Role of centriolar proteins in invasion
Primary cilia are microtubule-based organelles that detect mechanical and chemical stimuli. Although cilia house a number of oncogenic molecules (including Smoothened, KRAS, EGFR, and PDGFR), their precise role in cancer remains unclear. Centriole and cilia defects have been shown to be characteristic of breast cancers and to regulate cancer cell invasion. However, how ciliary signalling affects cancer survival and cell invasion is not known.
Using a number of cell lines generated in our laboratory, we will examine how centriole and cilia proteins regulate invasion in both normal and cancer cells. We will use biochemical, cell biology, molecular biology and cancer biology techniques. We will carry out western blots, invasion and proliferation assays. We will collaborate with cancer biologists, bioinformaticians and a number of laboratories in the UK and abroad.
Applicants for this project should be enthusiastic about science and willing to learn a number of new techniques.
How to apply
If you are interested in applying for the above PhD topic please follow the steps below:
- Contact the supervisor by email or phone to discuss your interest and find out if you woold be suitable. Supervisor details can be found on this topic page. The supervisor will guide you in developing the topic-specific research proposal, which will form part of your application.
- Click on the 'Apply here' button on this page and you will be taken to the relevant PhD course page, where you can apply using an online application.
- Complete the online application indicating your selected supervisor and include the research proposal for the topic you have selected.
This is a self funded topic
Brunel offers a number of funding options to research students that help cover the cost of their tuition fees, contribute to living expenses or both. See more information here: https://www.brunel.ac.uk/research/Research-degrees/Research-degree-funding. The UK Government is also offering Doctoral Student Loans for eligible students, and there is some funding available through the Research Councils. Many of our international students benefit from funding provided by their governments or employers. Brunel alumni enjoy tuition fee discounts of 15%.