Centre for Genome Engineering and Maintenance

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About us

We are a community of scientists dedicated to unraveling the mysteries of the genome and applying this knowledge to improve human health and the world around us.

Our research expertise

Genome Organisation and Dynamics; Cancer Mechanisms; Disease and Therapeutics; Organ-on-a-Chip and Bioinformatics are just some of our expertise areas
chromosone dna

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Genome engineering and maintenance experts

Get in touch with the people behind our research
Joanna Bridger - Biosciences_opt (1)

Centre leader

Professor Joanna Bridger

Browse our research projects

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Illustration of molecules and viruses

Nuclear Pore Complex: the entry gate into the nucleus for molecules and viruses
A stylized, translucent mesh model of a brain

Preclinical efficacy of targeting enzymes for Friedreich’s ataxia treatment
A floating molecular model.

AI-driven data analysis and modelling of protein dynamics for drug discovery
A close-up image of a chromosome.

How do cells divide?
Cell culture flasks in laboratory incubator.

Xcell: Studying cells and tissue biochemistry in simulated microgravity
Close-up of microscope objectives with a blue light shining through one lens.

HiLIGHT: Revolutionising medical imaging with advanced laser technologies
Microscopic view on cells on a dark background.

Understanding laminopathies: Diseases of the cell nucleus
Precision laboratory work with glowing samples.

Investigating therapeutic effect of antioxidants in Friedreich’s Ataxia (FRDA)
Colourful fluorescent microscopy image showing cells with blue nuclei and green and red fluorescence.

Cellular senescence and its impact on organismal ageing
Fluorescent microscopic image showing cells with bright blue nuclei and green cytoplasm.

Investigating variations in two genes that increase the risk of bowel cancer
A woman bathing a child outdoors

How the Schistosoma mansoni parasite manipulates its hosts' genomes
3D illustration of x-chromosomes on a blue background thumbnail

Chromosome behaviour and dynamics after exposure to simulated microgravity
Digital histopathology image of microscope alongside computer with monitor showing a scan

Innovate photonic devices for digital histopathology
man in lab

Evaluation of oligonucleotides for therapy of Friedreich ataxia
disabled child in wheelchair

Identifying the most potent and effective treatment of Friedreich ataxia
dna strands

Side effects of gene therapy vectors
Protein phosphatase

The maintenance of genome integrity
mother holding a sick child

The role of CDCA2 molecule in neuroblastoma
microscope image

Genetic and cytogenetic family trio study
genetic research

Towards a therapy for Friedreich’s Ataxia
sphingolipid

Investigating the role of bioactive sphingolipids in Friedreich’s ataxia
microscope image of cells

Modelling infant leukaemia using gene editing technology
cells

Common genetic variants that increase the risk of cancer
cancer

Does CRISPR-Cas9 treatment cause DNA damage in cancer cells?
Biosciences

Modelling adenoid cystic carcinoma in a mouse
radiation screenshot

Radiation exposure and heritable genetic effects
biomedical equipment

Cell signalling aimed at regulating cell proliferation
dna strand

Aberrant genome organisation in female cancers
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