I have been at Brunel University London since the start of this century. This is when I established my own independent laboratory - The Laboratory of Nuclear and Genomic Health. Our research concerns how the genome is spatially organised, influenced and manipulated within its environment, the cell nucleus. The group has had a number of major advances and is currently focused on aspects of genome behaviour in replicative senescence, the premature ageing disease Hutchinson-Gilford Progeria Syndrome, host:pathogen interactions and female cancers. We are wish to understand how structures such as the nuclear lamina, nucleoskeleton and nuclear motors influence the functionality of the genome.
I also teach Cell Biology at levels 2 and 3, Developmental Biology at level 2, Gene Expression and Epigenetics and Cellular and Organismal Ageing at Masters level. The lab is always full of PhD, Masters and undergraduate students doing their various projects.
I am also the Head of the Genome Engineering and Maintenance network established from the depth and interest in Genome Biology that has developed over time in Biosciences at Brunel. My other role is External Engagement where I organise all the external interactions we have in our division
Head of Genome Engineering and Mainenance Network
Module Coordinator for Gene Expression and Epigenetics Module
Newest selected publications
Bridger, JM., Arican-Goktas, HD. and Jobling, S. (2017) 'Whole genome analysis of a schistosomiasis-transmitting freshwater snail'. Nature Communications, 8. ISSN: 2041-1723 Open Access Link
Knight, M., Ittiprasert, W., Arican-Goktas, HD. and Bridger, JM. (2016) 'Epigenetic modulation, stress and plasticity in susceptibility of the snail host, Biomphalaria glabrata, to Schistosoma mansoni infection'. International Journal for Parasitology. ISSN: 0020-7519 Open Access Link
Gillespie, ZE., Mackay, K., Sander, M., Trost, B., Dawicki, W., Wickramarathna, A., (2015) 'Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/ B-mediated cytokine production'. Nucleus, 6 (6). pp. 490 - 506. ISSN: 1949-1034et al.
Arican-Goktas, HD., Ittiprasert, W., Bridger, JM. and Knight, M. (2014) 'Differential spatial repositioning of activated genes in Biomphalaria glabrata snails infected with Schistosoma mansoni'. PLoS Neglected Tropical Diseases, 8 (9). pp. e3013 - e3013. ISSN: 1935-2735 Open Access Link
Bridger, JM., Arican-Gotkas, HD., Foster, HA., Godwin, LS., Harvey, A., Kill, IR., (2014) 'The non-random repositioning of whole chromosomes and individual gene loci in interphase nuclei and its relevance in disease, infection, aging, and cancer'. Advances in Experimental Medicine and Biology, 773. pp. 263 - 279. ISSN: 0065-2598 Open Access Linket al.