Sahar Al-Mahdawi

Research centres

• Brunel Institute for Cancer Genetics and Pharmacogenomics (BICGP)

Publications

Journal Papers

(2012) Ezzatizadeh, V., Mouro Pinto, R., Sandi, C., Sandi, M., Al-Mahdawi, S., te Riele, H. and Pook, MA., The mismatch repair system protects against intergenerational GAA repeat instability in a Friedreich ataxia mouse model, Neurobiology of Disease 46 (1) : 165- 171 Download publication

(2011) Sandi, C., Pinto, RM., Al-Mahdawi, S., Ezzatizadeh, V., Barnes, G., Jones, S., Rusche, JR., Gottesfeld, JM. and Pook, MA., Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model, Neurobiology of Disease 42 (3) : 496- 505

(2008) Al-Mahdawi, S., Pinto, RM., Ismail, O., Varshney, D., Lymperi, S., Sandi, C., Trabzuni, D. and Pook, M., The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues, Human Molecular Genetics 17 (5) : 735- 746 Download publication

(2007) De Biase, I., Rasmussen, A., Monticelli, A., Al-Mahdawi, S., Pook, M., Cocozza, S. and Bidichandani, SI., Somatic instability of the expanded GAA triplet-repeat sequence in Friedreich ataxia progresses throughout life, Genomics 90 (1) : 1- 5 Download publication

(2007) De Biase, I., Rasmussen, A., Endres, D., Al-Mahdawi, S., Monticelli, A., Cocozza, S., Pook, M. and Bidichandani, S., Progressive GAA expansions in dorsal root ganglia of Friedreich's ataxia patients, Annals of Neurology 61 (1) : 55- 60

(2007) Clark, RM., De Biase, I., Malykhina, AP., Al-Mahdawi, S., Pook, M. and Bidichandani, SI., The GAA triplet-repeat is unstable in the context of the human FXN locus and displays age-dependent expansions in cerebellum and DRG in a transgenic mouse model, Human Genetics 120 (5) : 633- 640 Download publication

(2006) Al-Mahdawi, S., Pinto, RM., Varshney, D., Lawrence, L., Lowrie, MB., Hughes, S., Webster, Z., Blake, J., Cooper, JM., King, R. and Pook, MA., GAA repeat expansion mutation mouse models of Friedreich ataxia exhibit oxidative stress leading to progressive neuronal and cardiac pathology, Genomics 88 (5) : 580- 590 Download publication

(2004) Al-Mahdawi, S., Pinto, RM., Ruddle, P., Carroll, C., Webster, Z. and Pook, M., GAA repeat instability in Friedreich ataxia YAC transgenic mice, Genomics 84 (2) : 301- 310

(2002) Cemal, CK., Carroll, CJ., Lawrence, L., Lowrie, MB., Ruddle, P., Al-Mahdawi, S., King, RHM., Pook, MA., Huxley, C. and Chamberlain, S., YAC transgenic mice carrying pathological alleles of the MJD1 locus exhibit a mild and slowly progressive cerebellar deficit, Human Molecular Genetics 11 (9) : 1075- 1094

(2001) Pook, MA., Al-Mahdawi, S., Carroll, CJ., Cossée, M., Puccio, H., Lawrence, L., Clark, P., Lowrie, MB., Bradley, JL., Cooper, MJ., Kœnig, M. and Chamberlain, S., Rescue of the Friedreich's ataxia knockout mouse by human YAC transgenesis, neurogenetics 3 (4) : 185- 193