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Muscle heat shock proteins with passive heating

Ongoing

Project description

Local heating induces vascular and metabolic adjustments as a result of increased muscle tissue perfusion and delivery of oxygen and regulatory substances to the heated area(s). In addition to these responses, which are dependent on elevated flow and supply of regulatory substances, oxygen and nutrients, increased local temperature can also induce intracellular responses directly. One such molecular response to passive heating is increased heat shock proteins (HSPs). HSPs protect cells from damage during stress with the intention of maintaining/improving cell function; this has led to HSPs being classified as a “molecular chaperones”.

The purpose of this experiment is to understand how nutritional/pharmacological manipulations of HSPs during passive heating can alter the molecular pathways underlying vascular and metabolic adjustments and adaptation to thermal interventions.

Related Research Outputs

Gibson OR, Turner G, Tuttle JA, Taylor L, Watt PW, Maxwell NS (2015). Heat acclimation attenuates physiological strain and the HSP72, but not HSP90α, mRNA response to acute normobaric hypoxia. J Appl Physiol 119(8):889-899.

Chiesa ST, Trangmar SJ, González-Alonso J (2016). Temperature and blood flow distribution in the human leg with passive heat stress. J Appl Physiol 120, 1047-1058.

Wilhelm EN, González-Alonso J, Chiesa ST, Trangmar SJ, Kalsi Wilhelm EN, González-Alonso J, Chiesa ST, Trangmar SJ, Kalsi KK & Rakobowchuk M (2017). Whole body heat stress and intense exercise stimulate the appearance of platelet microvesicles in plasma with limited influence of vascular shear rate. Physiol Rep 5(21), e13496. 

Chiesa ST, Trangmar SJ, Kalsi K, Rakobowchuk M, Banker DS, Lotlikar MD, Ali L & González-Alonso J (2015). Local temperature-sensitive mechanisms are important mediators of limb tissue hyperemia in the heat-stressed human at rest and during small muscle mass exercise. Am J Physiol Heart Circ Physiol 309, H369-H380.