Ansar Pathan

Research interests

• Innate and adaptive immunity
• Host-pathogen interaction
• Immunity to Mycobacterium tuberculosis
• TB diagnostics
• Vaccinology

Research centres

• Centre for Infection, Immunity and Disease Mechanisms (CIIDM)

Publications

Journal Papers

(2013) Boswell, S., Pathan, AA., Pereira, SP., Williams, R. and Behboudi, S., Induction of CD152 (CTLA-4) and LAP (TGF-β1) in human Foxp3(-) CD4(+) CD25(-) T cells modulates TLR-4 induced TNF-α production., Immunobiology 218 (3) : 427- 434 Download publication

(2013) Rowland, R., Pathan, AA., Satti, I., Poulton, ID., Matsumiya, MM., Whittaker, M., Minassian, AM., O'Hara, GA., Hamill, M., Scott, JT., Harris, SA., Poyntz, HC., Bateman, C., Meyer, J., Williams, N., Gilbert, SC., Lawrie, AM., Hill, AV. and McShane, H., Safety and immunogenicity of an FP9-vectored candidate tuberculosis vaccine (FP85A), alone and with candidate vaccine MVA85A in BCG-vaccinated healthy adults: a phase I clinical trial., Hum Vaccin Immunother 9 (1) : 50- 62 Download publication

(2012) Pathan, AA., Minassian, AM., Sander, CR., Rowland, R., Porter, DW., Poulton, ID., Hill, AV., Fletcher, HA. and McShane, H., Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults., Vaccine 30 (38) : 5616- 5624 Download publication

(2012) Rowland, R., Brittain, N., Poulton, ID., Minassian, AM., Sander, C., Porter, DW., Williams, N., Satti, I., Pathan, AA., Lawrie, AM. and McShane, H., A review of the tolerability of the candidate TB vaccine, MVA85A compared with BCG and Yellow Fever vaccines, and correlation between MVA85A vaccine reactogenicity and cellular immunogenicity, Trials in Vaccinology 1 27- 35

(2011) Beveridge, NER., Price, DA., Casazza, JP., Pathan, AA., Sander, CR., Asher, TE., Ambrozak, DR., Precopio, ML., Scheinberg, P., Alder, NC., Roederer, M., Koup, RA., Douek, DC., Hill, AVS. and McShane, H., Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4(+) memory T lymphocyte populations (vol 37, pg 3089, 2007), EUROPEAN JOURNAL OF IMMUNOLOGY 41 (5) : 1501- 1501

(2011) Minassian, AM., Rowland, R., Beveridge, NE., Poulton, ID., Satti, I., Harris, S., Poyntz, H., Hamill, M., Griffiths, K., Sander, CR., Ambrozak, DR., Price, DA., Hill, BJ., Casazza, JP., Douek, DC., Koup, RA., Roederer, M., Winston, A., Ross, J., Sherrard, J., Rooney, G., Williams, N., Lawrie, AM., Fletcher, HA., Pathan, AA. and McShane, H., A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults., BMJ Open 1 (2) : e000223- Download publication

(2011) Griffiths, KL., Pathan, AA., Minassian, AM., Sander, CR., Beveridge, NE., Hill, AV., Fletcher, HA. and McShane, H., Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A., PLoS One 6 (8) : e23463- Download publication

(2010) de Cassan, SC., Pathan, AA., Sander, CR., Minassian, A., Rowland, R., Hill, AV., McShane, H. and Fletcher, HA., Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A., Clin Vaccine Immunol 17 (7) : 1066- 1073 Download publication

(2010) Behboudi, S., Alisa, A., Boswell, S., Anastassiou, J., Pathan, AA. and Williams, R., Expansion of anti-AFP Th1 and Tc1 responses in hepatocellular carcinoma occur in different stages of disease., Br J Cancer 102 (4) : 748- 753 Download publication

(2009) Todryk, SM., Pathan, AA., Keating, S., Porter, DW., Berthoud, T., Thompson, F., Klenerman, P. and Hill, AV., The relationship between human effector and memory T cells measured by ex vivo and cultured ELISPOT following recent and distal priming., Immunology 128 (1) : 83- 91 Download publication

(2009) Sander, CR., Pathan, AA., Beveridge, NE., Poulton, I., Minassian, A., Alder, N., Van Wijgerden, J., Hill, AV., Gleeson, FV., Davies, RJ., Pasvol, G. and McShane, H., Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in Mycobacterium tuberculosis-infected individuals., Am J Respir Crit Care Med 179 (8) : 724- 733 Download publication

(2009) Smith, SG., Joosten, SA., Verscheure, V., Pathan, AA., McShane, H., Ottenhoff, TH., Dockrell, HM. and Mascart, F., Identification of major factors influencing ELISpot-based monitoring of cellular responses to antigens from Mycobacterium tuberculosis., PLoS One 4 (11) : e7972- Download publication

(2009) Whelan, KT., Pathan, AA., Sander, CR., Fletcher, HA., Poulton, I., Alder, NC., Hill, AV. and McShane, H., Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A., PLoS One 4 (6) : e5934- Download publication

(2008) Beveridge, NE., Fletcher, HA., Hughes, J., Pathan, AA., Scriba, TJ., Minassian, A., Sander, CR., Whelan, KT., Dockrell, HM., Hill, AV., Hanekom, WA. and McShane, H., A comparison of IFNgamma detection methods used in tuberculosis vaccine trials., Tuberculosis (Edinb) 88 (6) : 631- 640 Download publication

(2008) Fletcher, HA., Pathan, AA., Berthoud, TK., Dunachie, SJ., Whelan, KT., Alder, NC., Sander, CR., Hill, AV. and McShane, H., Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1., Vaccine 26 (41) : 5269- 5275 Download publication

(2008) Alisa, A., Boswell, S., Pathan, AA., Ayaru, L., Williams, R. and Behboudi, S., Human CD4(+) T cells recognize an epitope within alpha-fetoprotein sequence and develop into TGF-beta-producing CD4(+) T cells., J Immunol 180 (7) : 5109- 5117 Download publication

(2007) Beveridge, NE., Price, DA., Casazza, JP., Pathan, AA., Sander, CR., Asher, TE., Ambrozak, DR., Precopio, ML., Scheinberg, P., Alder, NC., Roederer, M., Koup, RA., Douek, DC., Hill, AV. and McShane, H., Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations., Eur J Immunol 37 (11) : 3089- 3100 Download publication

(2007) Pathan, AA., Sander, CR., Fletcher, HA., Poulton, I., Alder, NC., Beveridge, NER., Whelan, KT., Hill, AVS. and McShane, H., Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: Different boosting intervals and implications for efficacy trials, PLoS ONE 2 (10) : e1052 Download publication

(2007) Ayaru, L., Pereira, SP., Alisa, A., Pathan, AA., Williams, R., Davidson, B., Burroughs, AK., Meyer, T. and Behboudi, S., Unmasking of alpha-fetoprotein-specific CD4(+) T cell responses in hepatocellular carcinoma patients undergoing embolization., J Immunol 178 (3) : 1914- 1922 Download publication

(2006) Gilbert, SC., Moorthy, VS., Andrews, L., Pathan, AA., McConkey, SJ., Vuola, JM., Keating, SM., Berthoud, T., Webster, D., McShane, H. and Hill, AV., Synergistic DNA-MVA prime-boost vaccination regimes for malaria and tuberculosis., Vaccine 24 (21) : 4554- 4561 Download publication

(2005) Alisa, A., Ives, A., Pathan, AA., Navarrete, CV., Williams, R., Bertoletti, A. and Behboudi, S., Analysis of CD4+ T-Cell responses to a novel alpha-fetoprotein-derived epitope in hepatocellular carcinoma patients., Clin Cancer Res 11 (18) : 6686- 6694 Download publication

(2005) McShane, H., Pathan, AA., Sander, CR., Goonetilleke, NP., Fletcher, HA. and Hill, AVS., Boosting BCG with MVA85A: The first candidate subunit vaccine for tuberculosis in clinical trials, Tuberculosis 85 (1-2 SPEC.ISS.) : 47- 52

(2005) McShane, H., Pathan, AA., Sander, CR., Goonetilleke, NP., Fletcher, HA. and Hill, AV., Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials., Tuberculosis (Edinb) 85 (1-2) : 47- 52 Download publication

(2005) Wilkinson, KA., Wilkinson, RJ., Pathan, A., Ewer, K., Prakash, M., Klenerman, P., Maskell, N., Davies, R., Pasvol, G. and Lalvani, A., Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis., Clin Infect Dis 40 (1) : 184- 187 Download publication

(2004) Liebeschuetz, S., Bamber, S., Ewer, K., Deeks, J., Pathan, AA. and Lalvani, A., Diagnosis of tuberculosis in South African children with a T-cell-based assay: a prospective cohort study., Lancet 364 (9452) : 2196- 2203 Download publication

(2004) McShane, H., Pathan, AA., Sander, CR., Keating, SM., Gilbert, SC., Huygen, K., Fletcher, HA. and Hill, AV., Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans., Nat Med 10 (11) : 1240- 1244 Download publication

(2003) Brookes, RH., Pathan, AA., McShane, H., Hensmann, M., Price, DA. and Hill, AV., CD8+ T cell-mediated suppression of intracellular Mycobacterium tuberculosis growth in activated human macrophages., Eur J Immunol 33 (12) : 3293- 3302 Download publication

(2003) McConkey, SJ., Reece, WH., Moorthy, VS., Webster, D., Dunachie, S., Butcher, G., Vuola, JM., Blanchard, TJ., Gothard, P., Watkins, K., Hannan, CM., Everaere, S., Brown, K., Kester, KE., Cummings, J., Williams, J., Heppner, DG., Pathan, A., Flanagan, K., Arulanantham, N., Roberts, MT., Roy, M., Smith, GL., Schneider, J., Peto, T., Sinden, RE., Gilbert, SC. and Hill, AV., Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans., Nat Med 9 (6) : 729- 735 Download publication

(2002) Chapman, AL., Munkanta, M., Wilkinson, KA., Pathan, AA., Ewer, K., Ayles, H., Reece, WH., Mwinga, A., Godfrey-Faussett, P. and Lalvani, A., Rapid detection of active and latent tuberculosis infection in HIV-positive individuals by enumeration of Mycobacterium tuberculosis-specific T cells., AIDS 16 (17) : 2285- 2293 Download publication

(2001) Pathan, AA., Wilkinson, KA., Klenerman, P., McShane, H., Davidson, RN., Pasvol, G., Hill, AV. and Lalvani, A., Direct ex vivo analysis of antigen-specific IFN-gamma-secreting CD4 T cells in Mycobacterium tuberculosis-infected individuals: associations with clinical disease state and effect of treatment., J Immunol 167 (9) : 5217- 5225 Download publication

(2001) Lalvani, A., Pathan, AA., Durkan, H., Wilkinson, KA., Whelan, A., Deeks, JJ., Reece, WH., Latif, M., Pasvol, G. and Hill, AV., Enhanced contact tracing and spatial tracking of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells., Lancet 357 (9273) : 2017- 2021 Download publication

(2001) Lalvani, A., Pathan, AA., McShane, H., Wilkinson, RJ., Latif, M., Conlon, CP., Pasvol, G. and Hill, AV., Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells., Am J Respir Crit Care Med 163 (4) : 824- 828 Download publication

(2001) Lalvani, A., Nagvenkar, P., Udwadia, Z., Pathan, AA., Wilkinson, KA., Shastri, JS., Ewer, K., Hill, AV., Mehta, A. and Rodrigues, C., Enumeration of T cells specific for RD1-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians., J Infect Dis 183 (3) : 469- 477 Download publication

(2000) Pathan, AA., Wilkinson, KA., Wilkinson, RJ., Latif, M., McShane, H., Pasvol, G., Hill, AV. and Lalvani, A., High frequencies of circulating IFN-gamma-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restricted Mycobacterium tuberculosis epitope in M. tuberculosis-infected subjects without disease., Eur J Immunol 30 (9) : 2713- 2721 Download publication

(1999) Lalvani, A., Moris, P., Voss, G., Pathan, AA., Kester, KE., Brookes, R., Lee, E., Koutsoukos, M., Plebanski, M., Delchambre, M., Flanagan, KL., Carton, C., Slaoui, M., Van Hoecke, C., Ballou, WR., Hill, AV. and Cohen, J., Potent induction of focused Th1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine., J Infect Dis 180 (5) : 1656- 1664 Download publication

(1998) Lalvani, A., Brookes, R., Wilkinson, RJ., Malin, AS., Pathan, AA., Andersen, P., Dockrell, H., Pasvol, G. and Hill, AV., Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis., Proc Natl Acad Sci U S A 95 (1) : 270- 275 Download publication

(1997) Lalvani, A., Dong, T., Ogg, G., Patham, AA., Newell, H., Hill, AV., McMichael, AJ. and Rowland-Jones, S., Optimization of a peptide-based protocol employing IL-7 for in vitro restimulation of human cytotoxic T lymphocyte precursors., J Immunol Methods 210 (1) : 65- 77 Download publication

(1992) Pathan, AA., Green, T., Brown, J. and Navarrete, C., Possible role of amino acids on the β pleated sheet of HLA-DR molecule on the binding of a polymorphic Moab MO2P5D7, European Journal of Immunogenetics 19 (6) : 465- 465

Book Chapters

(1991) Pathan, AA., Green, T., Brown, J. and Navarrete, C., Production and characterisation of a polymorphic HLA-DR monoclonal antibody by using transfectant L-cells. In: Tsuji, K., Aizawa, M. and Sasazuki, T. eds. HLA 1991: Proceedings of the Eleventh International Histocompatibility Workshop and Conference. Oxford Science Publications (1) : 933- 934