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Dr Elisabete Silva

Dr Elisabete Silva
Senior Lecturer In Human Toxicology

Summary

After graduating as a pharmacist in Portugal, I first became aware of endocrine disruption when I joined Prof. Kortenkamp’s group at the School of Pharmacy in London, as an Erasmus student in 1998. Since then, I have developed an interest in the effects of estrogens (both natural and man-made) and how exposure to such chemicals could have an impact on human health.

Currently, my research focuses on evaluating the effects of multi-component mixtures of estrogenic chemicals and their potential relationship with hormonal related diseases, in particular, breast cancer. I am interested in dissecting the mechanisms of action of steroidal estrogens and estrogen-like chemicals in breast development, carcinogenesis and tumour progression, in order to study the potential link between estrogenicity and cancer both at cellular and tissue level.

Qualifications

2009-2011: Postgraduate Certificate in Learning and Teaching. School of Hygiene and Tropical Medicine, University of London

1999–2003: PhD in Environmental Toxicology Thesis title: Understanding the mechanisms underlying the joint action of xenoestrogens. School of Pharmacy, University of London

1992–1998: Licenciatura in Pharmaceutical Sciences (Masters equivalent). First class degree. Faculty of Pharmacy, University of Porto, Portugal

Career

2011-present: Lecturer in Human Toxicology. Institute for the Environment, Brunel University

2007–2011: Lecturer in Toxicology. School of Pharmacy, University of London

2003–2007: Postdoctoral Research Fellow. School of Pharmacy, University of London

1999–2004: Teaching Assistant. School of Pharmacy, University of London

Newest selected publications

Corda, G., Sala, G., Lattanzio, R., Iezzi, M., Sallese, M., Fragassi, G., et al. (2016) 'Functional and prognostic significance of the genomic amplification of frizzled receptor 6 ( FZD6 ) in breast cancer'. The Journal of Pathology. ISSN: 0022-3417 Open Access Link

Journal article

Gérard, C., Mestdagt, M., Tskitishvili, E., Communal, L., Gompel, A., Silva, E., et al. (2015) 'Combined estrogenic and anti-estrogenic properties of estetrol on breast cancer may provide a safe therapeutic window for the treatment of menopausal symptoms'. Oncotarget, 6 (19). pp. 17621 - 17636.

Journal article

Da Silva, DD., Silva, E., Carvalho, F. and Carmo, H. (2014) 'Mixtures of 3,4-methylenedioxymethamphetamine (ecstasy) and its major human metabolites act additively to induce significant toxicity to liver cells when combined at low, non-cytotoxic concentrations'. Journal of Applied Toxicology, 34 (6). pp. 618 - 627. ISSN: 0260-437X

Journal article

Da Silva, DD., Silva, E. and Carmo, H. (2014) 'Combination effects of amphetamines under hyperthermia - the role played by oxidative stress'. Journal of Applied Toxicology, 34 (6). pp. 637 - 650. ISSN: 0260-437X

Journal article
More publications(23)