Ian Kill

Academic qualifications

 Continued professional development

• Special Interest Group Leader - London Technology Network.
• Buisiness Fellow - London Technology Network.
• Enrolled Post-Graduate Certificate in Higher Education, Brunel University.
• Presented Faculty teaching seminar “Using PowerPoint for Lectures”.
• Attended Staff Development courses “Large Group Teaching” and “Personal Tutoring”
• Attended Staff Development courses WebCT A, B.

Committee responsibilities

• Director, Cell and Chromosome Biology Group
• Deputy Director, Brunel Institute for Ageing Studies
• Director of Research, Biosciences
• MSc Coordinator
• Chair of Bioscience Research Committee
• Member of School Research Committee
• Member of Senate

Teaching responsibilities

• BB1402 – Molecular and cellular Biology.
• BB2401 - Molecular, Cellullular and Immunobiology

PhD supervision

• 2008-2011. Samir Niyazi.
• 2005-2008. Kate Widdows. Northwick Park.
• 2005-2008. Lisandra Bras. Northwick Park.
• 2003-2006. Martin Figgit. BBSRC Committee Studentship. Completed on time. 
• 2002-2005. Dr. Michael Egbor. Northwick Park. Completed on time.
• 2002-2005. Dr. Sergiy Tadtayev. Northwick Park. Completed on time. 
• 1999-2003. Fiona Bolland. Studentship sponsored by TSL. Awarded Jan 2004.
• 1993-1997. Eman El-Baker. D.Phil awarded Nov. 1997.

• 2007-2010. Georgios Malis.
• 2000-2004. Jennifer Boyle. Awarded May 2004.
• 2001-2004. Karen Meaburn. Awarded 2004.

• Since May 1997 - External Examiner on PhD's - 10
• Internal Examiner on PhD's - 3
• Independent Chair - 1
• External Examiner - MSc's - 3

Other responsibilities

• BB3218 - Cell Biology
• BB3207 - Cellular Pathologies
• BB5501 - Research Planning.
• BB5505 - Dissertation 

Academic appointments

• 2004 - Present: Managing Director, Khronos Consultants - The ageing consultancy. www.khronos.co.uk
• 2001- Present: Senior Lecturer in Human Cell Biology. Brunel University.
• 1997-2001: Lecturer in Human Cell Biology. Brunel University.
• 1995-1997: Lecturer in Zoology. Fixed term contract. University of Dundee.
• 1994-1995: Post-doctoral research fellow. University of Dundee. MRC. Grantholder.
• 1991-1994: CRC Post-doctoral research fellow. University of Dundee. Co-applicant.
• 1990-1991: MRC Post-doctoral research fellow. University of Dundee. Co-applicant.
• 1986-1989: D. Phil. University of Sussex.
• 1981-1986: Research Technician, Kennedy Institute of Rheumatology. (Dr. Fiona Watt).
• 1980-1981: Research Technician, St Mary’s Hospital, Paddington. (Dr. Hanna Braunsberg).
• 1976-1979: BSc. Portsmouth Polytechnic.

Research centres

• Brunel Institute for Ageing Studies (BIAS)
• Centre for Cell and Chromosome Biology (CCCB)

Publications

Journal Papers

(2011) Mehta, IS., Arican, HD., Eskiw, CH., Kill, IR. and Bridger, JM., Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford Progeria syndrome cells., Genome Biology: biology for the post-genomic era 12 (8) : R74 Download publication

(2011) Bridger, JM., Eskiw, CH., Makarov, EM., Tree, D. and Kill, IR., Progeria Research Day at Brunel University, Nucleus 2 (6) : 1- 6

(2010) Choudhury, A., Hopkins, W., Das, S., Kill, I. and Long, Q., Morphology analyses of human carotid plaque in assessing fibrous cap rupture risk, IFMBE Proceedings 31 IFMBE 887- 890

(2010) Mehta, IS., Bridger, JM. and Kill, IR., Progeria, the nucleolus and farnesyltransferase inhibitors., Biochem Soc Trans 38 (Pt 1) : 287- 291 Download publication

(2009) Choudhury, A., Luppi, M., Hopkins, W., Gao, H., Das, S., Kill, I., Pinelli, M. and Long, Q., High resolution 3d reconstruction of an atherosclorotic plaque by a combination of histology and 3d ultrasound, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009 (PART A) : 189- 190

(2009) Faragher, RG. and Kill, IR., The in vitro kinetics of senescence of Fischer 344 rat embryo fibroblasts, Biogerontology 10 (3) : 285- 289

(2008) He, X., Bridger, JM. and Kill, IR., Hutchinson-Gilford progeria syndrome: Too old, too soon, Biochemist 30 (5) : 18- 22

(2008) Mehta, IS., Elcock, LS., Amira, M., Kill, IR. and Bridger, JM., Nuclear motors and nuclear structures containing A-type lamins and emerin: is there a functional link?, Biochemical Society Transactions 36 (Part 6) : 1384- 1388

(2008) Pekovic, V., Kill, IR., Benham, AM., Dixon, D., Edwards, R., Foisher, R. and Hutchison, CJ., The functional involvement of lamin A in human ageing: implications for maintenance of proliferation via lamin A redox homeostasis, JOURNAL OF ANATOMY 212 (1) : 79- 80

(2008) Beard, GS., Bridger, JM., Kill, IR. and Tree, DR., Towards a Drosophila model of Hutchinson-Gilford progeria syndrome, Biochemical Society Transactions 36 (Part 6) : 1389- 1392

(2007) Mehta, IS., Figgitt, M., Clements, CS., Kill, IR. and Bridger, JM., Alterations to nuclear architecture and genome behavior in senescent cells, Annals of the New York Academy of Sciences 1100 (Biogerontology Mechanisms and Interventions) : 250- 263

(2007) Meaburn, KJ., Cabuy, E., Bonne, G., Levy, N., Morris, GE., Novelli, G., Kill, IR. and Bridger, JM., Primary laminopathy fibroblasts display altered genome organization and apoptosis, Aging Cell 6 (2) : 139- 153

(2007) Bridger, JM., Foeger, N., Kill, IR. and Herrmann, H., The nuclear lamina. Both a structural framework and a platform for genome organization, FEBS Journal 274 (6) : 1354- 1361

(2005) Al-Baker, EA., Oshin, M., Hutchison, CJ. and Kill, IR., Analysis of UV-induced damage and repair in young and senescent human dermal fibroblasts using the comet assay, Mechanisms of Ageing and Development 126 (6-7) : 664- 672

(2005) Boyle, J., Kill, IR. and Parris, CN., Heterogeneity of dimer excision in young and senescent human dermal fibroblasts, Aging Cell 4 (5) : 247- 255

(2004) Al Baker, EA., Boyle, J., Harry, R. and Kill, IR., A p53-independent pathway regulates nucleolar segregation and antigen translocation in response to DNA damage induced by UV irradiation, Experimental Cell Research 292 (1) : 179- 186

(2004) Bridger, JM. and Kill, IR., Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis, Experimental Gerontology 39 (5) : 717- 724 Download publication

(2000) Bridger, JM., Boyle, S., Kill, IR. and Bickmore, WA., Re-modelling of nuclear architecture in quiescent and senescent human fibroblasts, Current Biology 10 (3) : 149- 152

(1998) Kill, IR., Ageing research in the UK: Plenty of proliferative potential, Molecular Medicine Today 4 (11) : 466- 467

(1998) Kill, IR., Ageing research in the UK: plenty of proliferative potential. Cellular Senescence: the future of ageing. Oxford, United Kingdom, 16-17 July 1998., Mol Med Today 4 (11) : 466- 467 Download publication

(1998) Bridger, JM., Kill, IR. and Lichter, P., Association of pKi-67 with satellite DNA of the human genome in early G(1) cells, Chromosome Research 6 (1) : 13- 24

(1997) Dyer, JA., Kill, IR., Pugh, G., Quinlan, RA., Lane, EB. and Hutchison, CJ., Cell cycle changes in A-type lamin associations detected in human dermal fibroblasts using monoclonal antibodies, Chromosome Research: the international journal for all aspects of chromosome and nuclear biology 5 (6) : 383- 394

(1997) Thomas, E., al-Baker, E., Dropcova, S., Denyer, S., Ostad, N., Lloyd, A., Kill, IR. and Faragher, RG., Different kinetics of senescence in human fibroblasts and peritoneal mesothelial cells., Exp Cell Res 236 (1) : 355- 358 Download publication

(1997) Rawes, V., Kipling, D., Kill, IR. and Faragher, RG., The kinetics of senescence in retinal pigmented epithelial cells: A test for the telomere hypothesis of ageing?, Biochemistry (Mosc) 62 (11) : 1291- 1295

(1996) Kill, IR., Localisation of the Ki-67 antigen within the nucleolus - Evidence for a fibrillarin-deficient region of the dense fibrillar component, Journal of Cell Science 109 (6) : 1253- 1263 Download publication

(1995) Kill, IR. and Hutchison, CJ., S-phase phosphorylation of lamin B2, FEBS Letters 377 (1) : 26- 30

(1994) Kill, IR. and Hutchison, CJ., S-PHASE MODIFICATION OF LAMIN-B FOLLOWING SERUM RESTIMULATION OF QUIESCENT HUMAN DERMAL FIBROBLASTS, JOURNAL OF CELLULAR BIOCHEMISTRY 94- 94

(1994) Kill, IR., Faragher, RG., Lawrence, K. and Shall, S., The expression of proliferation-dependent antigens during the lifespan of normal and progeroid human fibroblasts in culture., Journal of Cell Science 107 (2) : 571- 579 Download publication

(1994) Hutchison, CJ., Bridger, JM., Cox, LS. and Kill, IR., Weaving a pattern from disparate threads: lamin function in nuclear assembly and DNA replication, Journal of Cell Science 107 (12) : 3259- 3269 Download publication

(1994) Crompton, CM., Kill, IR. and Hutchison, CJ., Xenopus Lamin l(iii) - Analysis of interphase and mitotic forms [Poster], Journal of Cellular Biochemistry 56 (Supplement 18C) : 93- 93

(1993) Bridger, JM., Kill, IR., O'Farrell, M. and Hutchison, CJ., Internal lamin structures within G1 nuclei of human dermal fibroblasts, Journal of Cell Science 104 (2) : 297- 306 Download publication

(1993) Faragher, RG., Kill, IR., Hunter, JA., Pope, FM., Tannock, C. and Shall, S., The gene responsible for Werner syndrome may be a cell division "counting" gene, Proceedings of the National Academy of the United States of America (PNAS) 90 (24) : 12030- 12034 Download publication

(1991) Kill, IR., Bridger, JM., Campbell, KH., Maldonado-Codina, G. and Hutchison, CJ., The timing of the formation and usage of replicase clusters in S-phase nuclei of human diploid fibroblasts, Journal of Cell Science 100 (4) : 869- 876 Download publication

(1990) Kill, IR. and Shall, S., Senescent human diploid fibroblasts are able to support DNA synthesis and to express markers associated with proliferation, Journal of Cell Science 97 (3) : 473- 478 Download publication

(1989) Hutchison, C. and Kill, IR., Changes in the nuclear distribution of DNA polymerase alpha and PCNA/cyclin during the progress of the cell cycle, in a cell-free extract of Xenopus eggs, Journal of Cell Science 93 (4) : 605- 613 Download publication

Conference Papers

(2004) Bridger, J., Meaburn, K., Foster, H., Figgitt, M., Bonne, G., Levy, N., Griffin, D. and Kill, I., The role of nuclear structure in genomic health, ICC XV, 15th International Chromosome Conference, Chromosome Research (12) : 22- 22