Reducing the risk of human infection to Schistosomiasis

Schistosomiasis is the second most socioeconomically devastating parasitic disease after malaria. Our vision is to develop a novel programme of applied research that will ultimately reduce the risk of human infection to Schistosomiasis. The aim is to develop an artificial snail that faithfully recapitulates the necessary chemical cues needed to attract Schistosome miracidia.

Being chemically indistinguishable to the parasites from live snail, the artificial snails will effectively draw the parasites into them, and away from their intermediate host. As the parasite is unable to replicate in the artificial snail, we will cause a break in the life cycle of the disease and reduce transmission of cercarie to humans by reducing the population of infected snails. Research to identify the most promising parasite attractant released by snails has been completed. 

Meet the Principal Investigator(s) for the project

Dr Edwin Routledge - I am a molecular endocrinologist and aquatic ecotoxicologist with an interest in the effects of endocrine active chemicals on aquatic wildlife.  I am also active in research to protect humans from diseases associated with exposure to biological contaminants in freshwater, including legionella (pathogenic bacteria) and schistosomiasis (parasitic disease) - see my grants for more details. I have published over 30 papers that have been collectively cited over 5500 times.  I am programme leader for the Masters in Sustainability, Entrepreneurship and Design which aims to provide entrepreneurial students with the skills and mind-set to help build a sustainable future; one that is environmentally responsible and socially inclusive.  I teach a number of subjects at Masters level, including Ecology, Sustainability, and Toxicology (Endocrine Disruption).  Qualifications 2001-2003 Post Graduate Certificate in Learning and Teaching in Higher Education 1998 Doctorate of Philosophy Title: Identification, Quantification and Assessment of Oestrogenic Chemicals in Sewage-Treatment Work Effluents. Brunel University, Uxbridge, Middlesex  1993 Bachelor of Science Degree II (i) BSc – Honours in Applied Biology Brunel University, Uxbridge, Middlesex Career   08/20 – Present:  Division Lead for Environmental Sciences 08/14 – Present:  PGR Academic Lead (Environmental Sciences Division) 10/14 – Present:   Reader in Aquatic Toxicology

Project last modified 02/10/2023