Scale-up
Most chromatography processes are difficult to scale up, but the liquid flow processes in the ABC, scale up remarkably well by just increasing the bore of the tubing. Of course as the tubing bores get bigger the centrifuges themselves get bigger, but the magnitude of the force field is always kept the same, from the Mini centrifuge (tubing bore 0.8mm) through to the Maxi centrifuge (tubing bore 10mm). The full range of centrifuges available in the ABC is given below. The difference between linear and volumetric scale-up is given in Section 3.1 while the predictability of scale-up is given in Section 3.2. Finally Section 3.3 discusses analytical to process scale technologies.
Mini CCC |
Specifications |
 |
Scale of application: Analytical Processing rate: mg/hr Main rotor radius (mm): 50 Volume of coils (ml): 17 Coil bore (mm): 0.8 Max rotor speed (rpm): 2100 Typical flow range (ml/min): 0.1 - 2 Typical run time (min): 30 |
Spectrum CCC |
Specifications |
 |
Scale of application: Semi/Prep Processing rate: mg-g/hr Main rotor radius (mm): 85 Volume of coils (ml): 143 Coil bore (mm): 1.6 Max rotor speed (rpm): 1600 Typical flow range (ml/min): 0.5 - 10 Typical run time (min): 30 |
Midi CCC |
Specifications |
 |
Scale of application: Preparative Processing rate: g/hr Main rotor radius (mm): 110 Volume of coils (ml): 912 Coil bore (mm): 4.0 Max rotor speed (rpm): 1400 Typical flow range (ml/min): 10 – 100 Typical run time (min): 30 |
Maxi CCC |
Specifications |
 |
Scale of application: Pilot Processing rate: kgs/day Main rotor radius (mm): 300 Volume of coils (ml): 4600 Coil bore (mm): 10.0 Max rotor speed (rpm): 850 Typical flow range (ml/min): 100-1000 Typical run time (min): 30 |
Maxi CCC |
Specifications |
 |
Scale of application: Pilot Processing rate: kgs/day Main rotor radius (mm): 300 Volume of coils (ml): ~18,000 Coil bore (mm): 10.0 Max rotor speed (rpm): 850 Typical flow range (ml/min): 300-1500 Typical run time (min): 30 |
