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Project description

Cancer researchers have known for decades that tumours use a faster metabolism than normal cells in our body. One classic example of this is that cancer cells increase their consumption of glucose to fuel their rapid growth and strike against programmed cell death. This means that limiting glucose consumption in cancer cells is becoming an attractive tool for cancer treatments.

Using a combination of genetic and molecular biology approaches, Dr Concetta Bubici in close collaboration with Dr Salvatore Papa and Professor Reuben Tooze from University of Leeds wants to do a series of laboratory testing to reduce the consumption of glucose of certain haematological cancer types.