Professor Robert Newbold
Honorary Professor - Life Sciences
Heinz Wolff 103
- Email: robert.newbold@brunel.ac.uk
- Tel: +44 (0)1895 266290
Creton, S., Aardema, MJ., Carmichael, PL., Harvey, JS., Martin, FL., Newbold, RF., et al. (2012) 'Cell transformation assays for prediction of carcinogenic potential: state of the science and future research needs'. Mutagenesis, 27 (1). pp. 93 - 101. ISSN: 0267-8357 Open Access Link
Yasaei, H., Gilham, E., Pickles, JC., Roberts, TP., O'Donovan, M. and Newbold, RF. (2012) 'Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells'. Oncogene, 32 (2). pp. 171 - 179. ISSN: 0950-9232
Patani, N., Jiang, W., Newbold, R. and Mokbel, K. (2010) 'Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer'. Journal of Carcinogenesis, 9 (Online Paper). pp. 9 - 9. ISSN: 1477-3163 Open Access Link
Newbold, RF. and Mokbel, K. (2010) 'Evidence for a tumour suppressor function of SETD2 in human breast cancer: a new hypothesis.'. Anticancer Res, 30 (9). pp. 3309 - 3311. ISSN: 0250-7005
Loizidou, MA., Cariolou, MA., Neuhausen, SL., Newbold, RF., Bashiardes, E., Marcou, Y., et al. (2010) 'Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population'. Breast Cancer Research and Treatment, 121 (1). pp. 147 - 156. ISSN: 0167-6806 Open Access Link
Al Sarakbi, W., Reefy, S., Jiang, WG., Roberts, T., Newbold, RF. and Mokbel, K. (2010) 'Evidence of a tumour suppressor function for DLEC1 in human breast cancer'. Anticancer Res., 30 (4). pp. 1079 - 1082. ISSN: 0250-7005
Abbaszadeh, F., Clingen, PH., Arlett, C., Plowman, PN., Bourton, EC., Themis, M., et al. (2010) 'A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitvity in a xeroderma pigmentosum patient'. Journal of Medical Genetics, 46 (11). pp. 1 - 24. ISSN: 0022-2593 Open Access Link
Al Sarakbi, W., Sasi, W., Jiang, WG., Roberts, W., Newbold, RF. and Mokbel, K. (2009) 'Gene transcripts in the tumour suppressor region of chromosome 3 (3p21)'.32nd Annual San Antonio Breast Cancer Symposium. San Antonio, TX. 9 - 13 December. AMER ASSOC CANCER RESEARCH. pp. 869S - 869S. ISSN: 0008-5472
Dafou, D., Ramus, SJ., Choi, K., Grun, B., Trott, DA., Newbold, RF., et al. (2009) 'Chromosomes 6 and 18 induce neoplastic suppression in epithelial ovarian cancer cells'. International Journal of Cancer, 124 (5). pp. 1037 - 1044. ISSN: 1097-0215 Open Access Link
Loizidou, MA., Michael, T., Neuhausen, SL., Newbold, RF., Marcou, Y., Kakouri, E., et al. (2009) 'DNA-repair genetic polymorphisms and risk of breast cancer in Cyprus'. Breast Cancer Research and Treatment, 115 (3). pp. 623 - 627. ISSN: 0167-6806 Open Access Link
Patani, N., Jiang, W., Mansel, R., Newbold, R. and Mokbel, K. (2009) 'The mRNA expression of SATB1 and SATB2 in human breast cancer'. Cancer Cell International, 9 (1). pp. 18. ISSN: 1475-2867 Open Access Link
Al Sarakbi, W., Sasi, W., Jiang, WG., Roberts, T., Newbold, RF. and Mokbel, K. (2009) 'The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters'. BMC Cancer, 9 (1). pp. 290. ISSN: 1471-2407 Open Access Link
Loizidou, MA., Michael, T., Neuhausen, SL., Newbold, RF., Marcou, Y., Kakouri, E., et al. (2008) 'Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus'. Breast Cancer Research and Treatment, 112 (3). pp. 575 - 579. ISSN: 0167-6806 Open Access Link
Coelho, D., Suormala, T., Stucki, M., Lerner-Ellis, JP., Rosenblatt, DS., Newbold, RF., et al. (2008) 'Gene identification for the cblD defect of vitamin B12 metabolism'. New England Journal of Medicine, 358 (14). pp. 1454 - 1464. ISSN: 1533-4406 Open Access Link
Sugiana, C., Pagliarini, DJ., McKenzie, M., Kirby, DM., Salemi, R., Abu-Amero, KK., et al. (2008) 'Mutation of C20orf7 disrupts complex I assembly and causes lethal neonatal mitochondrial disease'. The American Journal of Human Genetics, 83 (4). pp. 468 - 478. ISSN: 0002-9297 Open Access Link
Meaburn, KJ., Newbold, RF. and Bridger, JM. (2008) 'Positioning of human chromosomes in murine cell hybrids according to synteny'. Chromosoma, 117 (6). pp. 579 - 591. ISSN: 1432-0886 Open Access Link
Salhab, M., Jiang, WG., Newbold, RF. and Mokbel, K. (2008) 'The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome'. Breast Cancer Research and Treatment, 109 (1). pp. 35 - 46. ISSN: 0167-6806 Open Access Link
Worku, D., Jouhra, F., Jiang, GW., Patani, N., Newbold, RF. and Mokbel, K. (2008) 'Evidence of a tumour suppressive function of E2F1 gene in human breast cancer'. Anticancer Research, 28 (4B). pp. 2135 - 2139. ISSN: 0250-7005 Open Access Link
Mansfield, L., Subramanian, A., Devalia, H., Jiang, W., Newbold, RF. and Mokbel, K. (2007) 'hTERT mRNA expression correlates with matrix metalloproteinase-1 and vascular endothelial growth factor expression in human breast cancer: A correlative study using RT-PCR'. ANTICANCER RESEARCH, 27 (4B). pp. 2265 - 2268. ISSN: 0250-7005
Newbold, RF., Hadjiavvas, A., Loizidou, M., Marcou, Y., Anastasiadou, V. and Kyriacou, K. (2007) 'Contribution of BRCA1 and BRCA2 germline mutations to the incidence of early-onset breast cancer in Cyprus'. Clinical Genetics, 71 (2). pp. 165 - 170. ISSN: 0009-9163 Open Access Link
Elkak, A., Mokbel, R., Wilson, C., Jiang, WG., Newbold, RF. and Mokbel, K. (2006) 'hTERT mRNA expression is associated with a poor clinical outcome in human breast cancer'. Anticancer Research, 26 (6C). pp. 4901 - 4904. ISSN: 0250-7005
Elkak, AE., Meligonis, G., Salhab, M., Mitchell, B., Blake, JR., Newbold, RF. and et al. (2005) 'hTERT protein expression is independent of clinicopathological parameters and c-Myc protein expression in human breast cancer'. Journal of Carcinogenesis, 4 (1). pp. 17 - 17. ISSN: 1477-3163 Open Access Link
Leris, AC., Roberts, TR., Jiang, WG., Newbold, RF. and Mokbel, K. (2005) 'Evidence for a tumour suppressive function of APRG1 in breast cancer.'. Breast Cancer Res Treat, 93 (2). pp. 97 - 100. ISSN: 0167-6806 Open Access Link
Leris, AC., Roberts, TR., Jiang, WG., Newbold, RF. and Mokbel, K. (2005) 'WNT5A expression in human breast cancer'. Anticancer Research: international journal of cancer research and treatment, 25 (2A). pp. 731 - 734. ISSN: 0250-7005
Dafou, D., Trott, DA., Newbold, RF., Jacobs, IJ. and Gayther, SA. (2004) 'Establishing a cell biology model of suppression in epithelial ovarian cancer'.44th Annual Meeting of the American-Society-for-Cell-Biology. Washington, DC. 4 - 8 December. AMER SOC CELL BIOLOGY. pp. 250A - 250A. ISSN: 1059-1524
Newbold, RF., Coenen, MJH., Antonicka, H., Ugalde, C., Sasarman, F., Rossi, R., et al. (2004) 'Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency'. New England Journal of Medicine, 351 (20). pp. 2080 - 2086. ISSN: 1533-4406 Open Access Link
Flanagan, JM., Healey, S., Young, J., Whitehall, V., Trott, DA., Newbold, RF. and et al. (2004) 'Mapping of a candidate colorectal cancer tumor-suppressor gene to a 900-kilobase region on the short arm of chromosome 8'. Genes Chromosomes Cancer, 40 (3). pp. 247 - 260. ISSN: 1045-2257 Open Access Link
Dafou, D., Li, NF., Trott, DA., Jacobs, IJ., Gayther, SA. and Newbold, RF. (2004) 'In vitro model of malignant transformation for the identification of genes in breast cancer formation'.British Cancer Research Meeting 2004. Manchester, ENGLAND. 27 - 30 June. NATURE PUBLISHING GROUP. pp. S74 - S74. ISSN: 0007-0920
Kirkpatrick, KL., Newbold, RF. and Mokbel, K. (2004) 'There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer'. International Seminars in Surgical Oncology, 1 (1). pp. 2 - 2. ISSN: 1477-7800 Open Access Link
Kirkpatrick, KL., Newbold, RF. and Mokbel, K. (2004) 'The mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression'. Journal of Carcinogenesis, 3 (1). pp. 1 - 1. ISSN: 1477-3163 Open Access Link
Newbold, RF., Cabury, E., Newton, C., Roberts, T. and Slijepcevic, P. (2004) 'Identification of subpopulations of cells with differing telomere lengths in mouse and human cell lines by flow FISH'. Cytometry, 62 (2). pp. 150 - 161. ISSN: 0196-4763 Open Access Link
Themis, M., May, D., Coutelle, C. and Newbold, RF. (2003) 'Mutational effects of retrovirus insertion on the genome of V79 cells by an attenuated retrovirus vector: Implications for gene therapy'. Gene Therapy, 10 (19). pp. 1703 - 1711. ISSN: 0969-7128
Elkak, AE., Newbold, RF., Thomas, V. and Mokbel, K. (2003) 'Is telomerase reactivation associated with the down-regulation of TGF beta receptor-II expression in human breast cancer?'. Cancer Cell International, 3 (1). pp. 9 - 9. ISSN: 1475-2867 Open Access Link
Chastain-Moore, AM., Roberts, T., Trott, DA., Newbold, RF. and Ornelles, DA. (2003) 'An activity associated with human chromosome 21 permits nuclear colocalization of the adenovirus E1B-55K and E4orf6 proteins and promotes viral late gene expression'. Journal of Virology, 77 (14). pp. 8087 - 8098. ISSN: 0022-538X Open Access Link
Newbold, RF., Cosma, MP., Pepe, S., Annunziata, I., Grompe, M., Parenti, G. and et al. (2003) 'The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases'. Cell, 113 (4). pp. 445 - 456. ISSN: 0092-8674 Open Access Link
Kirkpatrick, KL., Clark, G., Ghilchick, M., Newbold, RF. and Mokbel, K. (2003) 'hTERT mRNA expression correlates with telomerase activity in human breast cancer'. EJSO - European Journal of Surgical Oncology, 29 (4). pp. 321 - 326. ISSN: 0748-7983
Mokbel, K. and Newbold, RF. (2003) 'Re: Poremba et al Telomerase as a prognostic marker in breast cancer: High-throughput tissue microarray analysis of hTERT and hTR. J Pathol 2002; 198: 181-189'. Journal of Pathology, 199 (4). pp. 542. ISSN: 0022-3417
Fitzsimmons, SA., Ireland, H., Barr, NI., Cuthbert, AP., Going, JJ., Newbold, RF. and et al. (2003) 'Human squamous cell carcinomas lose a mortality gene from chromosome 6q14.3 to q15'. Oncogene, 22 (11). pp. 1737 - 1746. ISSN: 0950-9232 Open Access Link
Kirkpatrick, KL., Ogunkolade, W., Elkak, AE., Bustin, S., Jenkins, P., Ghilchick, M., et al. (2003) 'hTERT expression in human breast cancer and non-cancerous breast tissue: correlation with tumour stage and c-Myc expression'. Breast Cancer Res Treat, 77 (3). pp. 277 - 284. ISSN: 0167-6806
Wilson, P., Cuthbert, A., March, A., Arnold, J., Flanagan, J., Mulford, C., et al. (2003) 'Transfer of chromosome 8 into two breast cancer cell lines: Total exclusion of three regions indicates location of putative in vitro growth suppressor genes'. Cancer Genetics and Cytogenetics, 143 (2). pp. 100 - 112. ISSN: 0165-4608 Open Access Link
Szutorisz, H., Lingner, J., Cuthbert, AP., Trott, DA., Newbold, RF. and Nabholz, M. (2003) 'A chromosome 3-encoded repressor of the Human Telomerase Reverse Transcriptase (hTERT) gene controls the state of hTERT chromatin'. Cancer Research, 63 (3). pp. 689 - 695. ISSN: 0008-5472 Open Access Link
Newbold, RF. (2002) 'The significance of telomerase activation and cellular immortalization in human cancer'. Mutagenesis, 17 (6). pp. 539 - 550. ISSN: 0267-8357
Bryce, SD., Morrison, V., Craig, NJ., Forsyth, NR., Fitzsimmons, SA., Ireland, H., et al. (2002) 'A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23'. Neoplasia, 4 (6). pp. 544 - 550. ISSN: 1522-8002 Open Access Link
Forsyth, NR., Morrison, V., Craig, NJ., Fitzsimmons, SA., Barr, NI., Ireland, H., et al. (2002) 'Functional evidence for a squamous cell carcinoma mortality gene(s) on human chromosome 4'. Oncogene, 21 (33). pp. 5135 - 5147. ISSN: 0950-9232 Open Access Link
Wilding, J., Meijne, E., Haines, J., Moody, J., Edwards, A., Newbold, RF., et al. (2002) 'Functional evidence from microcell-mediated chromosome transfer of myeloid leukemia suppressor genes on human chromosomes 7 and 11'. Genes, Chromosomes and Cancer, 34 (4). pp. 390 - 397. ISSN: 1045-2257
Boulos, N., Newbold, RF., Trott, DA., Pearson, ADJ., Tilby, MJ. and Lunec, J. (2002) 'Functional complementation analysis of chromosome 1 in neuroblastoma'. BRITISH JOURNAL OF CANCER, 86. pp. S91 - S91. ISSN: 0007-0920
Cosma, MP., Pepe, S., Parenti, G., Belli, A., Mankad, A., Grompe, M., et al. (2002) 'Mapping of the gene for multiple sulfatase deficiency (MSD) by functional complementation using microcell-mediated chromosome transfer'.European-Society-of-Human-Genetics European Human Genetics Conference in Conjuction With European Meeting on Psychosocial Aspects of Genetics. STRASBOURG, FRANCE. 25 - 28 May. NATURE PUBLISHING GROUP. pp. 207 - 208. ISSN: 1018-4813
Ducrest, AL., Amacker, M., Mathieu, YD., Cuthbert, AP., Trott, DA., Newbold, RF., et al. (2001) 'Regulation of human telomerase activity: Repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity'. Cancer Research, 61 (20). pp. 7594 - 7602. ISSN: 0008-5472 Open Access Link
Goodarzi, G., Mashimo, T., Watabe, M., Cuthbert, AP., Newbold, RF., Pai, SK., et al. (2001) 'Identification of tumor metastasis suppressor region on the short arm of human chromosome 20'. Genes Chromosomes Cancer, 32 (1). pp. 33 - 42. ISSN: 1045-2257
Hadjisavvas, A., Neuhausen, SL., Hoffman, MD., Adamou, A., Newbold, RF., Kyriacou, KC. and et al. (2001) 'BRCA1 germline mutations in Cypriot breast cancer patients from 26 families with family history'. Anticancer Research, 21 (5). pp. 3307 - 3311. ISSN: 0250-7005