After graduating as a pharmacist in Portugal, I first became aware of endocrine disruption when I joined Prof. Kortenkamp’s group at the School of Pharmacy in London, as an Erasmus student in 1998. Since then, I have developed an interest in the effects of estrogens (both natural and man-made) and how exposure to such chemicals could have an impact on human health.
Currently, my research focuses on evaluating the effects of multi-component mixtures of estrogenic chemicals and their potential relationship with hormonal related diseases, in particular, breast cancer. I am interested in dissecting the mechanisms of action of steroidal estrogens and estrogen-like chemicals in breast development, carcinogenesis and tumour progression, in order to study the potential link between estrogenicity and cancer both at cellular and tissue level.
2009-2011: Postgraduate Certificate in Learning and Teaching. School of Hygiene and Tropical Medicine, University of London
1999–2003: PhD in Environmental Toxicology Thesis title: Understanding the mechanisms underlying the joint action of xenoestrogens. School of Pharmacy, University of London
1992–1998: Licenciatura in Pharmaceutical Sciences (Masters equivalent). First class degree. Faculty of Pharmacy, University of Porto, Portugal
2011-present: Lecturer in Human Toxicology. Institute for the Environment, Brunel University
2007–2011: Lecturer in Toxicology. School of Pharmacy, University of London
2003–2007: Postdoctoral Research Fellow. School of Pharmacy, University of London
1999–2004: Teaching Assistant. School of Pharmacy, University of London
Newest selected publications
Corda, G., Sala, G., Lattanzio, R., Iezzi, M., Sallese, M., Fragassi, G., (2016) 'Functional and prognostic significance of the genomic amplification of frizzled receptor 6 ( FZD6 ) in breast cancer'. The Journal of Pathology. ISSN: 0022-3417 Open Access Linket al.
Gérard, C., Mestdagt, M., Tskitishvili, E., Communal, L., Gompel, A., Silva, E., (2015) 'Combined estrogenic and anti-estrogenic properties of estetrol on breast cancer may provide a safe therapeutic window for the treatment of menopausal symptoms'. Oncotarget, 6 (19). pp. 17621 - 17636.et al.
Scholze, M., Silva, E. and Kortenkamp, A. (2014) 'Extending the applicability of the dose addition model to the assessment of chemical mixtures of partial agonists by using a novel toxic unit extrapolation method'. PLoS ONE, 9 (2).Open Access Link
Riverso, M., Kortenkamp, A. and Silva, E. (2014) 'Non-tumorigenic epithelial cells secrete MCP-1 and other cytokines that promote cell division in breast cancer cells by activating ERα via PI3K/Akt/mTOR signaling'. International Journal of Biochemistry and Cell Biology, 53. pp. 281 - 294. ISSN: 1357-2725 Open Access Link
Da Silva, DD., Silva, E., Carvalho, F. and Carmo, H. (2014) 'Mixtures of 3,4-methylenedioxymethamphetamine (ecstasy) and its major human metabolites act additively to induce significant toxicity to liver cells when combined at low, non-cytotoxic concentrations'. Journal of Applied Toxicology, 34 (6). pp. 618 - 627. ISSN: 0260-437X