Professor Robert Newbold
Honorary Professor - Life Sciences
Heinz Wolff 103
- Email: robert.newbold@brunel.ac.uk
- Tel: +44 (0)1895 266290
Hadjisavvas, A., Neuhausen, SL., Hoffman, MD., Adamou, A., Newbold, RF., Kyriacou, KC. and et al. (2001) 'BRCA1 germline mutations in Cypriot breast cancer patients from 26 families with family history'. Anticancer Research, 21 (5). pp. 3307 - 3311. ISSN: 0250-7005
McIlrath, J., Bouffler, SD., Samper, E., Cuthbert, A., Wojcik, A., Szumiel, I., et al. (2001) 'Telomere length abnormalities in mammalian radiosensitive cells'. Cancer Research, 61 (3). pp. 912 - 915. ISSN: 0008-5472 Open Access Link
Seyda, A., Newbold, RF., Hudson, TJ., Verner, A., MacKay, N., Winter, S., et al. (2001) 'A novel syndrome affecting multiple mitochondrial functions, located by microcell-mediated transfer to chromosome 2p14-2p13'. American Journal of Human Genetics, 68 (2). pp. 386 - 396. ISSN: 0002-9297 Open Access Link
Sullivan, GJ., Bridger, JM., Cuthbert, AP., Newbold, RF., Bickmore, WA. and McStay, B. (2001) 'Human acrocentric chromosomes with transcriptionally silent nucleolar organiser regions associate with nucleoli'. European Molecular Biology Organization, 20 (11). pp. 2867 - 2877. ISSN: 1460-2075 Open Access Link
Steenbergen, RD., Kramer, D., Meijer, CJ., Walboomers, JM., Trott, DA., Cuthbert, AP., et al. (2001) 'Telomerase suppression by chromosome 6 in a human papillomavirus type 16-immortalized keratinocyte cell line and in a cervical cancer cell line.'. Journal of the National Cancer Institute, 93 (11). pp. 865 - 872. ISSN: 0027-8874 Open Access Link
Mashimo, T., Goodarzi, G., Watabe, M., Cuthbert, AP., Newbold, RF., Pai, SK., et al. (2000) 'Localization of a novel tumor metastasis suppressor region on the short arm of human chromosome 2'. Genes Chromosomes Cancer, 28 (3). pp. 285 - 293. ISSN: 1045-2257
Mokbel, KM., Parris, CN., Ghilchik, M., Amerasinghe, CN. and Newbold, RF. (2000) 'Telomerase activity and lymphovascular invasion in breast cancer'. European Journal of Surgical Oncology, 26 (1). pp. 30 - 33. ISSN: 0748-7983
Vermeulen, SJ., Debruyne, PR., Marra, G., Speleman, FP., Boukamp, P., Jiricny, J., et al. (1999) 'hMSH6 deficiency and inactivation of the αE-catenin invasion-suppressor gene in HCT-8 colon cancer cells'. Clinical and Experimental Metastasis, 17 (8). pp. 663 - 668. ISSN: 0262-0898
Mokbel, K., Ghilchik, M., Parris, CN. and Newbold, RF. (1999) 'Telomerase activity in phyllodes tumours'. Eur J Surg Oncol, 25 (4). pp. 352 - 355. ISSN: 0748-7983
Newbold, RF. (1999) 'Telomerase as an anti-cancer drug target: Will it fulfil its early promise?'. Anticancer Drug Design, 14 (4). pp. 349 - 354. ISSN: 0266-9536
Mokbell, K., Parris, CN., Ghilchik, M. and Newbold, RF. (1999) 'Telomerase activity in the human breast'. Breast, 8 (4). pp. 208 - 211. ISSN: 0960-9776
Mokbel, K., Parris, CN., Ghilchik, M., Williams, G. and Newbold, RF. (1999) 'The association between telomerase, histopathological parameters, and KI-67 expression in breast cancer'. American Journal of Surgery, 178 (1). pp. 69 - 72. ISSN: 0002-9610
Mokbel, K., Parris, CN., Radbourne, R., Ghilchik, M. and Newbold, RF. (1999) 'Telomerase activity and prognosis in breast cancer'. EJSO - European Journal of Surgical Oncology, 25 (3). pp. 269 - 272. ISSN: 0748-7983
Bryce, SD., Forsyth, NR., Fitzsimmons, SA., Clark, LJ., Bertram, MJ., Cuthbert, AP., et al. (1999) 'Genetic and functional analyses exclude mortality factor 4 (MORF4) as a keratinocyte senescence gene'. CANCER RESEARCH, 59 (9). pp. 2038 - 2040. ISSN: 0008-5472
Kipling, D., Wynford-Thomas, D., Jones, CJ., Akbar, A., Aspinall, R., Bacchetti, S., et al. (1999) 'Telomere-dependent senescence'. Nature Biotechnology, 17 (4). pp. 313 - 313. ISSN: 1087-0156
Parris, CN., Harris, JD., Griffin, DK., Cuthbert, AP., Silver, AJ. and Newbold, RF. (1999) 'Functional evidence of novel tumor suppressor genes for cutaneous malignant melanoma'. Cancer Research, 59 (3). pp. 516 - 520. ISSN: 0008-5472 Open Access Link
Cuthbert, AP., Bond, J., Trott, DA., Gill, S., Broni, J., Marriott, A., et al. (1999) 'Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast cancer cells'. Journal of the National Cancer Institute, 91 (1). pp. 37 - 45. ISSN: 0027-8874 Open Access Link
Parris, CN., Jezzard, S., Silver, A., MacKie, R., McGregor, JM. and Newbold, RF. (1999) 'Telomerase activity in melanoma and non-melanoma skin cancer'. British Journal of Cancer, 79 (1). pp. 47 - 53. ISSN: 0007-0920 Open Access Link
Russo, I., Silver, AR., Cuthbert, AP., Griffin, DK., Trott, DA. and Newbold, RF. (1998) 'A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization'. Oncogene, 17 (26). pp. 3417 - 3426. ISSN: 0950-9232 Open Access Link
Zhu, Z., Yao, J., Johns, T., Fu, K., De Bie, I., Macmillan, C., et al. (1998) 'SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome'. Nature Genetics, 20 (4). pp. 337 - 343. ISSN: 1061-4036 Open Access Link
Mashimo, T., Watabe, M., Cuthbert, AP., Newbold, RF., Rinker-Schaeffer, CW., Helfer, E. and et al. (1998) 'Human chromosome 16 suppresses metastasis but not tumorigenesis in rat prostatic tumor cells'. Cancer Research, 58 (20). pp. 4572 - 4576. ISSN: 0008-5472 Open Access Link
Ebeling, SB., Bos, HM., Slater, R., Overkamp, WJ., Cuthbert, AP., Newbold, RF., et al. (1998) 'Human chromosome 21 determines growth factor dependence in human/mouse B-cell hybridomas.'. Cancer Research, 58 (13). pp. 2863 - 2868. ISSN: 0008-5472
Parris, CN., Harris, JD. and Newbold, RF. (1998) 'Functional evidence of novel tumour suppressor genes for Cutaneous Malignant Melanoma.'. BRITISH JOURNAL OF CANCER, 78. pp. 11 - 11. ISSN: 0007-0920
Newbold, RF. (1997) 'Genetic control of telomerase and replicative senescence in human and rodent cells'.Symposium on Telomeres and Telomerase. LONDON, ENGLAND. 1 - 27 February. Wiley. pp. 177 - 197. ISSN: 0300-5208
Loughran, O., Clark, LJ., Bond, J., Baker, A., Berry, IJ., Edington, KG., et al. (1997) 'Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes'. Oncogene, 14 (16). pp. 1955 - 1964. ISSN: 0950-9232
Parkinson, EK., Newbold, RF. and Keith, WN. (1997) 'The genetic basis of human keratinocyte immortalisation in squamous cell carcinoma development: The role of telomerase reactivation'. Eur J Cancer, 33 (5). pp. 727 - 734. ISSN: 0959-8049
Brenner, S., Blasco, M., Kipling, D., Lundblad, V., Guarente, L., Cech, TR., et al. (1997) 'Mouse models for the study of telomerase - Discussion'.Symposium on Telomeres and Telomerase. LONDON, ENGLAND. 25 - 27 February. JOHN WILEY & SONS LTD. pp. 170 - 176. ISSN: 0300-5208
Gasser, SM., Newbold, RF., Wynford-Thomas, D., Shay, JW., Kipling, D., Holliday, R., et al. (1997) 'Genetic control of telomerase and replicative senescence in human and rodent cells - Discussion'.Symposium on Telomeres and Telomerase. LONDON, ENGLAND. 25 - 27 February. JOHN WILEY & SONS LTD. pp. 189 - 197. ISSN: 0300-5208
Kipling, D., Harley, CB., Cech, TR., Shall, S., Lansdorp, PM., Holliday, R., et al. (1997) 'Human ageing and telomeres - Discussion'.Symposium on Telomeres and Telomerase. LONDON, ENGLAND. 25 - 27 February. JOHN WILEY & SONS LTD. pp. 139 - 144. ISSN: 0300-5208
Shay, JW., Wynford-Thomas, D., Gasser, SM., Lundblad, V., Cech, TR., Guarente, L., et al. (1997) 'Are telomeres correlative or causative in cellular senescence? General discussion'.Symposium on Telomeres and Telomerase. LONDON, ENGLAND. 25 - 27 February. JOHN WILEY & SONS LTD. pp. 145 - 147. ISSN: 0300-5208
Newbold, RF., Shay, JW., Guarente, L., Kipling, D., Cech, TR., Blackburn, E., et al. (1997) 'Telomerase assays in the diagnosis and prognosis of cancer - Discussion'.Symposium on Telomeres and Telomerase. LONDON, ENGLAND. 25 - 27 February. JOHN WILEY & SONS LTD. pp. 155 - 159. ISSN: 0300-5208
Jongmans, W., Verhaegh, GW., Jaspers, NG., Demant, P., Natarajan, AT., Shiloh, Y., et al. (1996) 'The defect in the AT-like hamster cell mutants is complemented by mouse chromosome 9 but not by any of the human chromosomes'. Mutation Research/DNA Repair, 364 (2). pp. 91 - 102. ISSN: 0027-5107
England, NL., Cuthbert, AP., Trott, DA., Jezzard, S., Nobori, T., Carson, DA. and et al. (1996) 'Identification of human tumour suppressor genes by monochromosome transfer: rapid growth-arrest response mapped to 9p21 is mediated solely by the cyclin-D-dependent kinase inhibitor gene, CDKN2A (p16INK4A)'. Carcinogenesis, 17 (8). pp. 1567 - 1575. ISSN: 0143-3334
Yamasaki, H., Ashby, J., Bignami, M., Jongen, W., Linnainmaa, K., Newbold, RF., et al. (1996) 'Nongenotoxic carcinogens: development of detection methods based on mechanisms: a European project.'. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 353 (1-2). pp. 47 - 63. ISSN: 0027-5107
Trott, DA., Cuthbert, AP., Todd, CM., Themis, M. and Newbold, RF. (1995) 'Novel use of a selectable fusion gene as an "in-out" marker for studying genetic loss in mammalian cells'. Molecular Carcinogenesis, 12 (4). pp. 213 - 224. ISSN: 0899-1987
Trott, DA., Cuthbert, AP., Overell, RW., Russo, I. and Newbold, RF. (1995) 'Mechanisms involved in the immortalization of mammalian cells by ionizing radiation and chemical carcinogens'. Carcinogenesis, 16 (2). pp. 193 - 204. ISSN: 0143-3334
Cuthbert, AP., Trott, DA., Ekong, RM., Jezzard, S., England, NL., Themis, M., et al. (1995) 'Construction and characterization of a highly stable human:Rodent monochromosomal hybrid panel for genetic complementation and genome mapping studies'. Cytogenetics and Cell Genetics, 71 (1). pp. 68 - 76. ISSN: 0301-0171
Newbold, RF., Cuthbert, AP., Themis, M., Trott, DA., Blair, AL. and Li, W. (1993) 'Cell immortalization as a key, rate-limiting event in malignant transformation: approaches toward a molecular genetic analysis'.INTERNATIONAL SYMP ON APPROACHES FOR THE IDENTIFICATION OF LESIONS RELEVANT IN CARCINOGENESIS. UNIV WURZBURG, INST PHARM & TOXICOL, WURZBURG, GERMANY. 1 - 20 June. Elsevier BV. pp. 211 - 230. ISSN: 0378-4274
Shiner, AC., Newbold, RF. and Cooper, CS. (1988) 'Morphological transformation of immortalized hamster dermal fibroblasts following treatment with simple alkylating carcinogens'. Carcinogenesis, 9 (9). pp. 1701 - 1709. ISSN: 0143-3334
Newbold, RF. (1985) 'Malignant transformation of mammalian cells in culture: delineation of stages and role of cellular oncogene activation.'. IARC scientific publications, 67. pp. 31 - 53. ISSN: 0300-5038
Newbold, RF. (1985) 'Multistep malignant transformation of mammalian cells by carcinogens: induction of immortality as a key event.'. Carcinogenesis; a comprehensive survey, 9. pp. 17 - 28. ISSN: 0147-4006
NEWBOLD, RF. (1984) 'Transformation by the p21ras protein'. Nature, 312 (5992). pp. 314 - 314. ISSN: 0028-0836
Newbold, RF. and Overell, RW. (1983) 'Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene'. Nature, 304 (5927). pp. 648 - 651. ISSN: 0028-0836
Newbold, RF., Overell, RW. and Connell, JR. (1982) 'Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens'. Nature, 299 (5884). pp. 633 - 635. ISSN: 0028-0836
Brookes, P., King, HWS., Mundy, CR. and Newbold, RF. (1982) 'Biochemical and immunological characterisation of mutants induced in V79 Chinese hamster cells by a benzo[a]pyrene diolepoxide'. Carcinogenesis, 3 (6). pp. 687 - 692. ISSN: 0143-3334
Newbold, RF. and Amos, J. (1981) 'Inhibition of metabolic cooperation between mammalian cells in culture by tumour promoters'. Carcinogenesis, 2 (3). pp. 243 - 249. ISSN: 0143-3334
Parkinson, EK. and Newbold, RF. (1980) 'Benzo(a)pyrene metabolism and DNA adduct formation in serially cultivated strains of human epidermal keratinocytes'. International Journal of Cancer, 26 (3). pp. 289 - 299. ISSN: 0020-7136
Newbold, RF., Warren, W., Medcalf, ASC. and Amos, J. (1980) 'Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification'. Nature, 283 (5747). pp. 596 - 599. ISSN: 0028-0836
Newbold, RF., Brookes, P. and Harvey, RG. (1979) 'A quantitative comparison of the mutagenicity of carcinogenic polycyclic hydrocarbon derivatives in cultured mammalian cells'. International Journal of Cancer, 24 (2). pp. 203 - 209. ISSN: 0020-7136
Wigley, CB., Newbold, RF., Amos, J. and Brookes, P. (1979) 'Cell‐mediated mutagenesis in cultured chinese hamster cells by polycyclic hydrocarbons: Mutagenicity and DNA reaction related to carcinogenicity in a series of compounds'. International Journal of Cancer, 23 (5). pp. 691 - 696. ISSN: 0020-7136
Newbold, RF., Amos, J. and Connell, JR. (1979) 'The cytotoxic, mutagenic and clastogenic effects of chromium-containing compounds on mammalian cells in culture'. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 67 (1). pp. 55 - 63. ISSN: 0027-5107