Dr Ashraf William Khir

Publications

Journal Papers

(9999) Kolyva, C., Biglino, G., Pepper, JR. and Khir, AW., A mock circulatory system with physiological distribution of terminal resistance and compliance: Application for testing the intra-aortic balloon pump, Artificial Organs Forthcoming

(2013) Fresiello, L., Khir, AW., Di Molfetta, A., Kozarski, M. and Ferrari, G., Effects of intra-aortic balloon pump timing on baroreflex activities in a closed-loop cardiovascular hybrid model., Artif Organs 37 (3) : 237- 247 Download publication

(2012) Borlotti, A., Khir, AW., Rietzschel, ER., De Buyzere, ML., Vermeersch, S. and Segers, P., Noninvasive determination of local pulse wave velocity and wave intensity: changes with age and gender in the carotid and femoral arteries of healthy human., J Appl Physiol 113 (5) : 727- 735 Download publication

(2012) Biglino, G., Kolyva, C. and Khir, AW., Pressure-wave energy relationship during IABP counterpulsation in a mock circulation: changes with angle and assisting frequency., Int J Artif Organs 35 (1) : 15- 24 Download publication

(2011) Hughes, AD., Park, CM., Khir, AW., March, K., Coady, E., Chaturvedi, N. and Thom, SAM., Pioglitazone Treatment Improves Left Ventricular Function in Type 2 Diabetics, CIRCULATION 124

(2011) Ferrari, G., Khir, AW., Fresiello, L., Di Molfetta, A. and Kozarski, M., Hybrid model analysis of intra-aortic balloon pump performance as a function of ventricular and circulatory parameters., Artif Organs 35 (9) : 902- 911 Download publication

(2011) Khir, AW., Left ventricular temporary assistance: by blood propelling or counterpulsating?, Artif Organs 35 (9) : 840- 842 Download publication

(2011) Alastruey, J., Khir, AW., Matthys, KS., Segers, P., Sherwin, SJ., Verdonck, PR., Parker, KH. and Peiró, J., Pulse wave propagation in a model human arterial network: Assessment of 1-D visco-elastic simulations against in vitro measurements, Journal of Biomechanics 44 (12) : 2250- 2258

(2011) Bruti, G. and Khir, AW., PRESSURE MEASUREMENTS ALONG THE INTRA AORTIC BALLOON (IAB): IMPLICATIONS OF OPERATING AT AN ANGLE TO THE HORIZONTAL, INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS 34 680- 680

(2011) Khir, AW. and Bruti, G., SHAPE CHANGE OF THE INTRA-AORTIC BALLOON: CAN IT OFFSET THE OPERATIONAL DEFICIT AT ANGLES TO THE HORIZONTAL?, INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS 34 631- 631

(2011) Alastruey, J., Khir, AW., Matthys, KS., Segers, P., Sherwin, SJ., Verdonck, PR., Parker, KH. and Peiró, J., Pulse wave propagation in a model human arterial network: Assessment of 1-D visco-elastic simulations against in vitro measurements., J Biomech 44 (12) : 2250- 2258 Download publication

(2011) Henein, MY., Zhao, Y., Nicoll, R., Sun, L., Khir, AW., Franklin, K. and Lindqvist, P., The human heart: application of the golden ratio and angle., Int J Cardiol 150 (3) : 239- 242 Download publication

(2011) Li, Y. and Khir, AW., Experimental validation of non-invasive and fluid density independent methods for the determination of local wave speed and arrival time of reflected wave., J Biomech 44 (7) : 1393- 1399 Download publication

(2011) Li, Y. and Khir, AW., Experimental validation of non-invasive and fluid density independent methods for the determination of local wave speed and arrival time of reflected wave, Journal of Biomechanics 44 (7) : 1393- 1399

(2011) Ferrari, G., Khir, AW., Fresiello, L., di Molfetta, A. and Kozarski, M., Hybrid model analysis of intra-aortic balloon pump performance as a function of ventricular and circulatory parameters, Artificial Organs 35 (9) : 902- 911

(2011) Halliday, I., Atherton, M., Care, CM., Collins, MW., Evans, D., Evans, PC., Hose, DR., Khir, AW., König, CS., Krams, R., Lawford, PV., Lishchuk, SV., Pontrelli, G., Ridger, V., Spencer, TJ., Ventikos, Y., Walker, DC. and Watton, PN., Multi-scale interaction of particulate flow and the artery wall, Medical Engineering and Physics 33 (7) : 840- 848

(2011) Henein, MY., Zhao, Y., Nicoll, R., Sun, L., Khir, AW., Franklin, K. and Lindqvist, P., The human heart: Application of the golden ratio and angle, International Journal of Cardiology 150 (3) : 239- 242

(2011) Li, Y., Borlotti, A., Parker, KH. and Khir, AW., Variation of wave speed determined by the PU-loop with proximity to a reflection site, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 199- 202

(2011) Li, Y., Borlotti, A., Parker, KH. and Khir, AW., Variation of wave speed determined by the PU-loop with proximity to a reflection site., Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2011 199- 202

(2010) Khir, AW., What is it with patient's posture during intra aortic balloon pump therapy?, Artificial Organs 34 (12) : 1077- 1081

(2010) Halliday, I., Atherton, M., Care, CM., Collins, MW., Evans, D., Evans, PC., Hose, DR., Khir, AW., König, CS., Krams, R., Lawford, PV., Lishchuk, SV., Pontrelli, G., Ridger, V., Spencer, TJ., Ventikos, Y., Walker, DC. and Watton, PN., Multi-scale interaction of particulate flow and the artery wall, Medical Engineering & Physics Forthcoming

(2010) Page, C., Khir, AW., Hughes, AD. and Henein, MY., Normal asynchrony of left ventricular long and short axes: their relationship with aortic hemodynamics, International Journal of Cardiology 142 (2) : 166- 171

(2010) Ferrari, G., Fresiello, L., Di Molfetta, A., Khir, AW., Zielinski, K., Palko, KJ. and Kozarski, M., Application of a hybrid model to IABP investigation, International Journal of Artificial Organs 33 (7) : 443- 444

(2010) Swalen, MJP., Konig, CS., Sayma, AI. and Khir, AW., CFD modelling of a bi-directional axial flow LVAD (Abstract), International Journal of Artificial Organs 33 (7) : 450- 450

(2010) Khir, AW., Kolyva, C. and Pepper, JR., Hemodynamic effects of varying IAB inflation duration in vivo, International Journal of Artificial Organs 33 (7) : 443- 443

(2010) Kolyva, C., Pantalos, GM., Pepper, JR. and Khir, AW., How much of the intraaortic balloon volume is displaced toward the coronary circulation?, Journal of Thoracic and Cardiovascular Surgery 140 (1) : 110- 116 Download publication

(2010) Feng, J. and Khir, AW., Determination of wave speed and wave separation in the arteries using diameter and velocity, Journal of Biomechanics 43 (3) : 455- 462

(2010) Borlotti, A., Vermeersch, S., Rietzschel, E., Segers, P. and Khir, AW., A comparison between local wave speed in the carotid and femoral arteries in healthy humans: application of a new method., Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2010 2857- 2860

(2010) Clavica, F., Alastruey, J., Borlotti, A., Sherwin, SJ. and Khir, AW., One-dimensional computational model of pulse wave propagation in the human bronchial tree., Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2010 2473- 2476

(2010) Li, Y., Borlotti, A., Hickson, SS., McEniery, CM., Wilkinson, IB. and Khir, AW., Using magnetic resonance imaging measurements for the determination of local wave speed and arrival time of reflected waves in human ascending aorta., Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2010 5153- 5156

(2009) Kolyva, C., Pantalos, GM., Giridharan, GA., Pepper, JR. and Khir, AW., Discerning aortic waves during intra-aortic balloon pumping and their relation to benefits of counterpulsation in humans, Journal of Applied Physiology 107 (5) : 1497- 1503 Download publication

(2009) Swalen, MJ. and Khir, AW., Resolving the time lag between pressure and flow for the determination of local wave speed in elastic tubes and arteries, Journal of Biomechanics 42 (10) : 1574- 1577

(2009) Swalen, MJP., König, CS., Sayma, AI. and Khir, AW., Computational study of a novel axial flow pump as LVAD (Abstract), International Journal of Artificial Organs 32 (7) : 401-

(2009) Kolyva, C., Biglino, G. and Khir, AW., Distribution of volume displaced during intra-aortic balloon pump inflation in virto, International Journal of Artificial Organs 32 (7) : 423- 423

(2009) Biglino, G., Kolyva, C. and Khir, AW., Effect of angle on IAB hemodynamics in a mock circulation, International Journal of Artificial Organs 32 (7) : 414- 415

(2009) Patel, KN., König, CS., Sayma, AI. and Khir, AW., Transient behavior of different impeller design of a pulsative axial flow LVAD: A computational study (Abstract), International Journal of Artificial Organs 32 (7) : 424-

(2008) Atherton, M., Khir, AW., Cavazzuti, M., Barozzi, G. and Collins, M., Vascular device interaction with the endothelium (Abstract), Biomedicine and Pharmacotherapy 62 (8) : 504- 505

(2008) Swalen, MJP., König, CS., Sayma, AI. and Khir, AW., Abstract: Development of a novel ventricular assist device (VAD), International Journal of Artificial Organs 31 (7) : 624-

(2008) Khir, AW., Sherwin, SJ. and Pedley, TJ., Guest Editorial: Special issue on theoretical, computational, and experimental biofluid mechanics, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 222 (4) : i- iv

(2008) Feng, J. and Khir, AW., The compression and expansion waves of the forward and backward flows: An in-vitro arterial model, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 222 (4) : 531- 542

(2008) Khir, AW., Response: BCM ventricular assist device, Artificial Organs 32 (2) : 176- 176

(2008) Lawford, PV., Ventikos, Y., Khir, AW., Atherton, M., Evans, D., Hose, DR., Care, CM., Watton, PN., Halliday, I., Walker, DC., Hollis, AP. and Collins, MW., Modelling the interaction of haemodynamics and the artery wall: current status and future prospects, Biomedicine and Pharmacotherapy 62 (8) : 530- 535 Download publication

(2008) Biglino, G., Whitehorne, M., Pepper, JR. and Khir, AW., Pressure and flow-volume distribution associated with intra-aortic balloon inflation: An in vitro study, Artificial Organs 32 (1) : 19- 27

(2007) Khir, AW., Swalen, MJ., Feng, J. and Parker, KH., Simultaneous determination of wave speed and arrival time of reflected waves using the pressure-velocity loop., Medical and Biological Engineering and Computing 45 (12) : 1201- 1210 Download publication

(2007) Khir, AW., Biglino, G., Whitehorne, M. and Pepper, JR., A new face to an old technology: Effect of shape on IAB performance, ASAIO Journal 53 30A-

(2007) Page, C., Henein, MY., Hughes, AD. and Khir, AW., Evidence of left ventricle decelerating aortic flow, European Heart Journal Supplements

(2007) Matthys, KS., Alastruey, J., Peiró, J., Khir, AW., Segers, P., Verdonck, PR., Parker, KH. and Sherwin, SJ., Pulse wave propagation in a model human arterial network: assessment of 1-D numerical simulations against in vitro measurements, Journal of Biomechanics 40 (15) : 3476- 3486

(2007) Feng, J., Long, Q. and Khir, AW., Wave dissipation in flexible tubes in the time domain: in vitro model of arterial waves, Journal of Biomechanics 40 (10) : 2130- 2138

(2006) Khir, AW., Swalen, MJ., Segers, P., Verdonck, P. and Pepper, JR., Hemodynamics of a pulsatile left ventricular assist device driven by a counterpulsation pump in a mock circulation, Artificial Organs 30 (4) : 308- 312

(2006) Biglino, G., Whitehorne, M., Pepper, JR. and Khir, AW., Pressure and wave intensity distribution along the intra-aortic balloon: An in vitro study, ASAIO Journal 52 (2) : 45A-

(2006) Khir, AW., Hughes, AD. and Parker, KH., A modified augmentation index (AIX) using wave intensity analysis, Artery Research 1 (Supplement 1) : S37-

(2006) Matthys, KS., Alastruey-Arimon, J., Parker, KH., Khir, AW., Segers, P., Verdonck, PR., Peiró, J. and Sherwin, SJ., An experimental arterial network as validation of a 1D time-space numerical flow model, Journal of Biochemistry 39 S431-

(2006) Khir, AW. and Parker, KH., Wave intensity analysis: A new approach to studying waves in arteries and elastic tubes, Journal of Biochemistry 39 S431-

(2005) Swalen, MJ., Segers, P., Verdonck, P. and Khir, AW., Hemodynamic parameters of the Iabp in the ascending aorta of a tilted mock circulation, ASAIO Journal 51 (2) : 30A-

(2005) Swalen, MJ., Segers, P., Verdonck, P. and Khir, AW., The hemodynamic performance of the bcm lvad: An in vitro investigation, ASAIO Journal 51 (2) : 30A-

(2005) Khir, AW., Price, S., Hale, C., Young, DA., Parker, KH. and Pepper, JR., Intra-aortic balloon pumping: does posture matter?, Artificial Organs 29 (1) : 36- 40

(2005) Khir, AW. and Parker, KH., Wave intensity in the ascending aorta: effects of arterial occlusion, Journal of Biomechanics 38 (4) : 647- 655

(2005) Zambanini, A., Cunningham, SL., Parker, KH., Khir, AW., Thom, SAM. and Hughes, AD., Wave-energy patterns in carotid, brachial, and radial arteries: A noninvasive approach using wave-intensity analysis, AJP Heart and Circulatory Physiology 289 (1) : H270- H276

(2004) Khir, AW., Zanbanini, A. and Parker, KH., Local and regional wave speeds in the ascending aorta: effects of arterial occlusion, Medical Engineering and Physics 26 (1) : 23- 29

(2003) Khir, AW., Price, S., Hale, CP., Young, DA., Parker, KH. and Pepper, JR., Effect of posture on intra aortic balloon pumping, ASAIO Journal 49 (2) : P216-

(2003) Khir, AW., Price, S., Henein, MY., Parker, KH. and Pepper, JR., Intra-aortic balloon pumping: effects on left ventricular diastolic function, European Journal of Cardio-Thoracic Surgery 24 (2) : 277- 282

(2002) Khir, AW. and Parker, KH., Erratum to “Measurements of wave speed and reflected waves in elastic tubes and bifurcations”: [Journal of Biomechanics 35 (6) (2002) 775–783], Journal of Biomechanics 35 (8) : 1149- 1150

(2002) Khir, AW., Price, S., Henein, MY., Parker, KH. and Pepper, J., The effect of intra aortic balloon pumping on coronary and transmitral flow, Journal of the American College of Cardiology 39 (Supplement 1) : 200- 200

(2002) Henein, MY., O'Sullivan, C., Das, SK., Khir, AW., Anagnostopoulos, C., Underwood, RS. and Gibson, DG., Corrigendum to “Assessment of cardiac risk before peripheral vascular surgery: a comparison of myocardial perfusion imaging and long axis echocardiography at rest”: [International Journal of Cardiology 80 (2001) 125–132], International Journal of Cardiology 82 (2) : 195-

(2002) Khir, AW. and Parker, KH., Measurements of wave speed and reflected waves in elastic tubes and bifurcations, Journal of Biomechanics 35 (6) : 775- 783

(2001) Khir, AW., Henein, MY., Koh, T., Das, SK., Parker, KH. and Gibson, DG., Arterial waves in humans during peripheral vascular surgery, Clinical Science 101 (6) : 749- 757

(2001) Henein, MY., O'Sullivan, C., Das, SK., Khir, A., Anagnostopoulos, C., Underwood, RS. and Gibson, DG., Assessment of cardiac risk before peripheral vascular surgery: a comparison of myocardial perfusion imaging and long axis echocardiography at rest, International Journal of Cardiology 80 (2-3) : 125- 132

(2001) Khir, AW., O'Brien, A., Gibbs, JSR. and Parker, KH., Determination of wave speed and wave separation in the arteries, Journal of Biomechanics 34 (9) : 1145- 1155

(2000) Khir, AW., Nelson, G., Tyberg, JV. and Parker, KH., PV-loop revisited: Effects of energy carried by reflected waves on the left ventricular work, Heart Vessels 13 42-

(1998) Khir, AW., Koh, T., Henein, MY., Das, SK., Parker, KH. and Gibson, DG., Relationships between aortic pressure, velocity and reflected waves before and during aortic clamping in patients with peripheral vascular disease, Journal of the Americal College of Cardiology 31 (2) : 274C-

(1998) Khir, AW., Nelson, G., Tyberg, JV. and Parker, KH., Effect of aortic cross-clamping on pressure and velocity waves in the aorta and left ventricular performance, Journal of Cardiovascular Diagnosis and Procedures 15 153-