Professor Andreas Kortenkamp
Professor in Human Toxicology
Brunel University
Uxbridge
UB8 3PH
United Kingdom
About Andreas
We have prepared scientific reports for the European Commission, including the State of the Art Report on Mixture Toxicology. Currently we are writing a State of the Art Assessment for Endocrine Disrupters, a project also commissioned by the European Commission.
Another research interest is in unravelling the details of estrogen signalling and estrogen-mediated effects with a view to understanding hormonal cancers, especially breast cancer. Here, I closely collaborate with Dr Elisabete Silva.
Qualifications
1983: Degree in Chemistry, Philosophy and Educational Sciences from University of Muenster, Germany1989: PhD (with distinction) from Bremen University, Bremen, Germany
Career
- 1990-1991: Post-doctoral Fellow at Queen Mary London, University of London.
- 1991-2000: Lecturer in Environmental Toxicology, School of Pharmacy, University of London, London.
- 2000-2005: Senior Lecturer, School of Pharmacy, University of London, London.
- 2005-2007: Reader and Head of Centre for Toxicology, School of Pharmacy, University of London, London.
- 2007-2011: Professor for Molecular Toxicology, Head of Centre for Toxicology, School of Pharmacy, University of London, London.
- 2011-present: Professor in the Institute for the Environment, Brunel University.
Research
Research Interests
Research Activity
Research Projects
My research interest falls into three broad areas: understanding the combined effects of mixtures of environmental pollutants on human health and wildlife, developing strategies for handling mixtures in chemicals regulation, and dissecting the events important in hormonal carcinogenesis.
1. Understanding combination effects of mixtures
Not long ago, the topic of mixture effects of chemicals was deemed too difficult to be approached experimentally. There has been, and still is, a confusion of important terms and concepts in mixture toxicology, as well as experimental approaches. We have tried to understand mixture effects in terms of the toxicity of individual mixture components: Is it possible to predict accurately the effects of a mixture, when we have information about the toxicity of its components, and of the mixture ratio?
Another issue arising from the experimental mixture studies is: How many chemicals are humans or wildlife exposed to simultaneously, and which of these contribute substantially to a specific combination effect? We are currently pursuing this problem by investigating mixtures that are modelled on realistic exposure scenarios.
2. Regulatory strategies for dealing with mixtures
A new consensus is emerging that mixture effects should be the topic of chemicals risk assessment. Any strategy for dealing with combination effects has to address the question: Which chemicals should be grouped together to be subjected to mixtures risk assessment? There are at least two approaches to resolving this question: Firstly, those chemicals that humans and wildlife come into contact with simultaneously should be considered. Secondly, chemicals that can produce similar adverse outcomes should also be grouped together. Our team is engaged in developing viable, pragmatic grouping criteria for chemicals in mixture risk assessment.
3. Hormones and hormonal carcinogenesis
While it is clear that hormones play a role in cancers of the breast, prostate and testes, their precise involvement in the disease process is far from clear. Our team is interested in studying the details of cell division and differentiation, and the role that steroid hormones and other hormonally active chemicals play in these processes. Here, we are collaborating closely with Dr Elisabete Silva.
Current grants
- European Commission, £650,000 (over 3.5 years, ending 2012) for research into antiandrogens and human reproductive health, CONTAMED (Grant agreement number 212502)
- Oak Foundation (Geneva, Switzerland), £219,000 (over two years, ending 2012) for a project entitled “Combined exposures to endocrine disrupters: bridging the gap between science and chemicals risk assessment and regulation”
- European Commission (DG Environment), £253,000 (over 20 months, ending 2011) for a State of the Art Assessment of Endocrine Disrupters
- Food Standards Agency, £153,000 (over two years, ending 2012) for a project investigating the mixture effects of benzimidazole pesticides, contract T10053
- European Commission, £150,000 (over 5 years, ending 2013) for research into combination effects of neurotoxic agents, ESNATS project
- European Food Standards Authority, £170,000 (over 1 year) for developing grouping criteria for pesticides that act by different modes of action (contract CFT/EFSA/PPR/2010/02)
Completed projects
- European Commission (DG Environment), £ 150,000 for a State of the Art Report on Mixture Toxicology (completed 2009)
- Food Standards Agency, £482,112 (over three years) to investigate combination effects of multi-components mixtures of endocrine active food contaminants, contract T01045 (completed 2009)
- Bioforce Ltd, Switzerland, £85,000 (over three years) for a PhD studentship on the hormonal effects of plant extracts (awarded jointly to Dr Deniz Tasdemir, Centre for Pharmacognosy, School of Pharmacy), (completed 2011)
- 2004 Bioforce Ltd, Switzerland granted £75,000 (over three years) for a PhD studentship on adverse reactions to herbal medicine products (awarded jointly to Prof Heinrich, Centre for Pharmacognosy, School of Pharmacy) , (completed 2010)
- European Commission awarded 1,371,667 Euros (over four years, extended to 4.5 years) for research on endocrine disrupters. EDEN - Endocrine Disrupters: Exploring Novel Endpoints, Exposure, Low-Dose- and Mixture-Effects in Humans, Aquatic Wildlife and Laboratory Animals (EU-project Contract No QLRT-2001-00603), (completed 2007)
- European Commission awarded 264,322 Euros (over three years) for research on combination effects of aquatic pollutants with oestrogenic activity. ACE – Analysing combination effects of mixtures of estrogenic chemicals in marine and freshwater organisms (EU-project Contract No. EVK1-CT-2001-00100), (completed 2004)
- 1999 JNICT, Programa Ciencia, Portugal, awarded £55,000 (over three years) for support of a PhD project on mixture effects of xenoestrogens (completed 2002)
Impact
Our work is beginning to have significant political impact at the European Union level: In 2008 the Danish Government charged us with organizing an international workshop on combination effects of chemicals (28-30 January 2009, Hornbaek, Denmark)
The outcomes of this workshop were taken forward by the Danish Government to the European Council and have contributed to the Decision of the European Council of Environment Ministers of December 2009 on combinations effects of chemicals.
In December 2007 the European Commission, DG Environment commissioned a State of the Art Report on Mixture Toxicology which a consortium under our leadership won by competitive tender. The report was completed in December 2009 and was explicitly referred to in the European Council decision on combination effects of chemicals.
Research Supervision
Current PhD students
- Ms Alexandra Ouertani (Determinants of cell cycle entry in normal mammary epithelial cells, part-funded by a School of Pharmacy PhD Scholarship)
- Ms Maria Riverso (Cell-cell communication between mammary epithelial cells, jointly supervised with Dr Elisabete Silva, part-funded by a School of Pharmacy PhD Scholarship, and by a School of Pharmacy bequest)
External Duties
- 2005: Membership of the Technical Working Group “Research Needs”, advising the European Commission on research strategies on Environment and Health for the period from 2006 to 2010 (SCALE – European Environment and Health Strategy)
- 2005 – 2006: Member of the Scientific Committee of the “Weybridge +10" conference on endocrine disruption, 8-10 Nov 2006, Helsinki, Finland, an event organised under the auspices of the Finnish EU presidency
- 2006: Elected vice chair of the 2008 Gordon Research Conference on Environmental Endocrine Disrupters
- 2007 – 2008: Member of the National Research Council (US National Academy Sciences) panel on “Cumulative risk assessment for phthalates – the tasks ahead”
- Elected chair of the 2010 Gordon Research Conference on Environmental Endocrine Disrupters
- 2010-2012: On the nomination of the President of the US National Academy of Sciences appointed to the US Consumer Health Advisory Panel (CHAP) on risks of phthalate exposures
- 2010: Member of the World Health Organisation panel on updating the Global Assessment of Endocrine Disrupters
- 2010: Member of a panel of the European Food Standards Authority on assessing mixtures of pesticides with similar modes of action
Publications
Publications
Journal Papers
(2013) Krug, AK., Kolde, R., Gaspar, JA., Rempel, E., Balmer, NV., Meganathan, K., Vojnits, K., Baquié, M., Waldmann, T., Ensenat-Waser, R., Jagtap, S., Evans, RM., Julien, S., Peterson, H., Zagoura, D., Kadereit, S., Gerhard, D., Sotiriadou, I., Heke, M., Natarajan, K., Henry, M., Winkler, J., Marchan, R., Stoppini, L., Bosgra, S., Westerhout, J., Verwei, M., Vilo, J., Kortenkamp, A., Hescheler, J., Hothorn, L., Bremer, S., Van Thriel, C., Krause, K-H., Hengstler, JG., Rahnenführer, J., Leist, M. and Sachinidis, A., Human embryonic stem cell-derived test systems for developmental neurotoxicity: A transcriptomics approach, Archives of Toxicology 87 (1) : 123- 143
(2012) Orton, F., Rosivatz, E., Scholze, M. and Kortenkamp, A., Competitive androgen receptor antagonism as a factor determining the predictability of cumulative antiandrogenic effects of widely used pesticides, Environmental Health Perspectives 120 (11) : 1578- 1584
(2012) Evans, RM., Scholze, M. and Kortenkamp, A., Additive mixture effects of estrogenic chemicals in human cell-based assays can be influenced by inclusion of chemicals with differing effect profiles, PLoS One 7 (8) : e43606- Download publication
(2012) Kortenkamp, A., Martin, O., Evans, R., Orton, F., McKinlay, R., Rosivatz, E. and Faust, M., Response to A critique of the European Commission Document, "State of the Art Assessment of Endocrine Disrupters" by Rhomberg and colleagues--letter to the editor., Crit Rev Toxicol 42 (9) : 787- 789 Download publication
(2012) Christiansen, S., Kortenkamp, A., Axelstad, M., Boberg, J., Scholze, M., Jacobsen, PR., Faust, M., Lichtensteiger, W., Schlumpf, M., Burdorf, A. and Hass, U., Mixtures of endocrine disrupting contaminants modelled on human high end exposures: An exploratory study in rats, International Journal of Andrology 35 (3) : 303- 316
(2012) Snijder, CA., Kortenkamp, A., Steegers, EAP., Jaddoe, VWV., Hofman, A., Hass, U. and Burdorf, A., Intrauterine exposure to mild analgesics during pregnancy and the occurrence of cryptorchidism and hypospadia in the offspring: The Generation R Study, Human Reproduction 27 (4) : 1191- 1201
(2012) Christiansen, S., Kortenkamp, A., Axelstad, M., Boberg, J., Scholze, M., Jacobsen, PR., Faust, M., Lichtensteiger, W., Schlumpf, M., Burdorf, A. and Hass, U., Mixtures of endocrine disrupting contaminants modelled on human high end exposures: an exploratory study in rats., Int J Androl 35 (3) : 303- 316 Download publication
(2011) Ermler, S., Scholze, M. and Kortenkamp, A., The suitability of concentration addition for predicting the effects of multi-component mixtures of up to 17 anti-androgens with varied structural features in an in vitro AR antagonist assay, Toxicology and Applied Pharmacology 257 (2) : 189- 197
(2011) Ermler, S., Scholze, M. and Kortenkamp, A., The suitability of concentration addition for predicting the effects of multi-component mixtures of up to 17 anti-androgens with varied structural features in an in vitro AR antagonist assay., Toxicol Appl Pharmacol 257 (2) : 189- 197 Download publication
(2011) Silva, E., Rajapakse, N., Scholze, M., Backhaus, T., Ermler, S. and Kortenkamp, A., Joint effects of heterogeneous estrogenic chemicals in the E-screen--exploring the applicability of concentration addition., Toxicol Sci 122 (2) : 383- 394 Download publication
(2011) Orton, F., Rosivatz, E., Scholze, M. and Kortenkamp, A., Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens., Environ Health Perspect 119 (6) : 794- 800 Download publication
(2011) Modarai, M., Suter, A., Kortenkamp, A. and Heinrich, M., The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw (Harpagophyti radix) preparations., J Pharm Pharmacol 63 (3) : 429- 438 Download publication
(2011) Kortenkamp, A., Are cadmium and other heavy metal compounds acting as endocrine disrupters?, Met Ions Life Sci 8 305- 317 Download publication
(2010) Evans, RM., Rahte, S. and Kortenkamp, A., Inability to confirm estrogenicity of the heterocyclic amine PhIP in two in vitro assays., Toxicol In Vitro 24 (6) : 1757- 1763 Download publication
(2010) Ermler, S., Scholze, M. and Kortenkamp, A., The sensitivity of the MDA-kb2 cell in vitro assay in detecting anti-androgenic chemicals--identification of sources of variability and estimation of statistical power., Toxicol In Vitro 24 (6) : 1845- 1853 Download publication
(2010) Silva, E., Kabil, A. and Kortenkamp, A., Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens., Toxicol Appl Pharmacol 245 (2) : 160- 170 Download publication
(2010) Kortenkamp, A. and Faust, M., Combined exposures to anti-androgenic chemicals: steps towards cumulative risk assessment., Int J Androl 33 (2) : 463- 474 Download publication
(2010) Modarai, M., Yang, M., Suter, A., Kortenkamp, A. and Heinrich, M., Metabolomic profiling of liquid Echinacea medicinal products with in vitro inhibitory effects on cytochrome P450 3A4 (CYP3A4)., Planta Med 76 (4) : 378- 385 Download publication
(2009) Christiansen, S., Scholze, M., Dalgaard, M., Vinggaard, AM., Axelstad, M., Kortenkamp, A. and Hass, U., Synergistic Disruption of External Male Sex Organ Development by a Mixture of Four Antiandrogens, ENVIRONMENTAL HEALTH PERSPECTIVES 117 (12) : 1839- 1846
(2011) Modarai, M., Silva, E., Suter, A., Heinrich, M. and Kortenkamp, A., Safety of Herbal Medicinal Products: Echinacea and Selected Alkylamides Do Not Induce CYP3A4 mRNA Expression., Evid Based Complement Alternat Med 2011 213021- Download publication
(2009) Lopez-Espinosa, M-J., Silva, E., Granada, A., Molina-Molina, J-M., Fernandez, MF., Aguilar-Garduno, C., Olea-Serrano, F., Kortenkamp, A. and Olea, N., Assessment of the total effective xenoestrogen burden in extracts of human placentas, BIOMARKERS 14 (5) : 271- 277
(2008) Kabil, A., Silva, E. and Kortenkamp, A., Estrogens and genomic instability in human breast cancer cells--involvement of Src/Raf/Erk signaling in micronucleus formation by estrogenic chemicals., Carcinogenesis 29 (10) : 1862- 1868 Download publication
(2008) Modarai, M., Suter, A., Kortenkamp, A. and Heinrich, M., CYP3A4 inhibitory compounds from Echinacea extract (Echinaforce (R)), PLANTA MEDICA 74 (9) : 1070- 1071
(2008) Brian, JV., Harris, CA., Runnalls, TJ., Fantinati, A., Pojana, G., Marcomini, A., Booy, P., Lamoree, M., Kortenkamp, A. and Sumpter, JP., Evidence of temperature-dependent effects on the estrogenic response of fish: Implications with regard to climate change, Science of The Total Environment 397 (1-3) : 72- 81 Download publication
(2008) Heinrich, M., Modarai, M. and Kortenkamp, A., Herbal extracts used for upper respiratory tract infections: are there clinically relevant interactions with the cytochrome P450 enzyme system?, Planta Med 74 (6) : 657- 660 Download publication
(2008) Christiansen, S., Scholze, M., Axelstad, M., Boberg, J., Kortenkamp, A. and Hass, U., Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat, INTERNATIONAL JOURNAL OF ANDROLOGY 31 (2) : 241- 247
(2008) Kortenkamp, A., Low dose mixture effects of endocrine disrupters: implications for risk assessment and epidemiology., Int J Androl 31 (2) : 233- 240 Download publication
(2008) Kortenkamp, A., Combined effects of endocrine disruptors: Evaluation of the last 10 years | Effets combinés des perturbateurs endocriniens: Bilan des dix dernières années, Environnement, Risques et Sante 7 (3) : 172- 172
(2008) Johnson, AC., Jürgens, MD., Williams, RJ., Kümmerer, K., Kortenkamp, A. and Sumpter, JP., Do cytotoxic chemotherapy drugs discharged into rivers pose a risk to the environment and human health? An overview and UK case study, Journal of Hydrology 348 (1-2) : 167- 175
(2007) Silva, E., Scholze, M. and Kortenkamp, A., Activity of xenoestrogens at nanomolar concentrations in the E-Screen assay., Environ Health Perspect 115 Suppl 1 91- 97 Download publication
(2007) Hass, U., Scholze, M., Christiansen, S., Dalgaard, M., Vinggaard, AM., Axelstad, M., Metzdorff, SB. and Kortenkamp, A., Combined Exposure to Anti-Androgens Exacerbates Disruption of Sexual Differentiation in the Rat, ENVIRONMENTAL HEALTH PERSPECTIVES 115 122- 128
(2007) Kortenkamp, A., Introduction: endocrine disruptors-exposure assessment, novel end points, and low-dose and mixture effects., Environ Health Perspect 115 Suppl 1 7- Download publication
(2007) Kortenkamp, A., Faust, M., Scholze, M. and Backhaus, T., Low-level exposure to multiple chemicals: reason for human health concerns?, Environ Health Perspect 115 Suppl 1 106- 114 Download publication
(2007) Scholze, M. and Kortenkamp, A., Statistical power considerations show the endocrine disruptor low-dose issue in a new light., Environ Health Perspect 115 Suppl 1 84- 90 Download publication
(2007) Kortenkamp, A., Ten years of mixing cocktails: a review of combination effects of endocrine-disrupting chemicals., Environ Health Perspect 115 Suppl 1 98- 105 Download publication
(2007) Christiansen, S., Axelstad, M., Kortenkamp, A., Stolze, M. and Hass, U., Combined exposure to dissimilarly acting anti-androgens causes markedly increased frequency of hypospadias in the rat, TOXICOLOGY LETTERS 172 S179- +
(2007) Metzdorff, SB., Dalgaard, M., Christiansen, S., Axelstad, M., Hass, U., Kiersgaard, MK., Scholze, M., Kortenkamp, A. and Vinggaard, AM., Dysgenesis and histological changes of genitals and perturbations of gene expression in male rats after in utero exposure to antiandrogen mixtures, TOXICOLOGICAL SCIENCES 98 (1) : 87- 98
(2007) Modarai, M., Gertsch, J., Suter, A., Heinrich, M. and Kortenkamp, A., Cytochrome P450 inhibitory action of Echinacea preparations differs widely and co-varies with alkylamide content., J Pharm Pharmacol 59 (4) : 567- 573 Download publication
(2007) Heinrich, M., Modarai, M. and Kortenkamp, A., Drug interactions with Echinacea: does it matter how the product is made?, JOURNAL OF PHARMACY AND PHARMACOLOGY 59 A80- A80
(2007) Modarai, M., Wilson, N., Politi, M., Suter, A., Kortenkamp, A. and Heinrich, M., Echinacea liquid formulations - NMR spectroscopy and multivariate data analysis of fractions with CYP3A4 inhibitory activity, JOURNAL OF PHARMACY AND PHARMACOLOGY 59 A63- A63
(2007) Brian, JV., Harris, CA., Scholze, M., Kortenkamp, A., Booy, P., Lamoree, M., Pojana, G., Jonkers, N., Marcomini, A. and Sumpter, JP., Evidence of estrogenic mixture effects on the reproductive performance of fish, International Journal of Environmental Science and Technology 41 (1) : 337- 344 Download publication
(2006) Silva, E., Lopez-Espinosa, MJ., Molina-Molina, JM., Fernández, M., Olea, N. and Kortenkamp, A., Lack of activity of cadmium in in vitro estrogenicity assays., Toxicol Appl Pharmacol 216 (1) : 20- 28 Download publication
(2006) Kortenkamp, A., Breast cancer, oestrogens and environmental pollutants: a re-evaluation from a mixture perspective., Int J Androl 29 (1) : 193- 198 Download publication
(2006) Sumpter, JP., Johnson, AC., Williams, RJ., Kortenkamp, A. and Scholze, M., Modeling effects of mixtures of endocrine disrupting chemicals at the river catchment scale, Environmental Science and Technology 40 (17) : 5478- 5489
(2005) Rajapakse, N., Butterworth, M. and Kortenkamp, A., Detection of DNA strand breaks and oxidized DNA bases at the single-cell level resulting from exposure to estradiol and hydroxylated metabolites., Environ Mol Mutagen 45 (4) : 397- 404 Download publication
(2005) Schulte-Oehlmann, U. and Kortenkamp, A., The Prague declaration on endocrine disruption, Environmental Science and Pollution Research 12 (4) : 188- 188
(2004) Rajapakse, N., Silva, E., Scholze, M. and Kortenkamp, A., Deviation from additivity with estrogenic mixtures containing 4-nonylphenol and 4-tert-octylphenol detected in the E-SCREEN assay., Environ Sci Technol 38 (23) : 6343- 6352 Download publication
(2004) Peck, M., Gibson, RW., Kortenkamp, A. and Hill, EM., Sediments are major sinks of steroidal estrogens in two United Kingdom rivers, ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 23 (4) : 945- 952
(2004) Shayer, R., Kinchesh, P., Raffray, M. and Kortenkamp, A., Biomonitoring of chromium(VI) deposited in pulmonary tissues: pilot studies of a magnetic resonance imaging technique in a post-mortem rodent model., Biomarkers 9 (1) : 32- 46 Download publication
(2003) Tang, S., Bremner, P., Kortenkamp, A., Schlage, C., Gray, AI., Gibbons, S. and Heinrich, M., Biflavonoids with cytotoxic and antibacterial activity from Ochna macrocalyx., Planta Med 69 (3) : 247- 253 Download publication
(2002) Rajapakse, N., Silva, E. and Kortenkamp, A., Combining xenoestrogens at levels below individual no-observed-effect concentrations dramatically enhances steroid hormone action., Environ Health Perspect 110 (9) : 917- 921 Download publication
(2002) Silva, E., Rajapakse, N. and Kortenkamp, A., Something from "nothing"--eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects., Environ Sci Technol 36 (8) : 1751- 1756 Download publication
(2001) Rajapakse, N., Ong, D. and Kortenkamp, A., Defining the impact of weakly estrogenic chemicals on the action of steroidal estrogens., Toxicol Sci 60 (2) : 296- 304 Download publication
(2001) Payne, J., Scholze, M. and Kortenkamp, A., Mixtures of four organochlorines enhance human breast cancer cell proliferation., Environ Health Perspect 109 (4) : 391- 397 Download publication
(2000) Payne, J., Rajapakse, N., Wilkins, M. and Kortenkamp, A., Prediction and assessment of the effects of mixtures of four xenoestrogens., Environ Health Perspect 108 (10) : 983- 987 Download publication
(2000) Payne, J., Jones, C., Lakhani, S. and Kortenkamp, A., Improving the reproducibility of the MCF-7 cell proliferation assay for the detection of xenoestrogens., Sci Total Environ 248 (1) : 51- 62 Download publication
(2000) Jones, C., Payne, J., Wells, D., Delhanty, JD., Lakhani, SR. and Kortenkamp, A., Comparative genomic hybridization reveals extensive variation among different MCF-7 cell stocks., Cancer Genet Cytogenet 117 (2) : 153- 158 Download publication
(2000) Jones, C. and Kortenkamp, A., RAPD library fingerprinting of bacterial and human DNA: applications in mutation detection., Teratog Carcinog Mutagen 20 (2) : 49- 63 Download publication
(1999) Casadevall, M., da Cruz Fresco, P. and Kortenkamp, A., Chromium(VI)-mediated DNA damage: oxidative pathways resulting in the formation of DNA breaks and abasic sites., Chem Biol Interact 123 (2) : 117- 132 Download publication
(1999) Kortenkamp, A. and Altenburger, R., Approaches to assessing combination effects of oestrogenic environmental pollutants., Sci Total Environ 233 (1-3) : 131- 140 Download publication
(1999) Rajapakse, N. and Kortenkamp, A., Formation of DNA damage by 17 β-oestradiol in MCI-7 breast cancer cells, Journal of Pharmacy and Pharmacology 51 (SUPPL.) : 151- 151
(1998) Kortenkamp, A. and Altenburger, R., Synergisms with mixtures of xenoestrogens: a reevaluation using the method of isoboles., Sci Total Environ 221 (1) : 59- 73 Download publication
(1997) Kortenkamp, A., Jones, C. and Baker, J., Genotypic selection of mutated DNA sequences using mismatch cleavage analysis, a possible basis for novel mutation assays., Mutagenesis 12 (5) : 335- 338 Download publication
(1997) Kortenkamp, A., Problems in the biological monitoring of chromium(VI) exposed individuals, BIOMARKERS 2 (2) : 73- 79
(1996) Kortenkamp, A., Pharmacokinetic modelling in chromium risk assessment - A prediction of chromium (III) accumulation in humans from chromium dietary supplements - Comment, HUMAN & EXPERIMENTAL TOXICOLOGY 15 (7) : 601- 602
(1996) Kortenkamp, A., Casadevall, M., Faux, SP., Jenner, A., Shayer, RO., Woodbridge, N. and O'Brien, P., A role for molecular oxygen in the formation of DNA damage during the reduction of the carcinogen chromium (VI) by glutathione., Arch Biochem Biophys 329 (2) : 199- 207 Download publication
(1996) Kortenkamp, A., Casadevall, M. and Da Cruz Fresco, P., The reductive conversion of the carcinogen chromium (VI) and its role in the formation of DNA lesions., Ann Clin Lab Sci 26 (2) : 160- 175 Download publication
(1995) da Cruz Fresco, P., Shacker, F. and Kortenkamp, A., The reductive conversion of chromium (VI) by ascorbate gives rise to apurinic/apyrimidinic sites in isolated DNA., Chem Res Toxicol 8 (6) : 884- 890 Download publication
(1995) Casadevall, M. and Kortenkamp, A., The formation of both apurinic/apyrimidinic sites and single-strand breaks by chromate and glutathione arises from attack by the same single reactive species and is dependent on molecular oxygen., Carcinogenesis 16 (4) : 805- 809 Download publication
(1994) O'Brien, P. and Kortenkamp, A., Chemical models important in understanding the ways in which chromate can damage DNA., Environ Health Perspect 102 Suppl 3 3- 10 Download publication
(1994) da Cruz Fresco, P. and Kortenkamp, A., The formation of DNA cleaving species during the reduction of chromate by ascorbate., Carcinogenesis 15 (9) : 1773- 1778 Download publication
(1994) Kortenkamp, A. and O'Brien, P., The generation of DNA single-strand breaks during the reduction of chromate by ascorbic acid and/or glutathione in vitro., Environ Health Perspect 102 Suppl 3 237- 241 Download publication
(1994) Casadevall, M. and Kortenkamp, A., The generation of apurinic/apyrimidinic sites in isolated DNA during the reduction of chromate by glutathione., Carcinogenesis 15 (2) : 407- 409 Download publication
(1992) Kortenkamp, A., Curran, B. and O'Brien, P., Defining conditions for the efficient in vitro cross-linking of proteins to DNA by chromium(III) compounds., Carcinogenesis 13 (2) : 307- 308 Download publication
(1992) Kortenkamp, A., Obrien, P. and Beyersmann, D., FLUORESCENCE STUDIES OF DYE DISPLACEMENT FROM DNA BY CHROMIUM(III) COMPLEXES - EVIDENCE FOR CATION INDUCED DNA CONDENSATIONS, TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY 35 (3-4) : 149- 159
(1991) Kortenkamp, A., O'Brien, P. and Beyersmann, D., The reduction of chromate is a prerequisite of chromium binding to cell nuclei., Carcinogenesis 12 (6) : 1143- 1144 Download publication
(1991) Jones, P., Kortenkamp, A., O'Brien, P., Wang, G. and Yang, G., Evidence for the generation of hydroxyl radicals from a chromium(V) intermediate isolated from the reaction of chromate with glutathione., Arch Biochem Biophys 286 (2) : 652- 655 Download publication
(1991) Kortenkamp, A. and O'Brien, P., Studies of the binding of chromium(III) complexes to phosphate groups of adenosine triphosphate., Carcinogenesis 12 (5) : 921- 926 Download publication
(1989) Kortenkamp, A., Ozolins, Z., Beyersmann, D. and Obrien, P., GENERATION OF PM2 DNA BREAKS IN THE COURSE OF REDUCTION OF CHROMIUM(VI) BY GLUTATHIONE, MUTATION RESEARCH 216 (1) : 19- 26
(1987) Kortenkamp, A., Beyersmann, D. and Obrien, P., UPTAKE OF CHROMIUM(III) COMPLEXES BY ERYTHROCYTES, TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY 14 (1-2) : 23- 32
Conference Papers
(2010) Rahte, S., Suter, A., Kortenkamp, A. and Tasdemir, D., Selective serotonin re-uptake and acetylcholinesterase inhibitory activities of Salvia officinalis, 7th Tannin Conference/58th International Congress and Annual Meeting of the Society-for-Medical-Plant-and-Natural-Product-Research, PLANTA MEDICA (76) : 1213- 1213 Download publication
(2009) Modarai, M., Silva, E., Suter, A., Heinrich, M. and Kortenkamp, A., The effects of Echinacea and its alkylamides on CYP3A4 transcriptional activity, 55th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-Research-and-Natural-Product-Research, PLANTA MEDICA (75) : 998- 998
(2008) Kortenkamp, A., Breast cancer and environmental risk factors: an appraisal of the scientific evidence, Breast Cancer Research Meeting, BREAST CANCER RESEARCH (10) : S24- S24
(2007) Heinrich, M., Modarai, M. and Kortenkamp, A., CYP inhibitory action of Echinacea preparations differs widely, but is it clinically relevant?, 55th Annual Congress of the Society-for-Medicinal-Plant-Research, PLANTA MEDICA (73) : 823- 823
(2007) Modarai, M., Wilson, N., Politi, M., Suter, A., Kortenkamp, A. and Heinrich, M., Evaluating CYP3A4 inhibitory activity of Echinacea extracts using NMR and multivariate data analysis, 55th Annual Congress of the Society-for-Medicinal-Plant-Research, PLANTA MEDICA (73) : 990- 991
(2006) Modarai, M., Gertsch, J., Suter, A., Kortenkamp, A. and Heinrich, M., Echinacea and its alkamides - An assessment of potential CYP-P450 enzyme inhibition?, 54th Annual Congress on Medicinal Plant Research, PLANTA MEDICA (72) : 1068- 1068
(1999) Kortenkamp, A. and Sarkar, B., Chromium biomonitoring - Achievements, problems, and future challenges, 2nd International Symposium on Metals and Genetics, METALS AND GENETICS 87- 100
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