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Collaboration with Papworth Hospital

Funding body


Investigator(s)

External Principal investigator: Matthew Dyer
Principal investigator: Martin Buxton
 

Project description

Brief Summary

This long-standing collaboration with the Research & Development unit at Papworth Hospital currently involves HERG providing health economics expertise and analysis for a programme of trials in cardiac and thoracic interventions. Statistical support is provided by Dr Linda Sharples from the MRC Biostatistics Unit, Cambridge. Research currently being undertaken includes:

  • A trial evaluating ventricular assist devices (VADs) as a bridge to transplant. The research question to be addressed is: what are the benefits and costs of VADs for those patients who are waiting for a heart transplant or need mechanical support while their hearts recover?
  • A trial looking at the cost effectiveness of functional cardiac testing in the diagnosis and management of coronary artery disease. Techniques which measure blood flow to the heart (perfusion tests like stress echocardiography, MIBI and MRI) will be compared to angiography in terms of identifying those patients who are likely to benefit from revascularisation
  • A national, multi-centre trial evaluating the cost effectiveness of implementing rescue coronary angioplasty as a treatment for failed thrombolysis (in the treatment of acute coronary occlusion) and to compare it to repeat thrombolysis or standard conservative therapy
  • A randomised trial comparing the cost effectiveness of spinal cord stimulation (SCS) with percutaneous myocardial revascularisation (PMR) in the treatment of patients with refractory angina
  • A study comparing the cost effectiveness of the British Thoracic Society (BTS) guidelines with local (Papworth) clinical guidelines in terms of assessment of fitness for surgery in non-small cell lung cancer patients