Host:Pathogen interactions through the host genome
NIH, Clement Knight Foundation
Principal investigator: Dr Joanna Bridger
The trematode parasite Schistosoma mansoni has infected 200 million people worldwide. The parasite uses the fresh-water snail Biomphalaria glabrata as an intermediate host. We have discovered that genes induced to be expressed in the host are actively relocated to a new nuclear location and expressed (Arican-Goktas et al., 2014; Arican-Goktas et al., manuscript in prep.). Thisrelocation does not happen in resistant snails or with parasites that have been attenuated. Experiments are on-going that addresses the mechanism of signalling to and movement of specific genes and its relationship with the pathogenic control over the host at an epigenetic level.