Rob Newbold

Professor Robert Newbold

Director of Brunel Institute of Cancer Genetics and Pharmacogenomics - Biosciences

Room: Heinz Wolff Building 103
Brunel University
Uxbridge
UB8 3PH
United Kingdom
Tel: +44 (0)1895 266290
Email: robert.newbold@brunel.ac.uk

About Robert

Profile

PERSONAL DETAILS

Full Name:  
Robert Frank Newbold
Date of birth: 5 February 1950
Professional Institute of Cancer Genetics and Pharmacogenomics
Address   

School of Health Sciences

Brunel University

Uxbridge UB8 4SP

Email:    

robert.newbold@brunel.ac.uk

 

CURRENT POSITION

Brunel University -Professor of Cancer Genetics

Director:  Brunel Institute of Cancer Genetics & Pharmacogenomics

 

EDUCATION

1973-76                  University of London (Institute of Cancer Research)

1970-73                  University of Aston in Birmingham

1961-67                  Abingdon School, Oxford

 

DEGREES

2001                       DSc(Cancer Genetics) University of London

1976                       PhD (Biochemistry) University of London

1973                       BSc (Hons) Biological Sciences, University of Aston in Birmingham.

 

RESEARCH  APPOINTMENTS

June 1991-             Professor of Cancer Genetics, Brunel University

present                  Director: Brunel Institute of Cancer Genetics &  Pharmacogenomics,                           

1989–1991             Visiting Research Professor, Brunel University                        

19871989             Scientific Director, Sydney Branch, Ludwig Institute for Cancer Research, University of Sydney, Australia.

1981-87                  Permanent Career Appointment, Institute of Cancer Research, Royal Cancer Hospital, London. Team Leader: Cell Transformation Laboratory

1977-81                  Research Fellow, Institute of Cancer Research, London

1973-76                  PhD student, Institute of Cancer Research

1967-70                               Assistant Scientific Officer, Cellular Radiobiology Division, Atomic Energy Research Establishment (AERE) Harwell, UK


ACADEMIC  APPOINTMENTS

2001-2004              Brunel University                                  

Dean: Faculty of Life Sciences

Chairman: Faculty Board, Board of Heads of Department, Faculty Appointments Committees, Faculty Promotions Committee.

Member: Deans’ Committee, University Research Committee, Academic Promotions Committee, Strategic Planning and Resources Committee.

1992-2001            Brunel University

Head: Department of Biology and Biochemistry

Member: University Court, Council, Senate, Finance Committee, Strategic Planning Committee.

1996-1999           Brunel University

Dean: Faculty of Science

Chairman: Faculty Board, Board of Heads of Department, Faculty Appointments Committees, Faculty Promotions Committee.

Member: Deans’ Committee, University Research Committee, Academic Promotions Committee, Strategic Planning and Resources Committee.

1991-present         Professor of Cancer Genetics, Brunel University

1989-91                  Visiting Research Professor, Brunel University

1987-89                  Associate Professor of Cancer Medicine, University of Sydney, Australia

1985                       Member of the Board of Studies in Microbiology and Recognized Teacher, University of London

Research

Research centres

Research projects and grants

Substantive externally funded research support secured regularly (as Principal Investigator) from a variety of prestigious funding bodies, since 1980.

Main funding bodies:Cancer Research Campaign (CRC now CRUK), MRC (including NC3Rs), BBSRC, CRC Technology, United Kingdom Coordinating Committee for Cancer Research (UKCCCR), Association for International Cancer Research (AICR), NCRI, US Department of Health, Breast Cancer Campaign (BCC) and, as Coordinator (since 1992) the European Commission Framework FP3, FP4, FP5, FP6 & FP7 (Health, Environment, Quality of Life, EURATOM, & Genomics & Biotechnology for Health, Programmes).

Recent Grants & Contracts (all as Principal Investigator &, for all EC FP grants, Project Coordinator)

MRC (NC3Rs funding stream), 2012-2015: Development of human epithelial cell transformation models for carcinogen screening, employing defined phenotypic endpoints mechanistically representative of rate-limiting events in human carcinogenesis’. £500,000, 36 months.

MRC (NC3Rs funding stream), 2008-2012: Development and validation of mechanisms-based rodent and human in vitro transformation assays for carcinogen screening’. £300,000, 38 months.

BBSRC ‘CASE’ award with Unilever Plc, 2010-2014: Molecular characterization of events underlying morphological transformation (MT) phenotypes induced by genotoxic and non-genotoxic carcinogens in the SHE-MT assay’. £127,000, 48 months.

Breast Cancer Hope PhD Studentship (fully funded) 2011-2014: Molecular characterization of the role of histone modifying genes as targets for telomerase reactivation in human breast cancer development’ . £95,000 – 36 months.

Coordinator: European Commission: Framework 7 Programme. Identification and characterization of novel human telomere-related biomarkers that aid cancer management by improving patient diagnosis, treatment selection, response monitoring and drug development’ (TELOMARKER). EC Collaborative Project 200950; 8 Participating Institutions. €3,000,000 – 36 months, 2008-2011.

Coordinator: European Commission: Framework 6 Programme. Project title: ‘Developing Molecular Medicines for Cancer in the Post-Genome Era’ (MOL CANCER MED); Contract Number: 502943; 14 participating institutions. €4.8 million – 50 months, 2004-2009.

Breast Cancer Campaign (BCC). Molecular and functional characterization of the chromosome-3-linked sequence APRG1 as a novel breast cancer suppressor gene. £140,000. 36 months, 2005-2008.

Coordinator: European Commission: Framework 5 Programme. Three projects for FP5 in the EURATOM (1 project) and Quality of Life & Management of Living Resources (2 projects) Thematic Programmes (8 Partners in each project).

Funded to a total value of €4 million. 1-03-00 to 28-02-04.

1. Contract Number: QLG1-1999-01341; Title of Project: The role of telomerase in human cancer development and an evaluation of its potential as a therapeutic target (TACIT).

2. Contract Number: QLK4-1999-01084; Title of Project: Genetic mechanisms involving ultraviolet light in the development of cutaneous malignant melanoma (MAUVE).

3. Contract Number: FIGH-CT1999-00002; Title of Project: Identification and isolation of susceptibility genes involved in radiation-induced cancer in humans (SUS GENES IN RAD CAR).

Above funded to a total value of€4 million. 42-48months, 2000-2004.

Cancer Research Campaign. 5-year CRC (now CRUK) Programme Grant. Programme Title: Identification and isolation of novel genes involved in sporadic human breast and prostate cancer, and in cutaneous malignant melanoma. £557,000. 60 months, 2000-2005.

Xenova Plc.  Biological assays related to telomerase. Value: £112,028. 2003-2005.

AstraZeneca Plc.  Development and molecular characterization of a cell culture model for human breast cancer. Value: £205,000, 2003-2006.

 

 

 

External

Membership and affiliation

2002
  • Fellow of the Royal Society of Arts (FRSA)
2000
  • Fellow of the Royal College of Pathologists (FRCPath)
1994
  • Fellow of the Royal Society of Medicine (FRSM)
1991
  • Fellow of the Institute of Biology (FIBiol, CBiol)
1991-2000
  • Member of two UK Government Expert Advisory Committees (COC & COM) concerned with the carcinogenicity and mutagenicity of chemicals in food, consumer products and the environment, and reporting directly to the Chief Medical Officer.
1994-2004
  • Trustee, Hillingdon Hospital Postgraduate Research Centre
1996-present
  • Entry in Debrett’s People of Today
2003- present
  • International Union Against Cancer (UICC-WHO): UICC Fellowship
  • Advisory Board member
2004-present
  • Entry in Marquis (USA) Who’s Who in Science and Engineering, Who's Who in Medicine, Who's Who in the World
2004-present
  • Member of the Scientific Advisory Board of Oncostem Therapeutics, a Madrid-based biotechnology company.
2005
  • Member of the Board of Editors: International journal of Cancer

Publications

Publications

Journal Papers

(2013) Yasaei, H., Gilham, E., Pickles, JC., Roberts, TP., O'Donovan, M. and Newbold, RF., Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells., Oncogene 32 (2) : 171- 179

(2012) Creton, S., Aardema, MJ., Carmichael, PL., Harvey, JS., Martin, FL., Newbold, RF., O'Donovan, MRO., Pant, K., Poth, A. and Sakai, A., Cell transformation assays for prediction of carcinogenic potential: state of the science and future research needs, Mutagenesis 27 (1) : 93- 101 Download publication

(2010) Abbaszadeh, F., Clingen, PH., Arlett, C., Plowman, PN., Bourton, EC., Themis, M., Makarov, EM., Newbold, RF., Green, MHL. and Parris, CN., A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitvity in a xeroderma pigmentosum patient, Journal of Medical Genetics 46 (11) : 1- 24 Download publication

(2010) Newbold, RF. and Mokbel, K., Evidence for a tumour suppressor function of SETD2 in human breast cancer: a new hypothesis., Anticancer Res 30 (9) : 3309- 3311

(2010) Al Sarakbi, W., Reefy, S., Jiang, WG., Roberts, T., Newbold, RF. and Mokbel, K., Evidence of a tumour suppressor function for DLEC1 in human breast cancer, Anticancer Res. 30 (4) : 1079- 1082

(2010) Loizidou, MA., Cariolou, MA., Neuhausen, SL., Newbold, RF., Bashiardes, E., Marcou, Y., Michael, T., Daniel, M., Kakouri, E., Papadopoulos, P., Malas, S., Hadjisavvas, A. and Kyriacou, K., Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population, Breast Cancer Research and Treatment 121 (1) : 147- 156 Download publication

(2010) Patani, N., Jiang, W., Newbold, R. and Mokbel, K., Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer, Journal of Carcinogenesis 9 (Online Paper) : 9- Download publication

(2009) Dafou, D., Ramus, SJ., Choi, K., Grun, B., Trott, DA., Newbold, RF., Jacobs, IJ., Jones, C. and Gayther, SA., Chromosomes 6 and 18 induce neoplastic suppression in epithelial ovarian cancer cells, International Journal of Cancer 124 (5) : 1037- 1044 Download publication

(2009) Loizidou, MA., Michael, T., Neuhausen, SL., Newbold, RF., Marcou, Y., Kakouri, E., Daniel, M., Papadopoulos, P., Malas, S., Hadjisavvas, A. and Kyriacou, K., DNA-repair genetic polymorphisms and risk of breast cancer in Cyprus, Breast Cancer Research and Treatment 115 (3) : 623- 627 Download publication

(2009) Patani, N., Jiang, W., Mansel, R., Newbold, R. and Mokbel, K., The mRNA expression of SATB1 and SATB2 in human breast cancer, Cancer Cell International 918

(2009) Al Sarakbi, W., Sasi, W., Jiang, WG., Roberts, T., Newbold, RF. and Mokbel, K., The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters, BMC Cancer 9290 Download publication

(2008) Worku, D., Jouhra, F., Jiang, GW., Patani, N., Newbold, RF. and Mokbel, K., Evidence of a tumour suppressive function of E2F1 gene in human breast cancer, Anticancer Research 28 (4B) : 2135- 2139 Download publication

(2008) Coelho, D., Suormala, T., Stucki, M., Lerner-Ellis, JP., Rosenblatt, DS., Newbold, RF., Baumgartner, MR. and Fowler, B., Gene identification for the cblD defect of vitamin B12 metabolism, New England Journal of Medicine 358 (14) : 1454- 1464 Download publication

(2008) Loizidou, MA., Michael, T., Neuhausen, SL., Newbold, RF., Marcou, Y., Kakouri, E., Daniel, M., Papadopoulos, P., Malas, S., Kyriacou, K. and Hadjisavvas, A., Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus, Breast Cancer Research and Treatment 112 (3) : 575- 579 Download publication

(2008) Sugiana, C., Pagliarini, DJ., McKenzie, M., Kirby, DM., Salemi, R., Abu-Amero, KK., Dahl, HH., Hutchison, WM., Vascotto, KA., Smith, SM., Newbold, RF., Christodoulou, J., Calvo, S., Mootha, VK., Ryan, MT. and Thorburn, DR., Mutation of C20orf7 disrupts complex I assembly and causes lethal neonatal mitochondrial disease, The American Journal of Human Genetics 83 (4) : 468- 478 Download publication

(2008) Meaburn, KJ., Newbold, RF. and Bridger, JM., Positioning of human chromosomes in murine cell hybrids according to synteny, Chromosoma 117 (6) : 579- 591 Download publication

(2008) Salhab, M., Jiang, WG., Newbold, RF. and Mokbel, K., The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome, Breast Cancer Research and Treatment 109 (1) : 35- 46 Download publication

(2007) Newbold, RF., Hadjiavvas, A., Loizidou, M., Marcou, Y., Anastasiadou, V. and Kyriacou, K., Contribution of BRCA1 and BRCA2 germline mutations to the incidence of early-onset breast cancer in Cyprus, Clinical Genetics 71 (2) : 165- 170 Download publication

(2007) Mansfield, L., Subramanian, A., Devalia, H., Jiang, W., Newbold, RF. and Mokbel, K., hTERT mRNA expression correlates with matrix metalloproteinase-1 and vascular endothelial growth factor expression in human breast cancer: A correlative study using RT-PCR, ANTICANCER RESEARCH 27 (4B) : 2265- 2268

(2006) Elkak, A., Mokbel, R., Wilson, C., Jiang, WG., Newbold, RF. and Mokbel, K., hTERT mRNA expression is associated with a poor clinical outcome in human breast cancer, Anticancer Research 26 (6C) : 4901- 4904

(2005) Leris, AC., Roberts, TR., Jiang, WG., Newbold, RF. and Mokbel, K., Evidence for a tumour suppressive function of APRG1 in breast cancer., Breast Cancer Res Treat 93 (2) : 97- 100 Download publication

(2005) Elkak, AE., Meligonis, G., Salhab, M., Mitchell, B., Blake, JR., Newbold, RF. and Mokbel, K., hTERT protein expression is independent of clinicopathological parameters and c-Myc protein expression in human breast cancer., Journal of Carcinogenesis 417 Download publication

(2005) Leris, AC., Roberts, TR., Jiang, WG., Newbold, RF. and Mokbel, K., WNT5A expression in human breast cancer, Anticancer Research: international journal of cancer research and treatment 25 (2A) : 731- 734

(2004) Newbold, RF., Cabury, E., Newton, C., Roberts, T. and Slijepcevic, P., Identification of subpopulations of cells with differing telomere lengths in mouse and human cell lines by flow FISH, Cytometry 62 (2) : 150- 161 Download publication

(2004) Flanagan, JM., Healey, S., Young, J., Whitehall, V., Trott, DA., Newbold, RF. and Chenevix-Trench, G., Mapping of a candidate colorectal cancer tumor-suppressor gene to a 900-kilobase region on the short arm of chromosome 8, Genes Chromosomes Cancer 40 (3) : 247- 260 Download publication

(2004) Newbold, RF., Coenen, MJH., Antonicka, H., Ugalde, C., Sasarman, F., Rossi, R., Heister, A., Trijbels, FJMF., van den Heuval, LP., Shoubridge, EA. and Smeitink, JAM., Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency, New England Journal of Medicine 351 (20) : 2080- 2086 Download publication

(2004) Kirkpatrick, KL., Newbold, RF. and Mokbel, K., The mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression., Journal of Carcinogenesis 3 (1) : 1 Download publication

(2004) Kirkpatrick, KL., Newbold, RF. and Mokbel, K., There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer., International Seminars in Surgical Oncology 1 (1) : 2 Download publication

(2003) Szutorisz, H., Lingner, J., Cuthbert, AP., Trott, DA., Newbold, RF. and Nabholz, M., A chromosome 3-encoded repressor of the Human Telomerase Reverse Transcriptase (hTERT) gene controls the state of hTERT chromatin, Cancer Research 63 (3) : 689- 695 Download publication

(2003) Chastain-Moore, AM., Roberts, T., Trott, DA., Newbold, RF. and Ornelles, DA., An activity associated with human chromosome 21 permits nuclear colocalization of the adenovirus E1B-55K and E4orf6 proteins and promotes viral late gene expression, Journal of Virology 77 (14) : 8087- 8098 Download publication

(2003) Kirkpatrick, KL., Ogunkolade, W., Elkak, AE., Bustin, S., Jenkins, P., Ghilchick, M., Newbold, RF. and Mokbel, K., hTERT expression in human breast cancer and non-cancerous breast tissue: correlation with tumour stage and c-Myc expression, Breast Cancer Res Treat 77 (3) : 277- 284

(2003) Kirkpatrick, KL., Clark, G., Ghilchick, M., Newbold, RF. and Mokbel, K., hTERT mRNA expression correlates with telomerase activity in human breast cancer, EJSO - European Journal of Surgical Oncology 29 (4) : 321- 326

(2003) Fitzsimmons, SA., Ireland, H., Barr, NI., Cuthbert, AP., Going, JJ., Newbold, RF. and Parkinson, EK., Human squamous cell carcinomas lose a mortality gene from chromosome 6q14.3 to q15, Oncogene 22 (11) : 1737- 1746 Download publication

(2003) Elkak, AE., Newbold, RF., Thomas, V. and Mokbel, K., Is telomerase reactivation associated with the down-regulation of TGF beta receptor-II expression in human breast cancer?, Cancer Cell International 3 (1) : 9 Download publication

(2003) Themis, M., May, D., Coutelle, C. and Newbold, RF., Mutational effects of retrovirus insertion on the genome of V79 cells by an attenuated retrovirus vector: Implications for gene therapy, Gene Therapy 10 (19) : 1703- 1711

(2003) Mokbel, K. and Newbold, RF., Re: Poremba et al Telomerase as a prognostic marker in breast cancer: High-throughput tissue microarray analysis of hTERT and hTR. J Pathol 2002; 198: 181-189, Journal of Pathology 199 (4) : 542-

(2003) Newbold, RF., Cosma, MP., Pepe, S., Annunziata, I., Grompe, M., Parenti, G. and Ballabio, A., The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases, Cell 113 (4) : 445- 456 Download publication

(2003) Wilson, P., Cuthbert, A., March, A., Arnold, J., Flanagan, J., Mulford, C., Trott, D., Baker, E., Purdie, D., Newbold, R. and Chenevix-Trench, G., Transfer of chromosome 8 into two breast cancer cell lines: Total exclusion of three regions indicates location of putative in vitro growth suppressor genes, Cancer Genetics and Cytogenetics 143 (2) : 100- 112 Download publication

(2002) Bryce, SD., Morrison, V., Craig, NJ., Forsyth, NR., Fitzsimmons, SA., Ireland, H., Cuthbert, AP., Newbold, RF. and Parkinson, EK., A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23, Neoplasia 4 (6) : 544- 550 Download publication

(2002) Boulos, N., Newbold, RF., Trott, DA., Pearson, ADJ., Tilby, MJ. and Lunec, J., Functional complementation analysis of chromosome 1 in neuroblastoma, BRITISH JOURNAL OF CANCER 86 S91- S91

(2002) Forsyth, NR., Morrison, V., Craig, NJ., Fitzsimmons, SA., Barr, NI., Ireland, H., Gordon, KE., Dowen, S., Cuthbert, AP., Newbold, RF., Bryce, SD. and Parkinson, EK., Functional evidence for a squamous cell carcinoma mortality gene(s) on human chromosome 4, Oncogene 21 (33) : 5135- 5147 Download publication

(2002) Wilding, J., Meijne, E., Haines, J., Moody, J., Edwards, A., Newbold, RF., Parris, C., Cox, R. and Silver, A., Functional evidence from microcell-mediated chromosome transfer of myeloid leukemia suppressor genes on human chromosomes 7 and 11, Genes, Chromosomes and Cancer 34 (4) : 390- 397

(2002) Newbold, RF., The significance of telomerase activation and cellular immortalization in human cancer, Mutagenesis 17 (6) : 539- 550

(2001) Seyda, A., Newbold, RF., Hudson, TJ., Verner, A., MacKay, N., Winter, S., Feigenbaum, A., Malaney, S., Gonzalez-Halphen, D., Cuthbert, AP. and Robinson, BH., A novel syndrome affecting multiple mitochondrial functions, located by microcell-mediated transfer to chromosome 2p14-2p13., American Journal of Human Genetics 68 (2) : 386- 396 Download publication

(2001) Hadjisavvas, A., Neuhausen, SL., Hoffman, MD., Adamou, A., Newbold, RF., Kyriacou, KC. and Christodoulou, CG., BRCA1 germline mutations in Cypriot breast cancer patients from 26 families with family history, Anticancer Research 21 (5) : 3307- 3311

(2001) Sullivan, GJ., Bridger, JM., Cuthbert, AP., Newbold, RF., Bickmore, WA. and McStay, B., Human acrocentric chromosomes with transcriptionally silent nucleolar organiser regions associate with nucleoli, European Molecular Biology Organization 20 (11) : 2867- 2877 Download publication

(2001) Goodarzi, G., Mashimo, T., Watabe, M., Cuthbert, AP., Newbold, RF., Pai, SK., Hirota, S., Hosobe, S., Miura, K., Bandyopadhyay, S., Gross, SC., Balaji, KC. and Watabe, K., Identification of tumor metastasis suppressor region on the short arm of human chromosome 20, Genes Chromosomes Cancer 32 (1) : 33- 42

(2001) Ducrest, AL., Amacker, M., Mathieu, YD., Cuthbert, AP., Trott, DA., Newbold, RF., Nabholz, M. and Lingner, J., Regulation of human telomerase activity: Repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity, Cancer Research 61 (20) : 7594- 7602 Download publication

(2001) Steenbergen, RD., Kramer, D., Meijer, CJ., Walboomers, JM., Trott, DA., Cuthbert, AP., Newbold, RF., Overkamp, WJ., Zdzienicka, MZ. and Snijders, PJ., Telomerase suppression by chromosome 6 in a human papillomavirus type 16-immortalized keratinocyte cell line and in a cervical cancer cell line., Journal of the National Cancer Institute 93 (11) : 865- 872 Download publication

(2001) McIlrath, J., Bouffler, SD., Samper, E., Cuthbert, A., Wojcik, A., Szumiel, I., Bryant, PE., Riches, AC., Thompson, A., Blasco, MA., Newbold, RF. and Slijepcevic, P., Telomere length abnormalities in mammalian radiosensitive cells, Cancer Research 61 (3) : 912- 915 Download publication

(2000) Mashimo, T., Goodarzi, G., Watabe, M., Cuthbert, AP., Newbold, RF., Pai, SK., Hirota, S., Hosobe, S., Miura, K., Bandyopadhyay, S., Gross, SC. and Watabe, K., Localization of a novel tumor metastasis suppressor region on the short arm of human chromosome 2, Genes Chromosomes Cancer 28 (3) : 285- 293

(2000) Mokbel, KM., Parris, CN., Ghilchik, M., Amerasinghe, CN. and Newbold, RF., Telomerase activity and lymphovascular invasion in breast cancer, European Journal of Surgical Oncology 26 (1) : 30- 33

(1999) Parris, CN., Harris, JD., Griffin, DK., Cuthbert, AP., Silver, AJ. and Newbold, RF., Functional evidence of novel tumor suppressor genes for cutaneous malignant melanoma., Cancer Research 59 (3) : 516- 520 Download publication

(1999) Bryce, SD., Forsyth, NR., Fitzsimmons, SA., Clark, LJ., Bertram, MJ., Cuthbert, AP., Newbold, RF., Pereira-Smith, OM. and Parkinson, EK., Genetic and functional analyses exclude mortality factor 4 (MORF4) as a keratinocyte senescence gene., Cancer Res 59 (9) : 2038- 2040

(1999) Vermeulen, SJ., Debruyne, PR., Marra, G., Speleman, FP., Boukamp, P., Jiricny, J., Cuthbert, AP., Newbold, RF., Nollet, FH., van Roy, FM. and Mareel, MM., hMSH6 deficiency and inactivation of the alphaE-catenin invasion-suppressor gene in HCT-8 colon cancer cells., Clin Exp Metastasis 17 (8) : 663- 668

(1999) Mokbel, K., Parris, CN., Radbourne, R., Ghilchik, M. and Newbold, RF., Telomerase activity and prognosis in breast cancer, EJSO - European Journal of Surgical Oncology 25 (3) : 269- 272

(1999) Parris, CN., Jezzard, S., Silver, A., MacKie, R., McGregor, JM. and Newbold, RF., Telomerase activity in melanoma and non-melanoma skin cancer., British Journal of Cancer 79 (1) : 47- 53 Download publication

(1999) Mokbel, K., Ghilchik, M., Parris, CN. and Newbold, RF., Telomerase activity in phyllodes tumours, Eur J Surg Oncol 25 (4) : 352- 355

(1999) Mokbell, K., Parris, CN., Ghilchik, M. and Newbold, RF., Telomerase activity in the human breast, Breast 8 (4) : 208- 211

(1999) Newbold, RF., Telomerase as an anti-cancer drug target: Will it fulfil its early promise?, Anticancer Drug Design 14 (4) : 349- 354

(1999) Cuthbert, AP., Bond, J., Trott, DA., Gill, S., Broni, J., Marriott, A., Khoudoli, G., Parkinson, EK., Cooper, CS. and Newbold, RF., Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast cancer cells, Journal of the National Cancer Institute 91 (1) : 37- 45 Download publication

(1999) Kipling, D., Wynford-Thomas, D., Jones, CJ., Akbar, A., Aspinall, R., Bacchetti, S., Blasco, MA., Broccoli, D., DePinho, RA., Edwards, DR., Effros, RB., Harley, CB., Lansdorp, PM., Linskens, MHK., Prowse, KR., Newbold, RF., Olovnikov, AM., Parkinson, EK., Pawelec, G., Ponten, J., Shall, S., Zijlmans, M. and Faragher, RGA., Telomere-dependent senescence, NATURE BIOTECHNOLOGY 17 (4) : 313- 313

(1999) Mokbel, K., Parris, CN., Ghilchik, M., Williams, G. and Newbold, RF., The association between telomerase, histopathological parameters, and KI-67 expression in breast cancer, American Journal of Surgery 178 (1) : 69- 72

(1998) Russo, I., Silver, AR., Cuthbert, AP., Griffin, DK., Trott, DA. and Newbold, RF., A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization, Oncogene 17 (26) : 3417- 3426 Download publication

(1998) Parris, CN., Harris, JD. and Newbold, RF., Functional evidence of novel tumour suppressor genes for Cutaneous Malignant Melanoma., BRITISH JOURNAL OF CANCER 78 11- 11

(1998) Mashimo, T., Watabe, M., Cuthbert, AP., Newbold, RF., Rinker-Schaeffer, CW., Helfer, E. and Watabe, K., Human chromosome 16 suppresses metastasis but not tumorigenesis in rat prostatic tumor cells, Cancer Research 58 (20) : 4572- 4576 Download publication

(1998) Ebeling, SB., Bos, HM., Slater, R., Overkamp, WJ., Cuthbert, AP., Newbold, RF., Zdzienicka, MZ. and Aarden, LA., Human chromosome 21 determines growth factor dependence in human/mouse B-cell hybridomas., Cancer Research 58 (13) : 2863- 2868

(1998) Zhu, Z., Yao, J., Johns, T., Fu, K., De Bie, I., Macmillan, C., Cuthbert, AP., Newbold, RF., Wang, J., Chevrette, M., Brown, GK., Brown, RM. and Shoubridge, EA., SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome., Nature Genetics 20 (4) : 337- 343 Download publication

(1997) Loughran, O., Clark, LJ., Bond, J., Baker, A., Berry, IJ., Edington, KG., Ly, IS., Simmons, R., Haw, R., Black, DM., Newbold, RF. and Parkinson, EK., Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes, Oncogene 14 (16) : 1955- 1964

(1997) Parkinson, EK., Newbold, RF. and Keith, WN., The genetic basis of human keratinocyte immortalisation in squamous cell carcinoma development: The role of telomerase reactivation, Eur J Cancer 33 (5) : 727- 734

(1996) England, NL., Cuthbert, AP., Trott, DA., Jezzard, S., Nobori, T., Carson, DA. and Newbold, RF., Identification of human tumour suppressor genes by monochromosome transfer: rapid growth-arrest response mapped to 9p21 is mediated solely by the cyclin-D-dependent kinase inhibitor gene, CDKN2A (p16INK4A), Carcinogenesis 17 (8) : 1567- 1575

(1996) Yamasaki, H., Ashby, J., Bignami, M., Jongen, W., Linnainmaa, K., Newbold, RF., Nguyen-Ba, G., Parodi, S., Rivedal, E., Schiffmann, D., Simons, JW. and Vasseur, P., Nongenotoxic carcinogens: development of detection methods based on mechanisms: a European project., Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 353 (1-2) : 47- 63

(1996) Jongmans, W., Verhaegh, GW., Jaspers, NG., Demant, P., Natarajan, AT., Shiloh, Y., Oshimura, M., Stanbridge, EJ., Athwal, RS., Cuthbert, AP., Newbold, RF., Lohman, PH. and Zdzienicka, MZ., The defect in the AT-like hamster cell mutants is complemented by mouse chromosome 9 but not by any of the human chromosomes, Mutation Research/DNA Repair 364 (2) : 91- 102

(1995) Cuthbert, AP., Trott, DA., Ekong, RM., Jezzard, S., England, NL., Themis, M., Todd, CM. and Newbold, RF., Construction and characterization of a highly stable human: rodent monochromosomal hybrid panel for genetic complementation and genome mapping studies., Cytogenet Cell Genet 71 (1) : 68- 76

(1995) Trott, DA., Cuthbert, AP., Overell, RW., Russo, I. and Newbold, RF., Mechanisms involved in the immortalization of mammalian cells by ionizing radiation and chemical carcinogens, Carcinogenesis 16 (2) : 193- 204

(1995) Trott, DA., Cuthbert, AP., Todd, CM., Themis, M. and Newbold, RF., Novel use of a selectable fusion gene as an "in-out" marker for studying genetic loss in mammalian cells, Molecular Carcinogenesis 12 (4) : 213- 224

(1988) Shiner, AC., Newbold, RF. and Cooper, CS., Morphological transformation of immortalized hamster dermal fibroblasts following treatment with simple alkylating carcinogens, Carcinogenesis 9 (9) : 1701- 1709

(1985) Newbold, RF., Malignant transformation of mammalian cells in culture: delineation of stages and role of cellular oncogene activation., IARC Sci Publ 67 31- 53

(1985) Newbold, RF., Multistep malignant transformation of mammalian cells by carcinogens: induction of immortality as a key event., Carcinog Compr Surv 9 17- 28

(1984) Newbold, RF., Transformation by the p21ras protein., Nature 312 (5992) : 314-

(1983) Newbold, RF. and Overell, RW., Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene, Nature 304 (5927) : 648- 651

(1982) Brookes, P., King, HW., Mundy, CR. and Newbold, RF., Biochemical and immunological characterisation of mutants induced in V79 Chinese hamster cells by a benzo[a]pyrene diolepoxide., Carcinogenesis 3 (6) : 687- 692

(1982) Newbold, RF., Overell, RW. and Connell, JR., Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens., Nature 299 (5884) : 633- 635

(1981) Newbold, RF. and Amos, J., Inhibition of metabolic cooperation between mammalian cells in culture by tumor promoters., Carcinogenesis 2 (3) : 243- 249

(1980) Parkinson, EK. and Newbold, RF., Benzo(a)pyrene metabolism and DNA adduct formation in serially cultivated strains of human epidermal keratinocytes., Int J Cancer 26 (3) : 289- 299

(1980) Newbold, RF., Warren, W., Medcalf, AS. and Amos, J., Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification., Nature 283 (5747) : 596- 599

(1979) Newbold, RF., Brookes, P. and Harvey, RG., A quantitative comparison of the mutagenicity of carcinogenic polycyclic hydrocarbon derivatives in cultured mammalian cells, International Journal of Cancer 24 (2) : 203- 209

(1979) Wigley, CB., Newbold, RF., Amos, J. and Brookes, P., Cell-mediated mutagenesis in cultured Chinese hamster cells by polycyclic hydrocarbons: mutagenicity and DNA reaction related to carcinogenicity in a series of compounds., Int J Cancer 23 (5) : 691- 696

(1979) Newbold, RF., Amos, J. and Connell, JR., The cytotoxic, mutagenic and clastogenic effects of chromium-containing compounds on mammalian cells in culture, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 67 (1) : 55- 63

(1977) Newbold, RF., Wigley, CB., Thompson, MH. and Brookes, P., Cell-mediated mutagenesis in cultured Chinese hamster cells by carcinogenic polycyclic hydrocarbons: Nature and extent of the associated hydrocarbon-DNA reaction, Mutation Research 43 (1) : 101- 116

(1976) Newbold, RF. and Brookes, P., Exceptional mutagenicity of a benzo(a)pyrene diol epoxide in cultured mammalian cells., Nature 261 (5555) : 52- 54

Conference Papers

(2009) Al Sarakbi, W., Sasi, W., Jiang, WG., Roberts, W., Newbold, RF. and Mokbel, K., Gene transcripts in the tumour suppressor region of chromosome 3 (3p21), 32nd Annual San Antonio Breast Cancer Symposium, Cancer Research (69) : 869S- 869S

(2004) Dafou, D., Trott, DA., Newbold, RF., Jacobs, IJ. and Gayther, SA., Establishing a cell biology model of suppression in epithelial ovarian cancer, 44th Annual Meeting of the American-Society-for-Cell-Biology, MOLECULAR BIOLOGY OF THE CELL (15) : 250A- 250A

(2004) Dafou, D., Li, NF., Trott, DA., Jacobs, IJ., Gayther, SA. and Newbold, RF., In vitro model of malignant transformation for the identification of genes in breast cancer formation, British Cancer Research Meeting 2004, BRITISH JOURNAL OF CANCER (91) : S74- S74

(2002) Cosma, MP., Pepe, S., Parenti, G., Belli, A., Mankad, A., Grompe, M., Trott, DA., Newbold, RF. and Ballabio, A., Mapping of the gene for multiple sulfatase deficiency (MSD) by functional complementation using microcell-mediated chromosome transfer, European-Society-of-Human-Genetics European Human Genetics Conference in Conjuction With European Meeting on Psychosocial Aspects of Genetics, EUROPEAN JOURNAL OF HUMAN GENETICS (10) : 207- 208

(1997) Shay, JW., Wynford-Thomas, D., Gasser, SM., Lundblad, V., Cech, TR., Guarente, L., Brenner, S., Harley, CB. and Newbold, RF., Are telomeres correlative or causative in cellular senescence? General discussion, Symposium on Telomeres and Telomerase, TELOMERES AND TELOMERASE (211) : 145- 147

(1997) Gasser, SM., Newbold, RF., Wynford-Thomas, D., Shay, JW., Kipling, D., Holliday, R., Blasco, M., Reddel, R., Harley, CB., Guarente, L., Shall, S., Biessmann, H., Lundblad, V., Bacchetti, S. and Lindahl, T., Genetic control of telomerase and replicative senescence in human and rodent cells - Discussion, Symposium on Telomeres and Telomerase, TELOMERES AND TELOMERASE (211) : 189- 197

(1997) Kipling, D., Harley, CB., Cech, TR., Shall, S., Lansdorp, PM., Holliday, R., Shay, JW., Bacchetti, S., Blackburn, EH., Reddel, RR., Blasco, MA., Guarente, L., Wynford-Thomas, D. and Newbold, RF., Human ageing and telomeres - Discussion, Symposium on Telomeres and Telomerase, TELOMERES AND TELOMERASE (211) : 139- 144

(1997) Brenner, S., Blasco, M., Kipling, D., Lundblad, V., Guarente, L., Cech, TR., Holliday, R., Blackburn, E., Gasser, SM., Ishikawa, F., Shay, JW., Shall, S., Reddel, R., Bacchetti, S., Wynford-Thomas, D., Newbold, RF., Lundblad, V., Harley, SB. and Lansdorp, PM., Mouse models for the study of telomerase - Discussion, Symposium on Telomeres and Telomerase, TELOMERES AND TELOMERASE (211) : 170- 176

(1997) Newbold, RF., Shay, JW., Guarente, L., Kipling, D., Cech, TR., Blackburn, E., Bacchetti, S. and Holliday, R., Telomerase assays in the diagnosis and prognosis of cancer - Discussion, Symposium on Telomeres and Telomerase, TELOMERES AND TELOMERASE (211) : 155- 159

(1993) Newbold, RF., Cuthbert, AP., Themis, M., Trott, DA., Blair, AL. and Li, W., Cell immortalization as a key, rate-limiting event in malignant transformation: approaches toward a molecular genetic analysis., , Toxicol Lett (67) : 211- 230

(1997) Newbold, RF., Genetic control of telomerase and replicative senescence in human and rodent cells., , Ciba Found Symp (211) : 177- 189

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