The Role of Genetic, Epigenetic and Transcriptional Heterogeneities in Pre-leukaemia to Leukaemia Progression in AML
Funder: Lady Tata Memorial TrustDuration: October 2017 - September 2020
PhD Studentship to Shikha Gupta (University of Cambridge)
Outputs
Gupta, S., Dovey, OM., Domingues, AF., Cyran, OW., Cash, CM., Giotopoulos, G., et al. (2022) 'Transcriptional variability accelerates pre-leukemia by cell diversification and perturbation of protein synthesis'. Science advances, 8 (31). pp. 1 - 15. ISSN: 2375-2548 Open Access Link
Domingues, AF., Kulkarni, R., Giotopoulos, G., Gupta, S., Vinnenberg, L., Arede, L., et al. (2020) 'Loss of Kat2a Enhances Transcriptional Noise and depletes Acute Myeloid Leukaemia Stem-like Cells'. eLife, 9. pp. 1 - 29. ISSN: 2050-084X Open Access Link