Joanna Bridger

Summary

Research

Teaching/Supervision

Teaching

Teaching Responsibilities:

  • Cellular Pathologies (Level 3)
  • Professional Skills (Level 2)
  • Final Year Projects (Level 3)
  • Masters dissertations (M-level)

Other Teaching Responsibilities:

Module coordinator

  • Genetics and Development (Level 2)
  • Clinical Cytogenetics (M-level)
  • Clinical Cytogenetics and Cancer

Selected Publications

Journal articles

Knight, M. , Ittiprasert, W. , Arican-Goktas, HD.  and Bridger, JM.   (2016)   'Epigenetic modulation, stress and plasticity in susceptibility of the snail host, Biomphalaria glabrata, to Schistosoma mansoni infection'. International Journal for Parasitology. doi: 10.1016/j.ijpara.2016.03.003 Download publication 

Gillespie, ZE. , Mackay, K. , Sander, M. , Trost, B. , et al.   (2015)   'Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/ B-mediated cytokine production'. Nucleus, 6 (6).  pp. 490 - 506. doi: 10.1080/19491034.2015.1128610 

Rinaldi, G. , Yan, H. , Nacif-Pimenta, R. , Matchimakul, P. , et al.   (2015)   'Cytometric analysis, genetic manipulation and antibiotic selection of the snail embryonic cell line Bge from Biomphalaria glabrata, the intermediate host of Schistosoma mansoni.'. International Journal of Parasitology Research, 45 (8).  pp. 527 - 535. Download publication 

Arican-Goktas, HD. , Ittiprasert, W. , Bridger, JM.  and Knight, M.   (2014)   'Differential spatial repositioning of activated genes in Biomphalaria glabrata snails infected with Schistosoma mansoni'. PLoS Neglected Tropical Diseases, 8 (9).  pp. e3013 - e3013. doi: 10.1371/journal.pntd.0003013 Download publication 

Knight, M. , Arican-Goktas, HD. , Ittiprasert, W. , Odoemelam, EC. , et al.   (2014)   'Schistosomes and snails: A molecular encounter'. Frontiers in Genetics, 5 doi: 10.3389/fgene.2014.00230 Download publication 

Bridger, JM. , Arican-Gotkas, HD. , Foster, HA. , Godwin, LS. , et al.   (2014)   'The non-random repositioning of whole chromosomes and individual gene loci in interphase nuclei and its relevance in disease, infection, aging, and cancer'. Advances in Experimental Medicine and Biology, 773 pp. 263 - 279. doi: 10.1007/978-1-4899-8032-8-12 Download publication 

Foster, HA. , Estrada-Girona, G. , Themis, M. , Garimberti, E. , et al.   (2013)   'Relative proximity of chromosome territories influences chromosome exchange partners in radiation-induced chromosome rearrangements in primary human bronchial epithelial cells'. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 756 (1-2).  pp. 66 - 77. doi: 10.1016/j.mrgentox.2013.06.003 Download publication 

Wazir, U. , Sharma, AK. , Mokbel, K. , Ahmed, MH. , et al.   (2013)   'The clinicopathological significance of lamin A/C, lamin B1 and lamin B receptor mRNA expression in human breast cancer'. Cellular and Molecular Biology Letters. pp. 1 - 17. doi: 10.2478/s11658-013-0109-9 Download publication 

Adema, CM. , Bayne, CJ. , Bridger, JM. , Knight, M. , et al.   (2012)   'Will all scientists working on snails and the diseases they transmit please stand up?'. PLoS Neglected Tropical Diseases, 6 (12).  pp. . doi: 10.1371/journal.pntd.0001835 Download publication 

Foster, HA. , Griffin, DK.  and Bridger, JM.   (2012)   'Interphase chromosome positioning in in vitro porcine cells and ex vivo porcine tissues'. BMC Cell Biology, 13 doi: 10.1186/1471-2121-13-30 Download publication 

Knight, M. , Ittiprasert, W. , Odoemelam, EC. , Adema, CM. , et al.   (2011)   'Non-random organization of the Biomphalaria glabrata genome in interphase Bge cells and the spatial repositioning of activated genes in cells co-cultured with Schistosoma mansoni'. International Journal for Parasitology, 41 (1).  pp. 61 - 70. doi: 10.1016/j.ijpara.2010.07.015 Download publication 

Bridger, JM.   (2011)   'Chromobility: the rapid movement of chromosomes in interphase nuclei'. Biochemical Society Transactions, 39 (6).  pp. 1747 - 1751. doi: 10.1042/BST20110696 Download publication 

Bridger, JM. , Eskiw, CH. , Makarov, EM. , Tree, D.  and Kill, IR.   (2011)   'Progeria Research Day at Brunel University'. Nucleus, 2 (6).  pp. 1 - 6. 

Mehta, IS. , Arican, HD. , Eskiw, CH. , Kill, IR.  and Bridger, JM.   (2011)   'Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford Progeria syndrome cells.'. Genome Biology: biology for the post-genomic era, 12 (8).  doi: 10.1186/gb-2011-12-8-r74 Download publication 

Szczerbal, I.  and Bridger, JM.   (2010)   'Association of adipogenic genes with SC-35 domains during porcine adipogenesis'. Chromosome Research: the international journal for all aspects of chromosome and nuclear biology, 18 (8).  pp. 887 - 895. doi: 10.1007/s10577-010-9176-1 

Stimpson, KM. , Song, IY. , Jauch, A. , Holtgreve-Grez, H. , et al.   (2010)   'Telomere disruption results in non-random formation of De Novo dicentric chromosomes involving acrocentric human chromosomes'. PLOS Genetics, 6 (8).  doi: 10.1371/journal.pgen.1001061 Download publication 

Mehta, IS. , Amira, M. , Harvey, AJ.  and Bridger, JM.   (2010)   'Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts'. Genome Biology, 11 (1).  doi: 10.1186/gb-2010-11-1-r5 Download publication 

Mehta, IS. , Bridger, JM.  and Kill, IR.   (2010)   'Progeria, the nucleolus and farnesyltransferase inhibitors.'. Biochem Soc Trans, 38 (Pt 1).  pp. 287 - 291. doi: 10.1042/BST0380287 

Elcock, LS.  and Bridger, JM.   (2010)   'Exploring the relationship between interphase gene positioning, transcriptional regulation and the nuclear matrix.'. Biochem Soc Trans, 38 (Pt 1).  pp. 263 - 267. doi: 10.1042/BST0380263 

Odoemelam, E. , Raghavan, N. , Miller, A. , Bridger, JM.  and Knight, M.   (2009)   'Revised karyotyping and gene mapping of the Biomphalaria glabrata embryonic (Bge) cell line'. International Journal for Parasitology, 39 (6).  pp. 675 - 681. doi: 10.1016/j.ijpara.2008.11.011 Download publication 

Szczerbal, I. , Foster, HA.  and Bridger, JM.   (2009)   'The spatial repositioning of adipogenesis genes is correlated with their expression status in a porcine mesenchymal stem cell adipogenesis model system'. Chromosoma: biology of the nucleus, 118 (5).  pp. 647 - 663. doi: 10.1007/s00412-009-0225-5 

Meaburn, KJ. , Newbold, RF.  and Bridger, JM.   (2008)   'Positioning of human chromosomes in murine cell hybrids according to synteny'. Chromosoma, 117 (6).  pp. 579 - 591. doi: 10.1007/s00412-008-0175-3 Download publication 

Mehta, IS. , Elcock, LS. , Amira, M. , Kill, IR.  and Bridger, JM.   (2008)   'Nuclear motors and nuclear structures containing A-type lamins and emerin: is there a functional link?'. Biochemical Society Transactions, 36 (Part 6).  pp. 1384 - 1388. doi: 10.1042/BST0361384 

Beard, GS. , Bridger, JM. , Kill, IR.  and Tree, DR.   (2008)   'Towards a Drosophila model of Hutchinson-Gilford progeria syndrome'. Biochemical Society Transactions, 36 (Part 6).  pp. 1389 - 1392. doi: 10.1042/BST0361389 

Szczerbal, I. , Foster, HA.  and Bridger, JM.   (2008)   'Changes in gene position in interphase during porcine adipogenesis are correlated with changes in gene expression (Abstract)'. Chromosome Research, 16 (7).  pp. 1033 - 1034. doi: 10.1007/s10577-008-1922-2 

Elcock, LS.  and Bridger, JM.   (2008)   'Exploring the effects of a dysfunctional nuclear matrix'. Biochemical Society Transactions, 36 (Part 6).  pp. 1378 - 1383. doi: 10.1042/BST0361378 

Volpi, EV.  and Bridger, JM.   (2008)   'FISH glossary: an overview of the fluorescence in situ hybridization technique'. BioTechniques, 45 (4).  pp. 385 - 409. doi: 10.2144/000112811 

Mehta, IS. , Figgitt, M. , Clements, CS. , Kill, IR.  and Bridger, JM.   (2007)   'Alterations to nuclear architecture and genome behavior in senescent cells'. Annals of the New York Academy of Sciences, 1100 (Biogerontology Mechanisms and Interventions).  pp. 250 - 263. doi: 10.1196/annals.1395.027 

Meaburn, KJ. , Cabuy, E. , Bonne, G. , Levy, N. , et al.   (2007)   'Primary laminopathy fibroblasts display altered genome organization and apoptosis'. Aging Cell, 6 (2).  pp. 139 - 153. doi: 10.1111/j.1474-9726.2007.00270.x 

Bridger, JM. , Foeger, N. , Kill, IR.  and Herrmann, H.   (2007)   'The nuclear lamina. Both a structural framework and a platform for genome organization'. FEBS Journal, 274 (6).  pp. 1354 - 1361. doi: 10.1111/j.1742-4658.2007.05694.x 

Foster, HA. , Stokes, P. , Forsey, K. , Leese, HJ.  and Bridger, JM.   (2007)   'Lamins A and C are present in the nuclei of early porcine embryos, with lamin A being distributed in large intranuclear foci'. Chromosome Research, 15 (2).  pp. 163 - 174. doi: 10.1007/s10577-006-1088-8 

Foster, HA. , Abeydeera, LR. , Griffin, DK.  and Bridger, JM.   (2005)   'Non-random chromosome positioning in mammalian sperm nuclei, with migration of the sex chromosomes during late spermatogenesis'. Journal of Cell Science, 118 (9).  pp. 1811 - 1820. doi: 10.1242/jcs.02301 Download publication 

Foster, HA.  and Bridger, JM.   (2005)   'The genome and the nucleus: A marriage made by evolution - Genome organisation and nuclear architecture'. Chromosoma, 114 (4).  pp. 212 - 229. doi: 10.1007/s00412-005-0016-6 

Meaburn, KJ. , Parris, CN.  and Bridger, JM.   (2005)   'The manipulation of chromosomes by mankind: The uses of microcell-mediated chromosome transfer'. Chromosoma, 114 (4).  pp. 263 - 274. doi: 10.1007/s00412-005-0014-8 

Meaburn, KJ. , Levy, N. , Toniolo, D.  and Bridger, JM.   (2005)   'Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations'. Biochemical Society Transactions, 33 (Part 6).  pp. 1438 - 1440. doi: 10.1042/BST20051438 Download publication 

Bridger, JM.   (2004)   'Mammalian artificial chromosomes: modern day feats of engineering - Isambard Kingdom Brunel style'. Cytogenetic and Genome Research, 107 (1-2).  pp. 5 - 8. doi: 10.1159/000079563 

Bridger, JM.  and Kill, IR.   (2004)   'Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis'. Experimental Gerontology, 39 (5).  pp. 717 - 724. doi: 10.1016/j.exger.2004.02.002 Download publication 

Boyle, S. , Gilchrist, S. , Bridger, JM. , Mahy, NL. , et al.   (2001)   'The spatial organization of human chromosomes within the nuclei of normal and emerin-mutant cells'. Human Molecular Genetics, 10 (3).  pp. 211 - 219. doi: 10.1093/hmg/10.3.211 Download publication 

Sullivan, GJ. , Bridger, JM. , Cuthbert, AP. , Newbold, RF. , et al.   (2001)   'Human acrocentric chromosomes with transcriptionally silent nucleolar organiser regions associate with nucleoli'. European Molecular Biology Organization, 20 (11).  pp. 2867 - 2877. doi: 10.1093/emboj/20.11.2867 Download publication 

Vaughan, OA. , Alvarez-Reyes, M. , Bridger, JM. , Broers, JLV. , et al.   (2001)   'Both emerin and lamin C depend on lamin A for localization at the nuclear envelope'. Journal of Cell Science, 114 (14).  pp. 2577 - 2590. Download publication 

Bridger, JM. , Boyle, S. , Kill, IR.  and Bickmore, WA.   (2000)   'Re-modelling of nuclear architecture in quiescent and senescent human fibroblasts'. Current Biology, 10 (3).  pp. 149 - 152. doi: 10.1016/S0960-9822(00)00312-2 

Bickmore, WA.  and Bridger, JM.   (1999)   'A sense of time and place: Meeting report ofHUGO spatial organisation of the genome workshop, Edinburgh, 14-15 May 1999'. Chromosome Research, 7 (6).  pp. 425 - 429. doi: 10.1023/A:1009289511800 

Croft, JA. , Bridger, JM. , Boyle, S. , Perry, P. , et al.   (1999)   'Differences in the localization and morphology of chromosomes in the human nucleus'. Journal of Cell Biology, 145 (6).  pp. 1119 - 1131. Download publication 

King, JA. , Bridger, JM. , Gounari, F. , Lichter, P. , et al.   (1998)   'The extended packaging sequence of MoMLV contains a constitutive mRNA nuclear export function'. FEBS Letters, 434 (3).  pp. 367 - 371. doi: 10.1016/S0014-5793(98)00948-X 

Bridger, JM. , Kill, IR.  and Lichter, P.   (1998)   'Association of pKi-67 with satellite DNA of the human genome in early G(1) cells'. Chromosome Research, 6 (1).  pp. 13 - 24. doi: 10.1023/A:1009210206855 

Bridger, JM.  and Bickmore, WA.   (1998)   'Putting the genome on the map'. Trends in Genetics, 14 (10).  pp. 403 - 409. doi: 10.1016/S0168-9525(98)01572-8 Download publication 

Hutchison, CJ. , Bridger, JM. , Cox, LS.  and Kill, IR.   (1994)   'Weaving a pattern from disparate threads: lamin function in nuclear assembly and DNA replication'. Journal of Cell Science, 107 (12).  pp. 3259 - 3269. Download publication 

Bridger, JM. , Kill, IR. , O'Farrell, M.  and Hutchison, CJ.   (1993)   'Internal lamin structures within G1 nuclei of human dermal fibroblasts'. Journal of Cell Science, 104 (2).  pp. 297 - 306. Download publication 

Kill, IR. , Bridger, JM. , Campbell, KH. , Maldonado-Codina, G.  and Hutchison, CJ.   (1991)   'The timing of the formation and usage of replicase clusters in S-phase nuclei of human diploid fibroblasts'. Journal of Cell Science, 100 (4).  pp. 869 - 876. Download publication 

Books

Bridger, JM.  and Volpi, EV.   (2010) Fluorescence in situ hybridization (FISH).  Springer 

Book chapters

Odoemelam, EC. , Raghavan, N. , Ittiprasert, W. , Miller, A. , et al.  (2010)   'FISH on chromosomes derived from the snail model organism biomphalaria glabrata', in Bridger, JM.  and Volpi, EV. (eds.) Fluorescence in situ hybridization (FISH).  Springer (659)  

Knight, M. , Bridger, JM. , Ittiprasert, W. , Odoemelam, E. , et al.  (2007)   'Mobile genetic elements in metazoan parasites', in Brindley, PJ. (ed.) Mobile genetic elements in metazoan parasites.  Landes Bioscience pp. . Download publication 

Page last updated: Friday 08 April 2016