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Examples of past and current research

Clinical service evaluations

• Costs and benefits of heart transplantation
  Evaluation of liver transplantation
  
• Role of small bowel transplantation
  
• Management of women with mildly dyskarotic smears
  
• Role of detection and eradication of helicobacter pylori in the management of dyspepsia
  
• Relative cost of coronary artery bypass grafting and percutaneous transluminal coronary angioplasty
  
• Economic evaluation of adjuvant therapy for early breast cancer
  
• Evaluation of early discharge and home support schemes

Economic evaluation of screening programme

• Alternative screening policies for the early detection of breast cancer
  
• Alternative methods of screening for diabetic retinopathy
  
• Cervical cancer
  
• Randomised controlled trial of screening for abdominal aortic aneurysms
  
• National variation in the costs of breast screening
  
• Impact of breast screening on treatment costs
  

Economic evaluation methodology

• Construction and use of Quality Adjusted Life Years (QALYs)
  
• Hospital cost modelling and analysis of variation
  
• Problems of early health technology assessment
  
• The impact of health care systems on economic evaluation
  
• Economic evaluation alongside clinical trials
  
• Use of economic evaluation in the context of NICE

New technologies

• Cost-effectiveness of implantable cardioverter defibrillators (ICDs)
  
• The use of medical lasers, particularly in gastroenterology, ophthalmology and vascular surgery
  
• Evaluation of picture archiving and communication systems (PACS)
  
• Evaluation of hysteroscopic alternatives to hysterectomy for the treatment of menorrhagia
  Use of implantable cardiac assist devices
  
• Use of telemedicine in paediatric cardiology

Quality of life measurement and valuation

• Applied use of generic health related quality of life instruments
  
• Valuation of health states using the time trade-off approach
  
• Factors determining individuals’ health state valuations
  
• Collaborative development of the EUROQOLc EQ-5D instrument
  
• Patient preferences and risk perception in treatment of rheumatic disease
  
• Measuring and valuing quality of life in visual impairment
  
• Mapping of disease specific measures to utilities
  
• Use of conjoint analysis of patient and public preferences

Hospital management

• Evaluation of Resource Management in the six acute hospital pilot sites
  
• Analysis of structure to involve service providers in management
  
• Studies of role and value of IT systems in health service management

Pharmaceutical studies

• Costs of acute myocardial infarction (AMI) and cost-effectiveness of tissue plasminogen activation (TPA)
  
• Economic evaluation of glyceryl trinitrate in the reduction of peripheral intravenous infusion failure
  
• Effects of patient charges on use of prescription medicines
  
• Large, long-term international RCT of early intervention with inhaled cortico-steroids in asthma
  
• Evaluation of fluconazole in the treatment of cryptococcal meningitis in AIDS patients
  
• Pre-pricing study of economics of new antiemetic agent
  International study evaluating a new product for end-stage congestive heart failure

Payback studies

• Assessing the Payback from Health R&D: from Ad Hoc Studies to Regular Monitoring
  
• Assessment of the Benefits from North Thames R&D
  
• Reviewing the long-term outcomes of ARC funded research
  
• Evaluation of the MRC Consumer Liaison Group
  
• Evaluation of the NHS R&D Implementation Methods Programme
  
• Examining the payback from basic or early clinical science
  
• Developing a method of Structured Cross-national Thematic Studies (SCTS) to assess the health research utilization and its impact on health, health equity, and socio-economic development ,particularly as related to utilization in policy-making
  
• Assessing the payback from Department of Health R&D