Derek Fisher

Contact

Heinz Wolff 001 Brunel University Uxbridge UB8 3PH United Kingdom

Tel: +44 (0)1895 266907 Email: derek.fisher@brunel.ac.uk

About Derek

Derek Fisher, Professor for Biochemistry, joined BIB in 2002 after retiring from the Royal Free Hospital School of Medicine in London University where he was Reader in Biochemistry. He had taught Biochemistry and Cell Biology to Medical students for over 30 years and his research interests at the Free were membrane fusion, phase partitioning in aqueous 2-phase system and polymer (polyethylene glycol, PEG modification (PEGylation) of liposomes and peptides as new biopharmaceuticals. From 1995-2001 he was seconded, as Director of Biochemistry to PolyMASC Pharmaceutical plc, a spin out company in which he was a founding scientist. He has over 100 publications, 5 patents (2 granted) in the field of PEG-liposomes and PEG-cytokines and has co-edited 3 books on bioseparations: “Partitioning in Aqueous Two-Phase Systems. Theory, Methods, Uses and Applications in Biotechnology”; Separations Using Aqueous Phase Systems. Applications in Cell Biology and Biotechnology” and “Cell Separations”.

Research Interests

At BIB he is developing biological applications of countercurrent chromatography (CCC). These include separation of bioactive components of Chinese Herbal Medicine (with collaboration within the UK Consortium for the Globalisation of Chinese Medicines and with the XiangCam TCM Research Centre at Babraham) , peptides, proteins and nanoscale particles such as plasmids, viruses and virus-like particles. and using CCC as a bioreactor.

Research Area

Bioprocess Engineering

Publications

Journal Papers

(2009) Wei, Y., Xie, QQ., Fisher, D. and Sutherland, IA., Preparative isolation of imperatorin, oxypeucedanin and isoimperatorin from a traditional Chinese herb using a HSCCC strategy based on optimization of rapid flow rate, Chromatographia 70 (7-8) : 1185- 1189

(2009) Sutherland, IA. and Fisher, D., Role of counter-current chromatography in the modernisation of Chinese herbal medicines, Journal of Chromatography A 1216 (4) : 740- 753

(2009) Guan, YH., Bourton, EC., Hewitson, P., Sutherland, IA. and Fisher, D., The importance of column design for protein separation using aqueous two-phase systems on J-type countercurrent chromatography, Separation and Purification Technology 65 (1) : 79- 85

(2008) Yuan, Y., Wang, BQ., Chen, LJ., Luo, HD., Fisher, D., Sutherland, IA. and Wei, Y., How to realize the linear scale-up process for rapid purification using high-performance counter-current chromatography, Journal of Chromatography A 1194 (2) : 192- 198

(2008) Garrard, IJ., Fisher, D. and Sutherland, IA., Dynamic extraction: a high-speed, high-capacity purification process that is rapidly scalable, LC/GC North America 26 (5) : 2- 7

(2008) Sutherland, IA., Audo, G., Bourton, E., Couillard, F., Fisher, D., Garrard, I., Hewitson, P. and Intes, O., Rapid linear scale-up of a protein separation by centrifugal partition chromatography, Journal of Chromatography A 1190 (1-2) : 57- 62