Mechanistic Investigation of Histone Acetyl-transferase KAT2A in Acute Myeloid Leukaemia
Funder: Rosetrees TrustDuration: April 2017 - March 2020
PhD studentship to Liliana Jesus Arede (University of Cambridge)
Outputs
Arede, L., Foerner, E., Wind, S., Kulkarni, R., Domingues, AF., Giotopoulos, G., et al. (2021) 'KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia'. Blood advances, 6 (1). pp. 165 - 180. ISSN: 2473-9529 Open Access Link
Arede, L. and Pina, C. (2020) 'Buffering noise: KAT2A modular contributions to stabilization of transcription and cell identity in cancer and development'. Experimental Hematology, 93. pp. 25 - 37. ISSN: 0301-472X Open Access Link
Domingues, AF., Kulkarni, R., Giotopoulos, G., Gupta, S., Vinnenberg, L., Arede, L., et al. (2020) 'Loss of Kat2a Enhances Transcriptional Noise and depletes Acute Myeloid Leukaemia Stem-like Cells'. eLife, 9. pp. 1 - 29. ISSN: 2050-084X Open Access Link