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Institute for the Environment

Professor Susan Jobling

Professor Susan Jobling

Email: susan.jobling@brunel.ac.uk
Direct Line: 01895 266284
Building: Halsbury Building
Room No: 144

 

Susan JoblingI am Head of the Institute for the Environment and a Professorial Research Fellow with a team comprising two postdoctoral researchers, and four PhD students. I am interested in how environmental contaminants affect the health of wildlife and humans as exposure to these is a part of our everyday lives, particularly in urban environments where 80% of UK citizens live and work. The diversity and quantity of chemicals released into the environment has risen dramatically in the last few decades and this is causing serious concern about the possible adverse effects of mixtures of these multiple chemicals on human health. The effects of contaminants on wildlife have been studied for more than 30 years, since the publication of Rachel Carson's Silent Spring. My work over the last decade or so has focused on the ability of environmental contaminants to mimic chemical messengers (hormones) and alter functioning of the reproductive and endocrine systems. My current research areas include exploring new methods and models with which to determine the safety of mixtures of industrial chemicals and understanding the role of exposure to these chemicals in the manifestation of health problems, particularly reproductive health problems. From a regulatory perspective, my work has been influential in the development of widespread controls on some chemicals and I am always keen to make sure that my research informs policy. I also have a passion for communication of scientific results and their interpretation to the lay public.

Qualifications

  • 1991: BSc. (Hons) degree in Zoology with Marine Zoology, Upper Second Class (2i) degree. Bangor University College of North Wales.
  • 1994: PhD Environmental oestrogenic chemicals and their effects on sexual development in male rainbow trout (Oncorhynchus mykiss Walbaum)

Career

 DogI completed my PhD at Brunel University (Department of Biological Sciences) in 1991 and remained at Brunel first as Postdoctoral Researcher (1995-1999) and then as a (tenured) Research Lecturer until 2002; after which I became a Senior Research Fellow (100% research tenured post). From 2004, I set up and directed a consultancy which advises governments and industries on the risks posed by environmental chemicals.

Research Projects

 GiraffeMy research involves the development of collaborative inter- disciplinary approaches involving a wide range of specialisms to work towards an understanding of how contaminants influence wildlife and human health, from the individual to the population. Of great concern to me and an increasing number of other scientists is a group of contaminants known as endocrine-disrupting chemicals, endocrine disruptors or EDCs. EDCs are synthetic chemicals that interact with the human body's glands, hormones and hormone receptors, known collectively as the endocrine system. Health effects of EDC exposure can range from cancer to immune, endocrine, neurological and reproductive system impacts. I investigate effects right from the molecular level, through to the individual, right through to the population.

My research can be divided into two main areas:

1. Environmental Health Investigation.

 This is looking at the real world and the health problems and their possible connection with the contamination of the world by chemical contaminants. These are daunting scientific challenges and tracing down the causes of health problems can be very hard. My introduction to research started when I was asked to find the contraceptive pill hormone in water and its possible link with feminisation of fish populations in UK rivers. I have spent almost my entire career since that time trying to understand exactly which mixtures of chemicals cause feminisation in fish and how they do it. Lately this has involved both laboratory studies, field data collection on both exposure and effects and statistical modelling of these data. I now want to develop and apply methods to assist in identifying health risks from the low-level environmental exposures of today - methods which are sensitive enough to tease out the often subtle health effects of complex mixtures of micropollutants.

The new environment-health paradigm suggests that in utero neonatal exposures to mixtures of environmental toxicants at low doses alter susceptibility to disease later in life as a result of their ability to affect the programming of tissue function that occurs during development. My work here often involves a cross fertilization of ideas between toxicology and basic science as well as information science and mathematics.

2. The development of new models and test systems with which to test and predict the safety of chemicals and detect and monitor their presence in the environment.

 Society needs tools with which to protect us from any potential hazards posed by mixtures of contaminants; safety methods with which to test the chemicals we use, the air we breathe, the food we eat and the water we drink. Here, I have two interests:

  1. Exploration of new more ethically acceptable model test organisms with which to screen chemical safety: Current testing of chemicals (and medicines) is based largely on rodent models and public concern over vertebrate animal use in testing chemicals is increasing. The search for replacements to animals is a major long-term goal for medical research and now also for environmental safety testing. Two currently funded projects are exploring the use of snails as replacements for rodents in some reproductive toxicity screens. Our work here involves both fundamental research on the structure and function of the reproductive system in these new models and more applied reproductive toxicology research.
  2. Development of new intelligent biosensors with which detect and monitor the presence of contaminants and predict their effects on the health of humans and wildlife. This involves collaboration with materials scientists, biotechnologists and statistical modellers.

Grants Awarded

 Since 2002, I have been awarded several grants, totalling £1,605,294.00 in research funding, and an additional £434,803.52 in research consultancy.

  1. 2001-2004: Effects of treated sewage effluents on fish (Co-investigator with Professor Tyler, Exeter University). Value: 132,000. Source: UKWIR and The Environment Agency.
  2. 2001-2004: Genotoxic Effects of Putative Endocrine Disrupters in (co-investigato Co-investigator with Tamara Galloway, University of Plymouth and Mike Depledge of Environment Agency). Source Leverhulme Trust. Value: 98,460
  3. European Commission: £242,031 from 11/10/2002-31/03/2006 for a study entitled Comparative Responses of Vertebrates and Invertebrates to Androgenic and anti-androgenic chemicals (COMPRENDO). Co-investigator and work package leader.
  4. Natural Environment Research Council (NERC): £142,232 from 1/10/02-31/03/06 for a study entitled The Effects of Sewage Pollution on Freshwater Molluscs. (Principal and Sole Investigator)
  5. Department of Environment Food and Rural Affairs: £162,941 from 01/05/04-30/04/07 for a study entitled "Investigations into Endocrine Disruption in UK Freshwater Molluscs". (Principal Investigator). An additional £30,000 was obtained from the Environment Agency and then a further £48,000 for an extension till 2009.
  6. Biology and Biotechnology Research Council (BBSRC): £181,011 from 2004-2007 for a study entitled "Characterisation and Functional Role of Novel Oestrogen Receptors in the prosobranch Mollusc Marisa cornuarietis. (Principal Investigator). An additional £48,000 was obtained from the Environment Agency.
  7. Leverhulme Trust: £190,430 from 01/06/2009-30/05/2011 for a study entitled "Modelling and Mimicking the Effects of Pollution from Molluscs to Men". Principal Investigator (co-investigators Ed Routledge and Jo Bridger who are both at Brunel and Les Noble at Aberdeen University).
  8. NERC: £180,602 from 01/09/09 to 31/08/12 for a study entitled "Population Level Consequences of Exposure of Fish to Oestrogenic Wastewater Treatment Works Effluents". Collaborative study with Professor Charles Tyler at Exeter University (lead institute). I am the principal Investigator at Brunel and John Sumpter is the co-investigator.
  9. National Centre for the Refinement Reduction and Replacement of Animals in Research (NC3Rs): £380,047 from 1/11/2009 to 31/10/2012 for a study entitled "Molluscs Mice and Men". Principal Investigator. Co-investigators are Ed Routledge (Brunel), Tim Williams (AstraZeneca Pharmaceuticals in-kind contribution worth £80,000) and Les Noble and Catherine Jones (Aberdeen University). Brunel is the lead institution. Total value of the grant is £525,

Research Related Consultancy 

  1. 10. Environment Agency: Two contracts totalling £4869.53 from 17/07/2006-03/07 for reading and interpreting fish histopathology slides (Principle Investigator)
  2. 11. Melbourne Water: Three contracts (TO9724, TO9807 and TO9099 amounting to £56,610.65 from 01/2007-present for a consultancy and research project entitled "Survey of endocrine disruption in wild Black Bream (Acanthopagrus butcheri) from Australia". (Principal Investigator)
  3. 12. Severn Trent Water: Two contracts (TO9820) amounting to £110,728.59 from March 2008-Present for a study entitled "Feminizing Effects of Exposure to Ilkeston Sewage Effluents (Do improvements make a difference?)". Principal Investigator
  4. 13. Thames Water: £79,572.82 from 09/08-12/09 (Contract TO9870). To carry out Pair-breeding Tests on Fathead Minnows on Improved sewage effluent from Swindon STW as part of the UK Endocrine Disrupters Demonstration Programme. Principal Investigator
  5. 14. Wessex Water: £17,991.50 from 02/08-05/08 (Contract TO9800).To carry out and interpret the results of fish tests on the Swanage sewage effluent. Principal Investigator
  6. 15. Environment Agency: £21,892.50 from 02/08-07/08 (Contract TO9775) for carrying out Fish Histological Analysis for project entitled "Modelling the potential impacts of endocrine disruption of fish populations"
  7. 16. Severn Trent Water: Three contracts totalling £143,137.93 from 1/10/08-Present (Contracts TO9872 and TO9940, TO9950) for a research project entitled "Investigation of the role of anti-androgenic constituents of treated sewage effluents in causing feminisation of fish in UK rivers" (Principal Investigator. Collaborating also with Severn Trent Laboratories).

Impact

 My research has led to regulatory action (through the EU and Member States) on some chemicals (e.g. nonylphenol and some phthalates) leading to those chemicals being severely restricted or banned. This has led to rapid improvements in water quality and hence aquatic life health. For example, my research on nonylphenols led to immediate reductions in its use (especially in industries such as textiles), and contributed significantly to the agreed phase out of this chemical throughout the European Union.

Postdoctoral researchers

Susan and Friends05/09-05/12. Dr Margaret Mary Town (The Leverhulme Trust)

11/09-11/11. Dr Alice Baynes (3NCRs)

Postgraduate Researchers and Research Assistants

01/10-01/11. Christopher Green (Severn Trent Water & CSIRO Australia)

01/10-01-12 Elizabeth Nicol (NERC)

12/09-12/12 Satwant Kaur (3NCRs)

PhD Students Supervised

1995-2000: Monique Nolan. The Environment Agency (Joint first supervisor with Charles Tyler) (MPhil). Complete.

1996-2000: Trevor Rodgers-Gray (Joint first supervisor with Charles Tyler) The Environment Agency (PhD). Complete

2000-2003: Tamsin Runnalls (2nd supervisor with John Sumpter) NERC (PhD). Complete.

2001-2004: Katherine Liney (Joint First supervisor) The UKWIR (PhD). Complete.

2002-2004: David Hala The European Union (PhD) Complete

2002-2005: Neil Clarke NERC (PhD) Complete

2004-2007: Rachel Benstead Effects of oestrogenic chemicals on reproduction in Uk freshwater molluscs: Comparison of field and laboratory studies. DEFRA (PhD) Current

2004-2007: Alice Baynes Effects of estrogenic chemicals on freshwater mollusc reproduction in outdoor mesocosms (life cycle studies). DEFRA (PhD) Completed

2009-2012: Satwant Kaur (NC3Rs). (PhD) Current

Articles in refereed journals

  1. Jobling, S. and J.P. Sumpter (1993) Detergent components in sewage effluent are weakly oestrogenic to fish: An in-vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquatic Toxicology, 27, 361-372.(Impact Factor 3.517. Cited 637 times. first and corresponding author)
  2. Sumpter, J.P. and S. Jobling (1993) Male sexual development in a "sea of oestrogens". Lancet 342, 124-125 (Impact Factor 28.409. Cited 18 times. co-author)
  3. White, R., S. Jobling, S.A. Hoare, J.P. Sumpter and M.G. Parker (1994) Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 135(1): 175-182 (Impact Factor 4.945. Cited 893 times. Joint first author).
  4. Sumpter, J.P. and S. Jobling (1995). Vitellogenin as a biomarker of exposure to oestrogens. Environmental Health Perspectives 103(S7): 173-178 (Impact factor 6.12. Cited 662 times. Co-author)
  5. Jobling, S., T. Reynolds, R. White, M.G. Parker and J.P. Sumpter (1995). A variety of environmentally persistent chemicals, including some phthalate plasticizers are weakly estrogenic. Environmental Health Perspectives 103(6): 582-587. (Impact factor 6.12. Cited 633 times. First and corresponding author)
  6. Sharpe, R.M., J.S. Fisher, M.M. Millar, S. Jobling and J.P. Sumpter (1995). Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production. Environmental Health perspectives 103(12): 1136-1143. (Impact factor 6.12. Cited 302 times. Co-author)
  7. Jobling, S., Sheahan, D, Osborne JA, Matthiessen P, Sumpter J.P (1996) Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals. Environmental Toxicology and Chemistry 15, No.2, 194-202(Impact Factor 2.31. Cited 743 times. First and corresponding author )
  8. Tyler, C.R., B. Vandereerden, S. Jobling, G. Panter and J.P. Sumpter (1996). Measurement of vitellogenin, a biomarker for exposure to estrogenic chemicals in a wide variety of cyprinid fish. Journal of Comparative Physiology. B-Biochemical Systemic and Environmental Physiology 166(7): 418-426 (Impact Factor 1.698. Cited 118 times. Co-author)
  9. Harries, JE, Sheahan, DA, Jobling, S, Matthiessen, P, Neall, P, Routledge, EJ, Rycroft, R, Sumpter, J.P, Tylor, T. (1996) A survey of estrogenic activity in United Kingdom inland waters. Environmental Toxicology and Chemistry, 1996, 15 (11), 1993-2002.(Impact Factor 2.31. Cited 249 times. Co-author)
  10. Harries, J.E, Sheahan, D.A, Jobling, S, Matthiessen, P, Neall, M, Sumpter, JP, Taylor, T, Zaman, N. (1997). Estrogenic activity in five United Kingdom rivers detected by measurement of vitellogenesis in caged male trout Environmental Toxicology and Chemistry, 16(3), 534-542.( Impact Factor 2.31. Cited 358 times. Co-author)
  11. Jobling, S, Nolan, M, Tyler, CR, Brighty, G, Sumpter, JP (1998) Widespread sexual disruption in wild fish. Environmental Science and Technology, 32(17), 2498-2506.(Impact Factor 4.458. Cited 674 times, first and corresponding author)
  12. Tyler, CR, Jobling, S, Sumpter, JP.. (1998) Endocrine disruption in wildlife: A critical review of the evidence. Critical Reviews in Toxicology 28(4) 319-361 (Impact Factor 5.145. Cited 432 times. Joint first author)
  13. Jobling, S. (1998) Review of suggested testing methods for endocrine-disrupting Chemicals. Pure and Applied Chemistry 70(9) 1805-1814. (Impact Factor 2.37. cited 18 times. First author)
  14. Gimeno S, Komen H, Jobling S, Sumpter J, Bowmer T (1998). Demasculinisation of sexually mature male common carp, Carpio carpio, exposed to 4-tert-pentylphenol during spermatogenesis Aquatic Toxicology Vol.43,(2-3), 93-109 (Impact Factor 3.517, Cited 88 times. Co-author)
  15. Harries JE, Janbakhsh A, Jobling S, Matthiessen P, Sumpter JP, Tyler CR.(1999) Estrogenic potency of effluent from two sewage treatment works in the United Kingdom. Environmental Toxicology and Chemistry, Vol.18, No.5, 932-937 (Impact Factor 2.31. Cited 93 times. Co-author)
  16. Rodgers-Gray, T.P. Jobling,S, Morris, S. Kelly, C, Kirby, S, Janbakhsh,A, Harries, J.E., Waldock, MJ., Sumpter, J.P. and Tyler, C.R. (2000) Long-term temporal changes in the estrogenic composition of treated sewage effluent and its biological effects on fish. Environmental. Science and Technology, 34, 1521-1528 (Impact Factor 4.458. Cited 112 times. Co-author and second supervisor)
  17. Rodgers-Gray, T.P., Jobling, S. , Janbakash, A., Sumpter, J.P., and Tyler, C.R.(2001). Exposure of roach to sewage effluents during sexual differentiation causes permanent feminisation of the reproductive ducts. Environmental Science and Technology,35, 462-470 (Impact Factor 4.458. cited 31 times. Co-author and second supervisor)
  18. Nolan, M., Jobling, S, Sumpter, J.P., Brighty, G. and Tyler, C.R. (2001). A histological description of description of intersexuality in the roach (Rutilis rutilis). J, Fish Biology, 17, 160-176(Impact Factor 1.246. cited 45 times. Co-author and second supervisor)
  19. Van Aerle, R., Nolan, M., Jobling, S., Christiansen, L.,Sumpter, J.P., and C.R. Tyler. (2001) Evidence for sexual disruption in a second species of Cyprinid fish (the gudgeon Gobio gobio) Environmental Toxicology and Chemistry, 20, 2841-2847(Impact Factor 2.31. cited 82 times. Co-author and supervisor)
  20. Jobling, S, Beresford,N, Nolan, M., Rodgers-Gray, R., Tyler, C.R. and Sumpter, J.P. (2002) Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents. Biol Reprod. Vol 66, 66(2):272-281 (Impact Factor 3.469. Cited 133 times. First author and co-supervisor)
  21. Sheahan, D.A., Brighty, G.C., Daniel M, Jobling, S., Harries, JE., Hurst, M.R., Kennedy J., Kirby, S.J., Morris, S., Routledge, EJ., Sumpter, J.P., Waldock, M.J. (2002) Reduction in the estrogenic activity of a treated sewage effluent discharge to an English river as a result of a decrease in the concentration of industrially derived surfactants. Environ. Toxicol. And Chem. 21(3): 515-519 (Impact Factor 2.31. Cited 32 times. Co-author)
  22. Jobling, S, S. Coey, J.G. Whitmore, D.E. Kime, K.J.W Van Look, B.G. McAllister, N. Beresford, A.C. Henshaw, G. Brighty, C.R. Tyler, J.P. Sumpter (2002) Wild Intersex Roach (Rutilis rutilis) have reduced fertility. Biol Reprod. 67, 515-524 (Impact Factor 3.469. citations 125. first author and co-supervisor).
  23. Jobling, S and Tyler, C.R. (2003) Endocrine disruption, parasites and pollutants in wild fish. Parasitology, 126: S103-S108 (Impact Factor 2.071. citations 14. first and senior author).
  24. Jobling, S, D. Casey, T. Rodgers-Gray, J. Oehlmann, U. Schulte-Oehlmann, S. Pawlowski, T. Baunbeck, A. P. Turner and C. R. Tyler (2003). The Comparative Responses of Molluscs and Fish to Environmental oestrogens and their Mixtures. Aquatic Toxicology, Aquatic Toxicology 65. 205-220.( Impact Factor 3.517. cited 66 times. First and senior author).
  25. Jobling, S Endocrine disruption in wild fish (2004). IUPAC Pure and Applied Chemistry Vol 75: (11-12) 2219-2234 (Impact Factor 1.246. citations 47. Sole lead author)
  26. Beresford N, Jobling S, Williams R, Sumpter, J.P.(2004). Endocrine disruption in juvenile roach from English rivers: a preliminary study. J Fish Biol. 64 (2): 580-586. (Impact Factor 1.246. cited 8 times. Co-author
  27. Jobling, S; Tyler, CR. (2006). Introduction: The ecological relevance of chemically induced endocrine disruption in wildlife . Environmental Health Perspectives Volume: 114 Page: 7. (Impact factor 6.12. citations 7, first and lead author)
  28. Hagger, J. Oehlmann, J, Jobling, S. Depledge, M, and Galloway, T. (2006) Is there a causal association between genotoxicity and the imposex effect? Environmental Health Perspectives. 114 (S1) 20-26. Available at http://www.ehponline.org/docs/2006/suppl-1/toc.html (Impact factor 6.12. citations 9. co-author, external supervisor)
  29. Schulte-Oehlmann, U; Albanis T (Albanis, Triantafyllos), Allera A (Allera, Axel), Bachmann J (Bachmann, Jean), Berntsson P (Berntsson, Pia), Beresford N (Beresford, Nicola), Carnevali DC (Carnevali, Daniela Candia), Ciceri F (Ciceri, Francesca), Dagnac T (Dagnac, Thierry), Falandysz J (Falandysz, Jerzy), Galassi S (Galassi, Silvana), Hala D (Hala, David), Janer G (Janer, Gemma), Jeannot R (Jeannot, Roger), Jobling S (Jobling, Susan), King I (King, Isabella), Klingmuller D (Klingmueller, Dietrich), Kloas W (Kloas, Werner), Kusk KO (Kusk, Kresten Ole), Levada R (Levada, Ramon), Lo S (Lo, Susan), Lutz I (Lutz, Ilka), Oehlmann J (Oehlmann, Joerg), Oredsson S (Oredsson, Stina), Porte C (Porte, Cinta), Rand-Weaver M (Rand-Weaver, Marian), Sakkas V (Sakkas, Vasilis), Sugni M (Sugni, Michela), Tyler C (Tyler, Charles), van Aerle R (van Aerle, Ronny), van Ballegoy C (van Ballegoy, Christoph), Wollenberger L (Wollenberger, Leah (2006). Comprendo: Focus and approach. Environmental Health Perspectives. Volume: 114 Pages: 98-100 (Impact factor 6.12. citations 4. co-author and work package leader)
  30. S. Jobling, Williams R, Johnson A, Taylor A , Gross-Sorokin M, Nolan M, Tyler CR, van Aerle R, Santos E, Brighty G . (2006) Predicted exposures to steroid estrogens in U.K. rivers correlate with widespread sexual disruption in wild fish populations Environmental Health Perspectives 114(S1) 32-39. Available at http://www.ehponline.org/docs/2006/suppl-1/toc.html. (Impact factor 6.12. citations 49. Lead author)
  31. K. Liney, J. Hagger, C. Tyler, M. Depledge, T. Galloway and S Jobling (2006). Health Effects in fish of long-term exposure to effluents from wastewater treatment works. Environmental Health Perspectives 114 (S1) 81-89 Available at http://www.ehponline.org/docs/2006/suppl-1/toc.html (Impact factor 6.12, Cited 16 times. Senior author and co-supervisor)
  32. K. Liney, S. Jobling and C.R. Tyler. (2005) Investigating windows of potential sensitivity for disruption of sexual development in roach (Rutilus rutilus) exposed to Wastewater treatment works effluents. Environmental Health Perspectives. 113(10): 1299-1307 (Impact factor 6.12. Cited 32 times. Co-author and second supervisor).Available at http://www.ehponline.org/docs/2006/suppl-1/toc.html
  33. Bannister R, Beresford N, May D, Routledge EJ, Jobling S, Rand-Weaver M (2007) Novel estrogen receptor ñrelated transcripts in Marisa Cornuarietis; a freshwater snail with reported sensitivity to estrogenic chemicals. Environ. Sci. Technol. 41, 2643-2650 (Impact Factor 4.458. cited 11 times. Co-author and PI).
  34. Frederick S. vom Saal, Benson T. Akingbemi, Scott M. Belcher, Linda S. Birnbaum, D. Andrew Crain, Marcus Eriksen, Francesca Farabollini, Louis J. Guillette Jr., Russ Hauser, Jerrold J. Heindel, Shuk-Mei Ho, Patricia A. Hunt, Taisen Iguchi, Susan Jobling, Jun Kanno, Ruth A. Keri, Karen E. Knudse, Hans Laufer, Gerald A. LeBlanc, Michele Marcust, John A. McLachlan, John Peterson Myers, Angel Nadal, Retha R. Newbold, Nicolas Olea, Gail S. Prins, Catherine A. Richter, Beverly S. Rubin, Carlos Sonnenschein, Ana M. Soto, Chris E. Talsness, John G. Vandenbergh, Laura N. Vandenberg, Debby R. Walser-Kuntz, Cheryl S. Watson, Wade V. Welshons, Yelena Wetherill and R. Thomas Zoeller. (2007). Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reproductive Toxicology 24 131-138 (Impact Factor 2.957. Cited 47 times. Co-author)
  35. Crain, DA; Eriksen, M; Iguchi, T, Jobling S, Laufer H, LeBlanc GA, Guillette LJ . (2007) An ecological assessment of bisphenol-A: Evidence from comparative biology. Reproductive Toxicology. Volume: 24 Pages: 225-239. (Impact Factor 2.957. cited 20 times. Co-author)
  36. Yoshinao Katsu, Anke Lange, Rie Ichikawa, Hiroshi Urushitani, Gregory C. Paull, Laura L. Cahill, Susan Jobling, Charles R. Tyler, Taisen Iguchi. (2007). Functional associations between two estrogen receptors and sexual disruption in the roach (Rutilus rutilus). Environmental Science and Technology Volume: 41 Issue: 9 Pages: 3368-3374 (Impact factor 4.458. citations 16. co-author)
  37. Tyler, CR; Jobling, S. (2008) Roach, Sex, and Gender-Bending Chemicals: The Feminization of Wild Fish in English Rivers. Bioscience Volume: 58 Issue: 11 Pages: 1051-1059 (Impact factor 4.058. Citations 1. co-author)
  38. Althaus, FR; Hungerbuhler, K; Jobling, S, Ruegg U, Soto A , Studer C (2008). Endocrine disruptors: Relevance to humans, animals and ecosystems research highlights from the National Research Programme NRP50. CHIMIA Volume: 62 Issue: 5 Pages: 316-317 (Impact factor 0.92 citations 0. co-author)
  39. Hala, D, Van Look K, Holt, WV, Jobling, S. (2009). Validation of a Method for Measuring Sperm Quality and Quantity in Reproductive Toxicity Tests with Pair-Breeding Male Fathead Minnows (Pimephales promelas). ILAR Volume 50(4) (Impact factor 2.32. Citations 0. Senior author)
  40. Jobling S, Burn RW, Thorpe K, Williams R and Tyler C. (2009) Statistical Modelling suggests that Anti-androgens from Wastewater Treatment Works Contribute to Widespread Sexual Disruption in Fish Living in English Rivers. Environ Health Perspect 117:797ñ802 (Impact factor 6.12. citations 1. First and corresponding author)
  41. Myers, JP; vom Saal, FS; Akingbemi, BT, Arizono K, Belcher S, Colborn T, Chahoud I Crain DA, Farabollini F, Guillette LJ, Hassold T, Ho SM , Hunt PA , Iguchi T , Jobling S, Kanno J , Laufer H, Marcus M, McLachlan JA, Nadal A, Oehlmann J, Olea N, Palanza P, Parmigiani S, Rubin BS, Schoenfelder G, Sonnenschein C, Soto AM , Taisness CE, Taylor JA , Vandenberg LN, Vandenbergh JG, Vogel S, Watson CS, Welshons WV, Zoeller RT. (2009). Why Public Health Agencies Cannot Depend on Good Laboratory Practices as a Criterion for Selecting Data: The Case of Bisphenol A. Environmental Health Perspectives Volume: 117 Issue: 3 Pages: 309-315 (Impact Factor 6.12. Citations 5. co-author)
  42. Clarke, N., Routledge, E.J., Casey, D, Benstead R., Walker, D, Watermann, B., Kelly, C, Jobling, S.J. (2009). Exposure to Treated Sewage Effluent disrupts the seasonal reproductive cycle of Freshwater Snails. Part I: The Ramshorn snail (Sub-class: Pulmonata, Planorbarius corneus). Environ. Sci. Technol., 43 (6), 2092ñ2098. (Impact factor 4.458. Citations 0. Senior author)
  43. D.N. Hala S. Bristeau , T. Dagnac , S. Jobling . Problems Associated with Exposure Studies in Aquatic Toxicology: 2. Unexpected Sources of Contamination in Aquatic Toxicological Laboratory Studies. Hala, D., Submitted to Aquatic Toxicology November 2009 Accepted

Chapters in Books

  1. Sumpter, J.P., S.Jobling, and C.R. Tyler. (1996) Oestrogenic chemicals in the aquatic environment. Toxicology of Aquatic Pollution. Physiological, Molecular, and Physiological Approaches. Editors: E.W. Taylor. Cambridge University Press. 205-224
  2. Veethaak, D.; S. Jobling, M.Waldock, P. Bjerregard, R. Dickerson, J. Giesy, D. Grothe, K. Munkittrick, M. Schlumph, and J. Sumpter (1997). Approaches for the conduct of field studies and toxicity identification and evaluation in identifying the hazards of endocrine modulating compounds to wildlife. In: SETAC Europe/OECD/EC Expert Workshop on Endocrine Modulators and Wildlife. Assessment and Testing EMWAT. Chapter 5. Editors L. Tattersfield, Peter Matthiessen, Pamela Campbell, Nicky Grandy, Reinhardt Lange.Brussels Belgium. SETAC Europe 59-76.

Editorial work

 Guest Editor for a special issue of Environmental Health Perspectives on endocrine disruption in wildlife May 2006. Jobling S and Tyler CR. (2006) The ecological relevance of chemically induced endocrine disruption in wildlife. Environmental Health Perspectives 114 (S1) 7-8.Environmental Health Perspectives is one of the most highly ranked environmental health journals

Associate Editor for General and Comparative Endocrinology 2003-2005

Co-editor of Endocrine Disruptors: Relevance to Humans, Animals and Ecosystems: Research Highlights from the National Research Programme NRP50. CHIMIA International Journal for Chemistry, Special Issue Volume 62, Number 5, May 2008 , Swiss Chemical Society (see supporting evidence)

Reports Written

 I have written/co-written many reports for the Environment agency, the DEFRA and the water industry. Most recently completed reports are:

  1. Review of the relative contribution of industrial chemicals in causing reproductive health problems in wild fish (Review for CEFIC)
  2. Report on the suitability of various VTG assays for measuring VTG in fathead minnows (for the UK Environment Agency)
  3. Report on the suitability of various in-vitro screens for measuring hormonal activity in sewage effluents (for the UK Environment Agency)
  4. Spatial survey of the extent of sexual disruption in wild roach in English and Welsh rivers. Science Report P6-018/SR (In Press)
  5. The suitability of the Yeast Oestrogen Screen for use in the Endocrine Disrupting Chemicals demonstration Programme. July 2006. (For the UK Environment Agency and provided to the Water Industry and contractors. Explanatory document)
  6. A summary of research papers, current projects and research calls concerning engineered nanoparticles (for the UK Environment Agency 2006).
  7. Draft technical assessment method for steroid oestrogens (Prepared for the UK Environment Agency for consideration under the Water Framework Directive).

Digital and broadcast media:

 The media have shown much interest in my research, and I often help them with their articles and films. Articles based around aspects of my research have featured in many national, local and international newspapers and magazines and continue to do so. Much of the research done during my PhD was made available to the public through Deborah Cadbury's book "The Feminization of Nature", first published in 1997, and through her BBC Horizon programme "Assault on the Male" (which won an EMMY).

Besides that programme, my research has featured in other television programmes, such as BBC's Country file, News 21 and also on Japanese and Australian T.V and (more recently) in a documentary called "The Plastic Planet" (Austrian production).

The latest media attention occurred this year when Country file did a feature based around my latest research paper (copy available on request).

Invited Presentations:

 I have presented my research as a plenary speaker at national and international venues and have acted as a session chair at several of these venues. I was also invited to present my research at the prestigious Gordon conferences in the U.S.A. both to present work on fish and to present new research on invertebrates

Sewage Effluent is oestrogenic to fish. Institute of Fisheries management. Long-term impact of pollution on U.K. freshwaters. Nottingham U.K. 21st May 1994

Alkylphenols and their effects on fish. Society of the Chemical Industry. Ecotoxicology and Environmental factors in pesticide use. 5th December 1995.

Oestrogens at Large. An international chemical congress of Pacific Basin Societies. Honolulu, Hawaii, USA. Dec17th-22nd 1995

Oestrogens in the Aquatic Environment. Royal Society of Chemistry, Autumn meeting, 9th-13th September 1995.

Widespread Sexual Disruption in wild fish populations in U.K. Rivers. 27th Annual conference of the industrial histology discussion group October 1997.

Endocrine Disruptors in Freshwater Environments. Society of Toxicology. Sex, Drugs and Ageing Bodies. University of Ulster, Ireland, 1999.

Unravelling the causes and consequences of intersexuality in wild fish. Oestrogens in the Environment 3. New Orleans, U.S.A, 1999

Can Intersex Fish Reproduce? ...Some Preliminary Answers. The Gordon Conference on Endocrine Disruption, New Plymouth, U.S.A. 2000

Sexual Disruption in U.K. Wild Fish....What does it all mean? International Symposium on Environmental Endocrine Disrupters, Japan 2000 December 16th-18th

Endocrine Disruption in Fish..... Gaps in the Knowledge Japan-U.K Workshop, University of Plymouth U.K. 26th-30th January. 2001

The Consequences of Endocrine Disruption in wild fish. 65th NIBB Conference, Okazaki, Japan, 2001

Endocrine Disruption, Problem or Hype? State of the Art Lecture. 14th International Conference of Comparative Endocrinology, "Unity and Diversity" May 26-30th Sorrento (Napoli) Italy. 2001

Effects of Endocrine Disruptors in Fish. Endocrine Disruptors: State of the Art. April 22, 2002, University Campus Zurich Irchel, Switzerland

Comparative effects of endocrine disruptors on molluscs and Fish. Gordon Conference . Mount Holyoke, Massachussetts USA. 15th July-19th July 2002

Endocrine disruptors in wild fish ..Does the dose really make the poison? " European Environment Agency conference "A matter of timing" , Copenhagen 2nd October 2003.

Beyond Receptor Binding ..Interspecies extrapolation of the effects of endocrine disruptors on wildlife. CREDO conference Mallorca. April 2004

Predicting the effects of oestrogens in wild populations of roach. CREDO conference on the Ecological Relevance of Endocrine Disruption in Wildlife. Exeter University, U.K. 5-7th July 2004

Fundamental facts about hormones. BA Festival Of Science, Exeter University, 2004.

The causes and consequences of endocrine disruption in freshwater fish ...a UK case history. Plenary Lecture. Australian Society for Ecotoxicology, Annual Conference in Melbourne, Australia. 26-28th September 2005

How should we deal with complex chemicals that compromise life? A UK demonstration. Australian Society for Ecotoxicology, Annual Conference in Melbourne, Australia. 26-28th September 2005

From Data to Decisions. Lecture to the Australian Water Industry. 30th September 2005, Melbourne Australia.

Endocrine disruption in the aquatic environment. Biological and political responses to exposure 2nd October. 2005. University of Technology, Sydney, Australia

Comparative aspects of endocrine disruption in invertebrates and vertebrates: New animal models for extrapolation to human health. COMPRENDO final workshop. February 17th 2006. Frankfurt University, Germany. http://www.comprendo-project.org/_files/Jobling.pdf

How to generate Research Ideas. May 2006 Workshop for new lecturers. Brunel University.

Whats in our water? Lecture given in the public library in Melbourne Australia. November 2007.

Drugs are in the water. Does it matter? Plenary given in Canberra. Australia November 2007.

Communicating complexity and causality. Talk given at the expert workshop organised by David Gee of the European EEA on Multi-Causality and Complexity: Implications for Evaluating Evidence and Precautionary Prevention. January 2008

UK-Australia cooperation on Water Safety. Introductory talk at a workshop organised to facilitate and progress this cooperation. August 2008

Endocrine Disruption in the Aquatic Environment in the UK-Research to Policy. Given in Canberra to the National Water Commission and in Wellington New Zealand at a workshop on developing a strategy for micropollutants in New Zealand 2009.

Complexity and Causality in Ecotoxicology, Melbourne Australia. 2009.

I have also given numerous talks to the Institute of Water management, the environment agency and the water authorities.

External Duties

 FishI have served on several Government expert committees in Europe and the USA advising on test methods for chemicals present in food, consumer products and the environment. I was also one of two international steering committee members on the Swiss National Programme on Endocrine Disruptors from 2001-2008. I regularly sit on panels to review and evaluate proposals for funding at the European Commission in both 2007 and 2008 and currently serve as a risk assessment advisor (Public Health and Risk Assessment) also for the European Commission

I am often asked to chair conference sessions, give plenary research talks and lead research projects/parts of research projects. I am currently leading a programme to establish cooperative and collaborative links between the UK and Australasia in my research area. In this role, I have spent some time over the last 4 years travelling to Australia and New Zealand both to raise awareness (public, industrial and governmental) and to liaise with stakeholders and potential funders of the collaboration.
More at: Australasian Society for Ecotoxicology, History

I am external examiner of Ph.Ds for several Universities.

 
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