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Organ-on-a-chip models for ovarian cancer


Project description

Ovarian cancer is a lethal gynaecological malignancy that affects over 295,000 women globally, with a 20% survival rate for advanced stage. Often diagnosed at a late stage, due to the non-specific nature of symptoms, detection of ovarian cancer at an early stage is paramount. The discovery of novel hormones and influencers of the tumour microenvironment provide a promising avenue of research for the identification of cancer biomarkers. This project aims to expand research of a novel glucogenic hormone within the tumour microenvironment using traditional mono-layer tissue culture techniques as well as 3D co-culture organ-on-a-chip technology in addition to clinical liquid biopsies in order to advance the molecular understanding of ovarian cancer aetiology.

Meet the Principal Investigator(s) for the project

Dr Emmanouil Karteris - Dr Manos Karteris graduated with a BSc (Hons) in Medical Biochemistry from the University of Surrey in 1995. He then was awarded an MSc with Distinction in Medical Genetics with Immunology from Brunel University London in 1996 and completed his PhD in Molecular Endocrinology from the University of Warwick in 2000. He then undertook post-doctoral appointments at the University of Warwick, including a prestigious VIP Research Fellowship from the Wellcome Trust. He was appointed as Lecturer in Endocrinology at the University of Warwick from 2005-2006 and then he transferred to Brunel University London as a Lecturer in Biomedical Sciences in June 2006. In October 2017 Dr Karteris became a Senior Lecturer in the Division of Biomedical Sciences. He is also the head of the Cancer Biomarkers and Cellular Endocrinology Lab (CBCEL). For more information please visit the lab webpage: www.cbcel.org Qualifications: - BSc Medical Biochemistry, University of Surrey MSc Medical Genetics with Immunology, Brunel University PhD Molecular Endocrinology, University of Warwick PGCert HE & PGCERT IP Law, Brunel University