I have been at Brunel University London since the start of this century. This is when I established my own independent laboratory - The Laboratory of Nuclear and Genomic Health. Our research concerns how the genome is spatially organised, influenced and manipulated within its environment, the cell nucleus. The group has had a number of major advances and is currently focused on aspects of genome behaviour in replicative senescence, the premature ageing disease Hutchinson-Gilford Progeria Syndrome, host:pathogen interactions and female cancers. We are wish to understand how structures such as the nuclear lamina, nucleoskeleton and nuclear motors influence the functionality of the genome.
I also teach Cell Biology at levels 2 and 3, Developmental Biology at level 2, Gene Expression and Epigenetics and Cellular and Organismal Ageing at Masters level. The lab is always full of PhD, Masters and undergraduate students doing their various projects.
I am also the Head of the Genome Engineering and Maintenance network established from the depth and interest in Genome Biology that has developed over time in Biosciences at Brunel. My other role is External Engagement where I organise all the external interactions we have in our division
Head of Genome Engineering and Mainenance Network
Module Coordinator for Gene Expression and Epigenetics Module
Newest selected publications
Bikkul, MU., Clements, CS., Godwin, LS., Goldberg, MW., Kill, IR. and Bridger, JM. (2018) 'Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson-Gilford progeria syndrome fibroblasts.'. Biogerontology. pp. 1 - 24. ISSN: 1389-5729 Open Access Link
Adema, CM., Hillier, LW., Jones, CS., Loker, ES., Knight, M., Minx, P., (2017) 'Whole genome analysis of a schistosomiasis-transmitting freshwater snail.'. Nat Commun, 8. pp. 15451. ISSN: 2041-1723 Open Access Linket al.
Mitta, G., Gourbal, B., Grunau, C., Knight, M., Bridger, JM. and Théron, A. (2017) 'The Compatibility Between Biomphalaria glabrata Snails and Schistosoma mansoni: An Increasingly Complex Puzzle.'. Adv Parasitol, 97. pp. 111 - 145. ISSN: 0065-308X Open Access Link
Knight, M., Ittiprasert, W., Arican-Goktas, HD. and Bridger, JM. (2016) 'Epigenetic modulation, stress and plasticity in susceptibility of the snail host, Biomphalaria glabrata, to Schistosoma mansoni infection.'. Int J Parasitol, 46 (7). pp. 389 - 394. ISSN: 0020-7519 Open Access Link
Rinaldi, G., Yan, H., Nacif-Pimenta, R., Matchimakul, P., Bridger, J., Mann, VH., (2015) 'Cytometric analysis, genetic manipulation and antibiotic selection of the snail embryonic cell line Bge from Biomphalaria glabrata, the intermediate host of Schistosoma mansoni.'. Int J Parasitol, 45 (8). pp. 527 - 535. ISSN: 0020-7519et al.