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Summary

Hanieh is a lecturer in genetics of cardiometabolic disorders. She obtained her PhD in 2013 in genetics of human complex traits from University of Exeter. In 2017, she was awarded a prestigious Diabetes UK RD Lawrence fellowship to study healthy fat genes or genes associated with a favourable adiposity phenotype. Hanieh leads genetic studies to understand what protects some obese people from developing Type 2 diabetes. She uses MRI scans of abdominal fat to understand how certain genes influence the way we store fat and if they can protect people from developing Type 2 diabetes or other cardiometabolic diseases. She is also using genetics to unravel the aetiology of cardiometabolic diseases and their links. She has been using different methods from Mendelian randomization studies to more sophisticated clustering analysis to find causal directions between biomarkers (such as body fat distribution, adiponectin, lipids etc) and risk of cardiometabolic diseases.

Qualifications

MD, MSc, PhD

Newest selected publications

Martin, S., Tyrrell, J., Thomas, EL., Bown, MJ., Wood, AR., Beaumont, RN., et al. (2022) 'Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation'. eLife, 11. pp. 1 - 32. ISSN: 2050-084X Open Access Link

Journal article

Martin, S., Sorokin, EP., Thomas, EL., Sattar, N., Cule, M., Bell, JD. and et al. (2021) 'Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study'. Diabetes Care, 0 (in press). pp. 1 - 9. ISSN: 0149-5992 Open Access Link

Journal article

Heald, AH., Martin, S., Fachim, H., Green, HD., Young, KG., Malipatil, N., et al. (2021) 'Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile'. Diabetic Medicine, 38 (9). pp. e14531. ISSN: 0742-3071

Journal article

Martin, S., Cule, M., Basty, N., Tyrrell, J., Beaumont, RN., Wood, AR., et al. (2021) 'Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease'. Diabetes, 70 (8). pp. 1843 - 1856. ISSN: 0012-1797

Journal article

Rob Taal, H., St Pourcain, B., Thiering, E., Das, S., Mook-Kanamori, DO., Warrington, NM., et al. (2021) 'Common variants at 12q15 and 12q24 are associated with infant head circumference'. Nature Genetics, 44 (5). pp. 532 - 538. ISSN: 1061-4036

Journal article
More publications(62)