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Muscle response to exercise in cerebral palsy



Funding body

Brunel University London Research Catalyst Fund and Royal National Orthopaedic Hospital Charity (Fripp Fund)


Principal investigator: Dr Amir A Mohagheghi
Co-investigator: Professor Neil Reeves (Manchester Metropolitan University)
Co-investigator: Mr Tahir Khan (Consultant Orthopaedic Surgeon, Royal National Orthopaedic Hospital)
Co-investigator: Dr Alexander Nowicky (Brunel University London)
Co-investigator: Mrs Nazanin Haseli Mashhadi (Principal Statistician, GSK Ltd.)
Co-investigator: Mr Matt Thornton (Motor Learning Laboratory, Royal National Orthopaedic Hospital)

Project description

Shortening of muscle fascicles in individuals with spastic cerebral palsy may contribute to the motor impairments in this population. Attempts to increase muscle fascicle length using different medical (e.g. surgery) and physiotherapeutic interventions (e.g. stretching, concentric/eccentric exercise) have been generally unsuccessful. The study investigates biomechanical and neurological responses of spastic muscles to exercise in cerebral palsy. We aim to identify potential pre-requisites for increasing fascicle length in spastic cerebral palsy.