Rob Newbold

Professor Robert Newbold

Director of Brunel Institute of Cancer Genetics and Pharmacogenomics - Biosciences

Room: Heinz Wolff Building 103
Brunel University London
Uxbridge
UB8 3PH
United Kingdom
Tel: +44 (0)1895 266290
Email: robert.newbold@brunel.ac.uk

About Robert

Profile

CURRENT POSITION

Brunel University London: Professor of Cancer Genetics

Director:  Brunel Institute of Cancer Genetics & Pharmacogenomics

EDUCATION

1973-76 University of London (Institute of Cancer Research)

1970-73 University of Aston in Birmingham

1961-67  Abingdon School, Oxford

DEGREES

2001  DSc (Cancer Genetics) University of London

1976 PhD (Biochemistry) University of London

1973 BSc (Hons) Biological Sciences, University of Aston in Birmingham.

RESEARCH  APPOINTMENTS

June 1991- present

  •  Professor of Cancer Genetics, Brunel University London
  •  Director: Brunel Institute of Cancer Genetics & Pharmacogenomics,    

1989–1991 Visiting Research Professor, Brunel University London

19871989 Scientific Director, Sydney Branch, Ludwig Institute for Cancer Research, University of Sydney, Australia.

1981-1987 Permanent Career Appointment, Institute of Cancer Research, Royal Cancer Hospital, London. Team Leader: Cell Transformation Laboratory

1977-1981  Research Fellow, Institute of Cancer Research, London

1973-1976  PhD student, Institute of Cancer Research

1967-1970  Assistant Scientific Officer, Cellular Radiobiology Division, Atomic Energy Research Establishment (AERE) Harwell, UK


ACADEMIC  APPOINTMENTS

2001-2004  Brunel University London

  • Dean: Faculty of Life Sciences
  • Chairman: Faculty Board, Board of Heads of Department, Faculty Appointments Committees, Faculty Promotions Committee.
  • Member: Deans’ Committee, University Research Committee, Academic Promotions Committee, Strategic Planning and Resources Committee.

1992-2001 Brunel University London

  • Head: Department of Biology and Biochemistry
  • Member: University Court, Council, Senate, Finance Committee, Strategic Planning Committee.

1996-1999  Brunel University London

  • Dean: Faculty of Science
  • Chairman: Faculty Board, Board of Heads of Department, Faculty Appointments Committees, Faculty Promotions Committee.
  • Member: Deans’ Committee, University Research Committee, Academic Promotions Committee, Strategic Planning and Resources Committee.

1991-present  Professor of Cancer Genetics, Brunel University London

1989-1991 Visiting Research Professor, Brunel University London

1987-1989 Associate Professor of Cancer Medicine, University of Sydney, Australia

1985  Member of the Board of Studies in Microbiology and Recognized Teacher, University of London

Research

Research centres

Research projects and grants

Substantive externally funded research support secured regularly (as Principal Investigator) from a variety of prestigious funding bodies, since 1980.

Main funding bodies:Cancer Research Campaign (CRC now CRUK), MRC (including NC3Rs), BBSRC, CRC Technology, United Kingdom Coordinating Committee for Cancer Research (UKCCCR), Association for International Cancer Research (AICR), NCRI, US Department of Health, Breast Cancer Campaign (BCC) and, as Coordinator (since 1992) the European Commission Framework FP3, FP4, FP5, FP6 & FP7 (Health, Environment, Quality of Life, EURATOM, & Genomics & Biotechnology for Health, Programmes).

Recent Grants & Contracts (all as Principal Investigator &, for all EC FP grants, Project Coordinator)

MRC (NC3Rs funding stream), 2012-2015: ‘Development of human epithelial cell transformation models for carcinogen screening, employing defined phenotypic endpoints mechanistically representative of rate-limiting events in human carcinogenesis’. £500,000, 36 months.

MRC (NC3Rs funding stream), 2008-2012: Development and validation of mechanisms-based rodent and human in vitro transformation assays for carcinogen screening’. £300,000, 38 months.

BBSRC ‘CASE’ award with Unilever Plc, 2010-2014: ‘Molecular characterization of events underlying morphological transformation (MT) phenotypes induced by genotoxic and non-genotoxic carcinogens in the SHE-MT assay’. £127,000, 48 months.

Breast Cancer Hope PhD Studentship (fully funded) 2011-2014: ‘Molecular characterization of the role of histone modifying genes as targets for telomerase reactivation in human breast cancer development’ . £95,000 – 36 months.

Coordinator: European Commission: Framework 7 Programme. ‘Identification and characterization of novel human telomere-related biomarkers that aid cancer management by improving patient diagnosis, treatment selection, response monitoring and drug development’ (TELOMARKER). EC Collaborative Project 200950; 8 Participating Institutions. €3,000,000 – 36 months, 2008-2011.

Coordinator: European Commission: Framework 6 Programme. Project title: ‘Developing Molecular Medicines for Cancer in the Post-Genome Era’ (MOL CANCER MED); Contract Number: 502943; 14 participating institutions. €4.8 million – 50 months, 2004-2009.

Breast Cancer Campaign (BCC). Molecular and functional characterization of the chromosome-3-linked sequence APRG1 as a novel breast cancer suppressor gene. £140,000. 36 months, 2005-2008.

Coordinator: European Commission: Framework 5 Programme. Three projects for FP5 in the EURATOM (1 project) and Quality of Life & Management of Living Resources (2 projects) Thematic Programmes (8 Partners in each project).

Funded to a total value of €4 million. 1-03-00 to 28-02-04.

  1. Contract Number: QLG1-1999-01341; Title of Project: The role of telomerase in human cancer development and an evaluation of its potential as a therapeutic target (TACIT).
  2. Contract Number: QLK4-1999-01084; Title of Project: Genetic mechanisms involving ultraviolet light in the development of cutaneous malignant melanoma (MAUVE).
  3. Contract Number: FIGH-CT1999-00002; Title of Project: Identification and isolation of susceptibility genes involved in radiation-induced cancer in humans (SUS GENES IN RAD CAR).

Above funded to a total value of €4 million. 42-48months, 2000-2004.

Cancer Research Campaign. 5-year CRC (now CRUK) Programme Grant. Programme Title: Identification and isolation of novel genes involved in sporadic human breast and prostate cancer, and in cutaneous malignant melanoma. £557,000. 60 months, 2000-2005.

Xenova Plc.  Biological assays related to telomerase. Value: £112,028. 2003-2005.

AstraZeneca Plc.  Development and molecular characterization of a cell culture model for human breast cancer. Value: £205,000, 2003-2006.

External

Membership and affiliation

2002
  • Fellow of the Royal Society of Arts (FRSA)
2000
  • Fellow of the Royal College of Pathologists (FRCPath)
1994
  • Fellow of the Royal Society of Medicine (FRSM)
1991
  • Fellow of the Institute of Biology (FIBiol, CBiol)
1991-2000
  • Member of two UK Government Expert Advisory Committees (COC & COM) concerned with the carcinogenicity and mutagenicity of chemicals in food, consumer products and the environment, and reporting directly to the Chief Medical Officer.
1994-2004
  • Trustee, Hillingdon Hospital Postgraduate Research Centre
1996-present
  • Entry in Debrett’s People of Today
2003- present
  • International Union Against Cancer (UICC-WHO): UICC Fellowship
  • Advisory Board member
2004-present
  • Entry in Marquis (USA) Who’s Who in Science and Engineering, Who's Who in Medicine, Who's Who in the World
2004-present
  • Member of the Scientific Advisory Board of Oncostem Therapeutics, a Madrid-based biotechnology company.
2005
  • Member of the Board of Editors: International journal of Cancer

Publications

Journal Papers

(2012)  Yasaei, H. , Gilham, E. , Pickles, JC. , Roberts, TP. , et al. , Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells, Oncogene

(2012)  Creton, S. , Aardema, MJ. , Carmichael, PL. , Harvey, JS. , et al. , Cell transformation assays for prediction of carcinogenic potential: state of the science and future research needs, Mutagenesis 27 (1)  : 93- 101 Download publication

(2010)  Abbaszadeh, F. , Clingen, PH. , Arlett, C. , Plowman, PN. , et al. , A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitvity in a xeroderma pigmentosum patient, Journal of Medical Genetics 46 (11)  : 1- 24 Download publication

(2010)  Newbold, RF.  and Mokbel, K. , Evidence for a tumour suppressor function of SETD2 in human breast cancer: a new hypothesis., Anticancer Res 30 (9)  : 3309- 3311 Download publication

(2010)  Al Sarakbi, W. , Reefy, S. , Jiang, WG. , Roberts, T. , et al. , Evidence of a tumour suppressor function for DLEC1 in human breast cancer, Anticancer Res. 30 (4)  : 1079- 1082

(2010)  Loizidou, MA. , Cariolou, MA. , Neuhausen, SL. , Newbold, RF. , et al. , Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population, Breast Cancer Research and Treatment 121 (1)  : 147- 156 Download publication

(2010)  Patani, N. , Jiang, W. , Newbold, R.  and Mokbel, K. , Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer, Journal of Carcinogenesis 9 (Online Paper)  : 9- 9 Download publication

(2009)  Dafou, D. , Ramus, SJ. , Choi, K. , Grun, B. , et al. , Chromosomes 6 and 18 induce neoplastic suppression in epithelial ovarian cancer cells, International Journal of Cancer 124 (5)  : 1037- 1044 Download publication

(2009)  Loizidou, MA. , Michael, T. , Neuhausen, SL. , Newbold, RF. , et al. , DNA-repair genetic polymorphisms and risk of breast cancer in Cyprus, Breast Cancer Research and Treatment 115 (3)  : 623- 627 Download publication

(2009)  Patani, N. , Jiang, W. , Mansel, R. , Newbold, R.  and Mokbel, K. , The mRNA expression of SATB1 and SATB2 in human breast cancer, Cancer Cell International 918 Download publication

(2009)  Al Sarakbi, W. , Sasi, W. , Jiang, WG. , Roberts, T. , et al. , The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters, BMC Cancer 9290 Download publication

(2008)  Worku, D. , Jouhra, F. , Jiang, GW. , Patani, N. , et al. , Evidence of a tumour suppressive function of E2F1 gene in human breast cancer, Anticancer Research 28 (4B)  : 2135- 2139 Download publication

(2008)  Coelho, D. , Suormala, T. , Stucki, M. , Lerner-Ellis, JP. , et al. , Gene identification for the cblD defect of vitamin B12 metabolism, New England Journal of Medicine 358 (14)  : 1454- 1464 Download publication

(2008)  Loizidou, MA. , Michael, T. , Neuhausen, SL. , Newbold, RF. , et al. , Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus, Breast Cancer Research and Treatment 112 (3)  : 575- 579 Download publication

(2008)  Sugiana, C. , Pagliarini, DJ. , McKenzie, M. , Kirby, DM. , et al. , Mutation of C20orf7 disrupts complex I assembly and causes lethal neonatal mitochondrial disease, The American Journal of Human Genetics 83 (4)  : 468- 478 Download publication

(2008)  Meaburn, KJ. , Newbold, RF.  and Bridger, JM. , Positioning of human chromosomes in murine cell hybrids according to synteny, Chromosoma 117 (6)  : 579- 591 Download publication

(2008)  Salhab, M. , Jiang, WG. , Newbold, RF.  and Mokbel, K. , The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome, Breast Cancer Research and Treatment 109 (1)  : 35- 46 Download publication

(2007)  Newbold, RF. , Hadjiavvas, A. , Loizidou, M. , Marcou, Y. , et al. , Contribution of BRCA1 and BRCA2 germline mutations to the incidence of early-onset breast cancer in Cyprus, Clinical Genetics 71 (2)  : 165- 170 Download publication

(2007)  Mansfield, L. , Subramanian, A. , Devalia, H. , Jiang, W. , et al. , hTERT mRNA expression correlates with matrix metalloproteinase-1 and vascular endothelial growth factor expression in human breast cancer: A correlative study using RT-PCR, ANTICANCER RESEARCH 27 (4B)  : 2265- 2268

(2006)  Elkak, A. , Mokbel, R. , Wilson, C. , Jiang, WG. , et al. , hTERT mRNA expression is associated with a poor clinical outcome in human breast cancer, Anticancer Research 26 (6C)  : 4901- 4904

(2005)  Leris, AC. , Roberts, TR. , Jiang, WG. , Newbold, RF.  and Mokbel, K. , Evidence for a tumour suppressive function of APRG1 in breast cancer., Breast Cancer Res Treat 93 (2)  : 97- 100 Download publication

(2005)  Elkak, AE. , Meligonis, G. , Salhab, M. , Mitchell, B. , et al. , hTERT protein expression is independent of clinicopathological parameters and c-Myc protein expression in human breast cancer, Journal of Carcinogenesis 417 Download publication

(2005)  Leris, AC. , Roberts, TR. , Jiang, WG. , Newbold, RF.  and Mokbel, K. , WNT5A expression in human breast cancer, Anticancer Research: international journal of cancer research and treatment 25 (2A)  : 731- 734

(2004)  Newbold, RF. , Cabury, E. , Newton, C. , Roberts, T.  and Slijepcevic, P. , Identification of subpopulations of cells with differing telomere lengths in mouse and human cell lines by flow FISH, Cytometry 62 (2)  : 150- 161 Download publication

(2004)  Flanagan, JM. , Healey, S. , Young, J. , Whitehall, V. , et al. , Mapping of a candidate colorectal cancer tumor-suppressor gene to a 900-kilobase region on the short arm of chromosome 8, Genes Chromosomes Cancer 40 (3)  : 247- 260 Download publication

(2004)  Newbold, RF. , Coenen, MJH. , Antonicka, H. , Ugalde, C. , et al. , Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency, New England Journal of Medicine 351 (20)  : 2080- 2086 Download publication

(2004)  Kirkpatrick, KL. , Newbold, RF.  and Mokbel, K. , The mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression, Journal of Carcinogenesis 3 (1)  : 1 Download publication

(2004)  Kirkpatrick, KL. , Newbold, RF.  and Mokbel, K. , There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer, International Seminars in Surgical Oncology 1 (1)  : 2 Download publication

(2003)  Szutorisz, H. , Lingner, J. , Cuthbert, AP. , Trott, DA. , et al. , A chromosome 3-encoded repressor of the Human Telomerase Reverse Transcriptase (hTERT) gene controls the state of hTERT chromatin, Cancer Research 63 (3)  : 689- 695 Download publication

(2003)  Chastain-Moore, AM. , Roberts, T. , Trott, DA. , Newbold, RF.  and Ornelles, DA. , An activity associated with human chromosome 21 permits nuclear colocalization of the adenovirus E1B-55K and E4orf6 proteins and promotes viral late gene expression, Journal of Virology 77 (14)  : 8087- 8098 Download publication

(2003)  Kirkpatrick, KL. , Ogunkolade, W. , Elkak, AE. , Bustin, S. , et al. , hTERT expression in human breast cancer and non-cancerous breast tissue: correlation with tumour stage and c-Myc expression, Breast Cancer Res Treat 77 (3)  : 277- 284

(2003)  Kirkpatrick, KL. , Clark, G. , Ghilchick, M. , Newbold, RF.  and Mokbel, K. , hTERT mRNA expression correlates with telomerase activity in human breast cancer, EJSO - European Journal of Surgical Oncology 29 (4)  : 321- 326

(2003)  Fitzsimmons, SA. , Ireland, H. , Barr, NI. , Cuthbert, AP. , et al. , Human squamous cell carcinomas lose a mortality gene from chromosome 6q14.3 to q15, Oncogene 22 (11)  : 1737- 1746 Download publication

(2003)  Elkak, AE. , Newbold, RF. , Thomas, V.  and Mokbel, K. , Is telomerase reactivation associated with the down-regulation of TGF beta receptor-II expression in human breast cancer?, Cancer Cell International 3 (1)  : 9 Download publication

(2003)  Themis, M. , May, D. , Coutelle, C.  and Newbold, RF. , Mutational effects of retrovirus insertion on the genome of V79 cells by an attenuated retrovirus vector: Implications for gene therapy, Gene Therapy 10 (19)  : 1703- 1711

(2003)  Mokbel, K.  and Newbold, RF. , Re: Poremba et al Telomerase as a prognostic marker in breast cancer: High-throughput tissue microarray analysis of hTERT and hTR. J Pathol 2002; 198: 181-189, Journal of Pathology 199 (4)  : 542-

(2003)  Newbold, RF. , Cosma, MP. , Pepe, S. , Annunziata, I. , et al. , The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases, Cell 113 (4)  : 445- 456 Download publication

(2003)  Wilson, P. , Cuthbert, A. , March, A. , Arnold, J. , et al. , Transfer of chromosome 8 into two breast cancer cell lines: Total exclusion of three regions indicates location of putative in vitro growth suppressor genes, Cancer Genetics and Cytogenetics 143 (2)  : 100- 112 Download publication

(2002)  Bryce, SD. , Morrison, V. , Craig, NJ. , Forsyth, NR. , et al. , A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23, Neoplasia 4 (6)  : 544- 550 Download publication

(2002)  Boulos, N. , Newbold, RF. , Trott, DA. , Pearson, ADJ. , et al. , Functional complementation analysis of chromosome 1 in neuroblastoma, BRITISH JOURNAL OF CANCER 86 S91- S91

(2002)  Forsyth, NR. , Morrison, V. , Craig, NJ. , Fitzsimmons, SA. , et al. , Functional evidence for a squamous cell carcinoma mortality gene(s) on human chromosome 4, Oncogene 21 (33)  : 5135- 5147 Download publication

(2002)  Wilding, J. , Meijne, E. , Haines, J. , Moody, J. , et al. , Functional evidence from microcell-mediated chromosome transfer of myeloid leukemia suppressor genes on human chromosomes 7 and 11, Genes, Chromosomes and Cancer 34 (4)  : 390- 397

(2002)  Newbold, RF. , The significance of telomerase activation and cellular immortalization in human cancer, Mutagenesis 17 (6)  : 539- 550

(2001)  Seyda, A. , Newbold, RF. , Hudson, TJ. , Verner, A. , et al. , A novel syndrome affecting multiple mitochondrial functions, located by microcell-mediated transfer to chromosome 2p14-2p13, American Journal of Human Genetics 68 (2)  : 386- 396 Download publication

(2001)  Hadjisavvas, A. , Neuhausen, SL. , Hoffman, MD. , Adamou, A. , et al. , BRCA1 germline mutations in Cypriot breast cancer patients from 26 families with family history, Anticancer Research 21 (5)  : 3307- 3311

(2001)  Sullivan, GJ. , Bridger, JM. , Cuthbert, AP. , Newbold, RF. , et al. , Human acrocentric chromosomes with transcriptionally silent nucleolar organiser regions associate with nucleoli, European Molecular Biology Organization 20 (11)  : 2867- 2877 Download publication

(2001)  Goodarzi, G. , Mashimo, T. , Watabe, M. , Cuthbert, AP. , et al. , Identification of tumor metastasis suppressor region on the short arm of human chromosome 20, Genes Chromosomes Cancer 32 (1)  : 33- 42

(2001)  Ducrest, AL. , Amacker, M. , Mathieu, YD. , Cuthbert, AP. , et al. , Regulation of human telomerase activity: Repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity, Cancer Research 61 (20)  : 7594- 7602 Download publication

(2001)  Steenbergen, RD. , Kramer, D. , Meijer, CJ. , Walboomers, JM. , et al. , Telomerase suppression by chromosome 6 in a human papillomavirus type 16-immortalized keratinocyte cell line and in a cervical cancer cell line., Journal of the National Cancer Institute 93 (11)  : 865- 872 Download publication

(2001)  McIlrath, J. , Bouffler, SD. , Samper, E. , Cuthbert, A. , et al. , Telomere length abnormalities in mammalian radiosensitive cells, Cancer Research 61 (3)  : 912- 915 Download publication

Conference Papers

(2009)  Al Sarakbi, W. , Sasi, W. , Jiang, WG. , Roberts, W. , et al. , Gene transcripts in the tumour suppressor region of chromosome 3 (3p21), 32nd Annual San Antonio Breast Cancer Symposium, Cancer Research (69)  : 869S- 869S

(2004)  Dafou, D. , Trott, DA. , Newbold, RF. , Jacobs, IJ.  and Gayther, SA. , Establishing a cell biology model of suppression in epithelial ovarian cancer, 44th Annual Meeting of the American-Society-for-Cell-Biology, MOLECULAR BIOLOGY OF THE CELL (15)  : 250A- 250A

(2004)  Dafou, D. , Li, NF. , Trott, DA. , Jacobs, IJ. , et al. , In vitro model of malignant transformation for the identification of genes in breast cancer formation, British Cancer Research Meeting 2004, BRITISH JOURNAL OF CANCER (91)  : S74- S74

(2002)  Cosma, MP. , Pepe, S. , Parenti, G. , Belli, A. , et al. , Mapping of the gene for multiple sulfatase deficiency (MSD) by functional complementation using microcell-mediated chromosome transfer, European-Society-of-Human-Genetics European Human Genetics Conference in Conjuction With European Meeting on Psychosocial Aspects of Genetics, EUROPEAN JOURNAL OF HUMAN GENETICS (10)  : 207- 208

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