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Endocrine disruptors linked to developmental neurotoxicity

Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research project ENDpoiNTs (no. 825759) has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity.

ENDpoiNTs will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. ENDpoiNTs aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks

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ENDpoiNTs

Meet the Principal Investigator(s) for the project

Mr Martin Scholze - I am a mathematician with a strong background in statistics and biology. My academic research has covered a wide range of areas, encompassing epidemiology, ecotoxicology, toxicology and pharmacology. Having gained an international reputation for my research in biomathematics and statistics in various interdisciplinary international Research projects, I can draw on a wide range of expertise and experience. Since 2007 I am working mainly as an independent consultant, providing consultancy and training in biostatistics, biomathematics and data management to a broad client base in the UK and Europe. My clients include industry, government, international organisations and the academic world. My aim is to make biostatistics accessible and effective as a tool to solve practical problems, based on sound statistical knowledge and modern developments in biostatistics and biomathematics. Qualifications Diploma in mathematics (major subject: statistics) Prediploma in biology Post-graduate qualification in epidemiology (German society for medical informatics, biometrics and epidemiology) Career 2011 - present: Research fellow. Institute for the Environment, Brunel University2007 – present: Independent biostatistical Consultant (Scholze Consultancy, London, UK) 2003 – 2007: Research scientist in two European Union-funded research projects, Centre for Toxicology, The School of Pharmacology, University of London. 1997 – 2003: Research scientist and Co-coordination in two European Union-funded research projects, University of Bremen, Department of Biology and Chemistry. 1996 – 1997: Research scientist, University of Bremen, Department of Statistics, Germany. 1994 – 1996: Research scientist in Epidemiological studies, Bremen Institute for Prevention Research and Social Medicine, Germany. 1992 – 1994: Research scientist in Epidemiological studies, University of Bremen, Department of Statistics, Germany.

Related Research Group(s)

Pollution Research and Policy

Pollution Research and Policy - Predictive approaches in toxicology, including combined chemical exposures and development of new frameworks for non-animal approaches for predicting toxicity; Endocrine disruptor research with an emphasis on mechanisms of disease and test method development; Pollution monitoring, clean-up technologies and chemical analytics.


Project last modified 19/01/2021