What do we do?
- Cellular and Organismal Ageing – understanding the biological basis underlying the ageing process.
- Genome Organisation – understanding how chromosomes are organised within the cell nucleus.
- Nuclear and Genomic Health – understanding how disruption to factors that regulate genome organisation can lead to disease.
- Embryonic Development – how the organisation of the genome alters during embryonic growth.
- Stem Cells – new technologies to use stem cells in muscle and neural regeneration. How to ensure the quality of stem cell cultures.
- Mechanisms of Chromosome Rearrangement – identifying mechanisms that lead to breakage and inappropriate rejoining of parts of chromosomes following damage.
- Chromosome Rearrangements in Cancer/Leukaemia – understanding how breakage and joining of chromosomes leads to cancer.
- Wnt signalling in Cancer and Development – understanding intracellular signalling pathways that govern embryonic development and, when they operate inappropriately, can cause cancer.
- The Cellular Biology of Bone – understanding the normal process of bone production and how the different cell types present in bone signal to one-another.
- Biomaterials – generation of novel materials for use in wound repair and tissue augmentation.
Trinucleotide Repeat Disorders – understanding the genetics, cell biology and chromosome biology involved in this class of inherited genetic disorder.
Breast Cancer - The role of Brk/PTK6 in breast carcinoma development and metastasis.
The CCCB is also host to the Progeria research fund
We have well equipped laboratories for tissue culture, molecular biology, confocal microscopy, live cell imaging, microdissection, 3-D image analysis and histology. We hold regular meetings of the CCCB Club where we discuss individual projects, new journal articles and practical issues of the group.