Development of mechanisms-based human epithelial cell transformation assays for carcinogen screening employing defined phenotypic endpoints mechanistically representative of rate-limiting events in human carcinogenesis
Funder: National Centre for the Replacement Refinement and Reduction of Animals in Research (NC3Rs)Duration: March 2012 - February 2015
People
| Name | Telephone | Office | ||
|---|---|---|---|---|
|
Professor Robert Newbold Honorary Professor - Life Sciences (Principal investigator)
T: +44 (0)1895 266290
E: robert.newbold@brunel.ac.uk |
+44 (0)1895 266290 | robert.newbold@brunel.ac.uk | Heinz Wolff 103 |
Outputs
Linne, H., Yasaei, H., Marriott, A., Harvey, A., Mokbel, K., Newbold, R. and et al. (2017) 'Functional role of SETD2, BAP1, PARP-3 and PBRM1 candidate genes on the regulation of hTERT gene expression'. Oncotarget, 8 (37). pp. 61890 - 61900. ISSN: 1949-2553 Open Access Link
Newbold, RF., Pickles, JC., Pant, K., McGinty, LA., Yasaei, H., Roberts, T. and et al. (2016) 'A mechanistic evaluation of the Syrian hamster embryo cell transformation assay (pH 6.7) and molecular events leading to senescence bypass in SHE cells'. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 802 (May 2016). pp. 50 - 58. ISSN: 1383-5718 Open Access Link