I am a Research Fellow in Toxicology and Group Leader at the Institute of Environment, Health and Societies. My research focuses on understanding the multi-scale effects of pharmaceuticals, alone and in combination, and developing predictive models able to inform drug safety assessment for both humans and wildlife.
2015-to date: Group Leader & Research Fellow, Translational Pharmacology & Toxicology, Insitute of Environment, Health and Socities/College of Life Sciences, Brunel University London, UK
2011-2013: Visiting Scientist, AstraZeneca, UK
2011-2015: Post-doctoral Research Fellow, AstraZenenca/Brunel University London, London, UK (funded by BBSRC/AstraZeneca).
2007–2011: Ph.D. in Environmental Toxicology, Brunel University, London, UK (supported by GlaxoSmithKline). Integrated testing strategy for the study of the effects of the human pharmaceutical dutasteride on fish.
2003-2005: MSc Marine Biology, Universita’ Politecnica delle Marche, Ancona, Italy.
2000-2003: BSc Biological Sciences, Universita’ Politecnica delle Marche, Ancona, Italy.
Newest selected publications
Knapen, D., Angrish, MM., Fortin, MC., Katsiadaki, I., Leonard, M., Margiotta-Casaluci, L., (2018) 'Adverse Outcome Pathway Networks I: Development and Applications.'. Environ Toxicol Chem.Open Access Linket al.
Villeneuve, DL., Angrish, MM., Fortin, MC., Katsiadaki, I., Leonard, M., Margiotta-Casaluci, L., (2018) 'Adverse Outcome Pathway Networks II: Network Analytics.'. Environ Toxicol Chem.Open Access Linket al.
Tanoue, R., Margiotta-Casaluci, L., Huerta, B., Runnalls, TJ., Nomiyama, K., Kunisue, T., (2017) 'Uptake and Metabolism of Human Pharmaceuticals by Fish - A Case Study with the Opioid Analgesic Tramadol.'. Environmental science & technology. ISSN: 1520-5851 Open Access Linket al.
Huerta, B., Margiotta-Casaluci, L., Rodríguez-Mozaz, S., Scholze, M., Winter, MJ., Barceló, D. and (2016) 'Anti-anxiety drugs and fish behavior: Establishing the link between internal concentrations of oxazepam and behavioral effects'. Environmental Toxicology and Chemistry. ISSN: 0730-7268 Open Access Linket al.
Margiotta-Casaluci, L., Owen, SF., Huerta, B., Rodríguez-Mozaz, S., Kugathas, S., Barceló, D., (2016) 'Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish'. Scientific Reports. ISSN: 2045-2322 Open Access Linket al.