I am a Research Fellow in Toxicology and Group Leader at the Institute of Environment, Health and Societies. My research focuses on understanding the multi-scale effects of pharmaceuticals, alone and in combination, and developing predictive models able to inform drug safety assessment for both humans and wildlife.
2007–2011: Ph.D. in Environmental Toxicology, Brunel University, London, UK (supported by GlaxoSmithKline). Integrated testing strategy for the study of the effects of the human pharmaceutical dutasteride on fish.
2003-2005: MSc Marine Biology, Universita’ Politecnica delle Marche, Ancona, Italy.
2000-2003: BSc Biological Sciences, Universita’ Politecnica delle Marche, Ancona, Italy.
2015-to date: Research Fellow & Group Leader, Translational Toxicology, Insitute of Environment, Health and Socities/College of Life Sciences, Brunel University London, UK
2011-2013: Visiting Scientist, AstraZeneca, UK
2011-2015: Post-doctoral Research Fellow, AstraZenenca/Brunel University London, London, UK (funded by BBSRC/AstraZeneca).
Newest selected publications
Tanoue, R., Margiotta-Casaluci, L., Huerta, B., Runnalls, TJ., Nomiyama, K., Kunisue, T., (2017) 'Uptake and Metabolism of Human Pharmaceuticals by Fish - A Case Study with the Opioid Analgesic Tramadol.'. Environmental science & technology. ISSN: 1520-5851 Open Access Linket al.
Huerta, B., Margiotta-Casaluci, L., Rodríguez-Mozaz, S., Scholze, M., Winter, MJ., Barceló, D. and (2016) 'Anti-anxiety drugs and fish behavior: Establishing the link between internal concentrations of oxazepam and behavioral effects'. Environmental Toxicology and Chemistry. ISSN: 0730-7268 Open Access Linket al.
Margiotta-Casaluci, L., Owen, SF., Huerta, B., Rodríguez-Mozaz, S., Kugathas, S., Barceló, D., (2016) 'Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish'. Scientific Reports. ISSN: 2045-2322 Open Access Linket al.
Runnalls, TJ., Beresford, N., Kugathas, S., Margiotta-Casaluci, L., Scholze, M., Scott, AP. and (2015) 'From single chemicals to mixtures-Reproductive effects of levonorgestrel and ethinylestradiol on the fathead minnow.'. Aquatic Toxicology, 169. pp. 152 - 167. ISSN: 1879-1514 Open Access Linket al.
Margiotta-Casaluci, L., Owen, SF., Cumming, RI., De Polo, A., Winter, MJ., Panter, GH., (2014) 'Quantitative cross-species extrapolation between humans and fish: The case of the anti-depressant fluoxetine'. PLoS One, 9 (10). ISSN: 1932-6203 Open Access Linket al.