Continuous Flow Processing
Continuous flow bioprocessing in the Advanced Bioprocessing Centre at Brunel generally takes place along a continuous length of tubing. The tubing is wound on a drum (more commonly referred to as the bobbin) and the drum/bobbin is rotated in planetary motion. Liquids in the tubing experience a variable force (CCC animation) which can have different effects depending on whether two immiscible liquids are used for liquid-liquid chromatography/extraction (Liquid-liquid flow processes) or a single phase liquid is used for particle separation involving a form of field flow fractionation (Single phase flow processing). Both processing methods can be used in different ways for particle purification (Particles and Cells) and complementary processes like filtration (Filtration) can also play a role. The process can also be used as a bioreactor, where product streams can react under controlled mixing conditions and then get separated as they move on down the column (Flow reactor)
