Dr Alessandro Esposito
Lecturer in Biosciences (Epigenetics)

Research Interests

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Our research focuses on understanding how networks of biochemical reactions control cellular decisions and maintain tissue homeostasis. We investigate how oncogenes contribute to early tumour initiation and promotion by reprogramming these fundamental cellular processes. Key areas of study include checkpoint signalling, the DNA damage response (DDR), and oncogenic signalling, with a particular interest in the heterogeneity of cellular responses within a population. We are currently studying KRAS signalling in the context of pancreatic and colorectal cancers.

To achieve this, we are dedicated to establishing a 'live single-cell systems biology' approach, which involves a transdisciplinary programme (nicknamed Systems Microscopy or SysMic) aimed at overcoming technological barriers to study biochemistry in living cells. This involves combining expertise from Optogenetics, Biophotonics, Theoretical Physics, Applied Mathematics, and Cancer Biology. Our ultimate goal is to translate the knowledge and technologies developed to improve early cancer detection and intervention.

Additionally, we are developing a new research line in Space Biology, investigating the effects of microgravity on cellular signalling and epigenetics, with a specific focus on pharmacological responses and cancer. We also aim to innovate technological solutions for studying biology in microgravity environments.

Grants