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Dr Mark Pook

Dr Mark Pook
Reader in Biosciences


Dr Mark Pook graduated with a BSc (Hons) Genetics from the University of Leeds in 1985 and a PhD in Medical Genetics from the University of Manchester in 1990. He then undertook post-doctoral appointments in the MRC Molecular Medicine Group, RPMS, Hammersmith Hospital from 1989-1993 and the Cell and Molecular Biology Section, Imperial College London from 1993-2002. He was appointed as Lecturer in Genetics at Imperial College London from 2002-2005. He then transferred to Brunel University as a Lecturer in Biosciences from 2005-2007. He was promoted to Senior Lecturer in Biosciences from 2007-2012 and then Reader in Biosciences from 2012 to present.




Committee Responsibilities:

  • College Research Ethics Committee
  • College Human Tissue Authority (HTA) Person Designate
  • University Animal Welfare and Ethical Review Board (AWERB)
  • University HTA-Compliance Committee

Administration Responsibilities:

  • Mitigating Circumstances Chair
  • Biosciences Research Ethics Representative
  • Royal Literary Fund Fellow coordinator


Teaching Interests:

Molecular Genetics


Neurodegenerative diseases

Trinucleotide Repeat Expansion Diseases

Newest selected publications

Kemp, KC., Cerminara, N., Hares, K., Redondo, J., Cook, AJ., Haynes, HR., et al. (2016) 'Cytokine therapy-mediated neuroprotection in a Friedreich's ataxia mouse model.'. Annals of neurology, 81 (2). pp. 212 - 226. ISSN: 0364-5134 Open Access Link

Journal article

Themis, M., Khonsari, H., Pook, M., Parris, C., Al-Mahdawi, S., Gozaly Chianea, Y. and et al. (2016) 'Lentivirus-meditated frataxin gene delivery reverses genome instability in Friedreich ataxia patient and mouse model fibroblasts'. Nature Gene Therapy, 23 (12). pp. GT-2015-00164R - GT-2015-00164R. ISSN: 0969-7128 Open Access Link

Journal article

Crombie, DE., Van Bergen, N., Davidson, KC., Anjomani Virmouni, S., Mckelvie, PA., Chrysostomou, V., et al. (2015) 'Characterization of the retinal pigment epithelium in Friedreich ataxia'. Biochemistry and Biophysics Reports, 4. pp. 141 - 147. ISSN: 2405-5808 Open Access Link

Journal article

Chutake, YK., Costello, WN., Lam, CC., Parikh, AC., Hughes, TT., Michalopulos, MG., et al. (2015) 'FXN Promoter Silencing in the Humanized Mouse Model of Friedreich Ataxia'. PLOS ONE, 10 (9). pp. e0138437 - e0138437. ISSN: 1932-6203 Open Access Link

Journal article

Abeti, R., Uzun, E., Renganathan, I., Honda, T., Pook, MA. and Giunti, P. (2015) 'Targeting lipid peroxidation and mitochondrial imbalance in Friedreich's ataxia'. Pharmacological Research, 99. pp. 344 - 350. ISSN: 1043-6618 Open Access Link

Journal article
More publications(48)