Investigating the dysfunction of the cerebral microvasculature in sickle cell disease
Funder: 1. The National Institute of Health/National Heart, Lung and Blood Institute (NIH/NHLBI)Duration: April 2017 - April 2021
People
| Name | Telephone | Office | ||
|---|---|---|---|---|
|
Professor Felicity Gavins Professor - Pharmacology (Principal investigator)
T: +44 (0)1895 267151
E: felicity.gavins@brunel.ac.uk |
+44 (0)1895 267151 | felicity.gavins@brunel.ac.uk | Heinz Wolff 111 |
Outputs
Ansari, J., Senchenkova, EY., Vital, SA., Al-Yafeai, Z., Kaur, G., Sparkenbaugh, E., et al. (2021) 'Targeting AnxA1/Fpr2/ALX Regulates Neutrophil Function Promoting Thrombo-Inflammation Resolution in Sickle Cell Disease'. Blood, 137 (11). pp. 1538 - 1549. ISSN: 0006-4971 Open Access Link
Senchenkova, EY., Ansari, J., Becker, F., Vital, SA., Al-Yafeai, Z., Sparkenbaugh, EM., et al. (2019) 'Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation'. Circulation, 140 (4). pp. 319 - 335. ISSN: 0009-7322 Open Access Link
Senchenkova, EY., Russell, J., Yildirim, A., Granger, DN. and Gavins, FNE. (2019) 'Novel Role of T Cells and IL-6 (Interleukin-6) in Angiotensin II–Induced Microvascular Dysfunction'. Hypertension, 73 (4). pp. 829 - 838. ISSN: 0194-911X Open Access Link
Al-Kofahi, M., Omura, S., Tsunoda, I., Sato, F., Becker, F., Gavins, FNE., et al. (2018) 'IL-1β reduces cardiac lymphatic muscle contraction via COX-2 and PGE2 induction: Potential role in myocarditis'. Biomedicine & Pharmacotherapy, 107 (November 2018). pp. 1591 - 1600. ISSN: 0753-3322 Open Access Link
Gillespie, S., Holloway, PM., Becker, F., Rauzi, F., Vital, SA., Taylor, KA., et al. (2018) 'The isothiocyanate sulforaphane modulates platelet function and protects against cerebral thrombotic dysfunction'. British Journal of Pharmacology, 175 (16). pp. 3333 - 3346. ISSN: 0007-1188
Ansari, J., Moufarrej, YE., Pawlinski, R. and Gavins, FNE. (2018) 'Sickle cell disease: a malady beyond a hemoglobin defect in cerebrovascular disease'. Expert Review of Hematology, 11 (1). pp. 45 - 55. ISSN: 1747-4086 Open Access Link
Becker, F., Holthoff, C., Anthoni, C., Rijcken, E., Alexander, JS., Gavins, FNE., et al. (2016) 'Downregulation of CX3CR1 ameliorates experimental colitis: evidence for CX3CL1-CX3CR1-mediated immune cell recruitment'. International Journal of Colorectal Disease, 32 (3). pp. 315 - 324. ISSN: 0179-1958
Vital, SA. and Gavins, FNE. (2016) 'Surgical Approach for Middle Cerebral Artery Occlusion and Reperfusion Induced Stroke in Mice'. Journal of Visualized Experiments, 2016 (116). pp. 1 - 9. ISSN: 1940-087X Open Access Link
Becker, F., Kurmaeva, E., Gavins, FNE., Stevenson, EV., Navratil, AR., Jin, L., et al. (2016) 'A Critical Role for Monocytes/Macrophages During Intestinal Inflammation-associated Lymphangiogenesis'. Inflammatory Bowel Diseases, 22 (6). pp. 1326 - 1345. ISSN: 1078-0998