Su-Ling Li

Academic qualifications

• 1983 Suzhou Medical University, China, MD
• 1994 Karolinska Institute, Sweden, PhD (Doctor of Medical Sciences)

• 1978-1983: MD Suzhou Medical University, China.
• 1989-1994: PhD Department of Immunpathology,Karolinska Institute, Stockholm, Sweden.
• 1994-96: Postdoctoral fellow, Department of Clinical Virology, Hudding Hospital, Karolinska Institute

Committee responsibilities

iDivision Director for Biosciences

• Group Leader of Molecular Immunology
• Head of Microarray Facility

Module Coordinating Responsibilities

• BB3213/BB3220 – Medical Immunology/Immunology
• MSc:BB5503/BB5513 – Genomic Technologies and Cancer/Genomic Technologies

Academic Appointments

• 1996-2000: Assistant Professor, and then Associate Professor since 2000, Institute of Cell and Molecular Biology, Lund University, Sweden
• 2001-2005: Lecturer in Immunology and Biochemistry, Division of Biosciences, Brunel University
• 2005-2009: Reader in Immunology and Biochemistry, Division of Biosciences, Brunel University 
• 2009-Present: Division Director for Biosciences and Reader in Immunology, Division of Biosciences, Brunel University
  

PhD supervision

• Elisavet Primpidou (started 2002) - Development of peptide-edited microsome vaccine (1^st supervision)
• Sabah Khalid (started 2003) - Microarray Bioinformatics (1^st supervision)
• Z. L.Deenmahama (started 2004) - T cell signalling (1^st supervision)
• Mohsin Khan (started 2005) - Immuno-Bioinformatics (1^st supervision)

PhD Students Previously Supervised

• Kajsa Paulsson (finished 2001) - Quality control of MHC class I antigen presentation (1^st supervision)
• Anderson Per (finished 2003) - Orchestration of the signalling network in T cells (1^st supervision)
• Li Li (finsihed 2004) - SOCS family and its function in regulation of intracellular signalling(1^st supervision)

Research centres

• Brunel Institute for Cancer Genetics and Pharmacogenomics (BICGP)
• Centre for Infection, Immunity and Disease Mechanisms (CIIDM)

Publications

Journal Papers

(2012) Liu, M., Miao, T., Zhu, H., Symonds, ALJ., Li, L., Schurich, A., Maini, MK., Zhang, J., Kennedy, PTF., Li, S. and Wang, P., IL-2–Engineered nano-APC effectively activates viral antigen-mediated T cell responses from chronic Hepatitis B virus-infected patients, Journal of Immunology 188 (3) : 1534- 1543

(2011) Li, S., Symonds, ALJ., Zhu, B., Liu, M., Raymond, M., Miao, T. and Wang, P., Early growth response gene-2 (Egr-2) regulates the development of B and T cells, PLoS ONE 6 (4) : e18498 Download publication

(2009) Sofra, V., Mansour, S., Liu, M., Gao, B., Primpidou, E., Wang, P. and Li, S., Antigen-loaded ER microsomes from APC induce potent immune responses against viral infection., Eur J Immunol 39 (1) : 85- 95 Download publication

(2008) Zhu, B., Symonds, AL., Martin, JE., Kioussis, D., Wraith, DC., Li, S. and Wang, P., Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease., J Exp Med 205 (10) : 2295- 2307 Download publication

(2008) Khalid, S., Khan, M., Gorle, CB., Fraser, K., Wang, P., Liu, X. and Li, S., MaXlab: A novel application for the cross comparison and integration of biological signatures from microarray studies, In Silico Biology 8 (3-4) : 363- 376

(2008) Khalid, S., Grazio, D., Wang, P., Liu, X. and Li, S., Designing customised gene expression arrays based on specific biological questions or functions, Journal of Integrated Design & Process Science 11 (3) : 67- 81

(2007) Khalid, S., Khan, M., Symonds, A., Fraser, K., Wang, P., Liu, X. and LI, S., CIDA: an integrated software for the design, characterisation and global comparison of microarrays, J. integrated Bioinformatics 4 (3) : 78-

(2006) Paulsson, KM., Jevon, M., Anderson, P., Li, S. and Wang, P., The double lysine motif of tapasin is a retrieval signal for retention of unstable MHC class I molecules in the endoplasmic reticulum, The Journal of Immunology 176 (12) : 7482- 7488

(2006) Anderson, PO., Manzo, BA., Sundstedt, A., Minaee, S., Symonds, A., Khalid, S., Rodriguez-Cabezas, ME., Nicolson, K., Li, S., Wraith, DC. and Wang, P., Persistent antigenic stimulation alters the transcription program in T cells, resulting in antigen-specific tolerance, European Journal of Immunology 36 (6) : 1374- 1385 Download publication

(2006) Khalid, S., Khan, M., Wang, P., Liu, X. and Li, S., Application of Bioinformatics in the Design of Gene Expression Microarrays, Proceedings of the Second International Symposium on Leveraging Applications of Formal Methods, Verification and Validation 163- 177

(2006) Khalid, S., Fraser, K., Khan, M., Wang, P., Liu, X. and LI, S., Analysing Microarray Data using the Multi-functional Immune Ontounlogiser, J. integrated Bioinformatics 3 25-

(2005) Anderson, PO., Sundstedt, A., Yazici, Z., Minaee, S., O'Neill, EJ., Woolf, R., Nicolson, K., Whitley, N., Li, L., Li, S., Wraith, DC. and Wang, P., IL-2 overcomes the unresponsiveness but fails to reverse the regulatory function of antigen-induced T regulatory cells., J Immunol 174 (1) : 310- 319 Download publication

(2004) Li, L., Grønning, LM., Anderson, PO., Li, S., Edvardsen, K., Johnston, J., Kioussis, D., Shepherd, PR. and Wang, P., Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism., J Biol Chem 279 (33) : 34107- 34114 Download publication

(2003) Anderson, P., Sundstedt, A., Li, L., O'Neill, EJ., Li, S., Wraith, DC. and Wang, P., Differential activation of signal transducer and activator of transcription (STAT)3 and STAT5 and induction of suppressors of cytokine signalling in T(h)1 and T(h)2 cells., Int Immunol 15 (11) : 1309- 1317 Download publication

(2003) Chen, S., Anderson, PO., Li, L., Sjögren, HO., Wang, P. and Li, S., Functional association of cytokine-induced SH2 protein (CIS) and protein kinase C in activated T cells, International Immunology 15 (3) : 403- 409

(2003) Anderson, P., Sundstedt, A., Massey, E., LI, S., Wraith, D. and Wang, P., Differential Activation of Signal Transducers and Activators of Transcription -3 and –5 (STAT)s and Induction of Suppressors Of Cytokine Signaling (SOCS) in T helper (Th) 1 and Th2 cells, Int Immunol. 15 (11) : 1309- 1317

(2002) Paulsson, KM., Kleijmeer, MJ., Griffith, J., Jevon, M., Chen, S., Anderson, PO., Sjogren, HO., Li, S. and Wang, P., Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum., J Biol Chem 277 (21) : 18266- 18271 Download publication

(2002) Turnquist, HR., Vargas, SE., McIlhaney, MM., Li, S., Wang, P. and Solheim, JC., Calreticulin binds to the alpha1 domain of MHC class I independently of tapasin., Tissue Antigens 59 (1) : 18- 24 Download publication

(2001) Turnquist, HR., Vargas, SE., Reber, AJ., McIlhaney, MM., Li, S., Wang, P., Sanderson, SD., Gubler, B., van Endert, P. and Solheim, JC., A region of tapasin that affects L(d) binding and assembly., J Immunol 167 (8) : 4443- 4449 Download publication

(2001) Paulsson, KM., Wang, P., Anderson, PO., Chen, S., Pettersson, RF. and Li, S., Distinct differences in association of MHC class I with endoplasmic reticulum proteins in wild-type, and β2-microglobulin- and TAP-deficient cell lines, International Immunology 13 101- 111

(2001) Wang, P., Anderson, PO., Chen, S., Paulsson, KM., Sjögren, HO. and Li, S., Inhibition of the transcription factors AP-1 and NF-kappaB in CD4 T cells by peroxisome proliferator-activated receptor gamma ligands., Int Immunopharmacol 1 (4) : 803- 812 Download publication

(2001) Paulsson, KM., Chen, S., Sjögren, HO., Wang, P. and Li, S., Assembly of tapasin-associated MHC class I in the absence of the transporter associated with antigen processing (TAP), International Immunology 13 (1) : 23- 37

(2001) Su, J., Naghavi, MH., Jejcic, A., Horal, P., Furuta, Y., Wu, YP., Li, SL., Hall, WW., Goobar-Larsson, L., Svennerholm, B. and Vahlne, A., The tripeptide glycyl-prolyl-glycine amide does not affect the early steps of the human immunodeficiency virus type 1 replication., J Hum Virol 4 (1) : 8- 15 Download publication

(2000) Li, S., Chen, S., Xu, X., Sundstedt, A., Paulsson, KM., Anderson, P., Karlsson, S., Sjögren, HO. and Wang, P., Cytokine-induced Src homology 2 protein (CIS) promotes T cell receptor-mediated proliferation and prolongs survival of activated T cells., J Exp Med 191 (6) : 985- 994 Download publication

(2000) Li, S., Paulsson, KM., Chen, S., Sjögren, HO. and Wang, P., Tapasin is required for efficient peptide binding to transporter associated with antigen processing., J Biol Chem 275 (3) : 1581- 1586 Download publication

(1999) Li, S., Paulsson, KM., Sjögren, HO. and Wang, P., Peptide-bound major histocompatibility complex class I molecules associate with tapasin before dissociation from transporter associated with antigen processing., J Biol Chem 274 (13) : 8649- 8654 Download publication

(1997) Li, S., Sjögren, HO., Hellman, U., Pettersson, RF. and Wang, P., Cloning and functional characterization of a subunit of the transporter associated with antigen processing., Proc Natl Acad Sci U S A 94 (16) : 8708- 8713 Download publication

(1995) Putkonen, P., Walther, L., Zhang, YJ., Li, SL., Nilsson, C., Albert, J., Biberfeld, P., Thorstensson, R. and Biberfeld, G., Long-term protection against SIV-induced disease in macaques vaccinated with a live attenuated HIV-2 vaccine., Nat Med 1 (9) : 914- 918 Download publication

(1995) Li, SL., Kaaya, EE., Ordónez, C., Ekman, M., Feichtinger, H., Putkonen, P., Böttiger, D., Biberfeld, G. and Biberfeld, P., Thymic immunopathology and progression of SIVsm infection in cynomolgus monkeys., J Acquir Immune Defic Syndr Hum Retrovirol 9 (1) : 1- 10 Download publication

(1994) Li, SL., Biberfeld, P. and Ernberg, I., DNA of lymphoma-associated herpesvirus (HVMF1) in SIV-infected monkeys (Macaca fascicularis) shows homologies to EBNA-1, -2 and -5 genes., Int J Cancer 59 (2) : 287- 295 Download publication

(1993) Li, SL., Feichtinger, H., Kaaya, E., Migliorini, P., Putkonen, P., Biberfeld, G., Middeldorp, JM., Biberfeld, P. and Ernberg, I., Expression of Epstein-Barr-virus-related nuclear antigens and B-cell markers in lymphomas of SIV-immunosuppressed monkeys., Int J Cancer 55 (4) : 609- 615 Download publication

(1993) Li, SL., Kaaya, E., Feichtinger, H., Biberfeld, G. and Biberfeld, P., Immunohistochemical distribution of leucocyte antigens in lymphoid tissues of cynomolgus monkeys (Macaca fascicularis)., J Med Primatol 22 (5) : 285- 293 Download publication

(1993) Kaaya, E., Li, SL., Feichtinger, H., Stahmer, I., Putkonen, P., Mandache, E., Mgaya, E., Biberfeld, G. and Biberfeld, P., Accessory cells and macrophages in the histopathology of SIVsm-infected cynomolgus monkeys., Res Virol 144 (1) : 81- 92 Download publication

(1992) Böttiger, D., Ståhle, L., Li, SL. and Oberg, B., Long-term tolerance and efficacy of 3'-azidothymidine and 3'-fluorothymidine treatment of asymptomatic monkeys infected with simian immunodeficiency virus., Antimicrob Agents Chemother 36 (8) : 1770- 1772 Download publication

(1992) Feichtinger, H., Li, SL., Kaaya, E., Putkonen, P., Grünewald, K., Weyrer, K., Böttiger, D., Ernberg, I., Linde, A. and Biberfeld, G., A monkey model for Epstein Barr virus-associated lymphomagenesis in human acquired immunodeficiency syndrome., J Exp Med 176 (1) : 281- 286 Download publication

(1992) Putkonen, P., Kaaya, EE., Böttiger, D., Li, SL., Nilsson, C., Biberfeld, P. and Biberfeld, G., Clinical features and predictive markers of disease progression in cynomolgus monkeys experimentally infected with simian immunodeficiency virus., AIDS 6 (3) : 257- 263 Download publication

(1992) Feichtinger, H., Kaaya, E., Putkonen, P., Li, SL., Ekman, M., Gendelman, R., Biberfeld, G. and Biberfeld, P., Malignant lymphoma associated with human AIDS and with SIV-induced immunodeficiency in macaques., AIDS Res Hum Retroviruses 8 (3) : 339- 348 Download publication

(1991) Mellstedt, H., Frödin, JE., Biberfeld, P., Fagerberg, J., Giscombe, R., Hernandez, A., Masucci, G., Li, SL. and Steinitz, M., Patients treated with a monoclonal antibody (ab1) to the colorectal carcinoma antigen 17-1A develop a cellular response (DTH) to the "internal image of the antigen" (ab2)., Int J Cancer 48 (3) : 344- 349 Download publication

(1991) Li, SL., Kaaya, EE., Feichtinger, H., Putkonen, P., Parravicini, C., Böttiger, D., Biberfeld, G. and Biberfeld, P., Monocyte/macrophage giant cell disease in SIV-infected cynomolgus monkeys., Res Virol 142 (2-3) : 173- 182 Download publication

(1991) Wang, P., Vánky, F., Li, SL., Végh, Z., Persson, U. and Klein, E., Expression of MHC-class-I antigens in human carcinomas and sarcomas analyzed by isoelectric focusing., Int J Cancer Suppl 6 106- 116 Download publication

(1990) Feichtinger, H., Putkonen, P., Parravicini, C., Li, SL., Kaaya, EE., Böttiger, D., Biberfeld, G. and Biberfeld, P., Malignant lymphomas in cynomolgus monkeys infected with simian immunodeficiency virus., Am J Pathol 137 (6) : 1311- 1315 Download publication

(1990) Wang, P., Vánky, F., Li, SL., Patarroyo, M. and Klein, E., Functional characteristics of the intercellular adhesion molecule-1 (CD54) expressed on cytotoxic human blood lymphocytes., Cell Immunol 131 (2) : 366- 380 Download publication

Book Chapters

(2007) Wang, P. and Li, S., Genetic Models: A Powerful Technology for the Study of Cancer. In: Alison, MR. ed. The Cancer Handbook.

(1993) Feichinger, H., Kaaya, E., LI, S., Putkonen, P., Ekman, M., Mandache, E., Grunewald, K., Biberfeld, G. and Biberfeld, P., Pathology of the lymphoid system in cynomolgus monkeys infected with SIVsm. In: Racz, P., Letvin, NL. and Gluckman, JC. eds. Animal Models of HIV and Other Retroviral infection. Basel : Karger 49- 63