Krishna Burugapalli

Contact

Heinz Wolff 001 Brunel University Uxbridge UB8 3PH United Kingdom

Tel: +44 (0)1895 266926 Email: krishna.burugapalli@brunel.ac.uk Web: Personal Website

About Krishna

Krishna Burugapalli joined BIB as a Research Fellow in April 2008, after a Post Doctoral training in the field of Tissue Engineering at National University of Ireland, Galway (NUIG). He has over 10 years experience in the design of novel biomaterials for biomedical applications such as drug delivery and tissue engineering. His doctoral work at Indian Institute of Technology, Delhi and All India Institute of Medical Sciences, Delhi resulted in patented drug delivery vehicles based on natural and synthetic polymers, while his post doctoral work at NUIG, led to the development of novel extracellular matrix based bio-mimetic scaffold (platform technology) for a variety of tissue engineering applications. In particular, the focus of his research has been the development of novel polymeric biomaterials with tailored biodegradation and biocompatibility. Currently, he is developing novel tissue engineering coatings for biosensors at BIB. In addition to the development and testing of novel biomaterials, Dr. Burugapalli has significant expertise in biocompatibility assessment of medical devices, and has also developed quantitative systems for objective evaluation of biological responses to materials.

Research Interests

Biomaterials; tissue engineering; biosensors; drug and gene delivery; glucose biosensing; hydrogels; interpenetrating polymer networks (IPNs); composites; combinatorial biomaterials; biodegradable biomaterials; scaffolds; decellularised extracellular matrix; biocompatibility; in vitro, ex vivo and in vivo functional efficacy testing of biomedical devices; coatings for implantable biomedical devices to combat biological rejection; stereology; histomorphometry; histopathology; image analysis.

Research Area

Biomedical Engineering

Publications

Journal Papers

(2013) Wang, N., Burugapalli, K., Song, W., Halls, JAT., Moussy, F., Ray, A. and Zheng, Y., Electrospun fibro-porous polyurethane coatings for implantable glucose biosensors, Biomaterials 34 (4) : 888- 901

(2013) Wang, N., Burugapalli, K., Song, W., Halls, J., Moussy, F., Zheng, Y., Ma, Y., Wu, Z. and Li, K., Tailored fibro-porous structure of electrospun polyurethane membranes, their size-dependent properties and trans-membrane glucose diffusion, Journal of Membrane Science 247 207- 217

(2012) Cao, B., Zheng, Y., Xi, T., Zhang, C., Song, W., Burugapalli, K., Yang, H. and Ma, Y., Concentration-dependent cytotoxicity of copper ions on mouse fibroblasts in vitro: Effects of copper ion release from TCu380A vs TCu220C intra-uterine devices, Biomedical Microdevices 14 (4) : 709- 720

(2012) de la Cruz, EF., Zheng, Y., Torres, E., Li, W., Song, W. and Burugapalli, K., Zeta Potential of Modified Multi-walled Carbon Nanotubes in Presence of poly(vinyl alcohol) Hydrogel, International Journal of Electrochemical Science 7 3577- 3590

(2011) Trzebinski, J., Radomska-Botelho Moniz, A., Sharma, S., Burugapalli, K., Moussy, F. and Cass, AEG., Hydrogel Membrane Improves Batch-to-Batch Reproducibility of an Enzymatic Glucose Biosensor, Electroanalysis 23 (12) : 2789- 2795

(2010) Zhu, Z., Song, W., Burugapalli, K., Moussy, F., Li, YL. and Zhong, XH., Nano-yarn carbon nanotube fiber based enzymatic glucose biosensor, Nanotechnology 21 (16) : 165501-

(2009) Burugapalli, K., Chan, JC., Naik, H., Kelly, JL. and Pandit, A., Tailoring the properties of cholecyst-derived extracellular matrix using carbodiimide cross-linking, Journal of Biomaterials Science, Polymer Edition 20 (7-8) : 1049- 1063

(2009) Henry, JA., Burugapalli, K., Neuenschwander, P. and Pandit, A., Structural variants of biodegradable polyesterurethane in vivo evoke a cellular and angiogenic response that is dictated by architecture, Acta Biomaterialia 5 (1) : 29- 42

(2008) Burugapalli, K., Chan, JC., Kelly, JL. and Pandit, A., Buttressing staples with cholecyst-derived extracellular matrix (CEM) reinforces staple lines in an ex vivo peristaltic inflation model, Obesity Surgery 18 (11) : 1418- 1423

(2008) Chan, JC., Burugapalli, K., Naik, H., Kelly, JL. and Pandit, A., Amine functionalization of cholecyst-derived extracellular matrix with generation 1 PAMAM dendrimer, Biomacromolecules 9 (2) : 528- 536

(2007) Burugapalli, K., Thapasimuttu, A., Chan, JCY., Yao, L., Brody, S., Kelly, JL. and Pandit, A., Scaffold with a natural mesh-like architecture: Isolation, structural, and in vitro characterization, Biomacromolecules 8 (3) : 928- 936

(2007) Garcia, Y., Breen, A., Burugapalli, K., Dockery, P. and Pandit, A., Stereological methods to assess tissue response for tissue-engineered scaffolds., Biomaterials 28 (2) : 175- 186 Download publication

(2007) Burugapalli, K. and Pandit, A., Characterization of tissue response and in vivo degradation of cholecyst-derived extracellular matrix, BIOMACROMOLECULES 8 (11) : 3439- 3451

(2004) Burugapalli, K., Koul, V. and Dinda, AK., Effect of composition of interpenetrating polymer network hydrogels based on poly(acrylic acid) and gelatin on tissue response: a quantitative in vivo study., Journal of Biomedical Materials Research Part A 68 (2) : 210- 218

(2004) Changez, M., Koul, V., Burugapalli, K., Dinda, AK. and Choudhary, V., Studies on biodegradation and release of gentamicin sulphate from interpenetrating network hydrogels based on poly(acrylic acid) and gelatin: in vitro and in vivo, BIOMATERIALS 25 (1) : 139- 146

(2003) Changez, M., Burugapalli, K., Koul, V. and Choudhary, V., The effect of composition of poly(acrylic acid)-gelatin hydrogel on gentamicin sulphate release: in vitro, BIOMATERIALS 24 (4) : 527- 536

(2001) Burugapalli, K., Bhatia, D., Koul, V. and Choudhary, V., Interpenetrating polymer networks based on poly(acrylic acid) and gelatin. I: Swelling and thermal behavior, JOURNAL OF APPLIED POLYMER SCIENCE 82 (1) : 217- 227

Conference Papers

(2007) Burugapalli, K., Chan, JCY., Kelly, JL. and Pandit, A., Integrative tissue response and prolonged in situ life of minimally crosslinked CEM, Conference of the Tissue-Engineering-and-Regenerative-Medicine-International-Society (TERMIS-EU), TISSUE ENGINEERING (13) : 1717- 1718 Download publication

(2007) Chan, JCY., Burugapalli, K., Kelly, JL. and Pandit, A., Cell viability and morphology on starburst dendrimer-crosslinked CEM scaffolds, Conference of the Tissue-Engineering-and-Regenerative-Medicine-International-Society (TERMIS-EU), TISSUE ENGINEERING (13) : 1650- 1650

(2007) Burugapalli, K., Chan, JCY., Kelly, JL. and Pandit, A., Effect of crosslinking of CEM on cell attachment, proliferation and morphology, Conference of the Tissue-Engineering-and-Regenerative-Medicine-International-Society (TERMIS-EU), TISSUE ENGINEERING (13) : 1678- 1678

(2004) Burugapalli, K., Veena, K., Choudhary, V. and Dinda, AK., Biodegradable hydrogels for controlled release of antibiotics for treatment of osteomyelitis, , Transactions - 7th World Biomaterials Congress 983- 983