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Professor Robert Newbold

Professor Robert Newbold
Honorary Professor - Life Sciences

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Yasaei, H., Gilham, E., Pickles, JC., Roberts, TP., O'Donovan, M. and Newbold, RF. (2012) 'Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells'. Oncogene, 32 (2). pp. 171 - 179. ISSN: 0950-9232

Journal article

Creton, S., Aardema, MJ., Carmichael, PL., Harvey, JS., Martin, FL., Newbold, RF., et al. (2012) 'Cell transformation assays for prediction of carcinogenic potential: state of the science and future research needs'. Mutagenesis, 27 (1). pp. 93 - 101. ISSN: 0267-8357 Open Access Link

Journal article

Patani, N., Jiang, W., Newbold, R. and Mokbel, K. (2010) 'Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer'. Journal of Carcinogenesis, 9 (Online Paper). pp. 9 - 9. ISSN: 1477-3163 Open Access Link

Journal article

Newbold, RF. and Mokbel, K. (2010) 'Evidence for a tumour suppressor function of SETD2 in human breast cancer: a new hypothesis.'. Anticancer Res, 30 (9). pp. 3309 - 3311. ISSN: 0250-7005

Journal article

Loizidou, MA., Cariolou, MA., Neuhausen, SL., Newbold, RF., Bashiardes, E., Marcou, Y., et al. (2010) 'Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population'. Breast Cancer Research and Treatment, 121 (1). pp. 147 - 156. ISSN: 0167-6806 Open Access Link

Journal article

Al Sarakbi, W., Reefy, S., Jiang, WG., Roberts, T., Newbold, RF. and Mokbel, K. (2010) 'Evidence of a tumour suppressor function for DLEC1 in human breast cancer'. Anticancer Res., 30 (4). pp. 1079 - 1082. ISSN: 0250-7005

Journal article

Abbaszadeh, F., Clingen, PH., Arlett, C., Plowman, PN., Bourton, EC., Themis, M., et al. (2010) 'A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitvity in a xeroderma pigmentosum patient'. Journal of Medical Genetics, 46 (11). pp. 1 - 24. ISSN: 0022-2593 Open Access Link

Journal article

Al Sarakbi, W., Sasi, W., Jiang, WG., Roberts, W., Newbold, RF. and Mokbel, K. (2009) 'Gene transcripts in the tumour suppressor region of chromosome 3 (3p21)'.32nd Annual San Antonio Breast Cancer Symposium. San Antonio, TX. 9 - 13 December. AMER ASSOC CANCER RESEARCH. pp. 869S - 869S. ISSN: 0008-5472

Conference paper

Dafou, D., Ramus, SJ., Choi, K., Grun, B., Trott, DA., Newbold, RF., et al. (2009) 'Chromosomes 6 and 18 induce neoplastic suppression in epithelial ovarian cancer cells'. International Journal of Cancer, 124 (5). pp. 1037 - 1044. ISSN: 1097-0215 Open Access Link

Journal article

Loizidou, MA., Michael, T., Neuhausen, SL., Newbold, RF., Marcou, Y., Kakouri, E., et al. (2009) 'DNA-repair genetic polymorphisms and risk of breast cancer in Cyprus'. Breast Cancer Research and Treatment, 115 (3). pp. 623 - 627. ISSN: 0167-6806 Open Access Link

Journal article

Al Sarakbi, W., Sasi, W., Jiang, WG., Roberts, T., Newbold, RF. and Mokbel, K. (2009) 'The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters'. BMC Cancer, 9 (1). pp. 290. ISSN: 1471-2407 Open Access Link

Journal article

Patani, N., Jiang, W., Mansel, R., Newbold, R. and Mokbel, K. (2009) 'The mRNA expression of SATB1 and SATB2 in human breast cancer'. Cancer Cell International, 9 (1). pp. 18. ISSN: 1475-2867 Open Access Link

Journal article

Loizidou, MA., Michael, T., Neuhausen, SL., Newbold, RF., Marcou, Y., Kakouri, E., et al. (2008) 'Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus'. Breast Cancer Research and Treatment, 112 (3). pp. 575 - 579. ISSN: 0167-6806 Open Access Link

Journal article

Coelho, D., Suormala, T., Stucki, M., Lerner-Ellis, JP., Rosenblatt, DS., Newbold, RF., et al. (2008) 'Gene identification for the cblD defect of vitamin B12 metabolism'. New England Journal of Medicine, 358 (14). pp. 1454 - 1464. ISSN: 1533-4406 Open Access Link

Journal article

Meaburn, KJ., Newbold, RF. and Bridger, JM. (2008) 'Positioning of human chromosomes in murine cell hybrids according to synteny'. Chromosoma, 117 (6). pp. 579 - 591. ISSN: 1432-0886 Open Access Link

Journal article

Salhab, M., Jiang, WG., Newbold, RF. and Mokbel, K. (2008) 'The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome'. Breast Cancer Research and Treatment, 109 (1). pp. 35 - 46. ISSN: 0167-6806 Open Access Link

Journal article

Sugiana, C., Pagliarini, DJ., McKenzie, M., Kirby, DM., Salemi, R., Abu-Amero, KK., et al. (2008) 'Mutation of C20orf7 disrupts complex I assembly and causes lethal neonatal mitochondrial disease'. The American Journal of Human Genetics, 83 (4). pp. 468 - 478. ISSN: 0002-9297 Open Access Link

Journal article

Worku, D., Jouhra, F., Jiang, GW., Patani, N., Newbold, RF. and Mokbel, K. (2008) 'Evidence of a tumour suppressive function of E2F1 gene in human breast cancer'. Anticancer Research, 28 (4B). pp. 2135 - 2139. ISSN: 0250-7005 Open Access Link

Journal article

Mansfield, L., Subramanian, A., Devalia, H., Jiang, W., Newbold, RF. and Mokbel, K. (2007) 'hTERT mRNA expression correlates with matrix metalloproteinase-1 and vascular endothelial growth factor expression in human breast cancer: A correlative study using RT-PCR'. ANTICANCER RESEARCH, 27 (4B). pp. 2265 - 2268. ISSN: 0250-7005

Journal article

Newbold, RF., Hadjiavvas, A., Loizidou, M., Marcou, Y., Anastasiadou, V. and Kyriacou, K. (2007) 'Contribution of BRCA1 and BRCA2 germline mutations to the incidence of early-onset breast cancer in Cyprus'. Clinical Genetics, 71 (2). pp. 165 - 170. ISSN: 0009-9163 Open Access Link

Journal article

Elkak, A., Mokbel, R., Wilson, C., Jiang, WG., Newbold, RF. and Mokbel, K. (2006) 'hTERT mRNA expression is associated with a poor clinical outcome in human breast cancer'. Anticancer Research, 26 (6C). pp. 4901 - 4904. ISSN: 0250-7005

Journal article

Elkak, AE., Meligonis, G., Salhab, M., Mitchell, B., Blake, JR., Newbold, RF. and et al. (2005) 'hTERT protein expression is independent of clinicopathological parameters and c-Myc protein expression in human breast cancer'. Journal of Carcinogenesis, 4 (1). pp. 17 - 17. ISSN: 1477-3163 Open Access Link

Journal article

Leris, AC., Roberts, TR., Jiang, WG., Newbold, RF. and Mokbel, K. (2005) 'Evidence for a tumour suppressive function of APRG1 in breast cancer.'. Breast Cancer Res Treat, 93 (2). pp. 97 - 100. ISSN: 0167-6806 Open Access Link

Journal article

Leris, AC., Roberts, TR., Jiang, WG., Newbold, RF. and Mokbel, K. (2005) 'WNT5A expression in human breast cancer'. Anticancer Research: international journal of cancer research and treatment, 25 (2A). pp. 731 - 734. ISSN: 0250-7005

Journal article

Dafou, D., Trott, DA., Newbold, RF., Jacobs, IJ. and Gayther, SA. (2004) 'Establishing a cell biology model of suppression in epithelial ovarian cancer'.44th Annual Meeting of the American-Society-for-Cell-Biology. Washington, DC. 4 - 8 December. AMER SOC CELL BIOLOGY. pp. 250A - 250A. ISSN: 1059-1524

Conference paper

Newbold, RF., Coenen, MJH., Antonicka, H., Ugalde, C., Sasarman, F., Rossi, R., et al. (2004) 'Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency'. New England Journal of Medicine, 351 (20). pp. 2080 - 2086. ISSN: 1533-4406 Open Access Link

Journal article

Flanagan, JM., Healey, S., Young, J., Whitehall, V., Trott, DA., Newbold, RF. and et al. (2004) 'Mapping of a candidate colorectal cancer tumor-suppressor gene to a 900-kilobase region on the short arm of chromosome 8'. Genes Chromosomes Cancer, 40 (3). pp. 247 - 260. ISSN: 1045-2257 Open Access Link

Journal article

Dafou, D., Li, NF., Trott, DA., Jacobs, IJ., Gayther, SA. and Newbold, RF. (2004) 'In vitro model of malignant transformation for the identification of genes in breast cancer formation'.British Cancer Research Meeting 2004. Manchester, ENGLAND. 27 - 30 June. NATURE PUBLISHING GROUP. pp. S74 - S74. ISSN: 0007-0920

Conference paper

Kirkpatrick, KL., Newbold, RF. and Mokbel, K. (2004) 'There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer'. International Seminars in Surgical Oncology, 1 (1). pp. 2 - 2. ISSN: 1477-7800 Open Access Link

Journal article

Kirkpatrick, KL., Newbold, RF. and Mokbel, K. (2004) 'The mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression'. Journal of Carcinogenesis, 3 (1). pp. 1 - 1. ISSN: 1477-3163 Open Access Link

Journal article

Newbold, RF., Cabury, E., Newton, C., Roberts, T. and Slijepcevic, P. (2004) 'Identification of subpopulations of cells with differing telomere lengths in mouse and human cell lines by flow FISH'. Cytometry, 62 (2). pp. 150 - 161. ISSN: 0196-4763 Open Access Link

Journal article

Themis, M., May, D., Coutelle, C. and Newbold, RF. (2003) 'Mutational effects of retrovirus insertion on the genome of V79 cells by an attenuated retrovirus vector: Implications for gene therapy'. Gene Therapy, 10 (19). pp. 1703 - 1711. ISSN: 0969-7128

Journal article

Elkak, AE., Newbold, RF., Thomas, V. and Mokbel, K. (2003) 'Is telomerase reactivation associated with the down-regulation of TGF beta receptor-II expression in human breast cancer?'. Cancer Cell International, 3 (1). pp. 9 - 9. ISSN: 1475-2867 Open Access Link

Journal article

Chastain-Moore, AM., Roberts, T., Trott, DA., Newbold, RF. and Ornelles, DA. (2003) 'An activity associated with human chromosome 21 permits nuclear colocalization of the adenovirus E1B-55K and E4orf6 proteins and promotes viral late gene expression'. Journal of Virology, 77 (14). pp. 8087 - 8098. ISSN: 0022-538X Open Access Link

Journal article

Newbold, RF., Cosma, MP., Pepe, S., Annunziata, I., Grompe, M., Parenti, G. and et al. (2003) 'The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases'. Cell, 113 (4). pp. 445 - 456. ISSN: 0092-8674 Open Access Link

Journal article

Kirkpatrick, KL., Clark, G., Ghilchick, M., Newbold, RF. and Mokbel, K. (2003) 'hTERT mRNA expression correlates with telomerase activity in human breast cancer'. EJSO - European Journal of Surgical Oncology, 29 (4). pp. 321 - 326. ISSN: 0748-7983

Journal article

Mokbel, K. and Newbold, RF. (2003) 'Re: Poremba et al Telomerase as a prognostic marker in breast cancer: High-throughput tissue microarray analysis of hTERT and hTR. J Pathol 2002; 198: 181-189'. Journal of Pathology, 199 (4). pp. 542. ISSN: 0022-3417

Journal article

Fitzsimmons, SA., Ireland, H., Barr, NI., Cuthbert, AP., Going, JJ., Newbold, RF. and et al. (2003) 'Human squamous cell carcinomas lose a mortality gene from chromosome 6q14.3 to q15'. Oncogene, 22 (11). pp. 1737 - 1746. ISSN: 0950-9232 Open Access Link

Journal article

Kirkpatrick, KL., Ogunkolade, W., Elkak, AE., Bustin, S., Jenkins, P., Ghilchick, M., et al. (2003) 'hTERT expression in human breast cancer and non-cancerous breast tissue: correlation with tumour stage and c-Myc expression'. Breast Cancer Res Treat, 77 (3). pp. 277 - 284. ISSN: 0167-6806

Journal article

Wilson, P., Cuthbert, A., March, A., Arnold, J., Flanagan, J., Mulford, C., et al. (2003) 'Transfer of chromosome 8 into two breast cancer cell lines: Total exclusion of three regions indicates location of putative in vitro growth suppressor genes'. Cancer Genetics and Cytogenetics, 143 (2). pp. 100 - 112. ISSN: 0165-4608 Open Access Link

Journal article

Szutorisz, H., Lingner, J., Cuthbert, AP., Trott, DA., Newbold, RF. and Nabholz, M. (2003) 'A chromosome 3-encoded repressor of the Human Telomerase Reverse Transcriptase (hTERT) gene controls the state of hTERT chromatin'. Cancer Research, 63 (3). pp. 689 - 695. ISSN: 0008-5472 Open Access Link

Journal article

Newbold, RF. (2002) 'The significance of telomerase activation and cellular immortalization in human cancer'. Mutagenesis, 17 (6). pp. 539 - 550. ISSN: 0267-8357

Journal article

Bryce, SD., Morrison, V., Craig, NJ., Forsyth, NR., Fitzsimmons, SA., Ireland, H., et al. (2002) 'A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23'. Neoplasia, 4 (6). pp. 544 - 550. ISSN: 1522-8002 Open Access Link

Journal article

Forsyth, NR., Morrison, V., Craig, NJ., Fitzsimmons, SA., Barr, NI., Ireland, H., et al. (2002) 'Functional evidence for a squamous cell carcinoma mortality gene(s) on human chromosome 4'. Oncogene, 21 (33). pp. 5135 - 5147. ISSN: 0950-9232 Open Access Link

Journal article

Wilding, J., Meijne, E., Haines, J., Moody, J., Edwards, A., Newbold, RF., et al. (2002) 'Functional evidence from microcell-mediated chromosome transfer of myeloid leukemia suppressor genes on human chromosomes 7 and 11'. Genes, Chromosomes and Cancer, 34 (4). pp. 390 - 397. ISSN: 1045-2257

Journal article

Boulos, N., Newbold, RF., Trott, DA., Pearson, ADJ., Tilby, MJ. and Lunec, J. (2002) 'Functional complementation analysis of chromosome 1 in neuroblastoma'. BRITISH JOURNAL OF CANCER, 86. pp. S91 - S91. ISSN: 0007-0920

Journal article

Cosma, MP., Pepe, S., Parenti, G., Belli, A., Mankad, A., Grompe, M., et al. (2002) 'Mapping of the gene for multiple sulfatase deficiency (MSD) by functional complementation using microcell-mediated chromosome transfer'.European-Society-of-Human-Genetics European Human Genetics Conference in Conjuction With European Meeting on Psychosocial Aspects of Genetics. STRASBOURG, FRANCE. 25 - 28 May. NATURE PUBLISHING GROUP. pp. 207 - 208. ISSN: 1018-4813

Conference paper

Ducrest, AL., Amacker, M., Mathieu, YD., Cuthbert, AP., Trott, DA., Newbold, RF., et al. (2001) 'Regulation of human telomerase activity: Repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity'. Cancer Research, 61 (20). pp. 7594 - 7602. ISSN: 0008-5472 Open Access Link

Journal article

Goodarzi, G., Mashimo, T., Watabe, M., Cuthbert, AP., Newbold, RF., Pai, SK., et al. (2001) 'Identification of tumor metastasis suppressor region on the short arm of human chromosome 20'. Genes Chromosomes Cancer, 32 (1). pp. 33 - 42. ISSN: 1045-2257

Journal article

Hadjisavvas, A., Neuhausen, SL., Hoffman, MD., Adamou, A., Newbold, RF., Kyriacou, KC. and et al. (2001) 'BRCA1 germline mutations in Cypriot breast cancer patients from 26 families with family history'. Anticancer Research, 21 (5). pp. 3307 - 3311. ISSN: 0250-7005

Journal article