Professor Tom Hutchinson
Honorary professor
Brunel University
Uxbridge
UB8 3PH
United Kingdom
About Tom
Animals in Research (NC3Rs). In 2010, Tom was awarded the role of UK Science Leader for the UK-Japan intergovernmental research project on endocrine disrupters. He has recently been appointed to the UK government’s Advisory Committee on Pesticides from 2013-2016. Outside work, I enjoy sea and river kayaking with family and friends and am a qualified coach with the British Canoe Union.
Career history
2011 – pres Programme Director – Chemicals & Nanotechnology Risk Assessment, CEFAS
2009 - 2011 Programme Scientist for Environment & Health, CEFAS
2007 - 2009 Head of Science for Environment and Health, Plymouth Marine Laboratory UK
2006 – 2007 Associate Director, Environmental Safety Assessment, AstraZeneca, UK
2004 – 2006 Principal Scientist, Molecular Toxicology, AstraZeneca R&D, Sweden
1999 – 2004 Head of Environmental Research & Senior Project Manager, AstraZeneca Brixham Environmental Laboratory, UK
1992 – 1999 Senior Scientist, ZENECA Limited, Brixham Environmental Laboratory, UK
1986 – 1992 Research Scientist, Imperial Chemical Industries (ICI), Brixham Environmental Laboratory, UK
Qualifications & Awards
2009 Plymouth Marine Laboratory Fellow
2007 Honorary Professor, School of Biosciences, University of Exeter, UK
2005 Honorary Professor, Institute for the Environment, Brunel University, UK
2005 Elected Member of the British Toxicology Society
2003 Honorary Research Fellow, Department Biological Sciences Dept., University of Plymouth, UK
2001 Elected Fellow of the Society of Biology (previously the Institute of Biology)
1996 Ph.D. Marine Biology - University of Plymouth, UK (Effects of Environmental Contaminants on the Immune Function of Marine Fish)
1986 B.Sc. Hons. (2:1) Environmental Science - King's College London, University of London, UK
Research
Research Interests
Research Activity
My main research interest is in the risks posed by endocrine disrupters and other pharmacologically active chemicals on populations of fish, aquatic invertebrates and plants. Specific research activities are currently focussed on three key themes: (1) environmental risk assessment of endocrine disrupters in the context of the OECD conceptual framework; (2) reproductive and immunotoxic impacts of emerging contaminants and climate change factors on freshwater and marine molluscs; and (3) aquatic animal welfare through the use of validated of in vitro and other alternative techniques in ecotoxicology. Current research co-operations are with Prof Charles Tyler, University of Exeter (developmental toxicology), Dr Rod Wilson, University of Exeter (ocean acidification and marine contaminants) and Dr Steve Widdicombe, PML and Prof. John Spicer, University of Plymouth (ocean acidification and marine shellfish). I have current or recent joint projects with Prof. Kevin Chipman, Birmingham University (zebrafish toxicology), Dr. Andrew Johnson, Centre for Ecology & Hydrology, Wallingford (modelling the fate of drugs in the River Tamar), Prof. Mal Jones and Dr. Awadhesh Jha, Plymouth University (genotoxic and developmental screens in marine echinoderms), Prof. Richard Sibly & Dr. Amanda Callaghan, Reading University (genomics and population biology of crustaceans) and Prof. John Sumpter, Brunel University (effects of beta-blocker drugs in fish). In Europe, I have worked with Prof. Thomas Backhaus, University of Gothenburg, Sweden (chemical mixtures), Prof. Thomas Ternes, Federal Institute of Hydrology, Germany (analysis of beta-blocker drugs in water), Dr. Alfredo Alder, Eawag, Switzerland (residues of beta blocker drugs in fish), Prof. Peter Pärt, European Commission Joint Research Centre, Ispra, Italy (animal alternatives in ecotoxicology) and Dr. Jeanne Garric and co-workers, Cemagref, France (impacts of beta-blocker drugs on aquatic macroinvertebrates).Publications
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1 |
Pope ND, O'Hara SCM, Imamura M, Hutchinson TH, Langston WJ (2011) Influence of a collapsed coastal landfill on metal levels in sediments and biota - a portent for the future? Journal of Environmental Monitoring 13: 1961-1974 |
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2 |
Celander M, Goldstone J, Denslow N, Iguchi T, Kille P, Meyerhoff R, Smith B, Hutchinson TH, Wheeler JR (2011) Species extrapolation for the 21st century. Environmental Toxicology and Chemistry 30: 52-63 |
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3 |
Creton S, Douglas M, Wheeler JR, Hutchinson TH (2010) Challenging the requirement for chronic fish toxicity studies on formulated plant protection products. Toxicology Letters 199: 111-114 |
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4 |
Hutchinson TH (2010) Pharmaceuticals as Emerging Contaminants in Coastal Ecosystems. In: Ocean Year Book Volume 24 (ed. Coffen-Smout S), pp 269-281 Pub Martins Nijhoff Publishers, The Netherlands |
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5 |
Panter GH, Hutchinson TH, Hurd KS, Bamforth J, Stanley RD, Wheeler JR, Tyler CR (2010) Effects of a weak oestrogenic active chemical (4-tert-pentylphenol) on pair-breeding and F1 development in the fathead minnow (Pimephales promelas). Aquatic Toxicology 97: 314-323 |
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6 |
Craft JA, Gilbert JA, Temperton B, Dempsey KE, Ashelford K, Tiwari B, Hutchinson TH, Chipman JK (2010) Pyrosequencing of Mytilus galloprovincialis cDNAs: tissue-specific expression patterns. PLoS One 5(1):e8875 |
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7 |
Kádár E, Dashfield S, Hutchinson TH(2010) Developmental toxicity of benzotriazole in the protochordate Ciona intestinalis (Chordata, Ascidiae). Analytical Bioanalytical Chemistry 396: 641-647 |
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8 |
Kádár E, Lowe DM, Solé M, Fisher AS, Jha AN, Readman JW, Hutchinson TH(2010) Uptake and biological responses to nano-Fe versus soluble FeCl3 in excised mussel gills. Analytical Bioanalytical Chemistry 396: 657-666 |
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9 |
Solé M, Shaw JP, Frickers PE, Readman JW, Hutchinson TH(2010) Effects on feeding rate and biomarker responses of marine mussels experimentally exposed to propranolol and acetaminophen. Analytical Bioanalytical Chemistry 396: 649-656 |
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10 |
Küster A, Alder A, Escher B, Duis K, Fenner K, Garric J, Hutchinson TH, Lapen D, Duprey A, Römbke J, Snape J, Ternes T, Topp E, Wehrman A, Knacker T (2010) Environmental risk assessment of human pharmaceuticals in the European Union - a case study with the b-blocker atenolol. Integrated Environmental Assessment and Management 6: 514-523 |
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11 |
Schmitt H, Boucard T, Garric J, Jensen J, Parrott J, Péry A, Römbke J, Straub JO, Hutchinson TH, Sánchez-Argüello P, Wennmalm A, Duis K (2010) Recommendations on the environmental risk assessment of pharmaceuticals: Effect characterization. Integrated Environmental Assessment and Management 6: 588-602 |
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12 |
Jones HS, Panter GH, Hutchinson TH, Chipman JK (2010) Oxidative and conjugative xenobiotic metabolism in zebrafish larvae in vivo. Zebrafish 7: 23-30 |
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13 |
Canty MN, Hutchinson TH, Brown RJ, Jones MB, Jha AN (2009) Linking genotoxic responses with cytotoxic and behavioural or physiological consequences: differential sensitivity of echinoderms (Asterias rubens) and marine molluscs (Mytilus edulis). Aquatic Toxicology 94: 68–76 |
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14 |
Jones HS, Trollope HT, Hutchinson TH, Panter GH, Chipman JK (2009) Assessment of an ibuprofen metabolism by zebrafish larvae, using liquid chromatography-mass spectrometry (LC-MS). Toxicology 262: 14-15 |
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15 |
Boxall AB, Hardy A, Beulke S, Boucard T, Burgin L, Falloon PD, Haygarth PM, Hutchinson TH, Kovats RS, Leonardi G, Levy LS, Nichols G, Parsons SA, Potts L, Stone D, Topp E, Turley DB, Walsh K, Wellington EM, Williams RJ (2009) Impacts of climate change on indirect human exposure to pathogens and chemicals from agriculture. Environmental Health Perspectives 117: 508-514 |
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16 |
Owen SF, Huggett DB, Hutchinson TH, Hetheridge MJ, Kinter LB, Ericson JF and Sumpter JP (2009) Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry. Aquatic Toxicology 93: 217-224 |
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17 |
Giltrow E, Eccles PD, Winter MJ, McCormack PJ, Rand-Weaver M, Hutchinson TH, Sumpter JP (2009) Chronic effects assessment and plasma concentrations of the beta-blocker propranolol in fathead minnows (Pimephales promelas). Aquatic Toxicology 95:195-202 |
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18 |
Hutchinson TH, Bögi C, Winter MJ, Owens JW (2009) Benefits of the Maximum Tolerated Dose (MTD) and Maximum Tolerated Concentration (MTC) concept in aquatic toxicology. Aquatic Toxicology 91: 197–202 |
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19 |
Hutchinson TH, Beesley A, Frickers PE, Readman JW, Shaw JP, Straub JO (2009) Extending the environmental risk assessment for oseltamivir (Tamiflu®) under pandemic use conditions to the coastal marine compartment. Environment International 35: 931-936 |
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20 |
Jones HS, Panter GH, Hutchinson TH, Chipman KJ (2008) Cytochrome P450s and glucuronosyl transferase in zebrafish larvae. Toxicology 253: 12-13 |
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21 |
Hutchinson TH (2008) Realizing the potential benefits of small animal models for the aquatic hazard assessment of human pharmaceuticals: a conceptual approach. In Kümmerer K (ed.), Pharmaceuticals in the Environment: Sources, Fate, Effects and Risks, 3rd edition, pp 245-255 |
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25 |
Hutchinson TH, Björklund C, Jönsson R, Mahshid Y and Kenne K (2008) Proteomic biomarkers for early stage phospholipidosis in human U937 cell lines. Toxicology in Vitro 22: 1198–1204 |
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26 |
Richards FM, Alderton WK, Kimber GM, Liu Z, Strang I, Redfern WS, Valentin J-P, Winter MJ and Hutchinson TH (2008) Validation of the use of zebrafish larvae in visual safety assessment. Journal of Pharmacological and Toxicological Methods 58: 50-58 |
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27 |
Winter MJ, Redfern WS, Hayfield AJ, Owen SF, Valentin J-P and Hutchinson TH (2008) Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs. Journal of Pharmacological and Toxicological Methods 57: 176-187 |
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28 |
Caldwell D, Mastrocco F, Hutchinson TH, Länge R, Heijerick D, Janssen C, Anderson P and Sumpter J (2008) Derivation of an aquatic Predicted No-Effect-Concentration for the synthetic hormone, 17a-ethinylestradiol. Environmental Science & Technology 42: 7046-7054 |
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29 |
Pounds NA, Maclean S, Webley M, Pascoe D and Hutchinson TH (2008) Acute and chronic effects of ibuprofen in the freshwater mollusc Planorbis carinatus (Gastropoda: Planorbidae). Ecotoxicology & Environmental Safety 70(1): 47-52 |
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30 |
Hooper HL, Connon R, Callaghan A, Fryer G, Yarwood-Buchanan S, Biggs J, Maund SJ, Hutchinson TH, Sibly RM (2008) The ecological niche of Daphnia magna characterized using population growth rate. Ecology 89(4): 1015–1022 |
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31 |
Winter MJ, Lillicrap AD, Caunter JE, Schaffner C, Alder AC, Ramil M, Ternes TA, Giltrow E, Sumpter JP, Hutchinson TH (2008) Assessment of development and reproduction in fathead minnows (Pimephales promelas) exposed to atenolol. Aquatic Toxicology86(3): 361-369 |
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32 |
Heckmann LH, Sibly RM, Connon R, Hooper HL, Hutchinson TH, Maund SJ, Hill CJ, Bouetard A, Callaghan A (2008) Systems biology meets stress ecology: linking molecular and organismal stress responses in Daphnia magna. Genome Biology 9:R40 (available from http://genomebiology.com/2008/9/2/R40) |
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33 |
Montforts M, Brandt I, Hutchinson TH (2007) Summary of workshop on environmental assessment of human medicines: development and use of aquatic toxicity data. Drug Information Journal 41: 203-209 |
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34 |
Hutchinson TH, Caldwell D, Galay-Burgos M, Hartmann A, Holt M, Huggett D, Mastrocco F, Maund S, Oberwalder C, Versteeg D (2007) Intelligent testing strategies in ecotoxicology: mode of action approach for specifically acting chemicals. ECETOC Technical Report number 102, 145 pp |
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35 |
Heckmann L-H, Callaghan A, Hooper HL, Connon R, Hutchinson TH, Maund SJ, Sibly RM (2007) Chronic toxicity of ibuprofen to Daphnia magna: effects on life history traits and population dynamics. Toxicology Letters 172: 137-145 |
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36 |
Winter MJ, Ellis LCJ, Hutchinson TH (2007) Formation of micronuclei in erythrocytes of the fathead minnow (Pimephales promelas) after acute treatment with mitomycin C or cyclophosphamide.Mutation Research 629: 89-99 |
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37 |
Owen S, Giltrow E, Huggett D, Hutchinson TH, Kinter L, Winter MJ, Sumpter JP (2007). Comparative physiology, pharmacology and toxicology of b-blockers: mammals versus fish. Aquatic Toxicology82: 145-162 |
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38 |
Williams TD, Caunter JE, Lillicrap AD, Hutchinson TH, Gillings EG, Duffell S (2007) Evaluation of the reproductive effects of tamoxifen citrate in partial and full life-cycle studies using fathead minnows (Pimephales promelas). Environmental Toxicology and Chemistry 26: 695-707 |
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39 |
Hutchinson TH (2007) Small is useful in endocrine disrupter assessment – four key recommendations for aquatic invertebrate research. Ecotoxicology 16: 231-238 |
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40 |
Thorpe KL, Benstead R, Hutchinson TH, Tyler CR (2007) Associations between altered vitellogenin concentrations and adverse health effects in fathead minnow (Pimephales promelas).Aquatic Toxicology 85: 176-183 |
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41 |
Thorpe KL, Benstead R, Hutchinson TH, Tyler CR (2007) An optimised experimental test procedure for measuring chemical effects on reproduction in the fathead minnow, Pimephales promelas. Aquatic Toxicology 81: 90-98 |
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42 |
Hutchinson TH, Ankley GT Segner H, Tyler CR (2006) Screening and testing for endocrine disruption in fish - biomarkers as “signposts not traffic lights” in risk assessment. Environmental Health Perspectives 114 (Suppl 1): 106–114 |
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43 |
Iguchi T, Irie F, Urushitani H, Tooi O, Kawashima Y, Roberts M, Norrgren L, Hutchinson TH (2006) Availability of in vitro vitellogenin assay for screening of estrogenic and anti-estrogenic activities of environmental chemicals. Environmental Sciences 13: 161-183 |
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44 |
Crane HM, Pickford DB, Hutchinson TH, Brown JA (2006) The effects of methimazole on development of the fathead minnow, Pimephales promelas, from embryo to adult. Toxicological sciences 93: 278-285 |
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45 |
Cunningham VL, Buzby M, Hutchinson TH, Mastrocco F, Parke N, Roden N (2006) Effects of human pharmaceuticals on aquatic life: next steps. Environmental Science and Technology 40: 3456–3462 |
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46 |
Heckmann L H, Connon R, Hutchinson TH, Maund SJ, Sibly RM, Callaghan A (2006) Expression of target and reference genes in Daphnia magna exposed to ibuprofen. BMC Genomics 2006, 7:175 (article number #175) |
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47 |
Eidem JK, Kleivdal H, Kroll K, Denslow N, van Aerle R, Tyler CR, Panter GH, Hutchinson TH, Goksøyr A (2006) Development and validation of a direct homologous quantitative sandwich ELISA for fathead minnow (Pimephales promelas) vitellogenin. Aquatic Toxicology 78: 202–206 |
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48 |
Noël H, Hopkin S, Hutchinson TH, Williams TD, Sibly R (2006) Population growth rate and carrying capacity for springtails Folsomia candida exposed to ivermectin. Ecological Applications 16: 656–665 |
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49 |
Noël H, Hopkin S, Hutchinson TH, Williams TD, Sibly R (2006) Towards a population ecology of stressed environments: the effects of zinc on the springtail Folsomia candida. Journal of Applied Ecology 43:325–332 |
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50 |
Hutchinson TH, Shillabeer N, Winter MJ, Pickford DB (2006) Acute and chronic effects of carrier solvents in aquatic organisms: a critical review. Aquatic Toxicology 76(1): 69-92 |
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51 |
Ankley GT, Black MC, Garric J, Hutchinson TH, Iguchi T (2005) A framework for assessing the hazard of pharmaceutical materials to aquatic species. In Williams RT (ed) Human Pharmaceuticals - Assessing the Impacts on Aquatic Ecosystems. SETAC Press, SETAC Brussels, Belgium, pp 183-237 |
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52 |
Hutchinson TH, Kümmerer K, Servos MR, Williams RT (2005) Overview of research needs to improve the science supporting environmental stewardship of human pharmaceuticals. In Williams RT (ed) Human Pharmaceuticals - Assessing the Impacts on Aquatic Ecosystems. SETAC Press, SETAC Brussels, Belgium, pp 303-311 |
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53 |
Jeram S, Riego Sintes JM, Halder M, Baraibar Fentanes J, Sokull-Klüttgen B, Hutchinson TH (2005) A strategy to reduce the use of fish in acute ecotoxicity testing of new chemical substances notified in the European Union. Regulatory Toxicology and Pharmacology 42: 218-224 |
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54 |
Brown RJ, Rundle SD, Hutchinson TH, Williams TD, Jones MB (2005) A microplate freshwater copepod bioassay for evaluating acute and chronic effects of chemicals. Environmental Toxicology and Chemistry 24: 1528–1531 |
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55 |
Crane H, Pickford DB, Hutchinson TH, Brown JA (2005) Effects of ammonium perchlorate on thyroid function in developing fathead minnows, Pimephales promelas. Environmental Health Perspectives 113: 396–401 |
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56 |
Hooper HL, Sibly RM, Hutchinson TH, Maund SJ (2005) Joint effects of density and a growth inhibitor on the life history and population growth rate of the midge Chironomus riparius. Environmental Toxicology and Chemistry 24:1140-1145 |
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57 |
Knacker T, Duis K, Ternes T, Fenner K, Escher B, Schmitt H, Römbke J, Garric J, Hutchinson TH, Boxall ABA (2005) The EU-project ERAPharm: incentives for the further development of guidance documents? Environmental Science & Pollution Research 12: 62 – 65 |
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58 |
Snape JR, Maund SJ, Pickford DB, Hutchinson TH (2004) Ecotoxicogenomics: the challenge of integrating genomics into aquatic and terrestrial ecotoxicology. Aquatic Toxicology 67: 143-154 |
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59 |
Panter GH, Hutchinson TH, Hurd KS, Sherren A, Stanley RD, Tyler CR (2004) Successful detection of (anti-)androgenic and aromatase inhibitors in pre-spawning adult fathead minnows (Pimephales promelas) using easily measured endpoints of sexual development. Aquatic Toxicology 70(1):11-21 |
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60 |
Thomas-Jones E, Thorpe KL, Harrison N, Thomas G, Morris C, Hutchinson TH, Woodhead S, Tyler CR (2003) Dynamics of estrogen biomarker responses in rainbow trout exposed to 17b-oestradiol and 17a-ethinylestradiol. Environmental Toxicology and Chemistry 22: 3001-3008 |
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61 |
Wallis NT, Smith FM, Panter GH, Hutchinson TH (2003) Laboratory fish gonadal sex differentiation: a comparison of fathead minnow, sheepshead minnow and zebrafish. Toxicology Sciences 72: 192-193 |
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62 |
Hooper HL, Sibly RM, Hutchinson TH, Maund SJ (2003) The influence of larval density, food availability and habitat longevity on the life history and population growth rate of the midge, Chironomus riparius. Oikos 102: 515-524 |
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63 |
Hooper HL, Sibly RM, Maund SJ, Hutchinson TH (2003) The joint effects of larval density and 14C-cypermethrin on the life history and population growth rate of the midge, Chironomus riparius. Journal of Applied Ecology 40: 1049-1059 |
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64 |
Thorpe KL, Cummings RI, Hutchinson TH, Scholze M, Brighty, G, Sumpter JP, Tyler CR (2003) Relative potencies and combination effects of steroidal oestrogens in fish. Environmental Science & Technology 37: 1142-1149 |
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65 |
Thorpe KL, Benstead R, Hutchinson TH, Cummings RI, Tyler CR (2003) Reproductive effects of exposure to oestrone in the fathead minnow. Fish Physiology & Biochemistry 28: 451-452 |
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66 |
Hutchinson TH, Barrett S, Busby M, Constable D, Hartmann A, Hayes E, Huggett D, Länge R, Lillicrap AD, Straub JO, Thompson RS (2003) A strategy to reduce the numbers of fish used in acute ecotoxicity testing of pharmaceuticals. Environmental Toxicology and Chemistry 22: 3031-3036 |
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67 |
Pickford DB, Hetheridge MJ, Caunter JE, Tilghman Hall A, Hutchinson TH (2003) Assessing chronic toxicity of bisphenol A to larvae of the African clawed frog (Xenopus laevis) in a flow-through exposure system. Chemosphere 53: 223-235 |
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68 |
Brown RJ, Rundle SD, Hutchinson TH, Williams TD, Jones MB (2003) Small-scale detritus-invertebrate interactions: influence of detrital biofilm composition on development and reproduction in a meiofaunal copepod. Archives of Hydrobiology 157: 117-129 |
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69 |
Brown AR, Riddle AM, Cunningham NL, Kedwards TJ, Shillabeer N, Hutchinson TH (2003) Predicting the effects of endocrine disrupting chemicals on fish populations. Human & Ecological Risk Assessment 9: 761-788 |
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70 |
Hutchinson TH, Field MDR, Manning MJ (2003) Evaluation of non-specific immune functions in dab, Limanda limanda (L.), following short-term exposure to sediments contaminated with polyaromatic hydrocarbons and/or polychlorinated biphenyls. Marine Environmental Research 55: 193-202 |
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71 |
Brown RJ, Rundle S, Hutchinson TH, Williams TD, Jones MB (2003) A copepod life-cycle test and growth model for interpreting the effects of lindane. Aquatic Toxicology 63: 1–11 |
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72 |
Hutchinson TH, Pickford DB (2003) Ecological risk assessment and testing for endocrine disruption in the aquatic environment. Toxicology 181-182C: 383-387 |
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73 |
van Aerle R, Pounds N, Hutchinson TH, Maddix S, Tyler CR (2002) Windows of sensitivity for the estrogenic effects of ethynylestradiol in early lifestages of fathead minnow, Pimephales promelas. Ecotoxicology 11: 423-434 |
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74 |
Pounds NA, Hutchinson TH, Williams TD, Whiting P, Dinan L (2002) Assessment of putative endocrine disrupters in an in vivo crustacean assay and an in vitro insect assay. Marine Environmental Research 54: 709-713 |
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75 |
Dinan L, Bourne P, Cary F, Whiting P, Harmatha J, Lafont R, Marion-Poll F, Dhadialla TS, Hormann RE, Hutchinson TH (2002) Structure-activity studies on natural and non-natural ligands for ecdysteroid receptors. Journal of Insect Science 2.16: 5-6 |
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76 |
Matthiessen P, Allen Y, Bamber S, Craft J, Hurst M, Hutchinson TH, Feist S, Katsiadaki I, Kirby M, Robinson C, Scott AP, Thain JE, Thomas K (2002) The impact of oestrogenic and androgenic contamination on marine organisms in the UK – summary of the EDMAR programme. Marine Environmental Research 54: 645-649 |
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77 |
Hutchinson TH (2002) Impacts of endocrine disrupters on fish development: opportunities for adapting OECD Test Guideline 210. Environmental Sciences 9: 439-450 |
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78 |
Hutchinson TH (2002) Reproductive and developmental effects of endocrine disrupters in invertebrates: in vitro and in vivo approaches. Toxicology Letters131: 75-81 |
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79 |
Zerulla M, Länge R, Steger-Hartmann T, Panter GH, Hutchinson TH, Dietrich DR (2002) Morphological sex reversal upon short-term exposure to endocrine modulators in juvenile fathead minnow (Pimephales promelas). Toxicology Letters131: 51-63 |
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80 |
Panter GH, Hutchinson TH, Länge R, Lye C, Sumpter JP, Zerulla M, Tyler CR (2002) Utility of a juvenile fathead minnow screening assay for detecting (anti-)estrogenic substances. Environmental Toxicology and Chemistry 21: 319-326 |
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81 |
Halm S, Pounds NA, Maddix S, Rand-Weaver M, Sumpter JP, Hutchinson TH and Tyler CR (2002) Exposure to exogenous 17-oestradiol disrupts P450aromB mRNA expression in the brain and gonad of adult fathead minnows (Pimephales promelas). Aquatic Toxicology 60(3-4):285-299 |
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82 |
Tyler CR, van Aerle R, Nilsen MB, Blackwell R, Maddix S, Nilsen BM, Berg K, Hutchinson TH, Goksoyr A (2002) Development and validation of a monoclonal ELISA to quantify vitellogenin in the rainbow trout (Oncorhynchus mykiss) and its application for studies on environmental oestrogens. Environmental Toxicology and Chemistry. 21: 47-54 |
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83 |
Thorpe KL, Hutchinson TH, Hetheridge MJ, Scholze M, Sumpter JP, Tyler CR (2001) Assessing the interactive effects of binary mixtures of environmental oestrogens in rainbow trout (Oncorhynchus mykiss) using vitellogenin induction. Environmental Science & Technology 35: 2476-2481 |
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84 |
Dinan L,Bourne P, Whiting P, Dhadialla TS, Hutchinson TH (2001) Screening of environmental contaminants for ecdysteroid agonist and antagonist activity using the Drosophila melanogaster BII cell in vitro assay. Environmental Toxicology and Chemistry 20: 2038-2046 |
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85 |
Länge R, Hutchinson TH, Croudace CP, Siegmund F, Schweinfurth H, Hampe P, Panter GH, Sumpter JP (2001) Effects of the synthetic oestrogen 17a-ethinylestradiol over the life-cycle of the fathead minnow (Pimephales promelas). Environmental Toxicology and Chemistry 20: 1216 – 1227 |
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86 |
Hutchinson TH, Brown R, Brugger KE, Campbell PM, Holt M, Länge R, McCahon P, Tattersfield LJ, van Egmond R (2000). Ecological Risk Assessment of Endocrine Disruptors. Environmental Health Perspectives 108: 1007-1014 |
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87 |
Thorpe KL, Hetheridge MJ, Hutchinson TH, Tyler CR (2000) Development of an in vivo screening assay for estrogenic chemicals using juvenile rainbow trout (Oncorhynchus mykiss). Environmental Toxicology and Chemistry 19: 2812-2820 |
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88 |
Halm S, Sumpter JP, Rand-Weaver M, Hutchinson TH, Tyler CR (1999) The development of a quantitative RT-PCR to measure P450-aromatase mRNA expression in the fathead minnow (Pimephales promelas) with a view to its application for studying endocrine disruption. Proceedings of the 6th International Symposium on the Reproductive Physiology of Fish), Bergen, Norway, 4-9 July 1999, pp 386 |
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89 |
Ingersoll CG, Hutchinson TH, Crane M, Dodson S, DeWitt T, Gies A, Huet M-C, McKenney CL, Oberdörster E, Pascoe D, Versteeg DJ, Warwick O (1999) Laboratory toxicity tests for evaluating potential effects of endocrine disrupting compounds. In DeFur P, Crane M, Ingersoll C, Tattersfield L (Eds). Endocrine Disruption in Invertebrates: Endocrinology, Testing and Assessment. Proceedings of the EDIETA Workshop. SETAC Technical Publications Series ISBN 1-880611-27-9, pages 107-197 |
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90 |
Hutchinson TH, Matthiessen P (1999) Endocrine disruption and wildlife: identification and ecological relevance. The Science of the Total Environment 233: 1-3 |
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91 |
Hutchinson TH, Pounds NA, Hampel M, Williams TD (1999) Impact of natural and synthetic steroids on the survival, developmental and reproduction of marine copepods Tisbe battagliai. The Science of the Total Environment 233: 167-179 |
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92 |
Hutchinson TH, Field, MDR, Manning MJ (1999) Evaluation of immune function in juvenile turbot (Scopthalmus maximus L.) exposed to sediments contaminated with polychlorinated biphenyls. Fish and Shellfish Immunology 9: 457-472 |
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93 |
Hutchinson TH, Pounds NA, Hampel M, Williams TD (1999) Life-cycle studies with marine copepods (Tisbe battagliai) exposed to 20-hydroxyecdysone and diethylstilbestrol. Environmental Toxicology and Chemistry 18: 2914-2920 |
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94 |
Tyler CR, van Aerle R, Hutchinson TH, Maddix S, Trip H (1999) An in vivo testing system for endocrine disruptors in fish early life-stages using induction of vitellogenin.Environmental Toxicology and Chemistry 18: 337-347 |
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95 |
Hutchinson TH, Jha A N, Mackay J M, Elliott B M and Dixon D R (1998) Evaluation of the genotoxicity of disinfected sewage effluent using the marine worm Platynereis dumerilii (Polychaeta: Nereidae). Mutation Research 399: 97-108 |
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96 |
Campbell PM, Hutchinson TH (1998) Wildlife and endocrine disrupters: requirements for hazard identification. Environmental Toxicology and Chemistry 17: 127-135 |
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97 |
Ankley G, Hutchinson TH plus 28 workshop co-authors (1998) Overview of a workshop on screening methods for detecting potential (anti-) estrogenic/androgenic chemicals in wildlife. Environmental Toxicology and Chemistry 17: 68 – 87 |
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98 |
Solbé J F, Mark U, Buyle B, Guhl W, Hutchinson TH, Kloepper-Sams P J, Länge R, Munk R, Scholz N, Bontinck W, Niessen H (1998) Analysis of the ECETOC Aquatic Toxicity (EAT) Database. I. General Introduction. Chemosphere 36: 99-113 |
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99 |
Länge R, Hutchinson TH, Scholz N, Solbé J F (1998) Analysis of the ECETOC Aquatic Toxicity (EAT) Database. II. Comparison of acute to chronic ratios for various aquatic organisms and chemical substances. Chemosphere 36: 115-127 |
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100 |
Hutchinson TH, Solbé JF, Kloepper-Sams P J (1998) Analysis of the ECETOC Aquatic Toxicity (EAT) Database. III. Comparative toxicity of chemical substances to different life stages of aquatic organisms. Chemosphere 36: 129-142 |
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101 |
Hutchinson TH, Scholz N, Guhl W (1998) Analysis of the ECETOC Aquatic Toxicity (EAT) Database. IV. Comparative toxicity of chemical substances to freshwater versus saltwater organisms. Chemosphere 36: 143-153 |
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102 |
Palau-Casellas A and Hutchinson TH (1998) Acute toxicity of chlorinated organic chemicals to the embryos and larvae of the marine worm Platynereis dumerilii (Polychaeta: Nereidae). Environmental Toxicology and Water Quality 13: 149-155 |
|
103 |
Hutchinson TH and van Wijk D (1998) A review of the effects of bromate on aquatic organisms and toxicity of bromate to oyster embryos. In Sealey S (editor) Modern Chlor-Alkali Technology Number 7, pp 26 - 32. Published by the Royal Society of Chemistry, Cambridge. |
|
104 |
Hutchinson TH, Hutchings MJ, Moore K W (1997) A review of the effects of bromate on aquatic organisms and toxicity of bromate to oyster embryos. Ecotoxicology and Environmental Safety 38: 238 – 243 |
|
105 |
Jha A N, Hutchinson TH, Mackay J M, Elliott B M, Dixon D R (1997) Evaluation of the genotoxicity of municipal sewage effluent using the marine worm Platynereis dumerilii (Polychaeta: Nereidae). Mutation Research 391: 179-188 |
|
106 |
Carissan F M, Hutchinson TH, Beaumont A R, Pipe R K (1997) Investigation of the effects of sodium pentachlorophenol on the immune system of marine mussels. Developmental and Comparative Immunology 21: 125 (abstract only) |
|
107 |
Hutchinson TH, Manning MJ (1996) Effects of cadmium on marine fish (Limanda limanda L.) kidney phagocyte chemiluminescence. Marine Environmental Research 41: 327-342 |
|
108 |
Hutchinson TH, Manning M J (1996) Seasonal trends in serum total protein and lysozyme activity in marine fish (Limanda limanda L.) from Lyme Bay. Fish and Shellfish Immunology 6: 473-482 |
|
109 |
Jha A N, Hutchinson TH, Mackay J M, Elliott BM, Dixon D R (1996) Development of an in vivo marine genotoxicity test with Platynereis dumerilii (Polychaeta: Nereidae). Mutation Research 359: 141-150 |
|
110 |
Hutchinson TH, Jha AN, Dixon DR (1995) The polychaete Platynereis dumerilii: a new species for assessing the hazardous potential of chemicals in the marine environment. Ecotoxicology and Environmental Safety 31: 271-281 |
|
111 |
Jha A N, Hutchinson TH, Mackay JM, Elliott BM, Pascoe P and Dixon DR (1995) The chromosomes of Platynereis dumerilii (Polychaeta: Nereidae). Journal of the Marine Biological Association of the UK 75: 551-562 |
|
112 |
Jha AN, Dominquez I, Balajee AS, Hutchinson TH, Dixon DR, Natarajan AT (1995) Localization of telomeric chromosome regions in two species of marine polychaete. Chromosome Research 3: 507-508 |
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113 |
Field, MDR, Hutchinson TH, Manning M J (1995) Development of adherence techniques for collecting kidney phagocytes from marine fish (Limanda limanda L.). Fish and Shellfish Immunology 5: 505-517 |
|
114 |
Van Wijk D, Hutchinson TH (1995) The ecotoxicity of chlorate to aquatic organisms: a critical review. Ecotoxicology and Environmental Safety 32: 244-253 |
|
115 |
Hutchinson TH, Williams TD (1994) Culturing of fathead minnow larvae for aquatic toxicity testing: an observational note. Environmental Toxicology and Chemistry 13: 665‑669 |
|
116 |
Hutchinson TH, Williams TD, Eales GJ (1994) Toxicity of cadmium, hexavalent chromium and copper to marine fish larvae (Cyprinodon variegatus) and copepods (Tisbe battagliai). Marine Environmental Research 38: 275‑290 |
|
117 |
Williams TD, Hutchinson TH, Roberts GC, Coleman CA (1993) The assessment of industrial effluent toxicity using aquatic microorganisms, invertebrates and fish. Science of the Total Environment, supplement 1993 (part 2): 1129‑1141 |
|
118 |
Solbé J F, Buyle B, Guhl W, Hutchinson T H, Länge R, Mark U, Munk R, Scholz N (1993) Developing hazard identification for the aquatic environment. Science of the Total Environment, supplement 1993 (part 1): 47-61 |
|
119 |
Simpson MG, Hutchinson TH (1992) Toxicological pathology of dab Limanda limanda along pollution gradients in the southern North Sea. Marine Ecology Progress Series 91: 155-161 |
|
120 |
Hutchinson TH, Williams TD (1989) The use of sheepshead minnow (Cyprinodon variegatus) larvae and a benthic marine copepod (Tisbe battagliai) in short-term tests for estimating the chronic toxicity of industrial effluents. Hydrobiologia 188 & 189: 567-572 |
