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Studentship in Cell division, chromosome organisation, protein phosphatases

The division of bioscience at Brunel University London is offering a fully funded PhD studentship to investigate the role of protein phosphatases in cell division within the group of Prof Vagnarell.

Based in the College of Health and Life Sciences and funded by Brunel University London, the studentship offers an annual London rate stipend of £17,009 plus Home/EU tuition fees, for a maximum of 36 months.  Preferred start date is 1st October 2019.

Overview

Reversible protein phosphorylation is the most used regulatory mechanism adopted by cells and cell division (mitosis) heavily relies on this. Protein phosphatases are inactivated at the beginning of mitosis and must be re-activated at its end to produce viable products. The aim of this investigation is to provide the first integrated picture of the role of Protein Phosphatase 1 (PP1) at the Mitosis-G1 transition. By combining genetic, biochemistry and cell biology, the research plan is set to identify the main substrates of these phosphatase during mitotic exit and unveil how they modify chromatin architecture to allow the newly formed cells to survive and maintain their genome integrity.

The successful candidate will be supervised by Professor Paola Vagnarelli. For informal discussions about this studentship, please contact Professor Paola Vagnarelli  (Paola.vagnarelli@brunel.ac.uk).

 

Eligibility

Candidates should have an undergraduate degree (first or upper second class) or equivalent qualification in Bioscience or equivalent disciplines. Laboratory experience is essential and familiarity with R and genome analyses is desirable.  Applicants who have not been awarded a degree by a University in the UK will be expected to demonstrate English language skills to IELTS 7.0 (minimum 6.0 in any section).

How to apply

If you wish to apply, please e-mail the following to chls-pgr-office@brunel.ac.uk by June 30th 2019

  • An up-to-date CV.
  • A single-page A4 single-spaced personal statement stating the name of PhD being apolied for and setting out why you are a suitable candidate (i.e. outlining your qualifications and skills).
  • A single A page describing your laboratory experience.
  • Names and contact details for two academic referees.
  • A copy of your highest degree certificate and transcript.
  • A copy of your English language qualification, where applicable.

Short-listed applicants will be required to attend an interview week commencing July 8th 2019. Applicants chosen for interview will be instructed to submit a formal online application via Admissions. 

For further information about how to apply, please contact the College of Health and Life Sciences Postgraduate Research Student Office on chls-pgr-office@brunel.ac.uk.