Chiranjeevi Sandi

Academic qualifications

• PhD in Biological Sciences - Brunel University, UK
  
• MSc Biotechnology - Kakatiya University, Warangal, India
• BSc Biology - Kakatiya University, Warangal, India

Research centres

• Brunel Institute for Cancer Genetics and Pharmacogenomics (BICGP)
• Centre for Cell and Chromosome Biology (CCCB)

Membership and affiliation

• American Society of Human Genetics
• The Genetics Society
• The Biochemical Society

Publications

Journal Papers

(2013) Sandi, C., Al-Mahdawi, S. and Pook, M., Epigenetics in Friedreich's ataxia: Challenges and opportunities for therapy, Genetics Research International 2013852080 Download publication

(2013) Li, L., Lucille, V., Sandi, C., Pook, M., Panos, I., Delatycki, M. and Sarsero, J., Pharmacological Screening Using an FXN-EGFP Cellular Genomic Reporter Assay for the Therapy of Friedreich Ataxia, PLoS One 8(2)e55940

(2012) Bourn, RL., Pinto, RM., Sandi, C., Al-Mahdawi, S., Pook, M. and Bidichandani, S., Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues, PLoS One 7 (10) : e47085 Download publication

(2012) Tomassini, B., Arcuri, G., Fortuni, S., Sandi, C., Ezzatizadeh, V., Casali, C., Condò, I., Malisan, F., Al-Mahdawi, S., Pook, M. and Testi, R., Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia model., Hum Mol Genet 21 (13) : 2855- 2861 Download publication

(2012) Ezzatizadeh, V., Mouro Pinto, R., Sandi, C., Sandi, M., Al-Mahdawi, S., te Riele, H. and Pook, MA., The mismatch repair system protects against intergenerational GAA repeat instability in a Friedreich ataxia mouse model, Neurobiology of Disease 46 (1) : 165- 171 Download publication

(2011) Sandi, C., Pinto, RM., Al-Mahdawi, S., Ezzatizadeh, V., Barnes, G., Jones, S., Rusche, JR., Gottesfeld, JM. and Pook, MA., Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model, Neurobiology of Disease 42 496- 505 Download publication

(2008) Al-Mahdawi, S., Pinto, RM., Ismail, O., Varshney, D., Lymperi, S., Sandi, C., Trabzuni, D. and Pook, M., The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues, Human Molecular Genetics 17 (5) : 735- 746 Download publication

Conference Papers

(2011) Al-Mahdawi, S., Sandi, C. and Pook, M., Friedreich ataxia demonstrates increased levels of 5-hydroxymethylcytosine within the FXN gene, 12th International Congress of Human Genetics Conference

(2011) Ezzatizadeh, V., Sandi, C., Al-Mahdawi, S., Pinto, RM. and Pook, M., Analysis of GAA repeat instability in FRDA transgenic mouse models, Friedreich’s Ataxia Research Alliance 4th international meeting

(2010) Pook, M., Al-Mahdawi, S., Sandi, C., Mouro Pinto, R. and Ezzatizadeh, V., Epigenetic changes in Friedreich ataxia pathogenesis and therapy, 24th International Mammalian Genome Conference,

(2010) Pook, MA., Sandi, C., Mouro Pinto, R., Ezzatizadeh, V. and Al-Mahdawi, S., Epigenetic changes in Friedreich ataxia pathogenesis and therapy., International Symposium on Epigenetics, Chromatin Remodeling and Disease

(2010) Sandi, C., Pook, M., Mouro Pinto, R., Al-Mahdawi, S., Ezzatizadeh, V., Barnes, G., Jones, S., Rusche, JR. and Gottesfeld, JM., Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model, 4th International Friedreich's ataxia scientific conference

(2009) Pook, MA., Mouro Pinto, R., Sandi, C., Ezzatizadeh, V. and Al-Mahdawi, S., Analysis of GAA instability and epigenetic changes in Friedreich ataxia using a GAA repeat-containing FXN transgenic mouse model, Euro-Ataxia Conference 2009

(2009) Pook, M., Mouro Pinto, R., Sandi, C. and Al-Mahdawi, S., GAA repeat expansion-based FRDA transgenic mouse models, Friedreich's Ataxia Research Alliance Therapeutics Symposium

(2009) Al-Mahdawi, S., Mouro Pinto, R., Sandi, C., Ezzatizadeh, V., Aichinger, C., Boykin, D., Bidichandani, S. and Pook, MA., GAA repeat instability and GAA-induced epignetic effects in a mouse model of Friedreich Ataxia, 6th Unstable Microsatellites and Human Disease Conference

(2008) Sandi, C., Mouro Pinto, R., Al-Mahdawi, S. and Pook, MA., Investigating the pathogenesis and therapies of Friedreich ataxia using mouse model cell lines, 8th American Society of Human Genetics annual meeting

(2008) Sandi, C., Pinto, RM., Al-Mahdawi, S. and Pook, M., Investigating the pathogenesis and therapies of Friedreich ataxia using mouse model cell lines, 58th American Society of Human Genetics annual meeting

Other publications

Platform Presentations

Sandi C, Ezzatizadeh V, Pinto RM, Al-Mahdawi S, and Pook M (2011) Prolonged Treatment with Pimelic o-Aminobenzamide HDAC Inhibitors Ameliorates the Disease Phenotype of a Friedreich Ataxia Mouse Model - presented at the “Friedreich’s Ataxia Research Alliance 4th international meeting”, Strasbourg, France.

Poster Presentations

Al-Mahdawi S, Sandi C and Pook M (2011) Friedreich ataxia demonstrates increased levels of 5-hydroxymethylcytosine within the FXN gene - presented at the “12th International Congress of Human Genetics Conference”, Montreal, Canada.

Ezzatizadeh V, Pinto RM, Sandi C, Al-Mahdawi S and Pook M (2011) Analysis of GAA repeat instability in FRDA transgenic mouse models – poster presented at the “Friedreich’s Ataxia Research Alliance 4th international meeting”, Strasbourg, France.

Al-Mahdawi S, Sandi C, Pinto RM, Ezzatizadeh V and Pook M (2010) Epigenetic changes in Friedreich ataxia pathogenesis and therapy - poster presented at the “24th International Mammalian Genome Conference”, Crete, Greece.

Pinto RM, Sandi C, Al-Mahdawi S and Pook M (2009) Analysis of CTCF binding to the FXN gene  in Friedreich ataxia - poster presented at the “6th International Conference on Unstable Microsatellites and Human Disease, Guanacaste, Costa Rica

Sandi C, Al-Mahdawi S, Pinto RM, Ezzatizadeh V and Pook M (2009) Investigating the pathogenesis and therapy of Friedreich ataxia - poster presented at the “59th  American Society of Human Genetics annual meeting”, Hawaii, USA.

Sandi C, Al-Mahdawi S, Pinto RM and Pook M (2008) Investigating the pathogenesis and therapies of Friedreich ataxia using mouse model cell lines – poster presented at the “58th American Society of Human Genetics annual meeting”, Philadelphia, USA.