Martin Scholze
Research Fellow
Room: Halsbury Building 132
Brunel University
Uxbridge
UB8 3PH
United Kingdom
Brunel University
Uxbridge
UB8 3PH
United Kingdom
About Martin
I am a mathematician with a strong background in statistics and biology. My academic research has covered a wide range of areas, encompassing epidemiology, ecotoxicology, toxicology and pharmacology. Having gained an international reputation for my research in biomathematics and statistics in various interdisciplinary international Research projects, I can draw on a wide range of expertise and experience. Since 2007 I am working mainly as an independent consultant, providing consultancy and training in biostatistics, biomathematics and data management to a broad client base in the UK and Europe. My clients include industry, government, international organisations and the academic world. My aim is to make biostatistics accessible and effective as a tool to solve practical problems, based on sound statistical knowledge and modern developments in biostatistics and biomathematics.
Qualifications
- Diploma in mathematics (major subject: statistics)
- Prediploma in biology
- Post-graduate qualification in epidemiology (German society for medical informatics, biometrics and epidemiology)
Career
- 2007 – present: Independent biostatistical Consultant (Scholze Consultancy, London, UK)
- 2003 – 2007: Research scientist in two European Union-funded research projects, Centre for Toxicology, The School of Pharmacology, University of London.
- 1997 – 2003: Research scientist and Co-coordination in two European Union-funded research projects, University of Bremen, Department of Biology and Chemistry.
- 1996 – 1997: Research scientist, University of Bremen, Department of Statistics, Germany.
- 1994 – 1996: Research scientist in Epidemiological studies, Bremen Institute for Prevention Research and Social Medicine, Germany.
- 1992 – 1994: Research scientist in Epidemiological studies, University of Bremen, Department of Statistics, Germany.
External Duties
- Reviewer for a various life sciences journals
- Reviewer of research grants
- Consultancy for governmental organisations
Professional memberships
- International Biometric society
Publications
Full Refereed Papers
1. Ermler S, Scholze M, and Kortenkamp A (2010). The suitability of concentration addition for predicting the effects of multi-component mixtures of up to 17 anti-androgens with varied structural features in an in vitro AR antagonist assay. Toxicology and Applied Pharmacology (in press)2. Silva E, Rajapakse N, Scholze M, Backhaus T, Ermler S, and Kortenkamp A (2011). Joint Effects of Heterogeneous Estrogenic Chemicals in the E-Screen-Exploring the Applicability of Concentration Addition. Toxicological Sciences 122(2): 383-394.
3. Correia AD, Cunha SR, Scholze M, and Stevens ED (2011). A Novel Behavioural Fish Model of Nociception for Testing Analgesics. Pharmaceuticals 4: 665-680.
4. Orton F, Rosivatz E, Scholze M, and Kortenkamp A (2011). Widely Used Pesticides with Previously Unknown Endocrine Activity Revealed as in Vitro Antiandrogens. Environmental Health Perspectives 119(6): 794-800.
5. Ermler S, Scholze M, and Kortenkamp A (2010). The sensitivity of the MDA-kb2 cell in vitro assay in detecting anti-androgenic chemicals - Identification of sources of variability and estimation of statistical power. Toxicology in Vitro 24(6): 1845-1853.
6. Christiansen S, Scholze M, Dalgaard M, Vinggaard AM, Axelstad M, and Kortenkamp A, Hass U (2009). Synergistic Disruption of External Male Sex Organ Development by a Mixture of Four Antiandrogens. Environmental Health Perspectives 117(12): 1839-1846.
7. Goncalves R, Scholze M, Ferreira AM, Martins M, and Correia AD (2008). The joint effect of polycyclic aromatic hydrocarbons on fish behaviour. Environmental Research 108(2): 205-213.
8. Christiansen S, Scholze M, Axelstad M, Boberg J, Kortenkamp A, and Hass U (2008). Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat. International Journal of Andrology 31(2): 241-247.
9. Kortenkamp A, Faust M, Scholze M, and Backhaus T (2007). Low-Level Exposure to Multiple Chemicals: Reason for Human Health Concerns? Environmental Health Perspectives 115: 106-114.
10. Scholze M and Kortenkamp A (2007). Statistical power considerations show the endocrine disrupter low-dose issue in a new light. Environmental Health Perspectives 115 (suppl1):84-90.
11. Porsbring T, Arrhenius Å, Kuylenstierna M, Scholze M, and Blanck H (2007). The SWIFT periphyton test for high-capacity assessments of toxicant effects on microalgal community development. Journal of Experimental Marine Biology and Ecology 349: 299-312.
12. Silva E, Scholze M, and Kortenkamp A (2007). Activity of xenoestrogens at nanomolar concentrations in the E-Screen. Environmental Health Perspectives 115 (suppl1):91-97.
13. Metzdorff SB, Dalgaard M, Christiansen S, Axelstad M, Hass U, Kiersgaard MK, Scholze M, Kortenkamp A, and Vinggaard AM (2007). Dysgenesis and histological changes of genitals and perturbations of gene expression in male rats after in utero exposure to antiandrogen mixtures. Toxicological Sciences 98(1):87-98.
14. Kortenkamp A, Faust M, Scholze M, and Backhaus T (2007). Low-Level Exposure to Multiple Chemicals - Reason for Human Health Concerns? Environmental Health Perspectives 115 (suppl1):106-114.
15. Correia AD, Freitas S, Scholze M, Gonçalves JF, Booij P, Lamoree MH, Mañanós E, and Reis-Henriques MA (2007). Mixtures of Estrogenic Chemicals Enhance Vitellogenic Response in Sea Bass. Environmental Health Perspectives 115 (suppl1):115-121.
16. Hass U, Scholze M, Christiansen S, Dalgaard M, Vinggaard AM, Axelstad M, Metzdorff SB, and Kortenkamp A (2007). Combined exposure to anti-androgens exacerbates disruption of sexual differentiation in the rat. Environmental Health Perspectives 115 (suppl1):122-128.
17. Correia AD, Gonçalves R, Scholze M, Ferreira M, and Reis-Henriques MA (2007). Biochemical and behavioral responses in gilthead seabream (Sparus aurata) to phenanthrene. Journal of Experimental Marine Biology and Ecology 347:109-122.
18. Brian JV, Harris CA, Scholze M, Kortenkamp A, Booy P, Lamoree M, Pojana G, Jonkers N, Marcomini A, and Sumpter JP (2007). Evidence of mixture effects on the reproductive performance of fish. Environmental Science & Technology 41(1):337-344.
19. Sumpter JP, Johnson AC, Kortenkamp A, Scholze M, and Williams RJ (2006). Modelling effects of mixtures of endocrine disrupting chemicals at the river catchment scale. Environmental Science & Technology 40 (17):5478-5489.
20. Junghans M, Backhaus T, Faust M, Scholze M, and Grimme LH (2006). Application and validation of approaches for the predictive hazard assessment of realistic pesticide mixtures. Aquatic Toxicology 76:93-110.
21. Page YL, Scholze M, Kah O, and Pakdel F (2006). Assessment of Xenoestrogens Using Three Distinct Estrogen Receptors and Zebrafish Brain Aromatase Gene in a Highly Responsive Glial Cell System. Environmental Health Perspectives 114 (5):752-758.
22. Arrhenius Å, Backhaus T, Grönvall F, Junghans M, Scholze M, and Blanck H (2006). Effects of three antifouling agents on algal communities and algal reproduction: Mixture toxicity studies with TBT, Irgarol, and Sea-Nine. Archives of Environmental Contamination and Toxicology 50(3):335-345.
23. Brian JV, Harris CA, Scholze M, Backhaus T, Booy P, Lamoree M, Pojana G, Jonkers N,Runnalls T, Bonfà S, Marcomini A, and Sumpter JP (2005). Accurate prediction of the response of freshwater fish to a mixture of estrogenic chemicals. Environmental Health Perspectives 113 (6):721-728.
24. Kortenkamp A, Silva E, Rajapakse N, and Scholze M (2005). Are there risks from low dose mixture effects of endocrine disrupters? In: Chemikalien in der Umwelt mit Wirkung auf das endocrine System. 3. UBA Statusseminar. Fraunhofer IRB Verlag Stuttgart, Germany.
25. Rajapakse N, Silva E, Scholze M, and Kortenkamp A (2004). Deviation from additivity with estrogenic mixtures containing 4-nonylphenol and 4-tertoctylphenol detected in the E-SCREEN assay. Environmental Science & Technology 38 (23):6343-6352.
26. Arrhenius Å, Grönvall F, Scholze M, Backhaus T, and Blanck H (2004). Predictability of the mixture toxicity of 12 similarly acting congeneric inhibitors of photosystem II in marine periphyton and epipsammon communities. Aquatic Toxicology 68(4):351-367.
27. Backhaus T, Faust M, Scholze M, Gramatica P, Vighi M, and Grimme LH (2004). The Joint Algal Toxicity of Phenylurea Herbicides is Equally Predictable by Concentration Addition and Independent Action. Environmental Science & Technology 23 (2):258-264.
28. Backhaus T, Scholze M, et al (2003). The BEAM-project: prediction and assessment of mixture toxicities in the aquatic environment. Continental Shelf Research 23:1757–1769.
29. Junghans M, Backhaus T, Faust M, Scholze M, and Grimme LH (2003). Toxicity of Sulfonylurea Herbicides to the Green Alga Scenedesmus vacuolatus: Predictability of Combination effects. Bulletin of Environmental Contamination and Toxicology 71:585-593.
30. Junghans M, Backhaus T, Faust M, Scholze M, and Grimme LH (2003). Predictability of combined effects of eight chloroacetanilide herbicides on algal reproduction. Pest Management Science 59 (10):1101-1110.
31. Thorpe KL, Cummings RI, Hutchinson TH, Scholze M, Brighty G, Sumpter JP, Tyler CR (2003). Relative potencies and combination effects of steroidal estrogens in fish. Environmental Science & Technology 37:1142-1149.
32. Faust M, Altenburger R, Backhaus T, Blanck H, Boedeker W, Gramatica P, Hamer V, Scholze M, Vighi M, and Grimme LH (2003). Joint algal toxicity of 16 dissimilarly acting chemicals is predictable by the concept of independent action. Aquatic Toxicology 63:43-63.
33. Vighi M, Altenburger R, Arrhenius A, Backhaus T, Bodeker W, Blanck H, Consolaro F, Faust M, Finizio A, Froehner K, Gramatica P, Grimme LH, Gronvall F, Hamer V, Scholze M, Walter H (2003). Water quality objectives for mixtures of toxic chemicals: problems and perspectives. Ecotoxicology and Environmental Safety 54:139-150.
34. Walter H, Consolaro F, Gramatica P, Scholze M, and Altenburger R (2002). Mixture toxicity of Priority Pollutants at No Observed Effect Concentrations (NOECs). Ecotoxicology 11:299-310.
35. Scholze M, Boedeker W, Faust M, Backhaus T, Altenburger R, and Grimme LH (2001). A general best fit method for concentration-response curves and the estimation of low effect concentrations Environmental Toxicology and Chemistry 20:448-457.
36. Payne J, Scholze M, and Kortenkamp A (2001). Mixtures of four organochlorines enhance human breast cancer cell proliferation. Environmental Health Perspectives 109:391-397.
37. Thorpe KL, Hutchinson TH, Hetheridge MJ, Scholze M, Sumpter JP, Tyler CR (2001). Assessing the biological potency of binary mixtures of environmental estrogens using vitellogenin induction in juvenile rainbow trout (Oncorhynchus mykiss). Environmental Science & Technology 35:2476-2481.
38. Faust M, Altenburger R, Backhaus T, Blanck H, Boedeker W, Gramatica P, Hamer V, Scholze M, Vighi M, and Grimme LH (2001). Predicting the joint algal toxicity of multi-component s-triazine mixtures at low-effect concentrations of individual toxicants. Aquatic Toxicology 56:13-32.
39. Merzenich H, Hartwig A, Ahrens W, Beyersmann D, Schlepegrell R, Scholze M, Timm J, and Jöckel KH (2001). Biomonitoring on carcinogenic metals and oxidative DNA-damage in a cross-sectional study. Cancer Epidemiology, Biomarkers&Prevention 10:515-522.
40. Backhaus T, Scholze M, and Grimme LH (2000). The single substance and mixture toxicity of quinolones to the bioluminescent bacterium Vibrio fischeri. Aquatic Toxicology, 49(1-2):49-61.
41. Grimme LH, Altenburger R, Arrhenius Å, Backhaus T, Blanck H, Consolaro F, Faust M, Finizio A, Gramatica P, Grothe M, Junghans M, Pavan M, Scholze M, Todeschini R, Vighi M, Villa S, and Walter H (2000). Risk assessment of chemical mixtures in the aquatic environment: An outline of the BEAM project. In EurOCEAN 2000 - The European Conference on Marine Science and Ocean Technology, Vol. I: Marine processes, ecosystems and interactions (European Commission, Ed.), pp. 208-212. Office for Official Publications of the European Communities, Luxembourg.
42. Faust M, Altenburger R, Backhaus T, Bödeker W, Scholze M, and Grimme LH (2000). Predictive assessment of the aquatic toxicity of multiple chemical mixtures. Journal of Environmental Quality 29:1063-1068.
43. Backhaus T, Altenburger R, Bödeker W, Faust M, Scholze M, and Grimme LH (2000). Predictability of the toxicity of a multiple mixture of dissimilarly acting chemicals to Vibrio fischeri. Environmental Toxicology and Chemistry 19:2348-2356.
44. Altenburger R, Backhaus T, Bödeker W, Faust M, Scholze M, and Grimme LH (2000). Predictability of the toxicity of multiple chemical mixtures to Vibrio fisheri: Mixtures composed of similarly acting chemicals. Environmental Toxicology and Chemistry 19 (9):2341-2347.
45. Grimme LH, Altenburger R, Backhaus T, Faust M, Bödeker W, and Scholze M (2000). Kombinationswirkungen von Umweltchemikalien in der Ökotoxikologie - Konzepte für die Vorhersage und ihre experimentelle Prüfung. Umweltwissenschaften und Schadstoffforschung (UWSF), Zeitschrift für Umweltchemie und Ökotoxikologie 12:226-234. http://www.fb-envico.de/profile.html - top
