Pacific salmon, Oncorhynchus kisutch. Biotechnology, 3, 643‑646.
  24. Dye, H.M., Sumpter, J.P., McBridge, J.R., Fagerlund, U.H.M. and Donaldson, E.M. 1986. Changes in reproductive parameters during the spawning migration of pink salmon, Oncorhynchus gorbuscha. J. Fish Biol. 29, 167‑176.
  25. Sumpter, J.P. 1986. ACTH‑related material in the pituitary gland of the chinook salmon, Oncorhynchus tschawytscha. Gen. Comp. Endocrinol. 62, 359‑366.
  26. Sumpter, J.P. and Donaldson, E.M. 1986. The development and validation of a radioimmunoassay to measure blood ACTH levels in salmonid fishes. Gen. Comp. Endocrinol. 62, 367‑376.
  27. Sumpter, J.P., Dye, H.M. and Benfey, T.J. 1986. The effects of stress on blood ACTH, ‑MSH and cortisol levels in salmonid fishes. Gen. Comp. Endocrinol. 62, 377‑385 (cited 130 times)
  28. Copeland, P.A., Sumpter, J.P., Walker, T.K. and Croft, M. 1986. Vitellogenin levels in male and female rainbow trout, Salmo gairdneri Richardson, at various stages of the reproductive cycle. Comp. Biochem. Physiol. 83B, 487‑493. (cited 132 times)
  29. Pickering, A.D., Pottinger, T.G. and Sumpter, J.P. 1986. Independence of the pituitary‑interrenal axis and melanotroph activity in the brown trout, Salmo trutta L., under conditions of environmental stress. Gen. Comp. Endocrinol. 64, 206‑211.
  30. Williams, I.V., Brett, J.R., Bell, G.R., Traxler, G.S., Bagshaw, J., McBride, J.R., Fagerlund, U.H.M., Dye, H.M., Sumpter, J.P., Donaldson, E.M., Bilinksi, E., Tsuyuki, H., Peters, M.D., Choromanski, M., Chen, J.H.Y. and Coolidge, W.L. 1986. The 1983 early run Fraser and Thompson pink salmon: morphology, energetics and fish health. Int. Pacific Salmon Fisheries Commission. Bulletin 23, 64 pp.
  31. Pickering, A.D., Pottinger, T.G. and Sumpter, J.F. 1987. On the use of dexamethasone to block the pituitary‑interrenal axis in the brown trout, Salmo trutta L. Gen. Comp. Endocrinol. 65. 346‑353.
  32. Pickering, A.D., Pottinger, T.G., Carragher, J.F. and Sumpter, J.P. 1987. The effects of acute and chronic stress on the levels of reproductive hormones in the plasma of mature male brown trout, Salmo trutta L. Gen. Comp. Endocrinol. 68, 249‑259 (cited 137 times)
  33. Sumpter, J.P., Carragher, J.F., Pottinger, T.G. and Pickering, A.D. 1987. The interaction of stress and reproduction in trout. In: Idler, D.R., Crim, L.W. and Walsh, J.M. (eds). "Reproductive Physiology of Fish 1987" pp. 299‑302.
  34. Tyler, C.R., Sumpter, J.P. and Bromage, N.R. 1988. In vivo ovarian uptake and processing of vitellogenin in the rainbow trout, Salmo gairdneri. J. Exp. Zool., 246, 171‑179.
  35. Tyler, C.R., Sumpter, J.P. and Bromage, N.R. 1988. Selectivity of protein sequestration by vitellogenic oocytes of the rainbow trout, Salmo gairdneri, in vivo. J. Exp. Zool., 248, 199‑206.
  36. Scott, A.P., and Sumpter, J.P. 1989. Seasonal variations in testicular germ cell stages and in plasma concentrations of sex steroids in male rainbow trout (Salmo gairdneri) maturing at 2 years old. Gen. Comp. Endocrinol., 73, 46‑58.
  37. Sumpter, J.P. and Scott, A.P. 1989. Seasonal variations in plasma and pituitary levels of gonadotrophin in males and females of two strains of rainbow trout (Salmo gairdneri). Gen. Comp. Endocrinol. 75, 376‑388.
  38. Carragher, J.F., Sumpter, J.P. Pottinger, T.G. and Pickering, A.D. 1989. The deleterious effects of cortisol implantation on reproductive function in two species of trout, Salmo trutta L. and Salmo gairdneri Richardson. Gen. Comp. Endocrinol., 76, 310‑321 (cited 126 times)
  39. Tyler, C.R. and Sumpter, J.P. 1990. The purification and partial characterization of carp, Cyprinus carpio, vitellogenin. Fish Physiol. Biochem., 8, 111‑120.
  40. Tyler, C.R. and Sumpter, J.P. 1990. The development of a radioimmunoassay for carp, Cyprinus carpio, vitellogenin. Fish Physiol. Biochem., 8, 129‑140.
  41. Carragher, J.F. and Sumpter, J.P. 1990. The effect of cortisol on the secretion of sex steroids from cultured ovarian follicles of rainbow trout. Gen. Comp. Endocrinol., 77, 403‑407.
  42. Tyler, C.R., Sumpter, J.P. and Handford, R.M. 1990. The dynamics of vitellogenin sequestration into vitellogenic ovarian follicles of the rainbow trout, Salmo gairdneri. Fish Physiol. Biochem., 8, 211‑219.
  43. Tyler, C.R., Sumpter, J.P. and Bromage, N.R. 1990. An in vitro culture system for studying vitellogenin uptake into ovarian follicles of the rainbow trout, Salmo gairdneri. J. Exp. Zool., 255, 216‑231.
  44. Tyler, C.R., Sumpter, J.P. and Witthames, P.R. 1990. The dynamics of oocyte growth during vitellogenesis in the rainbow trout, Salmo gairdneri. Biol. Reprod., 43, 202‑209.
  45. Le Bail, P.Y., Sumpter, J.P., Carragher, J.F., Mourot, B., Niu, P.D. and Weil, C. 1991. Development and validation of a highly sensitive radioimmunoassay to chinook salmon (Oncorhynchus tshawytscha) growth hormone. Gen. Comp. Endocrinol. 83, 75‑85.
  46. Pickering, A.D., Pottinger, T.G., Sumpter, J.P., Carragher, J.F. and Le Bail, P.Y. 1991. Effects of acute and chronic stress on the levels of circulating growth hormone in the rainbow trout, Oncorhynchus mykiss. Gen. Comp. Endocrinol. 83, 86‑93.
  47. Sumpter, J.P., Le Bail, P.Y., Pickering, A.D., Pottinger T.G. and Carragher, J.F. 1991. The effect of starvation on growth and plasma growth hormone concentrations of rainbow trout, Oncorhynchus mykiss. Gen. Comp. Endocrinol. 83, 94‑102. (cited 104 times)
  48. Sumpter, J.P., Lincoln, R.F., Bye, V.J., Carragher, J.F. and Le Bail, P.Y. 1991. Plasma growth hormone levels during sexual maturation in diploid and triploid rainbow trout (Oncorhynchus mykiss). Gen. Comp. Endocrinol. 83, 103‑110.
  49. Carragher, J.F. and Sumpter, J.P. 1991. The mobilization of calcium from calcified tissues of rainbow trout (Oncorhynchus mykiss) induced to synthesize vitellogenin. Comp. Biochem. Physiol., 99A, 169‑172.
  50. Tyler, C.R., Sumpter, J.P. and Campbell, P. 1991. Uptake of vitellogenin into oocytes during early vitellogenic development in the rainbow trout, Oncorhynchus mykiss. J. Fish Biol. 38, 681‑689.
  51. Tyler, C.R., Sumpter, J.P., Kawauchi, H. and Swanson, P. 1991. Involvement of gonadotrophin in the uptake of vitellogenin into vitellogenic oocytes of the rainbow trout, Oncorhynchus mykiss. Gen. Comp. Endocrinol. 84, 291‑299. (cited 100 times)
  52. Pottinger, T.G., Campbell, P.M. and Sumpter, J.P. 1991. Stress‑induced disruption of the salmonid liver‑gonad axis. In: Scott, A.P. et al. (eds.) "Reproductive Physiology of Fish", pp. 114‑116. Fish Symp. 91, Sheffield.
  53. Pelissero, C., Foucher, J.L., Bennetau, B., Dunogues, J., Flouriot, G. and Sumpter, J.P. 1991. In vitro estrogenic activity of phytoestrogens on liver vitellogenin synthesis in the rainbow trout (Oncorhynchus mykiss). In: Scott, A.P. et al. (eds.) "Reproductive Physiology of Fish", pp. 247‑249. Fish Symp. 91, Sheffield.
  54. Sumpter, J.P. 1992. Control of growth of rainbow trout (Oncorhynchus mykiss). Aquaculture 100, 299‑320. Also published in: Gall, G.A.E. (ed.) "The Rainbow Trout", pp. 299‑320, Elsevier, Amsterdam.
  55. Pelissero, C. and Sumpter, J.P. 1992. Steroids and "steroid‑like" substances in fish diets. Aquaculture 107, 283‑301. (cited 108 times)
  56. Campbell, P.M., Pottinger, T.G. and Sumpter, J.P. 1992. Stress reduces the quality of gametes produced by rainbow trout. Biol. Reprod. 47, 1140‑1150.
  57. Pelissero, C., Flouriot, G., Foucher, J.L., Bennetau, B., Dunogues, J., Le Gac, F. and Sumpter, J.P. 1993. Vitellogenin synthesis in cultured hepatocytes: an in vitro test for the estrogenic potency of chemicals. J. Steroid Biochem. Mol. Biol. 44. 263‑272 (cited 180 times).
  58. Sumpter, J.P. and Jobling, S. 1993. Letter to the Editor titled "Male sexual development in ‘a sea of oestrogen’". Lancet, 342, 124‑125.
  59. Rand‑Weaver, M., Pottinger, T.G. and Sumpter, J.P. 1993. Plasma somatolactin concentrations in salmonid fish are elevated by stress. J. Endocrinol. 138, 509‑515.
  60. Jobling, S. and Sumpter, J.P. 1993. Detergent components in sewage effluent are weakly oestrogenic to fish: an in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquatic Toxicol. 27, 361-372 (cited 620 times).
  61. Sheahan, D.A., Bucke, D., Matthiessen, P., Sumpter, J.P., Kirby, M.G., Neall, P. and Waldock, M. 1994. The effects of low levels of 17‑ethynylestradiol upon plasma vitellogenin levels in male and female rainbow trout, Oncorhynchus mykiss (Walbaum), held at two acclimation temperatures. In: Müller, R. And Lloyd, R. (Eds.) Sublethal and chronic effects of pollutants on freshwater fish. Fishing News Books, Oxford. pp. 99-112.
  62. Campbell, P.M., Pottinger, T.G. and Sumpter, J.P. 1994. Preliminary evidence that chronic confinement stress reduces the quality of gametes produced by brown and rainbow trout. Aquaculture, 120, 151-169.
  63. Purdom, C.E., Hardiman, P.A., Bye, V.J., Eno, N.C., Tyler, C.R. and Sumpter, J.P. 1994. Estrogenic effects of effluents from sewage‑treatment works. Chemistry and Ecology, 8, 275-285 (cited 720 times).
  64. Nagler, J.J., Tyler, C.R. and Sumpter, J.P. 1994. Ovarian follicles of rainbow trout (Oncorhynchus mykiss) cultured within lamellae survive well, and sequester and process vitellogenin. J. Exp. Zool. 269, 45-52.
  65. White, R., Jobling, S., Hoare, S.A., Sumpter, J.P. and Parker, M.G. 1994. Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology, 135, 175-182 (cited 870 times).
  66. Campbell, P.M., Pottinger, T.G. and Sumpter, J.P. 1994. Changes in the affinity of estrogen and androgen receptors accompany changes in receptor abundance in brown and rainbow trout. Gen. Comp. Endocrinol. 94, 329-340.
  67. Sumpter, J.P. and Jobling, S. 1995. Vitellogenesis as a biomarker of oestrogenic contamination of the aquatic environment. Environ. Health. Persp. 103, Supplement 7, 173-178 (cited 640 times).
  68. Paul, M., Sumpter, J.P. and Lindsay, K. 1995. Action of pentoxifylline directly on semen. Human Reproduction, 10, 354-359.
  69. Bicknell, R.J., Herbison, A.E. and Sumpter, J.P. 1995. Oestrogen activity of an environmentally persistent alkylphenol in the reproductive tract but not the brain of rodents. J. Steroid. Biochem. Mol. Biol., 54, 7-9.
  70. Rand-Weaver, M., Pottinger, T.G. and Sumpter, J.P. 1995. Pronounced seasonal rhythms in plasma somatolactin levels in rainbow trout. J. Endocrinol., 146, 113-119.
  71. Jobling, S., Reynolds, T., White, R., Parker, M.G. and Sumpter, J.P. 1995. A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly oestrogenic. Environmental Health Perspectives 103, 582-587 (cited 615 times).
  72. Kaushik, S.J., Cravedi, J.P., Lalles, J.P., Sumpter, J.P., Fouconnau, B. and Laroche, M. 1995. Partial or total replacement of fish meal by soybean protein on growth, protein utilization, potential estrogenic or antiestrogenic effects, cholesterolemia and flesh quality in rainbow trout, Oncorhynchus mykiss. Aquaculture 133, 257-274 (cited 185 times).
  73. Sharpe, R.M., Fisher, J.S., Millar, M.M., Jobling, S. and Sumpter, J.P. 1995. Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production. Environmental Health Perspectives, 103, 1136-1143 (cited 290 times).
  74. Rand-Weaver, M., Pottinger, T.G., Guest, A., Martin, P., Smal, J. and Sumpter, J. P. 1995. Somatolactin and growth hormone are differentially correlated to various metabolic parameters in trout. Netherlands J. Zool. 45, 129-131.
  75. Sumpter, J.P. 1995. Feminized responses in fish to environmental estrogens. Toxicol. Lett., 82/83, 737-742.(cited 138 times)
  76. Tyler, C.R., Pottinger, T.G., Santos, E., Sumpter, J.P., Price, S-A., Brooks, S. and Nagler, J.J. 1996. Mechanisms controlling egg size and number in the rainbow trout, Oncorhynchus mykiss, Biol. Reprod., 54, 8-15.
  77. Jobling, S., Sheahan, D., Osborne, J.A., Matthiessen, P. and Sumpter, J.P. 1996. Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals. Environmental Toxicology and Chemistry, 15, 194-202 (cited 725 times).
  78. Routledge, E.J. and Sumpter, J.P. 1996. Oestrogenic activity of surfactants and some of their degradation products assessed using a recombinant yeast screen. Environmental Toxicology and Chemistry, 15, 241-248 (cited 590 times).
  79. Nagler, J.J., Scott, A.P., Tyler, C.R. and Sumpter, J.P. 1996. Gonadotropins I and II do not stimulate the in vitro secretion of 17a, 20b-dihydrox-4-pregnen-3-one 20-sulphate by rainbow trout gonads during final sexual maturation. Fish Physiol. Biochem.,15, 149-156.
  80. Pelissero, C., Lenczowski, M.J.P., Chinzi, D., Davail-Cuisset, B., Sumpter, J.P. and Fostier, A. 1996. Effects of flavonoids on aromatase activitiy: an in vitro study. J. Steroid Biochem. Mol. Biol., 57, 215-223.
  81. Harries, J.E., Sheahan, D.A., Jobling, S., Matthiessen, P., Neall, P., Routledge, E., Rycroft, R., Sumpter, J.P., and Tylor, T. 1996. A survey of estrogenic activity in United Kingdom inland waters. Environmental Toxicology and Chemistry, 15, 1993-2002. (cited 245 times)
  82. Paul, M., Sumpter, J.P. & Lindsay, K.S. 1996. The paradoxical effects of pentoxifyltine in the binding of spermatozoa to the human zona pellucida. Human Reproduction, 11, 814-819.
  83. Prat, F., Sumpter, J.P. and Tyler, C.R. 1996. Validation of radioimmunoassays for two salmon gonadotropins (GTH I and GTH II) and their plasma concentrations throughout the reproductive cycle in male and female rainbow trout (Oncorhynchus mykiss). Biol. Reprod. 54, 1375-1382. (cited 140 times)
  84. Tyler, C.R., van der Eerden, B., Jobling, S., Panter, G and Sumpter, J.P. 1996. Measurement of vitellogenin, a biomarker for exposure to oestrogenic chemicals, in a wide variety of cyprinid fish. J. Comp. Physiol., 166, 418-426. (cited 115 times)
  85. Paul, M., Sumpter, J.P. and Lindsay, K.S. 1996. Factors affecting pentoxifylline stimulation of sperm kinematics in suspensions. Human Reproduction, 11, 1929-1935.
  86. Toppari, J. et al (19 authors) 1996. Male reproductive health and environmental xenoestrogens. Environ. Health Perspect. 104, Supplement 4, 741-803 (cited 740 times).
  87. Harries, J.E., Sheahan, D.A., Jobling, S., Matthiessen, P., Neall, P., Sumpter, J.P., Tylor, T and Zaman, N. 1997. Estrogenic activity in five United Kingdom rivers detected by measurement of vitellogenesis in caged male trout. Environ. Toxicol. Chem 16, 534-542 (cited 350 times).
  88. Sumpter, J.P. 1997. Environmental Control of Fish Reproduction: a different perspective. Fish Physiol. Biochem., 17, 25-31.
  89. Routledge, E.J. and Sumpter, J.P. 1997. Structural features of alkylphenolic chemicals associated with estrogenic activity. J. Biol. Chem. 272, 3280-3288. (cited 285 times)
  90. Bon. E., Barbe, U., Nunez-Rodriguez, J., Cuisset, B., Pelissero, C., Sumpter, J.P. and Le Menn, F. 1997. Plasma vitellogenin levels during the annual reproductive cycle of the female rainbow trout (Oncorhynchus mykiss): establishment and validation of an ELISA. Comp. Biochem. Physiol. B. 117, 75-84.
  91. Ashby, J., Lefevre, P.A., Odum, J., Harris, C.A., Routledge, E.J. and Sumpter, J.P.1997. Synergy between synthetic oestrogens? Nature 385, 494. (Scientific Correspondence).
  92. Harris, C.A., Henttu, P., Parker, M.G. and Sumpter, J.P. 1997. The estrogenic activity of phthalate esters in vitro. Environmental Health Perspect., 105, 802-811. (cited 300 times)
  93. Odum, J., Lefevre, P.A., Tittensor, S., Paton, D., Routledge, E.J., Beresford, N.A., Sumpter, J.P. and Ashby, J. 1997. The rodent uterotrophic assay: critical protocol features, studies with nonylphenols, and comparison with a yeast estrogenicity assay. Reg. Toxicol. Pharm. 25, 176-188. (cited 180 times)
  94. Brooks, S., Tyler, C.R., Carnevali, O., Coward, K. and Sumpter, J.P. 1997. Molecular characterisation of ovarian cathepsin D in the rainbow trout, Oncorhynchus mykiss. Gene, 201, 45-54.
  95. Knudsen, F.R., Schou, A.E., Wiborg, M.L., Mona, E., Tollefsen, K.E., Stenersen, J. and Sumpter, J.P. 1997. Increase of plasma vitellogenin concentration in rainbow trout (Oncorhynchus mykiss) exposed to effluents from oil refinery treatment works and municipal sewage. Bull. Environ. Contam. Toxicol. 59, 802-806.
  96. Penlington, M.C., Williams, M.A., Sumpter, J.P., Rand-Weaver, M., Hoole, D. and Arme, C. 1997. Isolation and charaterization of mRNA encoding the salmon- and chicken-II type gonadotrophin-releasing hormones in the teleost fish Rutilus rutilus (Cyprinidae). J. Mol. Endocrinol., 19, 337-346.
  97. Ashby, J., Lefevre, P.A., Odum, J., Tinwell, H., Kennedy, S.J., Beresford, N. and Sumpter, J.P. 1997. Failure to confirm estrogenic activity for benzoic acid and clofibrate : implications for lists of endocrine-disrupting agents. Regulatory Toxicology and Pharmacology 26, 96-101.
  98. Prat, F., Coward, K., Sumpter, J.P. and Tyler, C.R. 1998. Molecular characterization and expression of two ovarian lipoprotein receptors in the rainbow trout, Oncorhynchus mykiss. Biol. Reprod.58, 1146-1153.
  99. Panter, G.H., Thompson, R.S. and Sumpter, J.P. 1998. Adverse reproductive effects in male fathead minnows (Pimephales promelas) exposed to environmentally-relevant concentrations of the natural oestrogens oestradiol and oestrone. Aquatic Toxicology, 42, 243-253 (cited 145 times).
  100. Ashfield, L.A., Pottinger, T.G. and Sumpter. J. P. 1998. Exposure of female juvenile rainbow trout to alkylphenolic compounds results in modifications to growth and ovo-somatic index. Environ. Toxicol. Chem. 17, 679-686.
  101. Desbrow, C., Routledge, E.J., Brighty, G.C., Sumpter, J.P. and Waldock, M. 1998. Identification of estrogenic chemicals in STW effluent. I : Chemical Fractionation and in vitro Biological Screening. Environ. Sci. Technol. 32, 1549-1558 (cited 740 times)
  102. Routledge, E.J., Waldock, M. and Sumpter, J.P. 1999. Response to Comment on ‘Identification of estrogenic chemicals in STW effluent. 1. Chemical fractionation and in vitro biological screening. Environ. Sci. Technol. 33, 371.
  103. Routledge, E.J., Sheahan, D., Desbrow, C., Brighty, G.C., Waldock, M. and Sumpter, J.P. 1998. Identification of estrogenic chemicals in STW effluent. II : In vivo responses in trout and roach. Environ. Sci. Technol. 32, 1559-1565. (cited 450 times)
  104. Sohoni, P. and Sumpter, J.P. 1998. Several environmental oestrogens are also anti-androgens. J. Endocrinol.158, 327-339. (cited 290 times)
  105. Jobling, S., Nolan, M., Tyler, C.R., Brighty, G. and Sumpter, J.P. 1998. Widespread sexual disruption in wild fish. Environ. Sci. Technol. 32, 2498-2506 (cited 630 times)
  106. Gimeno, S., Komen, H., Jobling, S., Sumpter, J.P. and Bowner, T. 1998. Demasculinisation of sexually mature male common carp, Cyprinus carpio, exposed to 4-tert-pentylphenol during spermatogenesis. Aquatic Toxicology 43, 93-109.
  107. Routledge, E.J., Parker, J., Odum, J., Ashby, J. and Sumpter, J.P. 1998. Some alkyl hydroxy benzoate preservatives (parabens) are estrogenic. Toxicol. Appl. Pharmacol., 153, 12-19. (cited 160 times)
  108. Harries, J.E., Janbakhsh, A., Jobling, S., Matthiessen, P., Sumpter, J.P. and Tyler, C.R. 1999.Estrogenic potency of effluent from two sewage treatment works in the United Kingdom. Environ. Toxicol. Chem., 18, 932-937.
  109. Ashby, J., Tinwell, H., Pennie, W., Brooks, A.N., Lefevre, P.A., Beresford, N. and Sumpter, J.P. 1999. Partial and weak estrogenicity of the red wine constituent resveratol: consideration of its superagonist activity in MCF-7 cells and its suggested cardiovascular protective effects. J. Applied Toxicol. 19, 39-45.
  110. Panter, G.H., Thompson, R.S., Beresford, N. and Sumpter, J.P. 1999. Transformation of a non-oestrogenic steroid metabolite to an oestrogenically active substance by minimal bacterial activity. Chemosphere, 38, 3579-3596.
  111. Andersen, H.R. et al (28 authors, including J. P. Sumpter). 1999. Comparison of short-term estrogenicity tests for identification of hormone-disrupting chemicals. Environ. Health Perspect., 107, S1, 89-108. (cited 220 times)
  112. Baker, V.A., Hepburn, P.A., Kennedy, S.J., Jones, P.A., Lea, L.J., Sumpter, J.P. and Ashby, J. 1999. Safety evaluation of phytosterol esters. Part 1. Assessment of oestrogenicity using a combination of in vivo and in vitro assays. Food and Chemical Toxicology, 37, 13-22.
  113. Carnevali, O., Centonze, F., Brooks, S., Marota, I. and Sumpter, J.P. 1999. Molecular cloning and expression of ovarian cathepsin D in seabream, (Sparus aurata). Biol. Reprod. 61, 785-791.
  114. Beresford, N., Routledge, E.J., Harris, C.A. and Sumpter, J.P. 2000. Issues arising when interpreting results from an in vitro assay for estrogenic activity. Toxicol. Appl. Pharmacol., 162, 22-33.
  115. Tyler, C.R., Beresford, N., van der Woning, M., Sumpter, J.P. and Thorpe, K. 2000. Metabolism and environmental degradation of pyrethroid insecticides produces compounds with endocrine activities. Environ. Toxicol. Chem., 19, 801-809.
  116. Rodgers - Gray, T.P., Jobling, S., Morris, S., Kelly, C., Kirby, S., Janbakhsh, A., Harries, J.E., Waldock, M.J., Sumpter, J.P. and Tyler, C.R. 2000. Long-term temporal changes in the estrogenic composition of treated sewage effluent and its biological effects on fish. Environ. Sci. Technol., 34, 1521-1528. (cited 110 times)
  117. Thorpe, K.L., Hutchinson, T.H., Hetheridge, M.J., Sumpter, J.P and Tyler, C.R. 2000. Development of an in vivo screening assay for estrogenic chemicals using juvenile rainbow trout (Oncorhynchus mykiss). Environ. Toxicol. Chem., 19, 2812-2820.
  118. Panter, G.H., Thompson, R.S. and Sumpter, J.P. 2000. Intermittent exposure of fish to oestradiol. Environ. Sci. Technol., 34, 2756-2760.
  119. Harries, J.E., Runnalls, T., Hill, E., Harris, C., Maddix, S., Sumpter, J.P. and Tyler, C.R. 2000. Development of a reproductive performance test for endocrine disrupting chemicals using pair-breeding fathead minnow (Pimephales promelas). Environ. Sci. Technol., 34, 3003-3011.
  120. Ashby, J., Odum, J, Paton, D., Lefevre, P.A., Beresford, N. and Sumpter, J.P. 2000. Re-evaluation of the first synthetic estrogen, 1-Keto-1,2,3,4 - tetrahydrophenanthrene, and Bisphenol A, using both the ovariectomised rat model used in 1933 and additional assays. Toxicology Letters, 115, 231-238.
  121. Schmieder, P.K., Aptula, A.O., Mekenyon, O.G., Routledge, E.J. and Sumpter, J.P. 2000. Estrogenicity of alkylphenolic compounds: a 3-D structure activity evaluation of gene activation. Environ. Toxicol. Chem. 19, 1727-1740.
  122. Elsby, R., Ashby, J., Sumpter, J.P., Brooks, A.N., Pennie, W.D., Maggs, J.L., Lefevre, P.A., Odum, J., Beresford, N., Paton, D. and Park, B.K. 2000. Obstacles to the prediction of estrogenicity from chemical structure: assay-mediated metabolic transformation and the apparent promiscuous nature of the estrogen receptor. Biochem. Pharmacol. 60, 1519-1530.
  123. Routledge, E.J., White, R., Parker, M.G., Sumpter, J.P. 2000. Differential effects of xenoestrogens on coactivator recruitment by ER  AND ER. J.Biol.Chem., 275, 35986-35993. (cited 108 times)
  124. Nolan, M., Jobling, S., Brighty, G., Sumpter, J.P. and Tyler, C.R. 2001. A histological description of intersexuality in the roach. J.Fish Biol., 58, 160-176.
  125. Miller, D., Wheals, B.B., Beresford, N. and Sumpter, J.P. 2001. Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay. Environ. Health Perspect., 109, 133-138.
  126. Rodgers-Gray, T.P., Jobling, S., Kelly, C., Morris, S., Brighty, G., Waldock, M.J., Sumpter, J.P. and Tyler, C.R. 2001. Exposure of juvenile roach (Rutilus rutilus) to treated sewage effluent induces dose-dependent and persistent disruption in gonadal duct development. Environ. Sci. Technol., 35, 462-470. (cited 113 times)
  127. Elsby, R., Maggs, J.L., Ashby, J., Paton, D., Sumpter, J.P. and Park, B.K. 2001. Assessment of the effects of metabolism on the estrogenic activity of xenoestrogens : a two-stage approach coupling human liver microsomes and a yeast estrogenicity assay. J. Pharm. Exp. Therap., 296, 329-337
  128. Länge, R., Hutchinson, T.H., Croudace, C.P., Siegmund, F., Schweinfurth, H., Hampe, P., Panter, G.H. and Sumpter, J.P. 2001. Effects of the synthetic oestrogen 17α-ethinylestradiol over the life-cycle of the fathead minnow (Pimephales promelas). Environ. Toxicol. Chem., 20, 1216-1227. (cited 195 times)
  129. Sohoni, P., Lefevre, P.A., Ashby, J. and Sumpter, J.P. 2001. Possible androgenic/anti-androgenic activity of the fungicide fenitrothion. J.Appl. Toxicol., 21, 173-178.
  130. Halm, S., Rand-Weaver, M, Sumpter, J.P. and Tyler, C.R. 2001. Cloning and molecular characterization of an ovarian-derived (brain-like) P450 aromatase cDNA and development of a competitive RT-PCR assay to quantify its expression in the fathead minnow (Pimephales promelas). Fish Physiol. Biochem., 24, 49-62.
  131. Harris, C.A., Santos, E.M., Janbakhsh, A., Pottinger, T.G., Tyler, C.R. and Sumpter, J.P. 2001. Nonylphenol affects gonadotropin levels in the pituitary gland and plasma of female rainbow trout. Environ. Sci, Technol., 35, 2909-2916.
  132. Van Aerle, R., Nolan, M., Jobling, S., Christiansen, L.B., Sumpter, J.P. and Tyler, C.R. 2001. Sexual disruption in a second species of wild cyprinid fish (the gudgeon, Gobio gobio) in U.K.fresh waters. Environ.Toxicol. Chem., 20, 2841-2847.
  133. Sohoni, P., Tyler, C.R., Hurd, K., Caunter, J., Hetheridge, M., Williams, T., Woods, C., Evans, M., Toy, R., Gargas, M. And Sumpter, J.P. 2001. Reproductive effects of long term exposure to Bisphenol-A in the fathead minnow (Pimephales promelas). Environ. Sci. Technol. 35, 2917-2925.
  134. Thorpe, K.L., Hutchinson, T.H., Hetheridge, M.J., Scholze, M., Sumpter, J.P. and Tyler, C.R. 2001. Assessing the biological potency of binary mixtures of environmental estrogens using vitellogenin induction in juvenile rainbow trout (Oncorhynchus mykiss). Environ. Sci. Technol. 35, 2476-2481. (cited 109 times)
  135. Johnson. A.C. and Sumpter, J.P. 2001. Removal of endocrine disrupting chemicals in activated sewage treatment works. Environ. Sci. Technol 35, 4697-4703. (cited 180 times)
  136. Panter, G.H., Hutchinson, T.H., Länge, R., Lye, C.M., Sumpter, J.P., Zerulla, M. and Tyler, C.R. 2002. Utility of a juvenile fathead minnow screening assay for detecting (anti)-estrogenic substances. Environ. Toxicol. Chem., 21, 319-326.
  137. Kirk, L.A., Lye, C.M., Tyler, C.R. and Sumpter, J.P. 2002. Changes in oestrogenic and androgenic activities at different stages of treatment in waste water treatment works. Environ.Toxicol. Chem., 21, 972-979.
  138. Jobling, S., Beresford, N., Nolan, M., Rodgers-Gray, T., Brighty, G.C., Sumpter, J.P. and Tyler, C.R. 2002. Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents. Biol. Reprod., 66, 272-281. (cited 120 times)
  139. Sheahan, D.A., Brighty, G.C., Daniel, M., Kirby, S., Hurst, M.R,, Kennedy, J., Morris, S., Routledge, E.J., Sumpter. J.P. and Waldock, M.J. 2002. Estrogenic activity measured in a sewage treatment works treating industrial inputs containing high concentrations of alkylphenolic compounds – a case study. Environ. Toxicol. Chem., 21, 507-514.
  140. Sheahan, D.A., Brighty, G.C., Daniel, M., Jobling, S., Harries, J.E., Hurst, M.R., Kennedy, J., Kirby, S.J., Morris, S., Routledge, E.J., Sumpter, J.P. and Waldock, M.J. 2002. Reduction in the estrogenic activity of a treated sewage effluent discharge to an English river as a result of a decrease in the concentration of industrially-derived surfactants. Environ. Toxicol. Chem., 21, 515-519.
  141. Jobling, S., Coey, S., Whitmore, J.G., Kime, D.E., Van Look, K.J.W., McAllister, B.G., Beresford, N., Henshaw, A.C., Brighty, G.C., Tyler, C.R. and Sumpter, J.P. 2002. Wild intersex roach (Rutilus rutilus) have reduced fertility. Biol. Reprod. 67, 515-524. (cited 112 times)
  142. Halm, S., Pounds, N., Maddix, S., Rand-Weaver, M., Sumpter, J.P., Hutchinson, T.H. and Tyler, C.R. 2002. Exposure to exogenous 17-oestradiol disrupts P450aromB mRNA expression in the brain and gonad of adult fathead minnows (Pimephales promelas). Aquatic Toxicology, 60, 285-299.
  143. Halm, S., Kwon, J.Y., Rand-Weaver, M., Sumpter, J.P., Pounds, N., Hutchinson, T.H., Tyler, C.R. 2003. Cloning and gene expression of P450 17 alpha-hydroxylase, 17, 20-lyase cDNA in the gonads and brain of the fathead minnow (Pimephales promelas). Gen. Comp. Endocr. 130, 256-266.
  144. Thorpe, K.L., Cummings, R.I., Hutchinson, T.H., Scholze, M., Brighty, G., Sumpter, J.P., Tyler, C.R. 2003. Relative potencies and combination effects of steroidal estrogens in fish. Environ. Sci. Technol. 37, 1142-1149. (cited 130 times)
  145. Faller, P., Kobler, B., Peter, A., Sumpter, J.P. and Burkhardt-Holm, P. 2003. Stress status of gudgeon (Gobio gobio) from rivers in Switzerland with and without input of sewage treatment plant effluent. Environ. Toxicol. Chem. 22, 2063-2072.
  146. Pickering, A.D. and Sumpter, J.P. 2003. COMPREHENDing endocrine disruptors in aquatic environments. Environ. Sci. Technol. 37, 331A-336A.
  147. Pottinger, T.G., Rand-Weaver, M. and Sumpter, J.P. 2003. Over-winter fasting and re-feeding in rainbow trout: plasma growth hormone and cortisol levels in relation to energy mobilization. Comp. Biochem. Physiol. B. 136, 403-417.
  148. Pickford, K.A., Thomas-Jones, R.E., Wheals, B., Tyler, C.R. and Sumpter, J.P. 2003. Route of exposure affects the oestrogenic response of fish to 4-tert-octylphenol. Aquatic Toxicol. 65, 267-279.
  149. Sumpter, J.P. 2003. Endocrine disruption in wildlife: the future? Pure and Applied Chemistry 75, 2355-2360.
  150. Beresford, N., Jobling, S., Williams, R. and Sumpter, J.P. 2004. Endocrine disruption in juvenile roach from English rivers: a preliminary study. J. Fish Biol. 64, 1-7.
  151. Sumpter, J.P., d’Ayala, R., Parfitt, A.J., Pratt, P. and Raper, C. 2004. The current status of Military (Orchis militaris) and Monkey (Orchis simia) orchids in the Chilterns. Watsonia, 25, 175-183.
  152. Coleman, H.M., Routledge, E.J., Sumpter, J.P., Eggins, B.R. and Burne, J.A. 2004. Rapid loss of estrogenicity of steroid estrogens by UVA photolysis and photocatalysis over an immobilized titanium dioxide catalyst. Water Research, 38, 3233-3240.
  153. Vine, E., Shears, J., van Aerle, R., Tyler, C.R., and Sumpter, J.P. 2005 . Endocrine (sexual) disruption is not a prominent feature in the pike, Esox lucius, a top predator, living in English rivers. Environ. Toxicol. Chem. 24, 1436-1443.
  154. Brian , J.V., Harris, C.A., Scholze, M., Backhaus, T., Booy, P., Lamoree, M., Pojana, G.,Jonkers, N., Runnalls, T., Bonfa, A., Marcomini, A. and Sumpter, J.P. 2005. Accurate prediction of the response of freshwater fish to a mixture of estrogenic chemicals. Environ. Health Perspect. 113, 721-728.
  155. Sumpter, J.P. and Johnson, A.C. 2005. Lessons from endocrine disruption and their application to other issues concerning trace organics in the aquatic environment. Environ. Sci. Technol. 39, 4321-4332.
  156. Sumpter, J.P. and Johnson, A.C. 2006. Response to Comment on “Lessons from Endocrine Disruption and their application to other issues concerning trace organics in the aquatic environment. Environ. Sci. Technol. 40, 1086-1087
  157. Sumpter, J.P., Johnson, A.C., Williams, R.J., Kortenkamp, A and Scholze, M. 2006. Modeling effects of mixtures of endocrine disrupting chemicals at the river catchment scale. Environ. Sci. Technol., 40, 5478-5489
  158. Brian, J.V., Harris, C.A., Scholze, M., Kortenkamp, A., Booy, P., Lamoree, M. Pojana, G., Jonkers, N. Marcomini, A. and Sumpter, J.P. 2007. Evidence of estrogenic mixture effects on the reproductive performance of fish. Environ. Sci. Technol., 41, 337-344
  159. Maunder, R.J., Matthiessen, P., Sumpter, J.P. and Pottinger, T.G. 2007. Rapid bioconcentration of steroids in the plasma of sticklebacks Gasterosteus aculeatus exposed to water-borne testosterone and 17β-estradiol. J. Fish Biol., 40, 678-690
  160. Sumpter, J.P. 2007. Environmental Effects of human pharmaceuticals. Drug Information Journal 41, 143-147.
  161. Harris, C.A., Routledge, E.J., Shaffner, C., Brian, J.V., Giger, W. and Sumpter, J.P. 2007. Benzotriazole is anti-estrogenic in vitro but not in vivo. Environ. Toxicol. Chem. 26, 2367-2372.
  162. Runnalls, T.J., Hala, D.N. and Sumpter, J.P. 2007. Preliminary studies into the effects of the human pharmaceutical clofibric acid on sperm parameters in adult Fathead Minnow. Aquatic Toxicol., 84, 111-118.
  163. Brian, J.V. and Sumpter, J.P. 2007. Mixtures of chemicals in water: implications for chemical regulation and environmental policy. J. Water Law 18, 62-65.
  164. Pash, S., Spooner, J and Sumpter, J.P. 2007. Albino common toads (Bufo bufo). Herpetological Bulletin 100, 8-11.
  165. Spooner, J, Pash, S and Sumpter, J.P. 2007. Occurrence of an albino newt and albino common toads (Bufo bufo) in the same garden pond. Herpetological Bulletin 100, 11-12.
  166. Maunder, R.J., Matthiessen, P., Sumpter, J.P. and Pottinger, T.G. 2007. Impaired reproduction in three-spined sticklebacks exposed to ethinylestradiol as juveniles. Biol. Reprod. 77, 999-1006.
  167. Ankley, G.T., Brooks, B.W., Huggett, D.B. and Sumpter, J.P. 2007. Repeating history: pharmaceuticals in the environment. Environ. Sci. Technol. 41, 8211-8217.
  168. Winter, M.J., Lillicrap, A.D., Caunter, J.F., Alder, A., Ramil, M., Ternes, T., Giltrow, E., Sumpter, J.P. and Hutchinson, T.H. 2008. Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas). Aquatic Toxicology, 86, 361- 369.
  169. Johnson, A.C., Jurgens, M.D., Williams, R.J., Kumerrer, K., Kortenkamp, A. and Sumpter, J.P. 2008. Do cytotoxic chemotherapy drugs discharged into rivers pose a risk to the environment and human health? An overview and UK case study. J. Hydrology 348, 167-175.
  170. Sumpter, J.P. 2008. The ecotoxicology of hormonally-active micropollutants. Water Science and Technology 57, 125-130.
  171. Brian, J. V., Harris, C. A., Runnalls, T. J., Fantinati, A., Pojana, G., Marcomini, A., Booy, P., Lamoree, M., Kortenkamp, A. and Sumpter, J. P. 2008. Evidence of Temperature-dependent effects on the estrogenic response of fish: implications with regard to climate change. Sci. Total Environ. 397, 72-81.
  172. Johnson, A. C., Ternes, T., William, R. J. and Sumpter, J.P. 2008. Assessing the concentrations of polar organic microcontaminants from point sources in the aquatic environment: measure or model? Environ. Sci. Technol.42, 5390-5399.
  173. Gabriel, F. L. P., Routledge, E. J., Heidlberger, A., Rentsch, D., Guenther, K., Giger, W., Sumpter, J. P, and Kohler, H. P, E. 2008. Isomer – specific degradation and evidence disrupting activity of nonylphenol. Environ. Sci. Technol., 42, 6399-6408.
  174. Caldwell, D.J, Mastrocco, F., Hutchinson, T. H., Lange, R., Heijerick, D., Janssen, C., Anderson, P.D. and Sumpter, J. P. 2008. Derivation of an aquatic predicted no-effect concentration for the synthetic hormone, 17α-ethinyl estradiol. Environ. Sci. Technol. 42, 7046-7054.
  175. Sumpter, J.P and Johnson, A.C. 2008. Reflections on endocrine disruption in the aquatic environment: from known knowns to unknown unknowns (and many things in between). J. Environ. Monit. 10, 1476-1485.
  176. Harris, C. A., Brian, J. V., Pojana, G., Lamoree, M., Booy, P., Marcomini, A. and Sumpter, J. P. 2009. The influence of a surfactant, linear alkylbenzene sulfonate, on the estrogenic response to a mixture of (xeno)estrogens in vitro and in vivo. Aq. Toxicol., in Press.
  177. Brian, J. V., Beresford, N., Walker, J., Pojana, G., Fantinati, A., Marcomini, A and Sumpter, J. P. 2009. Hypoxia does not influence the response of fish to a mixture of estrogenic chemicals. Environ. Sci. Technol., 43, 214-218.
  178. Jurgens, M. D., Johnson, A. C., Pottinger, T.G. and Sumpter, J. P. 2009. Do suspended sediments modulate the effects of ocytlphenol on rainbow trout? Water Res., 43, 1381-1391.
  179. Hannah, R., D’Aco, V. J., Anderson, P.D., Buzby, M. E., Caldwell, D. J., Cunnigham, V. L., Ericsoon, J. F., Johnson, A. C., Parkell, N. J., Samuelian, J. H., and Sumpter, J. P. 2009. Derivation of 17α-ethinyl estradiol concentrations in surface waters of the U.S. and Europe for risk assessment purposes. Environ. Toxicol. Chem., in press.
  180. Sumpter, J. P. 2009. Protecting aquatic organism from chemicals: the harsh realities. Phil. Trans. Royal Soc. A., in press.
  181. Owen, S. F., Huggett, D. B., Hutchinson, T. H., Hethridge, M. J., Kinter, L. B., Ericsson, J. F. and Sumpter, J. P. 2009. Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry. Aq. Toxicol, in press.
  182. Johnson, A. C., and 20 other authors (including Sumpter, J. P.) 2009. The British river of the future: how climate change and human activity might affect two contrasting river ecosystems in England. Sci. Total Environ., in press.

Reviews

  1. Follett, B.K., Davies, D.T., Gibson, R., Hodges, K.J., Jenkins, N., Maung, S.L., Maung, Z.W., Redshaw, M.R. and Sumpter, J.P. 1978. Avian gonadotrophins: their purification and assay. Pavo 16, 34‑55.
  2. Sumpter, J.P. and Wood. C.R.C. 1981. The trout. Biologist, 28, 219‑224.
  3. Scott, A.P. and Sumpter, J.P. 1983. The control of trout reproduction: basic and applied research on hormones. In: Rankin, J.C., Pitcher, T.J. and Duggan, R.T. (eds.) "Control processes in fish physiology", Chapter 11, pp. 200‑220. Croom Helm, Beckenham.
  4. Dodd, J.M. and Sumpter, J.P. 1984. Reproductive cycles of cyclostomes, elasmobranchs and bony fishes. In: Lamming, G.E. (ed.) "Marshall's Physiology of Reproduction", 4th edition, Volume A, Chapter 1, pp. 1‑126. Churchill Livingstone, London.
  5. Sumpter, J.P. 1984. The seasonal reproductive cycle of the rainbow trout. In: Labrie, F. and Proulx, L. (eds.) "Endocrinology", International Congress, series 655, Excerpta Medica, Elsevier, Amsterdam, pp. 793‑796.
  6. Sumpter, J.P. 1990. General concepts of seasonal reproduction in higher vertebrates. In: Munro, A.D., Scott, A.P. and Lam, T.J. (eds.) “Reproductive seasonality in teleosts: environmental influences”. CRC Press Inc., Florida. pp. 13‑31.
  7. Carragher, J.F. and Sumpter, J.P. 1990. Corticosteroid physiology in fish. In: Epple, A., Scanes, C.G. and Stetson, M.H. (eds.) “Progress in Comparative Endocrinology”. Wiley‑Liss, pp 487‑492.
  8. Sumpter, J.P. 1992. The stress response and its consequences in cultured fish. Bul. Inst. Zool., Academia Sinica, Monograph 16: 229‑236.
  9. Sumpter, J.P. 1993. The deleterious effects of stress and their significance to aquaculture. In: Barnabé, G. and Kestemont, P. (eds) “Production, Environment and Quality”. European Aquaculture Society Special Publication No. 18, pp 157‑165. Ghent, Belgium.
  10. Pelissero, C., Lenczowski, M., De Mones del Pujol, A., Sumpter, J.P. and Fostier, A. 1993. Potential effect of flavonoids from the vegetable component of the diet on the synthesis of estrogens in the rainbow trout, Oncorhynchus mykiss: an in vitro study. In: Barnabé, G. and Kestemont, P. (eds) “Production, Environment and Quality”. European Aquaculture Society Special Publication No. 18, pp 177‑184. Ghent, Belgium.
  11. Sumpter, J.P., Pottinger, T.G., Rand‑Weaver, M. and Campbell, P.M. 1994. The wide‑ranging effects of stress on fish. In: Davey, K.G., Peter, R.E. and Tobe, S.S. (eds.) “Perspectives in Comparative Endocrinology”. NRC Canada, pp. 535-538.
  12. Sumpter, J.P., Jobling, S., and Tyler, C.R. 1996. Oestrogenic substances in the aquatic environment and their potential impact on animals, particularly fish. In: “Toxicology of Aquatic Pollution”, Taylor, E.W. (ed.), Cambridge University Press, pp. 205-224.
  13. Tyler, C.R. and Sumpter, J.P. 1996. Oocyte growth and development in teleosts. Reviews in Fish Biology and Fisheries, 6, 287-318 (cited 220 times).
  14. Sumpter, J.P. 1997. The endocrinology of stress. In: Iwama, G.K. et al (eds). “Fish Stress and Health in Aquaculture”, pp. 95-118. Cambridge University Press.
  15. Brooks, S., Tyler, C.R. and Sumpter, J.P. 1997. Egg quality in fish: what makes a good egg? Reviews in Fish Biology and Fisheries, 7, 387-416. (cited 130 times).
  16. Sumpter, J.P. 1997. Reproductive effects from oestrogen activity in polluted water. Arch. Toxicol., Supplement 20, 143-150.
  17. Tyler, C.R., Jobling, S. and Sumpter, J.P. 1998. Endocrine disruption in wildlife : a critical review of the evidence. Critical Reviews in Toxicology, 28, 319-361. (cited 420 times)
  18. Matthiessen, P. and Sumpter, J.P. 1998. Effects of oestrogenic substances in the aquatic environment. In: Braunbeck, T., Hinton, D.E. and Streit, D. (eds), "Fish Ecotoxicology", pp 319-335. Birkhauser Verlag, Basel, Switzerland.
  19. Sumpter, J.P. and Sohoni, P. 1998. Endocrine disrupting chemicals in the aquatic environment. In: Proceedings of the 1998 Brighton Conference "Pests and Diseases", pp 225-232. British Crop Protection Council.
  20. Sumpter, J.P. 1998. Xenoendocrine Disruptors - environmental impacts. Toxicol. Lett. 102, 337-342.
  21. Sumpter, J.P. 2000. Endocrine disrupting chemicals in the aquatic environment. In: Norberg, B et al. (eds) “Reproductive Physiology of Fish”, pp. 349-355. Bergen 2000.
  22. Harris, C.A. and Sumpter, J.P. 2001. The endocrine disrupting potential of phthalates. In: Metzler, M. (ed) “Endocrine Disruptors : Part 1”. Pp. 169-201. Springer.
  23. Sumpter, J.P. 2002. Endocrine disruption in the aquatic environment. In: Metzler, M. (ed) “Endocrine Disruptors: Part II”. pp. 271-289. Springer.
  24. Eggen, R.I.L., Bengtsson, B-E., Bourmer, C.T., Gerritsen, A.A.M., Gibert, M., Hylland, K., Johnson, A.C., Leonards, P., Nakari, T., Norrgren, L., Sumpter, J.P., Suter, M.J-F., Svenson, A. and Pickering, A.D. 2003. Search for the evidence of endocrine disruption in the aquatic environment: lessons to be learned from joint biological and chemical monitoring in the European project COMPREHEND. Pure Appl. Chem. 75, 2445-2450.
  25. Sumpter, J.P. 2005. Endocrine disrupters in the aquatic environment: an overview. Acta Hydrochimica Hydrobiologica 33, 9-16
  26. Mihaich, E.M., Borgert, C.J., Brighty, G.C., Kortenkamp, A., Laenge, R., Snyder, S.A. and Sumpter, J.P. 2005. Evaluating simple and complex mixtures containing pharmaceuticals in the environment. In: Williams, R.T. (ed.) “Human Pharmaceuticals: assessing the impacts on aquatic ecosystems”, pp. 239-267 SETEC Press. Pensacola, USA.
  27. Sumpter, J.P. and Pickering, A.D. 2006. COMPREHEND: major findings and prospects. In: Vethaak, A.D., Schrap, S.M. and de Voogt, P. (eds). “Estrogens and xenoestrogens in the aquatic environment: an integraged approach for field monitoring and effect assessment”. pp. 407-424 SETAC Press, Pensacola, USA.
  28. Owen, S.F., Giltrow, E., Huggett, D.B., Hutchinson, T.H., Saye, J., Winter, M.J. and Sumpter, J.P. 2007. Comparative physiology, pharmacology and toxicology of β-blockers in fish: a critical review. Aquatic Toxicology, 82, 145-162
  29. Backhaus, T., Sumpter, J. P. and Blanck, H. 2008. On the ecotoxicology of pharmaceutical mixtures. In: Kümmerer, K. (ed). “Pharmaceuticals in the Environment”, Third Edition. Chapter 16, pp. 257-276. Springer-Verlag, Berlin.

Special Publications

  1. Sumpter, J.P. and Follett, B.K. 1991. James Munro Dodd. Biographical Memoirs of Fellows of the Royal Society. 37, 127‑ 147.
  2. Hermans, J.L.M., Ankley, G.T. and Sumpter, J.P. 2004. Ecotoxicology – A multidisciplinary problem-driven science. Environ. Sci. Technol. 38, 446A-447A.

The impact of my research

This is probably best measured by the number of times it is cited. Data compiled by the Institute of Scientific Information (ISI), and available through the Web of Knowledge, reveals that:

  1. My research has, to date, been cited over 18,000 times. This figure is currently increasing by over 1,500 per year.
  2. Forty six papers have been cited over 100 times.
  3. Of these, thirteen have been cited over 300 times, with the most highly cited paper currently cited over 800 times.
  4. Throughout my career I have published highly cited research: the ‘oldest’ highly cited paper was published in 1983, and the most recent in 2003.
  5. Some recently published (since 2000) papers have already been cited quite extensively, suggesting that some of these will, in due course, become highly cited.
  6. The very widely respected journal Environmental Science and Technology recently conducted an analysis of the most cited papers it had published in the last ten years (1997 to 2006, inclusive). Three out of the most highly cited top five were from my research group.
  7. In the list of “Most-cited researchers in Environment/Ecology” compiled by Thompson-ISI www.in-cites.com I have been ranked in the top ten continuously for the last 7 years. I was ranked number one in the world for two successive years (2004, 2005).
  8. The consequence of this very high rate of citation is that Brunel University’s environmental science research is extremely highly rated on an international scale. For example, in an article published by the Education Guardian in 2001 (and based on ISI citation data), Brunel was top of an international league table of the impact of environmental science research. Its research was described as “a small but powerful contribution”. It was not until much further down the league table (position 20) that the next Institute from the U.K. fared.

Impact of my research (on legislation)

My research has led to regulatory action (through the EU and Member States) on certain groups of chemicals, leading to those chemicals being severely restricted in use and/or banned. This in turn has led to rapid and major improvements in water quality and hence aquatic life (and possibly also human health). For example, my research on nonylphenol (a chemical originating primarily from the use of one class of surfactants), which showed how toxic this chemical was to fish, led to immediate reductions in its use (especially in industries such as textiles, which were major users of the surfactants), and contributed significantly to the agreed phase out of the chemical throughout the European Union. These actions led to rapid and major improvements in water quality in, for example, the River Aire, in Yorkshire, which can now support many species of fish.

Invitations to give plenary papers at major conferences

I am very often asked to give talks at conferences (of all sizes). I can accept only a minority of these invitations. As examples, in 2004/05 I spoke at the following meetings:

Gordon Conference on ‘Environmental Sciences: Water’ held June 27- July 2, 2004 in Plymouth New Hampshire, USA. I gave a plenary lecture. Credo Cluster Meeting on ‘Ecological relevance of chemically-induced endocrine disruption in wildlife’, held at the University of Exeter, 5-7 July, 2004. I gave two invited talks. Pfizer “Expert Panel” meeting to advise the company on the environmental risk assessment of one of their new drugs. Held 12-24 October, 2004, in London. I was one of six invited “experts”. Invited talk to the Environment Agency on “Old, new and emerging contaminants and their effects on aquatic organisms.” Delivered to a large audience of regulators at Wallingford, UK, on 21 October, 2004. 195th Meeting of the Society of Endocrinology, held 1-2 November, 2004 in London, UK. I gave an invited plenary talk entitled “Natural endocrine disruptors in aquatic environment”. UK-Japan Co-operation on research on endocrine disrupters in the aquatic environment. Meeting held 17-18 January, 2005, in Glasgow, UK. I gave an invited talk. Journalism and media interest in my research I rarely myself write articles for the general public (though I have done so occasionally, including for magazines aimed at school children). However, the media have shown a lot of interest in my research, and I often help them with their articles/films. Articles based around aspects of my research have featured in many local, national and international newspapers and magazines, and continue to do so. Much of our research was made available to the public through Deborah Cadbury’s book ‘The Feminization of Nature’, first published in 1997. I helped her a lot with her book. Before writing her book, Deborah was employed by the BBC as a producer of programmes for the ‘Horizon’ series. She made one called “Assault on the Male”, which extensively featured our research. It was one of the most successful ‘Horizon’ films ever made, was first shown in 1995, updated and shown again in 1996, and won an EMMY (an extremely rare event for a factually-based programme). Besides that programme, my research has featured in other television programmes, such as the BBC’s ‘Countryfile’. It has also featured in programmes shown in many other countries, such as Japan. The latest media attention occurred in the autumn of 2005, when the Japanese television company NHK (the equivalent of our BBC) came to Brunel to film me discussing my research in the field of endocrine disruption. The programme was shown on national television in Japan, and also as a video at an international conference. Awards and Achievements 1.Recipient of the 2003 ‘Environmental Education Award’ from the Society of Environmental Toxicology and Chemistry (SETAC). This is the most prestigious award from the Society, which is the major society (it has over 5000 members) covering ecotoxicology in its remit. 2.Recipient of the 2005 Beverton Medal from the Fisheries Society of the British Isles. This is the most prestigious award from the Society, and is a recognition of a lifetime of outstanding research that benefits fish and fisheries. 3.Recipient of the 2007 Founders Award of the Society for Environmental Chemistry and Toxicology (SETAC). This is the most prestigious award of this large, multi-national society. Recipient of the 2009 Toxicology Award from the Royal Society of Chemistry.

Teaching

I have been a University teacher since 1978, when I came to Brunel University. I attended an induction course, which had a strong emphasis on teaching, upon arrival. Since then, I have delivered between 40 and 70 lectures each year, held seminars (about 10 per year), and designed and run practical classes to complement my lecture courses (between 8 and 20 practicals per year). Student feedback, obtained primarily by anonymous questionnaires, has been collected each year, and used to change and improve the courses in subsequent years. In general, this feedback has been very positive.

Until recently, my main teaching had covered the area of Human and Animal Physiology (i.e. respiration, circulation, endocrinology, reproduction, etc.). For over 15 years, I taught a final-year course in Animal Reproduction, but more recently, as my research interests in environmental science grew, I replaced it with courses in Ecotoxicology, Biodiversity and Environmental Risk Assessment. These courses have been very well received by students, primarily, I think, because of the topicality of the subjects. I have introduced a number of modern teaching approaches into these courses, including group project work and presentations.

I also supervised between 3 and 6 final-year research projects each year, for twenty-five years. Some of the students have produced results which have been included in research papers (and hence the students have been authors), and many have gone on to do research (usually as PhD students) in the areas covered by their projects. I currently supervise students doing their MSc dissertations.

Between 1996 and 2001, I chaired the Teaching Policy Group within the Department of Biological Sciences. This Group was established primarily to ensure that teaching was not adversely affected when four senior staff (all with very considerable teaching experience) retired simultaneously, and were replaced by younger, more junior staff. Since transferring to the Institute for the Environment, I have played a major role in designing and developing Masters Courses in environmental science.

External Duties

  • Advisor to Department of Environment, Food and Rural Affairs (DEFRA) on chemicals policy.
  • Reviewer of research grants and scientific papers for many organisations.
  • Member of the Editorial Advisory Board of the prestigious journal “Environmental Science and Technology”.
  • Visiting Professor of the Centre for Ecology and Hydrology (CEH).
  • External examiner of Ph.D.’s for a large number of universities, both within the U.K. and abroad.
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