Cardiovascular Physiology Research Group
The research of the cardiovascular group primarily seeks to further our fundamental understanding of the cardiovascular determinants of human exercise performance and the factors regulating skeletal muscle blood flow and cardiac function during exercise and environmental stress.
An important discovery is that insufficient oxygen supply to exercising muscles and brain is a major limiting factor to exercise performance. This phenomenon is closely associated with limitations in stroke volume and increases in sympathetic nerve vasoconstrictor activity (see Figure 1, Cardiovascular Determinants of Exercise Performance).
The group has also made important contributions to the understanding of the role of the red blood cell and intravascular ATP in the regulation of the local processes matching the supply of oxygen to increases in metabolic demand in skeletal muscles in conditions of hypoxia, heat stress and dehydration (see Figure 2, Mechanisms of Erythrocyte Control of Oxygen Delivery).
Cardiovascular Determinants of Exercise Performance
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Mechanisms of Erythrocyte Control of Oxygen Delivery
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Staff Profiles
- Professor José González-Alonso
- Dr Kameljit Kalsi
- Dr Richard Godfrey
- Dr Carl Huston
- Associates: Mrs Leena Ali, Mr Horace Barker, Prof. Tom Smolenski, Prof. Niels Secher
Highlighted Publications
PROF. JOSÉ GONZÁLEZ-ALONSO
1. González-Alonso J, Mortensen SP, Jeppensen TD, Ali L, Barker H, Damsgaard R, Secher NH, Dawson EA & Dufour SP (2008). Haemodynamic responses to exercise, ATP infusion and thigh compression in humans: Insight into the role of muscle mechanisms on cardiovascular function. Journal of Physiology 586, 2405-2417. (Download PDF) (Download Perspective Article PDF)
2. Dufour SP, Patel RP, Brandon A, Teng X, Pearson J, Barker H, Ali L, Yuen AH, Smolenski RT, González-Alonso J (2010). Erythrocyte dependent regulation of human skeletal muscle blood flow: Role of varied oxyhemoglobin and exercise on nitrite, S-nitrosohemoglobin and ATP. American Journal of Physiol ogy Heart Circulatory Physiology 299: H1936-1946. (Download PDF)
3. Rosenmeier J, Yegutkin GG & González-Alonso J (2008). Activation of the ATP/UTP selective receptors increases blood flow and blunts sympathetic vasoconstriction in human skeletal muscle. Journal of Physiology 586, 4993-5002. (Download PDF) (Download Perspective Article PDF)
4. Mortensen SP, Damsgaard R, Dawson EA, Secher N & González-Alonso J (2008). Restrictions in systemic and locomotor skeletal muscle perfusion, oxygen supply and VO2 during high-intensity whole-body exercise in humans. Journal of Physiology 586, 2621-2635. (Download PDF)
DR. KAMELJIT KALSI
1. Kalsi K and González-Alonso J (2012). Temperature-dependent release of ATP from human erythrocytes: Mechanism for the control of local tissue perfusion. Experimental Physiology. expphysiol.2011.064238; published ahead of print January 6, 2012, doi:10.1113/expphysiol.2011.064238
2. Laitano O, Kalsi KK,Pearson J, Lotlikar M, Oliveira AR, González-Alonso J (2011) Effects of graded exercise-induced dehydration and rehydration on circulatory markers of oxidative stress across the resting and exercising human leg. European Journal of Applied Physiology.DOI 10.1007/s00421-011-2170-2
3. Pearson J, Low DA, Stöhr EJ, Kalsi K, Ali L, Barker H, González-Alonso J (2011). Hemodynamic responses to heat stress in the resting and exercising human leg: Insight into the effect of temperature on skeletal muscle blood flow. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300(3):R663-673. (Download PDF)
4.Laitano O, Kalsi KK, Pook M, Oliveira AR, González-Alonso J. (2010) Separate and combined effects of heat stress and exercise on circulatory markers of oxidative stress in euhydrated humans. European Journal of Applied Physiology. 110(5): 953-60. (Abstract)
DR. RICHARD GODFREY
1. Godfrey RJ, Whyte GP, Buckley J, Quinlivan R. (2009). The role of lactate in the exercise-induced human growth hormone response: evidence from McArdle's disease. Br J Sports Med. 43, 521-525.
2. Kay RG, Barton C, Velloso CP, Brown PR, Bartlett C, Blazevich AJ, Godfrey RJ, Goldspink G, Rees R, Ball GR, Cowan DA, Harridge SD, Roberts J, Teale P and Creaser CS. (2009). High-throughput ultra-high-performance liquid chromatography/tandem mass quantitation of insulin-like growth factor-1 and leucine-rich ?-2-glycoprotein in serum as biomarkers of recombinant human growth hormone administration. Rapid Commun. Mass Spectrom. 23, 3173-3182.
3. Wilson M, O’Hanlon R, Prasad S, Oxborough D, Godfrey R, Alpendurada F, Smith G, Wong J, Basavarajaiah S, Sharma S, Nevill A, Gaze D, George K, Whyte G. (2009). Biological markers of cardiac damage are not related to measures of cardiac systolic and diastolic function using cardiovascular magnetic resonance (CMR) and echocardiography following an acute bout of prolonged endurance exercise. Br J Sports Med: Online First 23rd Oct 2009. doi:10.1136/bjsm2009.064089.
4. Whyte G, Godfrey R, O'Hanlon R, Wilson M, Buckley J, Sharma S (2009). Acute myocardial infarction in the presence of normal coronaries and the absence of risk factors in a young, life-long regular exercisers. BMJ Case Reports 2009; doi:10.1136/bcr.07.2008.0384.
DR. CARL HULSTON
1. Carl J Hulston, Emil Wolsk, Thomas Sahl Grøndahl, Christina Yfanti and Gerrit van Hall. (2011) Protein intake does not increase vastus lateralis muscle protein synthesis during cycling. Med Sci Sports Exerc. [Feb 28th. Epub ahead of print]. DOI: 10.1249/MSS.0b013e31821661ab2. Niels Vidiendal Olsen, Niels-Jacob Aachmann-Andersen, Peter Oturai, Thor Munch-Andersen, Andreas Bornø, Carl J Hulston, Niels-Henrik Holstein-Rathlou, Paul Robach and Carsten Lundby. (2011) Recombinant human erythropoietin in humans down-regulates proximal renal tubular reabsorption and causes a fall in glomerular filtration rate. J Physiol. 589: 1273-1281
3. Carl J Hulston, Michelle C Venables, Christopher H Mann, Cara Martin, Andrew Philp, Keith Baar and Asker E Jeukendrup. (2010) Training with low muscle glycogen enhances fat metabolism in well-trained cyclists. Med Sci Sports Exerc. 42(11): 2046-2055
