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Determinants and mechanisms involved in alcohol consumption and its health consequences


Project description

We are using genetic, environmental and metabolite data from the UK Biobank, the Airwave health monitoring study and published genome-wide association studies as well as animal models in order to highlight determinants, mechanisms and pathways involved in alcohol consumption and related diseases. By interrogating the UK Biobank data we are able to study risk factors and determinants of alcohol consumption as well as diseases caused by alcohol consumption. By using alcohol consumption data and metabolites in the Airwave study, we are able to identify genes that are linked to alcohol-related metabolites, and then test alcohol-metabolite genes in the UK Biobank study. This will allow us to highlight pathways that are linked to fat accumulation in liver via alcohol consumption. This is supported by testing animal models to identify the underlying biology behind the association of genes and alcohol consumption.