Emmanouil Karteris

Academic qualifications

BSc, MSc, PhD, PGCert IP Law

Profile

Dr Manos Karteris graduated with a BSc (Hons) in Medical Biochemistry from the University of Surrey in 1995. He then was awarded an MSc with Distinction in Medical Genetics with Immunology from Brunel University in 1996 and completed his PhD in Molecular Endocrinology from the University of Warwick in 2000. He then undertook post-doctoral appointments at the University of Warwick, including a prestigious VIP Research Fellowship from the Welcome Trust. He was appointed as Lecturer in Endocrinology at the University of Warwick from 2005-2006 and then he transferred to Brunel University as a Lecturer in Biosciences from 2006 onwards.

Admin responsibilities

Biosciences Seminar Series Organiser (2006-2008).

Representative of Biosciences on the Ethics Committee. Brunel University (2008-2012).

Member of the Health and Safety Committee at Biosciences (2007-present).

Marketing Officer for Biosciences (September 2009-present).

UCAS/Open Day Co-ordinator for Biosciences (September 2009-present).

Representative of Biosciences on Admissions/Marketing Committee (September 2009-present).

Representative of Biosciences on the Communication Committee (November 2010-present).

PhD supervision

With regards to postgraduate supervision, I have so far successfully supervised 2 PhD students that graduated in June 2011 and currently supervising (as first supervisor) another four, and I act as a second supervisor for another PhD student. At the MSc level I have successfully supervised over 11 students, and this academic year I will be supervising another 3. At undergraduate level, 30 students have completed their FYP projects.

Teaching interest

Teaching Duties

I have created the following teaching blocks:

-Advanced Biochemistry BB3203

-Analytical Biochemistry BB2210

Delivered lectures for the following postgraduate modules:

-Intracellular Signalling in Cancer (MSc Level)

-Molecular Mechanisms of Human Disease (MSc Level)

Module leader for Endocrine Disorders (BB3214) and Medical Biochemistry (BB3203)

Research interests

Dr Karteris has a long standing interest in mTOR signalling with emphasis in reproductive endocrinology, ovarian cancer and Alzheimer’s disease. In particular, Dr Karteris is interested in dissecting the role of DEPTOR (an endogenous inhibitor of mTOR complexes) and how it can be modulated by steroids and neurohormones. Dr Karteris has a recognized publication record in receptor biochemistry and cell signalling. Dr Karteris has published 40 research manuscripts, presented over 80 research abstracts in leading national and international conferences.  Many of these papers are generating a strong and influential impact not only to the biomedical field (as it is evident from the high citation index) but also to the society as they deal with topical issues such as effects of stress during pregnancy. Moreover Dr Karteris has established collaborations with leading authorities in their fields and has been successful in obtaining research grants at national and international level.

Research centres

• Centre for Cell and Chromosome Biology (CCCB)
• Centre for Infection, Immunity and Disease Mechanisms (CIIDM)

Research projects and grants

(since joined Brunel)

• Industrial PhD studentship (BJS Biotechnology, 2011-2014): “mTOR signalling in ovarian cancer” (£150,000).
• National Institutes of Health (NIH) USA (2006-2012): “Characteristics of a putative steroid membrane receptor”. Co-applicant to Prof. P. Thomas, University of Texas, USA. ($1.6 million).
• Primer Design (2010-2011): First Year PhD Award for Q-PCR consumables (£3,000).
• Royal Society:Laboratory Visit award (£2,400 January 2011).
• The Wellcome Trust (2009-2010): Two summer research scholarships (£2,880).
• The State Scholarships Foundation (IKY): PhD studentship (£6,200 per year for fees, plus the stipend for the student; 2008-2011).
• Society for Endocrinology (2007-2008), UK: Small grant programme (£9,700).
• Young Investigator Award (2006), European Federation of Endocrine Societies (€ 2,000).

Other external activities

Invited Speaker

• E. Karteris. “Advances on mTOR inhibitors as therapeutic agents against ovarian cancer” 17th World Congress on Advances in Oncology and 15th International Symposium on Molecular Medicine; 11-13 October, 2012, Crete, Greece. Invited Speaker
• E. Karteris “mTOR signalling in health and disease” 4th International Congress of Molecular Medicine, Istanbul 27-20 June 2011, Turkey. Plenary Lecture and Chairing a session
• D. Mparmpakas, A. Goumenou, A. Harvey, E. Karteris, Y. Gidron. Environment and genetics: How GR polymorhism and maternal attitudes predict low birth weight. The 14th World Congress of Gynecological Endocrinology, Florence 4-7 March 2010, Italy. Oral Presentation

Interviews/Media

· Raising awareness about Ovarian Cancer

http://www.boobydoo.co.uk/news/news/march-is-ovarian-cancer-awareness-month/

Publications

Journal Papers

(2011) Zachariades, E., Foster, H., Goumenou, A., Thomas, P., Rand-Weaver, M. and Karteris, E., Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization, International Journal of Molecular Medicine 27 (6) : 767- 774 Download publication

(2010) Foster, H., Coley, HM., Goumenou, A., Pados, G., Harvey, A. and Karteris, E., Differential expression of mTOR signalling components in drug resistance in ovarian cancer, Anticancer Research 30 (9) : 3529- 3534 Download publication

(2010) Patel, VH., Chen, J., Ramanjaneya, M., Karteris, E., Zachariades, E., Thomas, P., Been, M. and Randeva, HS., G-protein coupled estrogen receptor 1 expression in rat and human heart: Protective role during ischaemic stress, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 26 (2) : 193- 199

(2010) Karteris, E., Foster, H., Karamouti, M. and Goumenou, A., Congenital imperforate hymen with hydrocolpos and hydronephrosis associated with severe hydramnios and increase of maternal ovarian steroidogenic enzymes., Journal of Pediatric and Adolescent Gynecology 23 (3) : 136- 141 Download publication

(2010) Mparmpakas, D., Zachariades, E., Foster, H., Kara, A., Harvey, A., Goumenou, A. and Karteris, E., Expression of mTOR and downstream signalling components in the JEG-3 and BeWo human placental choriocarcinoma cell lines, International Journal of Molecular Medicine 25 (1) : 65- 69 Download publication

(2010) Foster, H., Reynolds, A., Stenbeck, G., Dong, J., Thomas, P. and Karteris, E., Internalisation of membrane progesterone receptor-alpha after treatment with progesterone: Potential involvement of a clathrin-dependent pathway, Molecular Medicine Reports 3 (1) : 27- 35 Download publication

(2007) Mottershead, M., Karteris, E., Barclay, JY., Suortamo, S., Newbold, M., Randeva, H. and Nwokolo, CU., Immunohistochemical and quantitative mRNA assessment of ghrelin expression in gastric and oesophageal adenocarcinoma., J Clin Pathol 60 (4) : 405- 409 Download publication

(2006) Chen, J., Karteris, E., Collins, D. and Randeva, HS., Differential expression of mouse orexin receptor type-2 (OX2R) variants in the mouse brain., Brain Res 1103 (1) : 20- 24 Download publication

(2006) Karteris, E., Zervou, S., Pang, Y., Dong, J., Hillhouse, EW., Randeva, HS. and Thomas, P., Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term., Mol Endocrinol 20 (7) : 1519- 1534 Download publication

(2006) Chen, J., Tan, B., Karteris, E., Zervou, S., Digby, J., Hillhouse, EW., Vatish, M. and Randeva, HS., Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines., Diabetologia 49 (6) : 1292- 1302 Download publication

(2005) Karteris, E., Vatish, M., Hillhouse, EW. and Grammatopoulos, DK., Preeclampsia is associated with impaired regulation of the placental nitric oxide-cyclic guanosine monophosphate pathway by corticotropin-releasing hormone (CRH) and CRH-related peptides, Journal of Clinical Endocrinology & Metabolism 90 (6) : 3680- 3687

(2004) Keay, SD., Vatish, M., Karteris, E., Hillhouse, EW. and Randeva, HS., The role of hCG in reproductive medicine., BJOG 111 (11) : 1218- 1228 Download publication

(2004) Parham, KL., Zervou, S., Karteris, E., Catalano, RD., Old, RW. and Hillhouse, EW., Promoter analysis of human corticotropin-releasing factor (CRF) type 1 receptor and regulation by CRF and urocortin., Endocrinology 145 (8) : 3971- 3983 Download publication

(2004) Karteris, E., Chen, J. and Randeva, HS., Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system, Journal of Clinical Endocrinology & Metabolism 89 (4) : 1957- 1962

(2004) Karteris, E., Papadopoulou, N., Grammatopoulos, DK. and Hillhouse, EW., Expression and signalling characteristics of the corticotrophin-releasing hormone receptors during the implantation phase in the human endometrium., J Mol Endocrinol 32 (1) : 21- 32 Download publication

(2004) Karteris, E., Grammatopoulos, D. and Hillhouse, EW., Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: Potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility, Endocrinology 145 (2) : 890- 900

(2003) Zervou, S., Karteris, E., Goumenou, AG., Vatish, M., Koumantakis, EE. and Hillhouse, EW., The Glu298-->Asp polymorphism of the endothelial nitric oxide synthase gene is associated with endometriosis., Fertil Steril 80 (6) : 1524- 1525 Download publication

(2003) Karteris, E. and Randeva, HS., Orexin receptors and G-protein coupling: evidence for another "promiscuous" seven transmembrane domain receptor., J Pharmacol Sci 93 (1) : 126- 128 Download publication

(2003) Randeva, HS., Karteris, E., Lewandowski, KC., Sailesh, S., O'Hare, P. and Hillhouse, EW., Circadian rhythmicity of salivary leptin in healthy subjects., Mol Genet Metab 78 (3) : 229- 235 Download publication

(2003) KARTERIS., Goumenou, A.., Hillhouse, E.W.. and Koumantakis, E.., Reduced expression of corticotropin-releasing hormone receptor type-1? in human preeclamptic and growth-restricted placentas, Journal of Clinical Endocrinology & Metabolism 88 (1) : 363- 370

(2002) Zervou, S., Karteris, E., Hillhouse, EW. and Old, RW., Steroids mediate the expression of cytoplasmic and membrane-linked components in human myometrial cells., Mol Hum Reprod 8 (7) : 597- 605 Download publication

(2001) Randeva, HS., Karteris, E., Grammatopoulos, D. and Hillhouse, EW., Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis., J Clin Endocrinol Metab 86 (10) : 4808- 4813 Download publication

(2001) Karteris, E., Randeva, HS., Grammatopoulos, DK., Jaffe, RB. and Hillhouse, EW., Expression and coupling characteristics of the CRH and orexin type 2 receptors in human fetal adrenals., J Clin Endocrinol Metab 86 (9) : 4512- 4519 Download publication

(2001) Karteris, E., Grammatopoulos, DK., Randeva, HS. and Hillhouse, EW., The role of corticotropin-releasing hormone receptors in placenta and fetal membranes during human pregnancy., Mol Genet Metab 72 (4) : 287- 296 Download publication

(2000) Karteris, E., Grammatopoulos, D., Randeva, H. and Hillhouse, EW., Signal transduction characteristics of the corticotropin-releasing hormone receptors in the feto-placental unit., J Clin Endocrinol Metab 85 (5) : 1989- 1996 Download publication

(1999) Grammatopoulos, DK., Dai, Y., Randeva, HS., Levine, MA., Karteris, E., Easton, AJ. and Hillhouse, EW., A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes., Mol Endocrinol 13 (12) : 2189- 2202 Download publication

(1998) Grammatopoulos, D., Dai, Y., Chen, J., Karteris, E., Papadopoulou, N., Easton, AJ. and Hillhouse, EW., Human corticotropin-releasing hormone receptor: differences in subtype expression between pregnant and nonpregnant myometria., J Clin Endocrinol Metab 83 (7) : 2539- 2544 Download publication

(1998) Karteris, E., Grammatopoulos, D., Dai, Y., Olah, KB., Ghobara, TB., Easton, A. and Hillhouse, EW., The human placenta and fetal membranes express the corticotropin-releasing hormone receptor 1alpha (CRH-1alpha) and the CRH-C variant receptor., J Clin Endocrinol Metab 83 (4) : 1376- 1379

Conference Papers

(2007) Thomas, P., Karteris, E., Levine, J. and Pang, Y., G protein signaling and functions of the novel progesterone miem13rane receptors in reproductive tissues., 40th Annual Meeting of the Society-for-the-Study-of-Reproduction, BIOLOGY OF REPRODUCTION 72- 73