Dr Steven Smith
Senior Lecturer in Biomedical Sciences
Heinz Wolff 132
- Email: steven.smith@brunel.ac.uk
- Tel: +44 (0)1895 268956
Smith, SG., Bowness, R. and Cliff, JM. (2025) 'Host-directed therapy in diabetes and tuberculosis comorbidity toward global tuberculosis elimination'. International Journal of Infectious Diseases, 155. pp. 1 - 8. ISSN: 1201-9712 Open Access Link
Musvosvi, M., Huang, H., Wang, C., Xia, Q., Rozot, V., Krishnan, A., et al. (2023) 'T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection'. Nature Medicine, 29 (1). pp. 258 - 269. ISSN: 1078-8956 Open Access Link
Meier, S., Seddon, JA., Maasdorp, E., Kleynhans, L., du Plessis, N., Loxton, AG., et al. (2022) 'Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis'. PLoS ONE, 17 (12). pp. 1 - 24. ISSN: 1932-6203 Open Access Link
Bitencourt, J., Peralta-Álvarez, MP., Wilkie, M., Jacobs, A., Wright, D., Salman Almujri, S., et al. (2022) 'Induction of Functional Specific Antibodies, IgG-Secreting Plasmablasts and Memory B Cells Following BCG Vaccination'. Frontiers in Immunology, 12. pp. 1 - 1. ISSN: 1664-3224 Open Access Link
Kimuda, SG., Andia-Biraro, I., Sebina, I., Egesa, M., Nalwoga, A., Smith, SG., et al. (2020) 'Mycobacterium tuberculosis infection is associated with increased B cell responses to unrelated pathogens'. Scientific Reports, 10 (1). pp. 1 - 11. ISSN: 2045-2322 Open Access Link
Pérez-Hernández, CA., Kern, CC., Butkeviciute, E., McCarthy, E., Dockrell, HM., Moreno-Altamirano, MMB., et al. (2020) 'Mitochondrial Signature in Human Monocytes and Resistance to Infection in C. elegans During Fumarate-Induced Innate Immune Training'. Frontiers in Immunology, 11. pp. 1715. ISSN: 1664-3224 Open Access Link
Lubyayi, L., Mawa, PA., Nabakooza, G., Nakibuule, M., Tushabe, JV., Serubanja, J., et al. (2020) 'Maternal Latent Mycobacterium tuberculosis Does Not Affect the Infant Immune Response Following BCG at Birth: An Observational Longitudinal Study in Uganda'. Frontiers in Immunology, 11. pp. 929. ISSN: 1664-3224 Open Access Link
Prabowo, SA., Smith, SG., Seifert, K. and Fletcher, HA. (2019) 'Impact of individual-level factors on Ex vivo mycobacterial growth inhibition: Associations of immune cell phenotype, cytomegalovirus-specific response and sex with immunity following BCG vaccination in humans'. Tuberculosis, 119. pp. 101876 - 101876. ISSN: 1472-9792
Prabowo, SA., Painter, H., Zelmer, A., Smith, SG., Seifert, K., Amat, M., et al. (2019) 'RUTI vaccination enhances inhibition of mycobacterial growth ex vivo and induces a shift of monocyte phenotype in mice'. Frontiers in Immunology, 10 (APR). pp. 894. ISSN: 1664-3224 Open Access Link
Lee, H., Kim, J., Kang, YA., Kim, DR., Sim, B., Zelmer, A., et al. (2019) 'In vitro Mycobacterial Growth Inhibition in South Korean Adults With Latent TB Infection'. Frontiers in Immunology, 10 (APR). pp. 896. ISSN: 1664-3224 Open Access Link
Duffy, FJ., Weiner, J., Hansen, S., Tabb, DL., Suliman, S., Thompson, E., et al. (2019) 'Immunometabolic signatures predict risk of progression to active tuberculosis and disease outcome'. Frontiers in Immunology, 10 (MAR). pp. 1 - 16. ISSN: 1664-3224 Open Access Link
Tanner, R., Smith, SG., van Meijgaarden, KE., Giannoni, F., Wilkie, M., Gabriele, L., et al. (2019) 'Optimisation, harmonisation and standardisation of the direct mycobacterial growth inhibition assay using cryopreserved human peripheral blood mononuclear cells'. Journal of Immunological Methods, 469. pp. 1 - 10. ISSN: 0022-1759 Open Access Link
Weiner, J., Maertzdorf, J., Sutherland, JS., Duffy, FJ., Thompson, E., Suliman, S., et al. (2018) 'Metabolite changes in blood predict the onset of tuberculosis'. Nature Communications, 9 (1). pp. 1 - 12. ISSN: 2041-1723 Open Access Link
O’Shea, MK., Tanner, R., Müller, J., Harris, SA., Wright, D., Stockdale, L., et al. (2018) 'Immunological correlates of mycobacterial growth inhibition describe a spectrum of tuberculosis infection'. Scientific Reports, 8 (1). pp. 14480. ISSN: 2045-2322 Open Access Link
Hasso-Agopsowicz, M., Scriba, TJ., Hanekom, WA., Dockrell, HM. and Smith, SG. (2018) 'Differential DNA methylation of potassium channel KCa3.1 and immune signalling pathways is associated with infant immune responses following BCG vaccination'. Scientific Reports, 8 (1). pp. 13086. ISSN: 2045-2322 Open Access Link
Butkeviciute, E., Jones, CE. and Smith, SG. (2018) 'Heterologous effects of infant BCG vaccination: potential mechanisms of immunity'. Future Microbiology, 13 (10). pp. 1193 - 1208. ISSN: 1746-0913 Open Access Link
Smith, SG., Kleinnijenhuis, J., Netea, MG. and Dockrell, HM. (2017) 'Whole Blood Profiling of Bacillus Calmette–Guérin-Induced Trained Innate Immunity in Infants Identifies Epidermal Growth Factor, IL-6, Platelet-Derived Growth Factor-AB/BB, and Natural Killer Cell Activation'. Frontiers in Immunology, 8. pp. 644. ISSN: 1932-6203 Open Access Link
Dockrell, HM. and Smith, SG. (2017) 'What have we learnt about BCG vaccination in the last 20 years?'. Frontiers in Immunology, 8 (SEP). pp. 1134. ISSN: 1664-3224 Open Access Link
Smith, SG., Zelmer, A., Blitz, R., Fletcher, HA. and Dockrell, HM. (2016) 'Polyfunctional CD4 T-cells correlate with in vitro mycobacterial growth inhibition following Mycobacterium bovis BCG-vaccination of infants'. Vaccine, 34 (44). pp. 5298 - 5305. ISSN: 0264-410X Open Access Link
Biraro, IA., Egesa, M., Kimuda, S., Smith, SG., Toulza, F., Levin, J., et al. (2015) 'Effect of isoniazid preventive therapy on immune responses to mycobacterium tuberculosis: An open label randomised, controlled, exploratory study'. BMC Infectious Diseases, 15 (1). pp. 438. ISSN: 1471-2334
Smith, SG., Smits, K., Joosten, SA., Van Meijgaarden, KE., Satti, I., Fletcher, HA., et al. (2015) 'Intracellular cytokine staining and flow cytometry: Considerations for application in clinical trials of novel tuberculosis vaccines'. Plos One, 10 (9). pp. e0138042 - e0138042. ISSN: 1932-6203
Biraro, IA., Egesa, M., Toulza, F., Levin, J., Cose, S., Joloba, M., et al. (2014) 'Impact of co-infections and BCG immunisation on immune responses Among household contacts of tuberculosis patients in a ugandan cohort'. Plos One, 9 (11). pp. e111517 - e111517. ISSN: 1932-6203
Sebina, I., Cliff, JM., Smith, SG., Nogaro, S., Webb, EL., Riley, EM., et al. (2012) 'Long-Lived Memory B-Cell Responses following BCG Vaccination'. Plos One, 7 (12). pp. e51381 - e51381. ISSN: 1932-6203
Lalor, MK., Floyd, S., Gorak-Stolinska, P., Ben-Smith, A., Weir, RE., Smith, SG., et al. (2011) 'BCG vaccination induces different cytokine profiles following infant BCG vaccination in the UK and Malawi'. Journal of Infectious Diseases, 204 (7). pp. 1075 - 1085. ISSN: 0022-1899
Smith, SG., Lalor, MK., Gorak-Stolinska, P., Blitz, R., Beveridge, NER., Worth, A., et al. (2010) 'Mycobacterium tuberculosis PPD-induced immune biomarkers measurable in vitro following BCG vaccination of UK adolescents by multiplex bead array and intracellular cytokine staining'. BMC Immunology, 11 (1). pp. 35 - 35. ISSN: 1471-2172
Lalor, MK., Smith, SG., Floyd, S., Gorak-Stolinska, P., Weir, RE., Blitz, R., et al. (2010) 'Complex cytokine profiles induced by BCG vaccination in UK infants'. Vaccine, 28 (6). pp. 1635 - 1641. ISSN: 0264-410X
Smith, SG., Joosten, SA., Verscheure, V., Pathan, AA., McShane, H., Ottenhoff, TH., et al. (2009) 'Identification of major factors influencing ELISpot-based monitoring of cellular responses to antigens from Mycobacterium tuberculosis.'. PLoS One, 4 (11). pp. e7972 - e7972. ISSN: 1932-6203 Open Access Link
May, YL., Geluk, A., Smith, SG., Stewart, AL., Friggen, AH., Franken, KLMC., et al. (2007) 'Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination'. Infection and Immunity, 75 (7). pp. 3523 - 3530. ISSN: 0019-9567