Ian Sutherland

Contact

Heinz Wolff 005a Brunel University Uxbridge UB8 3PH United Kingdom

Tel: +44 (0)1895 266920 Email: ian.sutherland@brunel.ac.uk

About Ian

Prof Ian A Sutherland was educated at Rugby School and Bristol University. He graduated in Mechanical Engineering in 1967 and after a graduate apprenticeship in the machine tool industry, he returned to Bristol to do a PhD in machine tool technology. He then joined NASA as a National Academy of Sciences postdoctoral research fellow at the George C Marshall Space Flight Center, Huntsville Alabama before returning to the UK to join the MRC’s National Institute for Medical Research as a member of their scientific staff and head of Mechanical Engineering. In 1989 he moved to Brunel University’s Institute for Bioengineering, where he became director in 1995.

Prof Sutherland has had a long and distinguished research and development career in Biomedical Engineering. He has always worked as an engineer and scientist in a multi-disciplinary, collaborative environment at the forefront of a number of disciplines - notably portable insulin infusers, the treatment of infertility, the study of pelvic blood flow, the management of incontinence and the development of space flight hardware for NASA. The majority of these collaborations have resulted in commercial hardware and all have contributed to improved quality of life for the beneficiaries, albeit one being extra-terrestrial. He recently set up the Advanced Bioprocessing Centre at Brunel where he and his team are developing new methods of purifying drugs and getting them to market quickly in close collaboration with the pharmaceutical industry.

The success of Prof Sutherland’s research led to him being invited to give the 2004 IMechE James Clayton Lecture, being awarded a visiting professorship at Sichan University in China and receiving with his team at Brunel Institute for Bioengineering the Corac award for Engineering Research with Enterprise Promise. Prof Sutherland is invited to give keynote lectures on his research world wide (approximately 12 a year) and is currently on the IMechE Pharmaceutical Committee, an Executive Council Member of the Consortium for the Globalisation of Chinese Medicine (CGCM) and on the international organising committees of CCC2010 and BPP2011.

Research Interests

The majority of these collaborations have resulted in commercial hardware and all have contributed to improved quality of life for the beneficiaries

• Portable insulin infusers
• The treatment of infertility
• The study of pelvic blood flow
• The development of space flight hardware for NASA
• Separation technologies for the purification of drugs

Research Area

Bioprocess Engineering

Publications

Journal Papers

(2011) Zhang, M., Ignatova, S., Hu, P., Liang, Q., Wang, Y., Luo, G., Wu Jun, F. and Sutherland, I., Development of a strategy and process parameters for a green process in counter-current chromatography: Purification of tanshinone IIA and cryptotanshinone from Salvia miltiorrhiza Bunge as a case study, Journal of Chromatography A 1218 (36) : 6031- 6037

(2011) Ignatova, S., Sumner, N., Colclough, N. and Sutherland, I., Gradient elution in counter-current chromatography: A new layout for an old path, Journal of Chromatography A 1218 (36) : 6053- 6060

(2011) de Folter, J. and Sutherland, IA., Probabilistic model for immiscible separations and extractions (ProMISE)., Journal of Chromatography A 1218 (36) : 6009- 6014

(2011) Sutherland, I., Ignatova, S., Hewitson, P., Janaway, L., Wood, P., Edwards, N., Harris, G., Guzlek, H., Keay, D., Freebairn, K., Johns, D., Douillet, N., Thickitt, C., Vilminot, E. and Mathews, B., Scalable technology for the extraction of pharmaceutics (STEP): The transition from academic knowhow to industrial reality, Journal of Chromatography A 1218 (36) : 6114- 6121

(2011) Wei, Y., Sardar, MR., Sutherland, IA. and Fisher, D., Separation of Delphinidin-3-O-sambubioside, Cyanidin-3-O-sambubioside and p-Coumaric Acid from Cranberry by CCC Followed by prep-HPLC Using Robotic CCC Solvent System Selection, Chromatographia 74 (5-6) : 367- 373

(2011) Sutherland, IA., Hewitson, P. and De Folter, J., Toroidal coil chromatography: The effect of scale-up and "g" field on stage efficiency, Journal of Chromatography A 1218 (36) : 6144- 6147 Download publication

(2011) Sutherland, I., Hewitson, P., Siebers, R., van den Heuvel, R., Arbenz, L., Kinkel, J. and Fisher, D., Scale-up of protein purifications using aqueous two-phase systems: Comparing multilayer toroidal coil chromatography with centrifugal partition chromatography, Journal of Chromatography A 1218 (32) : 5527- 5530

(2011) Wei, Y., Xie, QQ., Fisher, D. and Sutherland, IA., Separation of patuletin-3-O-glucoside, astragalin, quercetin, kaempferol and isorhamnetin from Flaveria bidentis (L.) Kuntze by elution-pump-out high-performance counter-current chromatography, Journal of Chromatography A 1218 (36) : 6206- 6211

(2010) Ignatova, S., Hawes, D., van den Heuvel, R., Hewitson, P. and Sutherland, IA., A new non-synchronous preparative counter-current centrifuge – the next generation of dynamic extraction/chromatography devices with independent mixing and settling control, which offer a step change in efficiency, Journal of Chromatography A 1217 (1) : 34- 39

(2010) Qi, X., Ignatova, S., Luo, G., Liang, Q., Jun, FW., Wang, Y. and Sutherland, I., Preparative isolation and purification of ginsenosides Rf, Re, Rd and Rb1 from the roots of Panax ginseng with a salt/containing solvent system and flow step-gradient by high performance counter-current chromatography coupled with an evaporative light scattering detector, Journal of Chromatography A 1217 (13) : 1995- 2001

(2009) Sutherland, IA., Hewitson, P. and Ignatova, S., Scale-up of counter-current chromatography: Demonstration of predictable isocratic and quasi-continuous operating modes from the test tube to pilot/process scale, Journal of Chromatography A 1216 (50) : 8787- 8792

(2009) Ye, H., Ignatova, S., Peng, A., Chen, L. and Sutherland, IA., Optimising resolution for a preparative separation of Chinese herbal medicine using a surrogate model sample system, Journal of Chromatography A 1216 (26) : 5101- 5105

(2009) van den Heuvel, R., Mathews, B., Dubant, S. and Sutherland, I., Continuous counter-current extraction on an industrial sample using dual-flow counter-current chromatography, Journal of Chromatography A 1216 (19) : 4147- 4153

(2009) Hewitson, P., Ignatova, S., Ye, H., Chen, L. and Sutherland, I., Intermittent counter-current extraction as an alternative approach to purification of Chinese herbal medicine, Journal of Chromatography A 1216 (19) : 4187- 4192

(2009) Sutherland, IA., Hewitson, P. and Ignatova, S., New 18-l process-scale counter-current chromatography centrifuge, Journal of Chromatography A 1216 (19) : 4201- 4205

(2009) van den Heuvel, R. and Sutherland, IA., Phase distribution visualisation in continuous counter-current extraction, Journal of Chromatography A 1216 (19) : 4252- 4257

(2009) Zhang, M., Ignatova, S., Liang, Q., Wu Jun, F., Sutherland, I., Wang, Y. and Luo, G., Rapid and high-throughput purification of salvianolic acid B from Salvia miltiorrhiza Bunge by high-performance counter-current chromatography, Journal of Chromatography A 1216 (18) : 3869- 3873

(2009) Berthod, A., Maryutina, T., Spivakov, B., Shpigun, O. and Sutherland, IA., Countercurrent chromatography in analytical chemistry (IUPAC technical report), Pure and Applied Chemistry 81 (2) : 355- 387 Download publication

(2009) Berthod, A., Ignatova, S. and Sutherland, IA., Advantages of a small-volume counter-current chromatography column, Journal of Chromatography A 1216 (19) : 4169- 4175

(2009) Leito, GG., Berthod, A., Conway, W. and Sutherland, IA., Foreword for CCC2008 Special Edition of the Journal of Chromatography A, Journal of Chromatography A 1216 (19) : 4135- 4139

(2009) Rubio, N., Ignatova, S., Minguillón, C. and Sutherland, IA., Multiple dual mode countercurrent chromatography applied to chiral separations using a (S)-naproxen derivative as chiral selector, Journal of Chromatography A 1216 (48) : 8505- 8511

(2009) Wei, Y., Xie, QQ., Fisher, D. and Sutherland, IA., Preparative isolation of imperatorin, oxypeucedanin and isoimperatorin from a traditional Chinese herb using a HSCCC strategy based on optimization of rapid flow rate, Chromatographia 70 (7-8) : 1185- 1189

(2009) Sutherland, IA. and Fisher, D., Role of counter-current chromatography in the modernisation of Chinese herbal medicines, Journal of Chromatography A 1216 (4) : 740- 753

(2009) de Folter, J. and Sutherland, IA., Universal counter-current chromatography modelling based on counter-current distribution, Journal of Chromatography A 1216 (19) : 4218- 4224

(2008) Ye, H., Ignatova, S., Luo, H., Li, Y., Peng, A., Chen, L. and Sutherland, IA., Preparative separation of a terpenoid and alkaloids from Tripterygium wilfordii Hook. f. using high-performance counter-current chromatography: comparison of various elution and operating strategies, Journal of Chromatography A 1213 (2) : 145- 153

(2008) Sutherland, IA., Audo, G., Bourton, E., Couillard, F., Fisher, D., Garrard, I., Hewitson, P. and Intes, O., Rapid linear scale-up of a protein separation by centrifugal partition chromatography, Journal of Chromatography A 1190 (1-2) : 57- 62

(2008) Garrard, IJ., Fisher, D. and Sutherland, IA., Dynamic extraction: a high-speed, high-capacity purification process that is rapidly scalable, LC/GC North America 26 (5) : 2- 7

(2008) Yuan, Y., Wang, BQ., Chen, LJ., Luo, HD., Fisher, D., Sutherland, IA. and Wei, Y., How to realize the linear scale-up process for rapid purification using high-performance counter-current chromatography, Journal of Chromatography A 1194 (2) : 192- 198

(2008) Yuan, Y., Hou, WL., Tang, MH., Luo, HD., Chen, LJ., Guan, YH. and Sutherland, IA., Separation of flavonoids from the leaves of oroxylum indicum by HSCCC, Chromatographia 68 (11-12) : 885- 892

(2007) Chen, L., Zhang, Q., Yang, G., Fan, L., Tang, J., Garrard, I., Ignatova, S., Fisher, D. and Sutherland, IA., Rapid purification and scale-up of honokiol and magnolol using high-capacity high-speed counter-current chromatography, Journal of Chromatography A 1163 (1-2) : 337- 337

(2007) Sutherland, IA., Review of centrifugal liquid-liquid chromatography using aqueous two-phase solvent systems: its scale-up and prospects for the future production of high-value biologicals., Current Opinion in Drug Discovery and Development 10 (5) : 540- 549 Download publication

(2007) Wood, P., Ignatova, S., Janaway, L., Keay, D., Hawes, D., Garrard, I. and Sutherland, IA., Counter-current chromatography separation scaled up from an analytical column to a production column, Journal of Chromatography A 1151 (1-2) : 25- 30

(2007) Ignatova, S., Wood, P., Hawes, D., Janaway, L., Keay, D. and Sutherland, I., Feasibility of scaling from pilot to process scale, Journal of Chromatography A 1151 (1-2) : 20- 24

(2007) Guan, YH., Fisher, D. and Sutherland, IA., Model for spiral columns and stationary phase retention in synchronous coil planet centrifuges, Journal of Chromatography A 1151 (1-2) : 136- 141

(2007) König, CS. and Sutherland, IA., Numerical model for the investigation of dual-flow in a spiral counter-current chromatography column, Journal of Chromatography A 1151 (1-2) : 131- 135

(2007) van den Heuvel, R. and Sutherland, IA., Observations of established dual flow in a spiral dual-flow counter-current chromatography coil, Journal of Chromatography A 1151 (1-2) : 99- 102

(2007) Sutherland, IA., Recent progress on the industrial scale-up of counter-current chromatography, Journal of Chromatography A 1151 (1-2) : 6- 13

(2007) Guan, YH., Smulders, J., Fisher, D. and Sutherland, IA., Spiral coils for counter-current chromatography using aqueous polymer two-phase systems, Journal of Chromatography A 1151 (1-2) : 115- 120

(2007) Chen, LJ., Zhang, Q., Yang, GL., Fan, LY., Tang, J., Garrard, I., Ignatova, S., Fisher, D. and Sutherland, IA., Rapid purification and scale-up of honokiol and magnolol using high-capacity high-speed counter-current chromatography, Journal of Chromatography A 1142 (2) : 115- 122

(2006) Sutherland, IA. and Chen, L., How to achieve rapid separations in counter-current chromatography, Journal of Chromatography A 1114 (1) : 29- 33

(2005) Wood, PL., Jaber, B., Janaway, L., Terlinden, N. and Sutherland, IA., Effect of beta-value on the head and tail distribution of the upper and lower phases in helical coils, Journal of Liquid Chromatography and Related Technologies 28 (12-13) : 1819- 1837

(2005) Chen, LJ., Song, H., Games, DE. and Sutherland, IA., HSCCC-MS study of flavonoids in the extracts from the seeds of Oroxylum indicum, Journal of Liquid Chromatography and Related Technologies 28 (12-13) : 1993- 2003

(2005) Fisher, D., Garrard, IJ., van den Heuvel, R., Sutherland, IA., Chou, FE. and Fahey, JW., Technology transfer and scale up of a potential cancer-preventive plant dynamic extraction of glucoraphanin, Journal of Liquid Chromatography and Related Technologies 28 (12-13) : 1913- 1922

(2005) Chen, LJ., Song, H., Lan, XQ., Games, DE. and Sutherland, IA., Comparison of high-speed counter-current chromatography instruments for the separation of the extracts of the seeds of Oroxylum indicum, Journal of Chromatography A 1063 (1-2) : 241- 245

(2005) Berthod, A., Sutherland, IA. and Oka, H., CCC2004 – Tokyo, The Third International Symposium on Countercurrent Chromatography, Journal of Liquid Chromatography and Related Technologies 28 (12-13) : 1793- 1798

(2005) Sutherland, I., Hawes, D., Ignatova, S., Janaway, L. and Wood, P., Review of progress toward the industrial scale-up of CCC, Journal of Liquid Chromatography and Related Technologies 28 (12-13) : 1877- 1891

(2005) König, CS. and Sutherland, IA., The liquid-liquid interface under planetary rotation, Computational Methods in Multiphase Flow III 50 317- 326

(2004) Kostanian, AE., Berthod, A., Ignatova, SN., Maryutina, TA., Spivakov, BY. and Sutherland, IA., Countercurrent chromatographic separation: a hydrodynamic approach developed for extraction columns, Journal of Chromatography A 1040 (1) : 63- 72

(2004) Sutherland, IA. and Fisher, D., Dynamic extraction technology, Innovations in Pharmaceutical Technology 68- 71 Download publication

(2004) König, CS. and Sutherland, IA., Numerical modelling of liquid-liquid flow related to countercurrent chromatography (CCC), Computational Methods in Multiphase Flow II 37 63- 73

(2003) Maryutina, TA., Ignatova, SN., Spivakov, BY. and Sutherland, IA., The efficiency of substance separation in countercurrent liquid chromatography, Journal of Analytical Chemistry 58 (8) : 762- 767 Download publication

(2003) Ignatova, SN. and Sutherland, IA., A fast, effective method of characterizing new phase systems in CCC, Journal of Liquid Chromatography and Related Technology 26 (9-10) : 1551- 1564

(2003) König, CS. and Sutherland, IA., An investigation of the influence of the gravity field on the interface of two immiscible liquids - a computational study comparing prediction with experiment, Journal of Liquid Chromatography and Related Technologies 26 (9-10) : 1521- 1535

(2003) Wood, PL., Hawes, D., Janaway, L. and Sutherland, IA., Determination of J-type centrifuge extra-coil volume using stationary phase retentions at differing flow rates, Journal of Liquid Chromatography and Related Technologies 26 (9-10) : 1417- 1430

(2003) Sutherland, IA., de Folter, J. and Wood, P., Modelling CCC using an eluting countercurrent distribution model, Journal of Liquid Chromatography and Related Technologies 26 (9-10) : 1449- 1474

(2003) Maryutina, TA., Ignatova, SN. and Sutherland, IA., Organic phase retention in CCC: Effect of temperature, tubing material, tubing bore, mobile phase flow, and the addition of an extraction agent, Journal of Liquid Chromatography & Related Technology 26 (9-10) : 1537- 1550

(2003) Sutherland, IA., Hawes, D., van den Heuvel, R., Janaway, L. and Tinnion, E., Resolution in CCC: The effect of operating conditions and phase system properties on scale-up, Journal of Liquid Chromatomatography & Related Technologies 26 (9-10) : 1475- 1491

(2003) Booth, AJ., Sutherland, IA. and Lye, GJ., Modeling the performance of pilot-scale countercurrent chromatography: Scale-up predictions and experimental verification of erythromycin separation, Biotechnology and Bioengineering 81 (6) : 640- 649

(2003) Janaway, L., Hawes, D., Ignatova, S., Wood, P. and Sutherland, IA., A new small coil-volume CCC instrument for direct interfacing with MS, Journal of Liquid Chromatography and Related Technologies 26 (9-10) : 1345- 1354

(2003) Fedotov, PS., Sutherland, IA., Wood, P. and Spivakov, BY., Retention of solids in rotating coiled columns: The effect of beta value and tubing material, Journal of Liquid Chromatography and Related Technologies 26 (9-10) : 1649- 1657

(2003) Wood, PL., Hawes, D., Janaway, L. and Sutherland, IA., Stationary phase retention in CCC: Modelling the J-type centrifuge as a constant pressure drop pump, Journal of Liquid Chromatography & Related Technologies 26 (9-10) : 1373- 1396

(2003) Tinnion, E., Jowitt, F., Clarke-O'Neill, S., Cottenden, AM., Fader, M. and Sutherland, I., The further development of the active urine collection device: A novel continence management system, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 217 (4) : 291- 296

(2003) Tinnion, E., Jowitt, F., Clarke-O'Neill, S., Cottenden, AM., Fader, M. and Sutherland, I., The further development of the active urine collection device: a novel continence management system, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 217 (4) : 291- 296

(2002) Berthod, A., Sutherland, IA. and Zhang, T., CCC 2002 – Beijing, the Second International Conference on Countercurrent Chromatography, Trends in Research and Applications, Journal of Liquid Chromatography and Related Technologies 26 1335- 1344

(2002) Sutherland, IA., Hawes, D., Janaway, L., Tinnion, E., Kidwell, H. and Wood, P., From analytical to process scale liquid-liquid countercurrent chromatography (CCC) with 100% sample recovery – is it feasible?, Analytical Sciences 17 765- 768

(2002) Foong, LC., Gamble, J., Sutherland, IA. and Beard, RW., Microvascular changes in the peripheral microcirculation of women with chronic pelvic pain due to congestion, British Journal of Obstetrics & Gynaecology 109 (8) : 867- 873

(2002) Sutherland, IA., Modelling countercurrent chromatography: an eluting CCD model, Biochemical Society Transactions 8 173-

(2001) Wood, PL., Jaber, B. and Sutherland, IA., A new hypothesis on the hydrodynamic distribution of the upper and lower phases in CCC, Journal of Liquid Chromatography and Related Technologies 24 (11-12) : 1629- 1654

(2001) Sutherland, IA., Booth, AJ., Brown, L., Kemp, B., Kidwell, H., Games, D., Graham, AS., Guillon, GG., Hawes, D., Hayes, M., Janaway, L., Lye, GJ., Massey, P., Preston, C., Shering, P., Shoulder, T., Strawson, C. and Wood, P., Industrial scale-up of countercurrent chromatography, Journal of Liquid Chromatography and Related Technologies 24 (11-12) : 1533- 1553

(2001) Wood, PL. and Sutherland, IA., Mixing, settling, and the movement of the interface between the mobile and stationary phases in CCC, Journal of Liquid Chromatography & Related Technologies 24 (11-12) : 1699- 1710

(2001) Berthod, A. and Sutherland, IA., CCC2000 – London, The First International Conference on Countercurrent Chromatography, a Cornerstone for the Technique, Journal of Liquid Chromatography and Related Technologies 24 (11-12) : 1523- 1532

(2001) Sutherland, IA., Countercurrent Chromatography Research, European Pharmaceutical Review 3 35- 36

(2001) Sutherland, IA., Brown, L., Graham, AS., Guillon, GG., Hawes, D., Janaway, L., Whiteside, R. and Wood, P., Industrial scale-up of countercurrent chromatography: Predictive scale-up, Journal of Chromatographic Science 39 (1) : 21- 28

(2001) Sutherland, IA., Du, Q. and Wood, P., The relationship between retention, linear flow, and density difference in countercurrent chromatography, Journal of Liquid Chromatography & Related Technologies 24 (11-12) : 1669- 1683

(2000) Sutherland, IA., Muytjens, J., Prins, M. and Wood, P., A new hypothesis on phase distribution in countercurrent chromatography, Journal of Liquid Chromatography and Related Technologies 23 (15) : 2259- 2276

(2000) Sutherland, IA., Relationship between retention, linear velocity and flow for counter-current chromatography, Journal of Chromatography A 886 (1-2) : 283- 287

(2000) Torrens, GE., Hann, J., Webley, M., Joy, J. and Sutherland, IA., Hand performance assessment of ten people with Rheumatoid Arthritis when using a range of specified saucepans, Disability and Rehabilitation 22 (3) : 123- 134

(2000) Foong, LC., Gamble, J., Sutherland, IA. and Beard, RW., Altered peripheral vascular response of women with and without pelvic pain due to congestion, BJOG: an International Journal of Obstetrics and Gynaecology 107 (2) : 157- 164

(1998) Sutherland, IA., Brown, L., Forbes, S., Games, G., Hawes, D., Hostettmann, K., McKerrell, EH., Marston, A., Wheatley, D. and Wood, P., Countercurrent chromatography (CCC) and its versatile application as an industrial purification & production process, Journal of Liquid Chromatography and Related Technologies 21 (3) : 279- 298

(1996) Foong, LC., Gamble, J., Sutherland, IA. and Beard, RW., Laser Doppler-recorded reactive hyperaemia in the forearm skin during the menstral cycle, British Journal of Obstetrics & Gynaecology 103 (5) : 487-

(1995) Foong, LC., Thomas, DC., Gamble, J., Sutherland, IA. and Beard, RW., Changes in isovolumetric venous pressure during the menstrual cycle in normal women and those with pelvic venous congestion, International Journal of Microcirculation 15 206-

(1995) Burkitt, J., Torrens, G., Kay, G., Sandbach, D. and Sutherland, IA., The development of the Autosip: a hygienic, self-operated, drinking device for people with minimal sucking ability and/or minimal arm strength, Journal of Rehabilitation Sciences 8 (4) : 115- 118

(1994) Thomas, DC., Siddall-Allum, JN., Sutherland, IA. and Beard, RW., Correction of the non-uniform spatial sensitivity of electrical impedance tomography images, Physical Measurement 15 147- 152

(1993) Sutherland, IA., Wolff, HS., Helmke, H., Riesselmann, W., Nagy, M., Voeten, E. and Chassey, R., Glovebox in Orbit. ESA/NASA Glovebox: A Versatile USML-1 Experiment Facility, Spaceflight 35 15- 17

(1990) Gough, GW., Randall, NJ., Genevier, ES., Sutherland, IA. and Steer, PJ., Head to cervix forces and their relationship to the outcome of labour, Obstetrics and Gynecology 75 (4) : 613- 618

(1990) Carter, MC., Genevier, ES., Chong, LC., Sutherland, IA., Woodhouse, P., Murray, HC., Kirk, DL., Symonds, EM., Steer, PJ. and Beard, RW., The assessment of cardiotocographs, Journal of Biomedical Engineering 12 (3) : 267- 270

(1989) Homburg, R., Eshel, A., Armar, NA., Tucker, M., Mason, PW., Adams, J., Kilborn, J., Sutherland, IA. and Jacobs, HS., One hundred pregnancies after treatment with pulsatile luteinising hormone releasing hormone to induce ovulation, BMJ: British Medical Journal 198 (6676) : 809- 812 Download publication

(1989) Gough, GW., Randall, NJ., Steer, PJ. and Sutherland, IA., Forces between the fetal head and maternal cervix during labour, Journal of Physiology 413 P10-

(1988) Randall, NJ., Steer, PJ. and Sutherland, IA., Detection of fetal ECG during labour by an intrauterine probe, Journal of Biomedical Engineering 10 (2) : 159- 164 Download publication

(1988) Sutherland, IA., Chambers, GR., Polson, DW., Sagle, M., Kiddy, D., Mason, HD. and Franks, S., Pulsatile infusion of gonadotrophin-releasing hormone (GnRH): investigative and therapeutic applications, Journal of Biomedical Engineering 10 (2) : 110- 112 Download publication

(1988) Sutherland, IA., Chambers, GR., Polson, DW., Sagle, M., Kiddy, D., Mason, HD. and Franks, S., Pulsatile infusion of gonadotrophin-releasing hormone (GnRH) -investigative and therapeutic applications, Journal of Biomechanical Engineering 10 (2) : 110- 112

(1988) Heywood-Waddington, D., Sutherland, IA. and Peters, TJ., Sub-fractionation of rat liver microsomes by two-polymer phase partition in a toroidal coil centrifuge, Biochemical Society Transactions 16 (1) : 34- 35

(1988) Randall, NJ., Beard, RW., Sutherland, IA., Figueroa, JP., Drost, CJ. and Nathanielsz, PW., Validation of thermal techniques to measure pelvic organ blood flows in the non-pregnant sheep: comparison with transit time ultrasonic and microsphere measurements of blood flow, American Journal of Obstetrics and Gynecology 158 (3) : 651- 658

(1986) Heywood-Waddington, D., Peters, TJ. and Sutherland, IA., The dynamics of phase partition. A study of parameters affecting rat liver organelle partitioning in aqueous two-polymer phase systems, Biochemical Journal 235 (1) : 245- 249 Download publication

(1984) Sutherland, IA., White, S., Chambers, GR., Rothwell, D., Mason, PW., Tucker, M. and Jacobs, HS., A miniature infuser for the pulsatile administration of LHRH, Journal of Biomedical Engineering 6 (2) : 129- 133 Download publication

(1984) Flanagan, SD., Johansson, G., Yost, B., Ito, Y. and Sutherland, IA., Toroidal coil countercurrent chromatography in the affinity partitioning of nicotinic cholinergic receptor enriched membranes, Journal of Liquid Chromatography 7 (2) : 385- 402 Download publication

(1983) Rothwell, D., Sutherland, IA., Pickup, JC., Bending, JJ., Keen, H. and Parsons, JA., A new miniature, open-loop, extracorporeal insulin infusion pump, Journal of Biomedical Engineering 5 (3) : 178- 184 Download publication

(1977) Lightbown, JW., Newland, P., Sutherland, IA. and Dymond, JWA., Analysis of candicidin and related polyene antibiotics by means of the coil planet centrifuge, Proceedings of the Analytical Division of the Chemical Society 14 (2) : 34- 37 Download publication

Conference Papers

(2010) Sutherland, IA., Sieber, R., Hewitson, P., Arbenz, L., Kinkel, J., van den Heuvel, R. and Fisher, D., Commercial potential of a new dynamic extraction process for proteins, 13th Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA2010)

(2010) Ignatova, SN., Sumner, N., Colclough, N. and Sutherland, IA., Gradient elution in counter-current chromatography: a new layout for an old path, 6th International Symposium on Countercurrent Chromatography (CCC2010)

(2010) Sutherland, IA., Hewitson, P. and de Folter, J., Toroidal coil chromatography (TCC): the effect of scale-up and “g” field on stage efficiency, 6th International Symposium on Countercurrent Chromatography (CCC2010)

(2010) Sutherland, IA., Scalable technology for the extraction of pharmaceuticals (STEP), World Biopharm Forum 2010: Cancer Biologics and Therapy

(2008) Hewitson, P., Ignatova, SN. and Sutherland, IA., An 18 litre process scale high performance counter-current chromatography centrifuge, 5th International Conference on Countercurrent Chromatography (CCC2008)

(2008) Hawes, D., Ignatova, SN., van den Heuvel, R. and Sutherland, IA., Non-synchronous preparative CCC - the next generation countercurrent centrifuge where phase separation and mixing can be independently controlled, 5th International Conference on Countercurrent Chromatography (CCC2008)

(2008) Sutherland, IA. and Fisher, D., The role of counter-current chromatography in the modernisation of traditional Chinese medicines, 5th International Conference on Countercurrent Chromatography (CCC2008)

(2010) Gilhooly, ML., van den Heuvel, E., Jowitt, F., Sutherland, I., Bichard, J., Gaydecki, P., Ratcliff, N. and Parker, S., Tackling ageing continence through theory, tools and technology (TACT3) (Conference abstract), , Gerontologist (50) : 39- 39

Book Chapters

(2008) Sutherland, IA., Biomechanics of Movement: A Space Perspective. In: Bober, T. and Siemienski, A. eds. Contemporary Biomechanics: Selected Topics. Wroclaw : Wydawnictwo AWF 80- 87

(1989) Sutherland, IA., Siddiqi, S., Keightley, R. and Fisher, D., A new approach to countercurrent distribution combining separation with analysis in the Biomek automated laboratory workstation. In: Fisher, D. and Sutherland, IA. eds. Separations Using Aqueous Phase Systems: Applications in Cell Biology and Biotechnology. Kluwer Academic / Plenum Publishers 407- 416

(1989) Eggleton, P., Sutherland, IA. and Fisher, D., Rapid partitioning of human neutrophils by CCD. In: Fisher, D. and Sutherland, IA. eds. Separations Using Aqueous Phase Systems: Applications in Cell Biology and Biotechnology. Kluwer Academic / Plenum Publishers 423- 424

(1989) Sutherland, IA. and Eveleigh, J., Some rheological properties of perfluorocarbon emulsions and their potential use in countercurrent chromatography and chromatography separation systems. In: Fisher, D. and Sutherland, IA. eds. Separations Using Aqueous Phase Systems: Applications in Cell Biology and Biotechnology. Kluwer Academic / Plenum Publishers 477- 478

(1986) Sutherland, IA. and Fisher, D., Partitioning: A comprehensive bibliography. In: Walter, H., Brooks, DE. and Fisher, D. eds. Partitioning in aqueous two-phase systems: Theory, methods, uses and applications to biotechnology. Academic Press Inc 627- 676

Books

(1989) Fisher, D. and Sutherland, IA., Separations using aqueous phase systems: Applications in cell biology and biotechnology. Kluwer Academic /Plenum Publishing Corporation