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DNA replication and chromosome dynamics in Escherichia coli

Funded PhD Studentship in DNA replication and chromosome dynamics in Escherichia coli

The Rudolph laboratory is offering a fully funded PhD studentship for the investigation of DNA replication dynamics in the bacterium Escherichia coli, with particular focus on the processes involved in termination of DNA replication. This research position will involve molecular genetics and cell biology techniques as well as some bioinformatics analysis of the generated data to generate a more detailed understanding of the termination process and the consequences that arise if DNA replication is not brought to an accurate conclusion.

Based in the College of Health and Life Sciences, and funded by Brunel University London, the studentship offers an annual London rate stipend of £17,285 plus Home/EU tuition fees, for a maximum of 36 months.  Preferred start date is 1 October 2020

Overview

DNA encodes the information that provides the basis for all life. For cell division to take place the entire DNA of a cell has to be fully duplicated, ensuring that both the mother and the daughter cell can get one complete copy. The Rudolph lab investigates DNA replication dynamics and chromosome structure in the bacterial model Escherichia coli. A particular focus is how DNA replication can be brought to a successful conclusion and how termination of DNA replication can impact genomic stability, chromosome dynamics and cell cycle progression if it is not adequately choreographed. Bacteria, such as E. coli, are particularly suitable for investigating the fusion of replication machineries, because only one such fusion event occurs per cell cycle in a defined location of the chromosome. This allows the direct visualisation and tracking of single replication forks inside living cells via fluorescence microscopy, as well as other cell biology, genetic and molecular biology approaches, such as nucleotide analogue incorporation studies and marker frequency analysis by Deep Sequencing.

The successful candidate will be supervised by Dr Christian Rudolph. For informal discussions about this studentship, please contact Dr Christian Rudolph (Christian.Rudolph@brunel.ac.uk).

Eligibility

Candidates should have an undergraduate degree (first or upper second class) or equivalent qualification in Biosciences, Biochemistry or Biophysics. A Masters qualification in Biosciences is desirable. Experience in cell biology/molecular biology research is essential. Applicants who have not been awarded a degree by a University in the UK will be expected to demonstrate English language skills to IELTS 7.0 (minimum 6.0 in any section).

How to apply

If you wish to apply, please e-mail the following to chls-pgr-office@brunel.ac.uk by 30 June 2020.

  • An up-to-date CV.
  • A single-page A4 single-spaced personal statement stating the name of one of the three positions above and setting out why you are a suitable candidate (i.e. outlining your qualifications and skills).
  • One example of your academic writing (e.g. an essay, a section from an undergraduate or a Masters dissertation).
  • A summary of your teaching experience or teaching activities you feel you could support.
  • Names and contact details for two academic referees.
  • A copy of your highest degree certificate and transcript.
  • A copy of your English language qualification, where applicable.

Short-listed applicants will be required to attend an interview. Applicants chosen for interview will be instructed to submit a formal online application via Admissions. 

For further information about how to apply, please contact the College of Health and Life Sciences Postgraduate Research Student Office on chls-pgr-office@brunel.ac.uk.